Clinical trials: Innate Immunity, active
Attitudes
A Comparison of People's Responses to the Labels "Natural Immunity" Versus "Disease-induced Immunity".
A comparison of how people respond to the terms "natural immunity" versus "disease-induced immunity".
- Trial name
- NCT07102485
- Testing
- disease-induced immunity, natural immunity
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Laval University
Dry Eye Disease (DED)
The Effect of 0.1% Topical Ciclosporin A for 12-weeks on the Eye Surface Immune Cells in Dry Eyes
Dry eye disease (DED) is a common, long-lasting condition that affects the surface of the eye. It happens when there's a problem with tear production or quality, which can lead to inflammation and discomfort.
- Trial name
- NCT06898853
- Testing
- 0.1% Ciclosporin A eye drops, Mineral oils eye drops
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- The University of New South Wales
Endometriosis, Immunity
Innate Immunity, MIcrobiota and Inovative Treatments in Endometriosis
Endometriosis is a chronic inflammatory, polygenic, and multifactorial disease affecting approximately 10% of women of reproductive age, corresponding to over one million women in France.
- Conditions
- Endometriosis, Immunity, Microbiota
- Trial name
- IMIEndo (NCT07078435)
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines, Blood test, Stool samples
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
HPV Infection
Early Phase Clinical Trial About Therapeutic Biological Product Mix for Treating HPV
Conducting an early phase clinical trial to assess HPV Antigen Presentation Therapeutic Biological Product Mix activity that suggests the potential for clinical benefit of HPV patients. 1.
- Trial name
- 9vHPV-BCG (NCT06959563)
- Testing
- 9vHPV Vaccine plus BCG Vaccine Mix for percutaneous use
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair
Myocardial Infarction
Vegetarian Diet and Innate Immunity in Patients With Myocardial Infarction and in Healthy Volunteers (FRESH-MI Study)
The goal of this clinical trial is to assess the effect of a vegetarian diet on innate immunity of patients with a recent acute myocardial infarction and healthy participants.
- Trial name
- FRESH-MI (NCT06209723)
- Testing
- Vegetarian diet
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pheochromocytoma, Paraganglioma
Hereditary Pheochromocytoma Assessment of Tumour Immunologies
In this study, the investigators are examining the role of the immune system in pheochromocytoma and paraganglioma. The investigators aim to examine the differences in the immune system between people who have these tumors with…
- Trial name
- HEPHESTOS (NCT06444607)
- Testing
- Venepuncture
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Viral Infections
A Study of Intranasal LMN-1001 in Healthy Adults
The purpose of this study is to optimize the tolerability of LMN-1001 relative to its ability to activate the host immune response. LMN-1001 is an investigational dry powder containing recombinant interferon lambda (IFN-λ).
- Trial name
- NCT07852208
- Testing
- LMN-1001
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Lumen Bioscience, Inc.
Asthma
Innate Immunity in Allergic Asthma
The purpose of this study is to determine whether a potential type 2 signature, obtained through stimulation of cell lines with various allergens in vitro, correlates with an allergic or asthmatic disease state ex vivo.
- Trial name
- NCT06068335
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Tuberculosis, Latent Tuberculosis
Lung Innate Immunity and Microbiome After Tuberculosis Exposure
To characterise the innate pulmonary immune response and respiratory microbiome after recent exposure to M.tb and to evaluate how differences determine the outcome of M.tb exposure
- Trial name
- LIMBO-TB (NCT06526689)
- Where
- 3 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Asthma, Atherosclerosis
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
Background: Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation.
- Conditions
- Asthma, Atherosclerosis, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT01143480
- Where
- United States
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Cannabis Smoking, Oxidative Stress
Chronic Cannabis Smoking, Oxidative Stress and the Pulmonary Innate Immune Response
This study plans to evaluate the effects of chronic cannabis smoking on lung health by evaluating its effects on pulmonary health, lung physiology and alveolar macrophage function.
- Trial name
- NCT02480283
- Testing
- Bronchoscopy, Chest X-ray, Venipuncture
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Rectal Cancer
Early Phase Clinical Trial About Therapeutic Biological Product Mix for Treating CEA Positive Rectal Cancer
Conducting an early phase clinical trial to assess CEA Antigen Presentation Therapeutic Biological Product Mix activity that suggests the potential for clinical benefit of CEA positive rectal cancer patients. 1.
- Trial name
- CEA+RC-BCG (NCT02403505)
- Testing
- CEA protein antigen plus BCG Vaccine Mix for percutaneous use
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair
Inflammation
Immune Cell Response to Stimuli
This study will investigate the response of immune cells (neutrophils, monocytes) to various signals in the test tube to determine how they sense the signals in the body and what substances they produce in response to them.
- Trial name
- NCT00397280
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
COVID-19 Infection
Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVID-19 and Convalescence
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). The global outbreak of COVID-19 is a major public health problem. COVID-19 causes a wide range of symptoms.
- Trial name
- NCT04582903
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Exercise Training
Effect of Aronia Supplementation on the LPS-CD14-TLR2/4 Axis in Football Players
This randomized, double-blind, placebo-controlled trial will investigate the effects of 8-week Aronia melanocarpa supplementation on exercise-induced activation of the LPS-LBP-CD14-TLR2/TLR4 axis in trained male football players.
- Trial name
- ARONIA-TLR (NCT07829523)
- Testing
- Aronia melanocarpa Extract
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hanna Dziewiecka
Viral Infection, Sepsis
COMPArative Study of the Consequence on innaTe Immune Response du to Bacterial or Viral Infection in Patients Admitted to Intensive Care Unit
Patient admitted in intensive care unit (ICU) for acute infection whether it be viral or bacterial had major impairment of the immune response.
- Trial name
- COMPACT (NCT05671159)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Limoges
Pulmonary Disease, Chronic Obstructive, Airway Disease
Innate Immunity in Ozone-induced Airway Inflammation in COPD
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States. Patients with COPD are routinely exposed to indoor and outdoor air pollution, which appears to cause escalation of their…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Airway Disease, COPD Exacerbation, Pollution; Exposure
- Trial name
- CO3PD (NCT04669743)
- Testing
- Ozone exposure
- Where
- 3 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Gut Microbiome, Healthy Adult Male
Effect of Antifungals on the Intestinal Microbiome - a Randomized, Controlled, Proof-of-concept Trial
The goal of this clinical trial is to learn how the antifungal drug fluconazole affects the gut microbiome and immune system in healthy volunteers.
- Conditions
- Gut Microbiome, Healthy Adult Male, Antifungal Therapy
- Trial name
- FAME (NCT07295314)
- Testing
- Fluconazole 200mg tab
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP)
Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly Patients
This prospective observational cohort study aims to evaluate the role of innate immune immunoparalysis in the development of ventilator-associated pneumonia (VAP) in critically ill mechanically ventilated patients.
- Conditions
- Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP), Immunoparalysis
- Trial name
- IMP-VM (NCT07551258)
- Where
- Spain
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Chronic Obstructive Pulmonary Disease
Innate Immunity in COPD
Chronic Obstructive Pulmonary Disease (COPD) causes obstruction to airflow when breathing out. It is a leading cause of chronic lung disease, hospitalization and death.
- Trial name
- NCT05743582
- Testing
- Bronchoscopy for sample collection, Blood donation
- Where
- 2 sites in United Kingdom
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh