Clinical trials: Injury Prevention
Infection of Cesarian Section Wound Following Delivery
Antibiotic Prophylaxis for Elective Cesarean Section
A randomized controlled study comparing the effect of administration of 1 gm ceftriaxone in elective cesarean section 30-60 min before skin incision versus after cord clamping.
- Trial name
- TOAPFECSACT (NCT02177994)
- Testing
- ceftriaxone 1gm for intravenous infusion
- Where
- Egypt
- Volunteers
- 328 people
- Sponsor
- Ain Shams Maternity Hospital
Knee Injuries, Anterior Cruciate Ligament Rupture
Stopping OsteoARthritis After an ACL Tear
By 2040, 25% of Canadians will have osteoarthritis, a disabling joint condition. Most people think osteoarthritis only affects older adults, but 50% of the 700,000 Canadian youth who hurt their knee playing sports annually will…
- Conditions
- Knee Injuries, Anterior Cruciate Ligament Rupture, Osteoarthritis, Knee
- Trial name
- SOAR (NCT06195423)
- Testing
- Stop OsteoARthritis (SOAR) program, Living Well after ACLR program
- Where
- 2 sites in Canada
- Volunteers
- 210 people
- Sponsor
- University of British Columbia
Soft Tissue Injuries
"Enhancing Surgical Safety in Developing Nations: Investigating Antibiotics' Role in Hand Surgeries."
The goal of this clinical trial is to compare the use of antibiotics with no use in people undergoing soft tissue hand surgery in developing countries.
- Trial name
- NCT05990842
- Testing
- Antibiotic
- Volunteers
- 51 people
- Sponsor
- Marcos Felipe Marcatto de Abreu
Myocardial Infarction, Reperfusion Injury
Prevention of Reperfusion Injury Outcomes Through Effective Cardioprotection Targeting Myocardial Infarction
This study is open to adults with ST elevation myocardial infarction (heart attack) undergoing primary percutaneous coronary intervention (PCI).
- Conditions
- Myocardial Infarction, Reperfusion Injury, AMI, STEMI (ST Elevation MI)
- Trial name
- PROTECT-MI (NCT07362446)
- Testing
- Xolatryp
- Where
- 8 sites in Australia
- Volunteers
- 300 people
- Sponsor
- Nyrada Pty Ltd
Fall Injury, Frailty
A Personalized Video-based Exercise Program for Fall Prevention in Frail and Pre-frail Older Adult
This is a randomized interventional clinical trial, whereby 100 participants will be randomized to either follow the SAFE exercise program (experimental group) or not (control group).
- Conditions
- Fall Injury, Frailty, Old Age; Atrophy, Age-Related Atrophy
- Trial name
- NCT06363942
- Testing
- SAFE program (exercise intervention)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Urinary Tract Infection, Spinal Cord Injury
Vitamin C for Prevention of Urinary Tract Infections in the Spinal Cord Injured
After spinal cord injury, patients have frequent urinary tract infections (UVI). Vitamin C is usually prescribed to prevent such infection, but the efficacy of the treatment is poorly documented.
- Trial name
- NCT00869427
- Testing
- vitamin C
- Volunteers
- 40 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Surgical Infection
Routine Preoperative Antibiotic Prophylaxis in Modified Radical Mastectomy
This is a randomized, double blinded, placebo-controlled trial on the routine use of preoperative antibiotic prophylaxis in modified radical mastectomy to evaluate the efficacy of preoperative prophylactic antibiotics in the…
- Trial name
- NCT01558986
- Testing
- Cefazolin, Sterile water
- Where
- Philippines
- Volunteers
- 254 people
- Sponsor
- University of the Philippines
Prostate Cancer, Bladder Cancer
Mannitol Versus Nitroglycerin for Kidney Injury Prevention in Robotic-assisted Radical Prostatectomy or Cystectomy
Laparoscopic and minimally-invasive robotic access has transformed the delivery of urological surgery. While associated with numerous desirable outcomes including shorter post-operative stay and faster return to preoperative…
- Conditions
- Prostate Cancer, Bladder Cancer, Surgery, Renal Impairment
- Trial name
- NCT06408597
- Testing
- Nitroglycerin Infusion, Mannitol Infusion, Fluid Regimen
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Nazmy Edward Seif
Heart Failure Acute, Renal Dysfunction
Contrast-Induced Acute Kidney Injury Prevention in Acute Heart Failure
The K-PROSE study is a randomized clinical investigation evaluating strategies to prevent contrast-induced acute kidney injury (CI-AKI) in patients hospitalized with acute heart failure and moderate renal dysfunction (eGFR 30-75…
- Trial name
- K-PROSE (NCT07550790)
- Testing
- Furosemide, 0.9 % Normal Saline
- Where
- South Korea
- Volunteers
- 190 people
- Sponsor
- Jin Joo Park
Renal Failure
The Efficacy of "MediHoney" to Facilitate Catheter Exit-Site Surgical Wound Healing
To evaluate the efficacy of honey as a post surgical exit site care process to promote healing and prevent infectious bacterial colonization of newly created exit sites.
