Clinical trials: Inoperable HCC
Hepatocellular Carcinoma, Fibrolamellar Hepatocellular Carcinoma
Study of Sunitinib in Patients With Advanced/Inoperable Fibrolamellar Carcinoma
The purpose of this study is to evaluate the antitumor activity of sunitinib in patients with advanced/inoperable fibrolamellar hepatocellular carcinoma.
- Trial name
- Fibrolam (NCT01215565)
- Testing
- Sutent
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatocellular Carcinoma
Sorafenib and Micro-therapy Guided by Primovist Enhanced MRI in Patients With Inoperable Liver Cancer
The purpose of this study is to evaluate Sorafenib and local microtherapy guided by Primovist enhanced MRI in patients with inoperable liver cancer (HCC).
- Trial name
- SORAMIC (NCT01126645)
- Testing
- RFA, Radioembolization (SIRT)
- Where
- Germany
- Volunteers
- 529 people
- Sponsor
- University of Magdeburg
Unresectable Hepatocellular Carcinoma
Efficacy Evaluation of TheraSphere in Patients With Inoperable Liver Cancer
The safety and effectiveness of TheraSphere will be evaluated in patients with unresectable hepatocellular carcinoma in whom treatment with standard-of-care sorafenib is planned.
- Trial name
- STOP-HCC (NCT01556490)
- Testing
- TheraSphere
- Where
- 94 sites in United States, Belgium and 9 more
- Volunteers
- 526 people
- Sponsor
- Boston Scientific Corporation
Liver Cancer
Megestrol in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery
RATIONALE: Estrogen can stimulate the growth of cancer cells. Hormone therapy using megestrol may fight liver cancer by blocking the uptake of estrogen. It is not yet known if megestrol is an effective treatment for liver cancer.
- Trial name
- NCT00041275
- Testing
- megestrol acetate
- Where
- 12 sites in Bangladesh, Burma and 8 more
- Volunteers
- 300 people
- Sponsor
- National Medical Research Council (NMRC), Singapore
Carcinoma, Hepatocellular
Phase I Study of Image-Guided Radiation Concurrent With Double-Agent Chemotherapy for Hepatocellular Carcinoma
This is a phase I study to evaluate the safety of concurrent chemoradiation combining radiotherapy (IGRT) with two cytotoxic agents, capecitabine and oxaliplatin in patients with advanced or inoperable hepatocellular carcinoma.
- Trial name
- NCT02403544
- Testing
- IGRT, Capecitabine, Oxaliplatin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese Academy of Medical Sciences
Liver Cancer
Tamoxifen in Treating Patients With Primary Liver Cancer
RATIONALE: Estrogen can stimulate the growth of cancer cells. Hormone therapy using tamoxifen may fight liver cancer by blocking the absorption of estrogen.
- Trial name
- NCT00003424
- Testing
- tamoxifen citrate
- Where
- 8 sites in Hong Kong, Indonesia and 4 more
- Volunteers
- 300 people
- Sponsor
- National Medical Research Council (NMRC), Singapore
Hepatocellular Carcinoma, Colorectal Cancer
Prospective Clinical Validation of Next Generation Sequencing (NGS) and Patient-Derived Tumor Organoids (PDO) Guided Therapy in Patients With Advanced/ Inoperable Solid Tumors
Precision oncology aims to improve clinical outcome of patients by offering personalized treatment through identifying druggable genomic aberrations within their tumors.
- Trial name
- PDO (NCT06077591)
- Testing
- Patient-Derived Tumor Organoids
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Hepatocellular Carcinoma
Phase II Study of Fruquintinib Combined With Sintilimab and TACE for Inoperable Primary Hepatocellular Carcinoma
The goal of this prospective, interventional clinical trial is to evaluation of fruquintinib in combination with sintulimab and TACE for inoperable primary hepatocellular carcinoma for progression-free survival (PFS).
- Trial name
- NCT05971199
- Testing
- Fruquintinib, Sintilimab, Transcatheter arterial chemoembolization（TACE）
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Zhejiang Cancer Hospital
Inoperable Hepatocellular Carcinoma
MANDARIN (S6371)
To evaluate the efficacy and safety of TheraSphereTM yttrium [90Y] glass microsphere in the Chinese patients with inoperable hepatocellular carcinoma.
- Trial name
- NCT05016245
- Testing
- TheraSphere™ Yttrium-90 Glass Microspheres, conventional Transarterial Chemoembolization(cTACE)
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Boston Scientific Corporation
Hepatocellular Carcinoma
Hypofractionated Proton Beam Radiotherapy for Inoperable Hepatocellular Carcinoma
This phase II study is to evaluate the effectiveness of hypofractionated proton beam therapy (PBT) for Hepatocellular Carcinoma patients in hepatitis B endemic area.
- Trial name
- NCT02395523
- Testing
- Proton Beam Therapy
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- National Cancer Center, Korea