Clinical trials: Injury
Acute Spinal Cord Injury
AC105 in Patients With Acute Traumatic Spinal Cord Injury
The principal aim of this study was to establish the feasibility of rapid administration, safety, and tolerability of AC105 in patients with acute spinal cord injury.
- Trial name
- AC105 (NCT01750684)
- Testing
- AC105
- Volunteers
- 15 people
- Sponsor
- Acorda Therapeutics
Tennis Elbow, Epicondylitis, Lateral Humeral
A Randomized Control Trial to Evaluate the Efficacy of Autologous Blood Injection Versus Local Corticosteroid Injection for Treatment of Lateral Epicondylitis
Lateral epicondylitis, is a common problem encountered in the orthopaedic practice. Histopathological reports have shown that lateral epicondylitis is not an inflammatory process but a degenerative condition termed 'tendinosis'.
- Trial name
- NCT00947765
- Testing
- Autologous blood injection, Local corticosteroid injection
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dojode, Chetan M., MBBS, MS
Gum Injury
Assessing Effects of a Denture Gel on Gum Abrasions
This is a parallel design study. Up to 40 subjects with a full mandibular and full maxillary dentures will be enrolled into the study. Subjects will use their current denture care +/- a treatment gel for 4 weeks.
- Trial name
- NCT04913636
- Testing
- Treatment Gel
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Brain Tumor, Primary
A Pilot Study to Evaluate Neurocognitive Injury and Longitudinal Changes in White Matter During Radiation Therapy in Children With Primary Brain Tumors
This is a pilot study to assess the changes in white matter, in the brain, in response to radiation therapy and correlate these changes with later declines in cognitive function.
- Trial name
- NCT02006407
- Testing
- Cranial Radiotherapy, MRI with Diffusion Tensor Imaging (DTI), Neuro-cognitive Testing (CogState)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan Rogel Cancer Center
Concussion, Mild, Post-Concussion Symptoms
Effects of Bright Light Therapy in Mild Traumatic Brain Injury
Mild traumatic brain injuries (mTBI) or "concussions" are an increasingly prevalent injury in our society. Patients with post-concussion syndrome have been shown to have deficits on tests of short term memory, divided attention…
- Conditions
- Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
- Trial name
- NCT01747811
- Testing
- wavelength-1 bright light, wavelength-2 bright light
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Borderline Personality Disorder, Suicide
Comparing Treatments for Self-Injury and Suicidal Behavior in People With Borderline Personality Disorder
This study will compare the effectiveness of two treatments, dialectical behavior therapy versus fluoxetine with clinical management, for reducing the risk of self-injury and suicidal behavior in people with borderline…
- Trial name
- NCT00834834
- Testing
- Fluoxetine, DBT, Citalopram
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- New York State Psychiatric Institute
Metastatic Castration-resistant Prostate Cancer
Safety and Efficacy of Therapies for Metastatic Castration-resistant Prostate Cancer (mCRPC)
This is a master protocol designed to evaluate the safety and efficacy of investigational therapies in participants with metastatic castration-resistant prostate cancer (mCRPC).
- Trial name
- NCT04631601
- Testing
- Acapatamab, Enzalutamide, Abiraterone
- Where
- 14 sites in United States, Australia and 4 more
- Volunteers
- 55 people
- Sponsor
- Amgen
Spinal Cord Injury, Respiratory Muscle Weakness
Albuterol to Improve Respiratory Strength in SCI
Spinal cord injury (SCI), especially involving the cervical and upper thoracic segments, can significantly compromise respiratory muscle function.
- Trial name
- NCT02508311
- Testing
- Oral Albuterol Extended Release
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- VA Office of Research and Development
Injury as a Result of Positioning
Prospective Evaluation of Cognitive Outcomes After Anesthesia on Patients in the Beach Chair Position
The purpose of this study was to use Near Infrared Spectroscopy (NIRS) monitoring on participants undergoing shoulder surgery in the beach chair position (BCP) to determine cerebral desaturation events (CDE) and to further…
- Trial name
- BCP (NCT02674334)
- Testing
- NIRS, NIRS monitored not treated
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- West Virginia University
Hip Fractures, Blood Loss
Safety and Efficacy of Oral TXA in Reducing Blood Loss and Transfusion in Hip Fractures
The primary objective of this study is to assess the safety and efficacy of Tranexamic acid (TXA) in reducing blood loss and transfusion requirements for patients with osteoporotic hip fractures.
