Clinical trials: Injury, Spinal Cord
SCI - Spinal Cord Injury
Effect of tSCS on Ankle Movement Training in Individuals With SCI
This clinical trial explores the effectiveness of transcutaneous spinal cord stimulation (tSCS), a non-invasive technique, in facilitating spinal circuitry adaptation in individuals with spinal cord injury (SCI).
- Trial name
- NCT06596174
- Testing
- Transcutaneous spinal cord stimulation (tSCS), Short-term Machine-Assisted Ankle Movement Training with tSCS, Long-term Effects of Machine-Assisted Ankle Movement Training with tSCS
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Spinal Cord Injury
Lokomat Versus Strength Training in Chronic Incomplete Spinal Cord Injury
The purpose of this pilot study is to investigate whether gait specific robotic supported bodyweight supported treadmill training and lower extremity strength training have similar beneficial effects on walking function and other…
- Trial name
- NCT01087918
- Testing
- RAGT, Strength Training
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- University of Zurich
Safety Issues
SVF Combined With Functional Self-assembling Peptide Nanofiber Hydrogels in the Treatment of Spinal Cord Injury
Traumatic spinal cord injury (SCI) is a severe medical problem experienced by people worldwide with high mortality and long term morbidity.
- Trial name
- NCT05967325
- Testing
- Stromal Vascular Fraction (SVF) combined with Functional self-assembling peptide nanofiber hydrogels
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Kunming Tongren Hospital
Spinal Cord Injury
Neurofeedback for Treatment of Central Neuropathic Pain (CNP) in Sub-acute Spinal Cord Injury (SCI)
Spinal Cord Injury (SCI) affects a person's ability to move and feel sensation in the body. SCI is also an indirect cause of a persistent pain, called Central Neuropathic Pain (CNP).
- Trial name
- NCT02178917
- Testing
- Neurofeedback therapy, No neurofeedback therapy
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Neuropathic Pain, Spinal Cord Injury
Brain Activity in People With Chronic Neuropathic Pain and Spinal Cord Injury
The purpose of this research study is to learn more about how patterns of brain activity change during different thinking tasks and how these changes relate to the intensity and unpleasantness of the neuropathic pain that people…
- Trial name
- NCT04386174
- Testing
- Neurofeedback
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Traumatic Cervical Acute Spinal Cord Injury
Pilot Study of the Neuro-Spinal Scaffold for the Treatment of AIS A Cervical Acute SCI
Pilot Study of Clinical Safety and Feasibility of the Neuro-Spinal ScaffoldTM for the Treatment of Complete (AIS A) Traumatic Acute Spinal Cord Injury at the C5-T1 Neurological Levels The purpose of this study is to support an…
- Trial name
- NCT03105882
- Testing
- Neuro-Spinal Scaffold
- Where
- Canada
- Sponsor
- InVivo Therapeutics
Neurologic Disorders, Spinal Cord Injury
Reliability and Validity of the PReFS
This study is testing the psychometric properties of a new tool to determine recommendations for pressure relief frequency in wheelchair users.
- Conditions
- Neurologic Disorders, Spinal Cord Injury, Stroke, Traumatic Brain Injury
- Trial name
- PReFS (NCT07280923)
- Testing
- Interview
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Baylor University
Acute Spinal Cord Injury (SCI), Spinal Cord Diseases
NG004 in Incomplete Spinal Cord Injury Patients
This is a randomized, double-blind, placebo controlled, multicenter trial of NG004 in patients with acute traumatic incomplete cervical SCI.
- Conditions
- Acute Spinal Cord Injury (SCI), Spinal Cord Diseases, Spinal Cord Injuries, Trauma Nervous System
- Trial name
- SPROUT-2 (NCT07840196)
- Testing
- NG004
- Where
- 10 sites in Germany, Switzerland
- Volunteers
- 120 people
- Sponsor
- NovaGo Therapeutics AG
Blindness, Spinal Cord Injury
Use of "Smart Wheelchairs" to Provide Independent Mobility to Visual and Mobility Impairments
The goal of this project is to evaluate the Smart Wheelchair Component System (SWCS) for power wheelchairs and the Smart Power Assistance Module (SPAM) for manual wheelchairs in realistic indoor environments with target users…
- Trial name
- NCT00333762
- Testing
- Smart Power Assistance Module (SPAM), Smart Wheelchair Component System (SWCS)
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
SCI - Spinal Cord Injury
Nutrition and Pain Study
The purpose of this research is to assess the effectiveness of a nutrition intervention on diet quality in managing pain in individuals with spinal cord injury (SCI).
