Clinical trials: Insomnia Disorders
Sleep, Gut Microbiome
Impact of Nutritional Supplementation on Sleep Quality and Gut Microbiome Composition in Older Adults
The aim of this study is to assess the impact of 5-hydroxytryptophan (5-HTP) supplementation on sleep quality and gut microbiome composition in older adults with normal cognition vs.
- Trial name
- NCT04078724
- Testing
- 5-HTP, Without 5-HTP
- Where
- 2 sites in Singapore
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Obstructive Sleep Apnea, Comorbid Insomnia and Sleep Apnea
Does the Timing of Insomnia Therapy (CBT-i) Impact the Usage and Compliance of Upper Airway Stimulation (UAS) Treatment of Obstructive Sleep Apnea (OSA)
Obstructive sleep apnea, or OSA, affects over 1 billion adults worldwide. OSA is one of many sleep disorders. Individuals can suffer from more than one sleep disorder at a time.
- Conditions
- Obstructive Sleep Apnea, Comorbid Insomnia and Sleep Apnea, Insomnia
- Trial name
- CBT-i and UAS (NCT07838870)
- Testing
- Digital Cognitive Behavioral Therapy (CBT-i)-COAST
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Kaffenberger
Obstructive Sleep Apnea, Surgery
Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA
Patients with obstructive sleep apnea (OSA) are at increased risk of developing sleep disturbances after surgery. Dexmedetomidine is a highly selective α2-adrenergic agonist with sedative, analgesic, and anxiolytic effects.
- Conditions
- Obstructive Sleep Apnea, Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT06566482
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Insomnia
Internet Delivered Self-help for Insomnia
The current study aims to evaluate the effects of internet-delivered self-help CBT for insomnia through a randomised controlled trial.
- Trial name
- NCT00851188
- Testing
- Internet CBT self-help, CBT self-help booklet, Waiting list
- Where
- Netherlands
- Volunteers
- 626 people, healthy volunteers welcome
- Sponsor
- Jaap Lancee
Insomnia
Cognitive-behavioral Therapy for Insomnia in School-aged Children
This randomized controlled trial will test the efficacy of CBT-I intervention for school-aged children (7-11 years old) with insomnia. The trial will focus on the role of sleep restriction therapy in treatment.
- Trial name
- NCT07048340
- Testing
- Cognitive Behavioral Therapy for Insomnia, Cognitive Behavioral Therapy for Insomnia without SRT
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Tel Aviv University
Diabetic Peripheral Neuropathy
Exercise Effects on Pain, Sleep and Depression in Diabetic Peripheral Neuropathy
It is known that the pain experienced by individuals with diabetic neuropathy negatively impacts sleep and quality of life, leading to numerous psychosocial problems such as anxiety and depression.
- Trial name
- NCT07291596
- Testing
- Ankle-Foot Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Amasya University
Women in the Menopausal Period
Effect of Sleep Hygiene Education on Comfort and Sleep Quality in Menopausal Women
The decrease in estrogen levels in the body during menopause can lead to sleep disturbances by disrupting serotonin metabolism, which plays an important role in regular sleep.
- Trial name
- NCT06884917
- Testing
- Sleep Hygiene Training
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Saglik Bilimleri Universitesi
Sleep Quality
Sleep Quality Among HCWs
The novel coronavirus has brought the world into uncharted waters. Whole countries are on lockdown, the economy has ground to a halt, and many people are afraid for themselves and their loved ones.
- Trial name
- NCT04549350
- Testing
- PSQI
- Where
- Egypt
- Volunteers
- 217 people
- Sponsor
- Zagazig University
Cerebral Palsy (CP), Pain
EFFECTS OF AROMATHERAPY AND REFLEXOLOGY ON PAIN, SLEEP, AND SATISFACTION IN CHILDREN WITH CEREBRAL PALSY
This randomized controlled trial was conducted to evaluate the effects of aromatherapy and foot reflexology on pain, sleep quality, and parental satisfaction in children with cerebral palsy.
- Conditions
- Cerebral Palsy (CP), Pain, Sleep Disorder (Disorder)
- Trial name
- AROMA-REF CP (NCT07519291)
- Testing
- Aromatherapy, Reflexology
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Hakkari Universitesi
Insomnia
Long-term Follow-up of Functional Performance and Exercise Efficacy in Community-dwelling Elderly With Insomnia
Poor sleep quality has been recognized as a major public health concern in the world. The prevalence of insomnia in Taiwan is comparable to that of Western countries.