- Trial name
- NCT02908516
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Yale University
Osteosarcoma, Nephrotoxicity
Preventing Nephrotoxicity and Ototoxicity From Osteosarcoma Therapy
Osteosarcoma is the most common type of bone cancer in children, adolescents and young adults. Treatment with surgery and a combination of three conventional chemotherapy drugs can cure nearly two-thirds patients with…
- Conditions
- Osteosarcoma, Nephrotoxicity, Ototoxicity
- Trial name
- NCT01848457
- Testing
- Pantoprazole, High-dose methotrexate infusion duration
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospital of Philadelphia
Renal Failure, Acute Renal Failure
Premarket Clinical Safety Assessment of the ELISIO™-HX
The primary safety objective of this study is to evaluate the safety of the use of the high-permeability hemodialyzer series ELISIO™-HX, by showing that the pre-dialysis albumin levels are not affected using the investigational…
- Conditions
- Renal Failure, Acute Renal Failure, Chronic Renal Failure, Chronic Kidney Diseases
- Trial name
- NCT07058909
- Testing
- ELISIO™-HX Dialyzer
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Nipro Medical Corporation
Postoperative Wound Complications
Negative Pressure Wound Therapy in Cesarean Section
The investigators propose a prospective, randomized trial evaluating the use of negative pressure wound therapy (NPWT) with high risk obstetrical patients.
- Trial name
- NPWTCS (NCT02289157)
- Testing
- Negative pressure wound therapy
- Where
- United States
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Degenerative Sacroiliitis, Sacroiliac Joint Disruption
Sacroiliac Joint Fusion With iFuse Implant System (SIFI)
The purpose of this study is to evaluate the use of the iFuse Implant System to treat degenerative sacroiliitis (arthritis of the SI joint) and sacroiliac disruption (abnormal separation or tearing of the sacroiliac joint).
- Trial name
- SIFI (NCT01640353)
- Where
- 26 sites in United States
- Volunteers
- 194 people
- Sponsor
- SI-BONE, Inc.
Wounds and Injuries, Physical Activity
Swiss Army Physical Fitness Training
The purpose of this study is to determine whether the new sport concept of the Swiss Armed Forces influences the physical and psychological fitness of the recruits.
- Conditions
- Wounds and Injuries, Physical Activity, Mood (Psychological Function), Motivation
- Trial name
- SAFT (NCT02570295)
- Testing
- Swiss Army Physical Fitness Training
- Where
- Switzerland
- Volunteers
- 722 people
- Sponsor
- Swiss Federal Institute of Sport Magglingen
Head Trauma, Craniocerebral Injuries
Assessment of InfraScanner 2000™ in Detecting Subdural and Epidural Hematomas
The goal of this study is to determine the sensitivity, specificity, and positive and negative predictive values of the a portable near-infrared-based device (portable NIR-based device), the InfraScanner 2000™, to detect…
- Conditions
- Head Trauma, Craniocerebral Injuries, Crushing Skull Injury, Head Injuries
- Trial name
- NCT03353246
- Testing
- InfraScanner 2000™
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Wound Healing, Burns
Hypoxia-inducible Factor-1 (HIF-1) Regulated Circulating Angiogenic Cells (CACs) Recruitment in Burn Wound Healing
This research is being done to increase knowledge about wound healing and different factors that may affect healing in burn patients.
- Trial name
- NCT00796627
- Testing
- Healthy volunteers, Burn volunteers
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Post Traumatic Stress Disorder
An Evaluation of the Safety and Efficacy of Methylone for the Treatment of PTSD
This study is evaluating the safety and efficacy of methylone in adults with PTSD. The study is conducted in two parts. Part A is open-label and will enroll up to 15 participants with PTSD Part B is randomized (1:1:1)…
- Trial name
- IMPACT-2 (NCT06215261)
- Testing
- Methylone
- Where
- 12 sites in United States, Australia and 1 more
- Volunteers
- 62 people
- Sponsor
- Transcend Therapeutics
Hip Fracture
Effects of Bisphosphonates and Nutritional Supplementation After a Hip Fracture
The study hypothesis is that nutritional supplementation together with bisphosphonates have a better preserving effect on bone mineral density (BMD) after hip fracture than bisphosphonates alone and that nutritional…
- Trial name
- NCT01950169
- Testing
- Risedronate, Nutritional supplement, Calcium and vitamin D3
- Where
- Sweden
- Volunteers
- 79 people
- Sponsor
- Karolinska Institutet
Shoulder Injury
Blood Flow Restriction Therapy Following Acute Shoulder Injury Patients
Atrophy and weakness of the shoulder are a common problem following treatment of a number of shoulder and elbow pathologies. Even with relatively short periods of reduced activity, the magnitude of muscle loss can be quite…
- Trial name
- BFR (NCT06223373)
- Testing
- Blood Flow Restriction
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wake Forest University Health Sciences
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