- Trial name
- NCT01230489
- Testing
- MediHoney
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Missouri-Columbia
Postoperative Wound Infection Superficial Incisional, Postoperative Wound Infection Deep Incisional Surgical Site
Safety and Efficacy of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery.
This study is aimed to assess the anti-infective efficacy of D-PLEX over a period of 3 months post operation as well as the safety over a period of 6 months, by preventing sternal infection post cardiac surgery in patients above…
- Trial name
- NCT02731573
- Testing
- D-PLEX, Open heart surgery
- Where
- 5 sites in Israel
- Volunteers
- 81 people
- Sponsor
- PolyPid Ltd.
Dry Eye, MGD-Meibomian Gland Dysfunction
Study on Prevention and Treatment of Dry Eye in Patients Using Glaucoma Drops
A multicenter randomized controlled trial on prevention and treatment of ocular surface injury and meibomian gland dysfunction in patients using anti-glaucoma eye drops.
- Trial name
- NCT03515187
- Testing
- 0.3% sodium hyaluronate ophthalmic solution, 0.1% sodium bromide solution, Meibomian gland massage
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shenzhen Hospital of Southern Medical University
Intervention, Injury Prevention
Resistance Band Training Versus Nordic Hamstring Exercise on Hamstring Strength Among Football Players
The major aim of this project to compare the effects of Resistance band training and Nordic hamstring exercise on hamstring strength among football players.
- Trial name
- NCT05220215
- Testing
- Nordic Hamstring Exercise, Hamstring Curl with Resistance band
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Post Traumatic Stress Disorder
Early Prevention of Post Traumatic Stress Disorder
Sunnybrook Health Sciences Centre is Canada's largest trauma centre, treating 1,100 patients annually. A traumatic experience can lead to post-traumatic stress disorder, which increases hospital stays, emergency visits and…
- Trial name
- NCT02004743
- Testing
- Intervention, Treatment as usual
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Sunnybrook Health Sciences Centre
Alzheimer's Disease and Related Dementia, Fall Injury
Fall Detection and Prevention for Memory Care Through Real-time Artificial Intelligence Applied to Video
The purpose of the research is to study a new safety monitoring system developed by SafelyYou to help care for a loved one with dementia. The goal is to provide better support for unwitnessed falls.
- Trial name
- NCT03685240
- Testing
- SafelyYou Fall Prevention System
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- SafelyYou
Elbow Trauma Requiring Operative Management
Indomethacin Prophylaxis for Heterotopic Ossification After Surgical Treatment of Elbow Trauma
Patients who present to our institution with a traumatic injury to their elbow who need operative management will be randomized to one of two groups; a treatment arm and a control arm.
- Trial name
- NCT01744314
- Testing
- Indomethacin and Pantoprazole, microcrystalline cellulose powder tablets
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Otitis Media
Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children
This clinical trial was conducted in a population where tympanic membrane perforation occurs in 60% infants in the first year of life.
- Trial name
- COMIT1 (NCT00539149)
- Testing
- Amoxycillin
- Where
- Australia
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Menzies School of Health Research
Mild Traumatic Brain Injury
An Intervention Program to Reduce to the Risk of Persistent Symptoms After Concussion
This study investigates how well a new therapy program prevents persistent symptoms (e.g., headaches, fatigue, irritability, etc.) after concussion.
- Trial name
- NCT00893347
- Testing
- Treatment as usual, Cognitive-behavioural therapy
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of British Columbia
Peripheral Occlusive Disease, Wound Healing
Intraoperative Application of Cold Atmospheric Plasma to Prevent Postoperative Wound Complications in the Inguinal Region of High-risk Patients With Peripheral Arterial Occlusive Disease
The goal of this clinical trial is to learn if postoperative wound complications in the inguinal region of high-risk patients with peripheral arterial occlusive disease can be prevented by the intraoperative application of cold…
- Conditions
- Peripheral Occlusive Disease, Wound Healing, Wound Healing Complication, Cold Atmospheric Plasma
- Trial name
- PICPAD (NCT07571408)
- Testing
- Cold atmospheric plasma
- Where
- Germany
- Volunteers
- 214 people
- Sponsor
- Ursula Werra
Palatal Wound
Effects of Topical Hyaluronic Acid Gel on Postoperative Pain and Wound Healing
This clinical study aims to investigate the impact of a topical hyaluronic acid (HA) gel on postoperative pain and wound healing at palatal donor sites in patients undergoing mucogingival procedures involving a de-epithelialized…
- Trial name
- NCT05821725
- Testing
- Hyaluronic acid, Control
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive