Clinical trials: Injury Traumatic
Post-traumatic Stress Disorder
Brain Markers of Treatment Response in Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to examine if treatment of post-traumatic stress disorder in combat veterans with paroxetine changes brain responses as measured by functional magnetic resonance imaging and if brain responses can…
- Trial name
- NCT00700999
- Testing
- Paroxetine
- Where
- 3 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Brain Injury
Genotype Influence on Recovery After Traumatic Brain Injury
Genetic differences in response to brain injury may reasonably be expected to play a role in the initial consequences of traumatic brain injury and in the rate of recovery from such injury.
- Trial name
- NCT00018499
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Traumatic Brain Injury
A Health & Wellness Intervention for Individuals With Traumatic Brain Injury (TBI)
The primary goal of the proposed study is to evaluate the efficacy of a replicable community-based group intervention, designed to address both general wellness and specific TBI health-related issues.
- Trial name
- NCT01334398
- Testing
- Health & Wellness
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- VA Eastern Colorado Health Care System
Chronic Subdural Hematomas
PHIL™ Middle Meningeal Artery Embolization for First-Line Treatment of Chronic Subdural Hematoma IDE Trial
This is a prospective, randomized, controlled, open-label, blinded endpoint (PROBE) clinical investigation in which patients with non-emergent chronic subdural hematoma (cSDH) requiring treatment will be randomized (1:1) to…
- Trial name
- PHILFIRST (NCT07576998)
- Testing
- PHIL™ (Precipitating Hydrophobic Injectable Liquid), Surgical evacuation
- Volunteers
- 475 people
- Sponsor
- Microvention-Terumo, Inc.
Brain Injuries, Traumatic, Confusional State
Multisensory Stimulation and Enriched Environments During Post-traumatic Amnesia
The objective of this Phase II trial is to evaluate the feasibility of this study protocol to progress to a large-scale Phase III RCT in the future.
- Conditions
- Brain Injuries, Traumatic, Confusional State, Sensory Motor System Disorder, Alteration of Cognitive Function
- Trial name
- NCT02792985
- Testing
- Multisensory stimulation protocol, Control protocol
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Institut Guttmann
Anesthesia, Gastric Ultrasound
Gastric Emptying Time in Traumatic Injuries
The investigators plan to do serial sonographic examinations of the gastric antrum (quantity, quality) to estimate the gastric emptying time and dependant factors after traumatic injurys.
- Conditions
- Anesthesia, Gastric Ultrasound, Sonography, Point of Care Ultrasound (POCUS)
- Trial name
- NCT06643325
- Testing
- Gastric ultrasound
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Kantonsspital Winterthur KSW
The Efficacy of Percutaneous Catheter vs. Open Chest Tube, Traumatic Hemothorax
Multi-center:The Small (14F) Percutaneous Catheter vs. Large (28-40F) Open Chest Tube for Traumatic Hemothorax (P-CAT)
After sustaining severe trauma to the chest, patients will often bleed into the chest cavity (pleural space) which is called hemothorax or they may also experience air leakage within the chest cavity in combination with the…
- Trial name
- P-CAT (NCT03546764)
- Testing
- Percutaneous catheter
- Where
- 4 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Arizona
TBI (Traumatic Brain Injury)
Clinical Significance of circMETTL9 Gene in Traumatic Brain Injury
Objective: The relevance of circMETTL9 to the degree of injury, disturbance of consciousness, cognitive function and prognosis in patients with moderate to severe traumatic brain injury (TBI) remains unknown.
- Trial name
- NCT05484921
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nantong University
Post Traumatic Stress Disorder PTSD
Mind-body Skills Groups for War-Related Trauma in Adolescents in Gaza
The goal of this clinical trial is to learn if mind-body skills groups can reduce posttraumatic stress disorder and emotional and behavioral problems in war-traumatized adolescents in Gaza.