- Trial name
- NCT01689818
- Testing
- exercise training
- Where
- Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Nightmare
Nightmare Deconstruction and Reprocessing vs. NightWare Wristband
The overall goal of this Phase IIa randomized controlled pilot trial is to assess the potential efficacy of two emerging treatments for post-trauma nightmares and to test the feasibility of study design and methods.
- Trial name
- NDR/NW (NCT06399874)
- Testing
- Nightmare Deconstruction and Reprocessing, NightWare
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Uniformed Services University of the Health Sciences
Insomnia
Open-Label Study of Bioavailability of E2006 Tablet Versus Capsule Formulations
This is a single-center, open-label, randomized crossover study being conducted in three cohorts of healthy adult subjects. Approximately 36 subjects will be randomized to one of three cohorts (approximately 12 subjects per…
- Trial name
- NCT01673880
- Testing
- E2006
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Stress, Sleep Disturbance
Diaphragmatic Breathing and Global Postural Reeducation on Stress and Sleep Quality in University Students
Introduction: Nowadays, the reduction of perceived stress and the improvement of sleep quality are considered fundamental aspects in the quality of life of both healthy subjects and patients with disease.
- Trial name
- RPGBREATH23 (NCT06308783)
- Testing
- Diaphragmatic Breathing, Global Postural Reeducation
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
CKD, Sleep Disorder
Sucrosomial Iron on Insomnia in Non-dialysis Chronic Kidney Disease Patients With Iron Deficiency Anemia
Insomnia or sleep disturbance is a common disorder in patients with chronic kidney disease (CKD), but is often unrecognized and undertreated.
- Trial name
- NCT06279429
- Testing
- Sideral® Sucrosomial Iron, Iron chewable tablet
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Kuang Tien General Hospital
Chronic Insomnia
Enhancing Access to Insomnia (EASI) Care in VA PCMHI Clinics
This multi-site project (four VA Medical Centers) will test two approaches to improving the delivery of a behavioral insomnia treatment in the Primary Care setting to Veterans.
- Trial name
- NCT04350866
- Testing
- Expert Recommendations for Implementing Change bundle of strategies, Brief Behavioral Treatment for Insomnia
- Where
- United States
- Volunteers
- 277,920 people
- Sponsor
- VA Office of Research and Development
Alzheimer Disease, Dementia
Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase
This study seeks to improve clinical outcomes for an important, growing, and vulnerable population-nursing home residents with Alzheimer's disease or related dementias-by testing an evidence-based intervention to improve these…
- Conditions
- Alzheimer Disease, Dementia, Sleep Disorder, Sleep Disturbance
- Trial name
- 40Winks (NCT05820919)
- Testing
- LOCK Sleep Program, No intervention (control period/baseline data collection)
- Where
- 3 sites in United States
- Volunteers
- 456 people
- Sponsor
- University of Alabama, Tuscaloosa
Insomnia, Stress
Stress and Insomnia
Insomnia is characterized by rumination and worry over stressful events affecting nighttime sleep. Emotional reactions while stressful events are ongoing have not often been investigated in insomnia.
- Trial name
- StresSleep (NCT02591303)
- Testing
- Stress reactions measurement during stressful and neutral driving sessions
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Massage, Heart Failure
Effect of Massage Therapy on Fatigue and Sleep Quality in Patients With Heart Failure in Intensive Care Unit
The purpose of this study was to explore the effect of massage therapy on fatigue and sleep quality in patients with heart failure in the intensive care unit.
- Trial name
- NCT05366673
- Testing
- massage
- Where
- Taiwan
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Preoperative, Sleep
The Effect of the Use of Gel Pillows on the Sleep Quality and General Comfort Levels
The study was conducted to evaluate the effect of using gel pillows on the sleep quality and general comfort levels of patients in the preoperative period.The main hypotheses are: H1: 'The sleep quality of patients who use gel…
- Conditions
- Preoperative, Sleep, Comfort
- Trial name
- NCT06025136
- Testing
- Using a gel pillow
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Trakya University
Depressive Disorder, Sleep Disturbance
iACT & iTBS for Sleep Quality in Depressed Adolescents
This study evaluated whether combining an internet-delivered Acceptance and Commitment Therapy program with intermittent theta burst stimulation improves subjective sleep quality in adolescents with depressive disorders and sleep…
- Trial name
- NCT07807072
- Testing
- Internet-Delivered Acceptance and Commitment Therapy, Intermittent Theta Burst Stimulation
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Central China Normal University