- Trial name
- NCT07179588
- Testing
- Nutrition Education Program, Nutrition Counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Spinal Cord Injury
Spinal Cord Injury Series of Tampere - Retrospective Study
This prospective study will assess thoroughly functional deficits and their significance in the light of rehabilitation in spinal cord injured patients.
- Trial name
- scissors (NCT01421394)
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Tampere University Hospital
Spinal Cord Injury
Autologous Incubated Macrophages for Patients With Complete Spinal Cord Injuries
Autologous Incubated Macrophages (ProCord) is being developed as a therapy for acute, complete spinal cord injury (SCI). The therapy is intended to reverse the loss of motor and sensory function.
- Trial name
- NCT00073853
- Testing
- Autologous Incubated Macrophages (cell therapy)
- Where
- 7 sites in United States, Israel
- Volunteers
- 61 people
- Sponsor
- Proneuron Biotechnologies
Spinal Cord Injury
Cardiovascular Health/Outcomes: Improvements Created by Exercise and Education in SCI (CHOICES)
This study aims to determine whether body weight-supported treadmill training (BWSTT) has beneficial effects, over and above arm-cycle ergometry training (ACET) on indicators of cardiovascular disease (CVD) risk in individuals…
- Trial name
- CHOICES (NCT01718977)
- Testing
- Body Weight Supported Treadmill Training, Arm Cycle Ergometry Training
- Where
- 3 sites in Canada
- Volunteers
- 46 people
- Sponsor
- University of British Columbia
Spinal Cord Injury
Safety Study of Local Administration of Autologous Bone Marrow Stromal Cells in Chronic Paraplegia
The purpose of this study is to confirm the security, and detect the effect of the local administration in damaged nervous tissue, of autologous bone marrow stromal cells.
- Trial name
- CME-LEM1 (NCT01909154)
- Testing
- Mesenchymal stromal cell therapy
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Puerta de Hierro University Hospital
Lipid Metabolism Disorders, Peroxidase; Defect
Omega 3 in Intervention Spinal Cord Injured People
The objective of this study is to evaluate the effect of omega 3 fatty acid on neurological recovery, lipid profile and Antioxidant system in patients with spinal cord injury.
- Trial name
- NCT01311375
- Testing
- w3 supplement in SCI
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Spinal Cord Injuries, Constipation
Neostigmine and Glycopyrrolate by Iontophoresis
To determine a lower effective dose of neostigmine to induce bowel evacuation by transcutaneous administration by iontophoresis.
- Conditions
- Spinal Cord Injuries, Constipation, Fecal Incontinence, Neurogenic Bowel
- Trial name
- NCT06351995
- Testing
- Combination of Neostigmine and Glycopyrrolate, I-Box by Dynatronics
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Obstructive Sleep Apnea, Hypercapnia
Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury
Patients with spinal cord injury (SCI) usually breathe without any mechanical assistance, but significant breathing problems occur often during sleep, either because the upper airway closes (obstructive sleep apnea; OSA), or…
- Conditions
- Obstructive Sleep Apnea, Hypercapnia, Spinal Cord Injury
- Trial name
- NCT01882257
- Testing
- BiPAP, BiPAP/AVAPS (Phillips Respironics)
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- University of Michigan
Disuse Osteoporosis, Atrophy, Disuse
Activity Dependent Rehabilitation Model to Improve Bone and Muscle Outcomes
For many after spinal cord injury (SCI) there is immobilization, muscle atrophy, bone loss, fracture risk during transferring (or falls), and the risk of secondary complications, and increase in attendance care and cost.
- Conditions
- Disuse Osteoporosis, Atrophy, Disuse, Nervous System, Structural; Marker
- Trial name
- NCT02309983
- Testing
- Electrical Stimulation, Stand Retraining with Body Weight Support (BWS)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Kessler Foundation
Spinal Cord Injury Cervical
Functional Electrical Stimulation (FES) and Reconstructive Tetraplegia Hand and Arm Surgery
FES is a common and established method in the rehabilitation of persons with spinal cord injury (SCI). Some known effects of FES were investigated in several studies e.g.
- Trial name
- FES (NCT03048331)
- Testing
- Functional Electrical Stimulation
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Neuropathic Pain
Brain-Train Home Based Pain Treatment
A study examining the effectiveness of neurofeedback therapy for the treatment of Central Neuropathic Pain (CNP), in patients with a Spinal Cord Injury, using a small user-friendly device which can be operated by patients at home.
- Trial name
- NCT02678494
- Testing
- Neurofeedback training
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- NHS Greater Glasgow and Clyde