- Trial name
- NCT07302984
- Testing
- Mind-Body Skills Groups
- Where
- Palestinian Territories
- Volunteers
- 120 people
- Sponsor
- The Center for Mind-Body Medicine
Alcohol Use Disorder, Trauma, Psychological
Adverse Childhood Experiences in Alcohol Use Disorder
Adverse childhood experiences (ACE) and their relation to the development of an alcohol use disorder (AUD) will be measured with functional magnetic resonance imaging (fMRI).
- Trial name
- NCT05048758
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 43 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Photophobia, Traumatic Brain Injury
Objectively Diagnose and Monitor Treatment of Light Sensitivity
The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and…
- Conditions
- Photophobia, Traumatic Brain Injury, Migraine
- Trial name
- NCT03694626
- Testing
- Pupillography, Ocular Coherence Tomography (OCT), Wrist-watch sensor device
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
PTSD
Psilocybin-Assisted Therapy
This pilot study will examine the safety, tolerability, acceptability, and efficacy of combination psilocybin + psychotherapy to decrease PTSD symptoms.
- Trial name
- NCT07332143
- Testing
- psilocybin, Supportive Therapy, Prolonged Exposure Therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Emory University
Stress Disorders, Post-Traumatic
Examining the Role of Negative Emotional States on Sedative Drug Use in Individuals With Post-Traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a serious illness, in which individuals often experience anxiety and stress. Some individuals with PTSD use drugs to alleviate emotional distress.
- Trial name
- NCT00244335
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Traumatic Laceration of the Olecranon or Prepatellar Bursa
Treatment of Acute Traumatic Laceration of the Olecranon and Prepatellar Bursa
Following a recent publication by the authors [1], there is no standardized treatment regime for the treatment of lacerations of the olecranon or prepatellar bursa, although primary bursectomy seems to be the most common…
- Trial name
- NCT01714999
- Testing
- Bursectomy, Bursal reconstruction
- Where
- 2 sites in Austria, Germany
- Volunteers
- 100 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Depression - Major Depressive Disorder, Childhood Traumas
Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression
The RESPOND trial explores the link between early life adversity and later life depressive symptoms. The investigators have designed a new psychological therapy tailored to address the symptoms that can be caused by difficult…
- Trial name
- RESPOND (NCT07250893)
- Testing
- Psychotherapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Concussion, Mild Traumatic Brain Injury
Impact of a Paced Breathing Exercise Intervention on Autonomic Nervous System Function After Pediatric Concussion (Acute Phase)
The goal of this pilot clinical trial is to assess the feasibility of administering a paced breathing exercise intervention program to children and adolescents in the acute period after concussion.
- Trial name
- Breathe - PED (NCT07572734)
- Testing
- Paced breathing exercises
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Concussion
Evaluation of an EEG Based Concussion System
This study will evaluate the accuracy of a new concussion system at detecting concussions. The investigators will be evaluating the degree to which data collected with the device agrees with a physician's determination of a…
- Trial name
- NCT03710109
- Testing
- EEG
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pediatric Mild Traumatic Brain Injury
IVF in Pediatric Concussion
Children with concussion may improve with intravenous fluids.
- Trial name
- NCT02214316
- Testing
- Hypertonic Saline
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine
Trauma Associated Hemorrhage
Prehospital Transfusion Outcomes in Traumatic Hemorrhage: a Prospective Cohort Study
Traumatic injuries can cause severe bleeding, which causes a lot of deaths worldwide that could be prevented. Starting treatment as early as possible has been shown to improve survival, which makes fast care very important.
- Trial name
- PRONTO (NCT07883252)
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- Erasmus Medical Center
Stress Disorders, Post-Traumatic, Sleep Disorders
Prazosin vs Paroxetine in Combat Stress-Related Post-Traumatic Stress Disorder (PTSD) Nightmares & Sleep Disturbance
The purposes of this study are: to evaluate the efficacy and tolerability of the drug prazosin compared to placebo for combat stress-related nightmares, sleep disturbance and overall function in recently combat-exposed returnees…
- Trial name
- NCT00202449
- Testing
- prazosin, paroxetine
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research