Clinical trials: Insufficiency, Pulmonary
Asthma in Children
Sensitivity of Forced Oscillation Technique in Children With Asthma and Normal Spirometry
Exhibiting variable airway obstruction is a key factor in the diagnosis of asthma but too often it is undetected by spirometry. Study hypothesis: The forced oscillation technique (FOT) will show airway obstruction in asthmatic…
- Trial name
- NCT03755908
- Testing
- Forced oscillation technique (FOT)
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Rambam Health Care Campus
COVID-19, Vitamin D Deficiency
The Effects of a Sublingual Sprayable Microemulsion of Vitamin D on Inflammatory Markers in COVID-19 Patients
This placebo-controlled five-day study will be performed on 100 hospitalized COVID-19 patients with vitamin D insufficiency randomized into two groups.
- Trial name
- NCT05502068
- Testing
- Vitamin D 25 (OH) 12000 IU in the form of a sublingual sprayable microemulsion
- Where
- Latvia
- Volunteers
- 102 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Effects of L-arginine and Liposomial Vitamin C on Severe Copd Patients Undergoing Pulmonary Rehabilitation.
The hypothesis that is being tested is that the supplementation of L-arginine plus Vitamin C to multidisciplinary pulmonary rehabilitation (PR) in patients with a previous diagnosis of chronic obstructive pulmonary disease (COPD)…
- Trial name
- NCT06439875
- Testing
- effect of L-arginine and liposomial vitamin C on pulmonary rehabilitation
- Where
- 3 sites in Italy
- Volunteers
- 101 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Atrial Fibrillation, Deep Vein Thrombosis
Pharmacogenetics of Warfarin in Puerto Ricans.
Warfarin (Coumadin) is a prescribed "blood thinner" medication used to make the blood less thick in people with high risk of forming blood clots.
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Cardiac Valvular Insufficiency, Antiphospholipid Syndrome
- Trial name
- NCT01318057
- Where
- Puerto Rico
- Volunteers
- 350 people
- Sponsor
- University of Puerto Rico
Heart Failure With Reduced Ejection Fraction, Mitral Regurgitation
The CardioClip Study
The CardioClip study is exploring the use of a wireless sensor to monitor pressure in the pulmonary artery. This sensor is inserted much like the mTEER procedure, a non-surgical method through a vein in the groin.
- Trial name
- CardioClip (NCT06241430)
- Testing
- CardioMEMS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
Breathing, Mouth, Lung Function Decreased
Evaluating the Use of a Device Called Impulse Oscillometry in Participants With Vocal Cord Disorders or Asthma
This study will determine if airway resistance to airflow and pressure, measured by Impulse Oscillometry, is impacted in subjects with vocal cord disorders and whether these measurements are different when compared to subjects…
- Conditions
- Breathing, Mouth, Lung Function Decreased, Vocal Cord Dysfunction, Laryngeal Obstruction
- Trial name
- NCT05246930
- Testing
- Impulse Oscillometer
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Rochester
Pulmonary Arterial Hypertension, Renal Dysfunction
The Effect of Renal Impairment on the Pharmacokinetics of Oral Treprostinil
This is a single-center, open-label, single-dose evaluation of 1 mg UT-15C SR pharmacokinetics, safety, and tolerability in subjects with normal, mild, moderate and end stage renal disease (ESRD; on dialysis).
- Trial name
- NCT01131845
- Testing
- UT-15C SR (treprostinil diethanolamine)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- United Therapeutics
COPD, Asthma (Diagnosis)
A Study to Evaluate the Diagnostic Performance of Portable Oscillometry Across Chronic Respiratory Diseases
This is a prospective, multicenter, observational cohort study enrolling approximately 4,000 subjects across about 50 centers, including patients with COPD (confirmed and suspected), asthma (confirmed and suspected)…
- Conditions
- COPD, Asthma (Diagnosis), Chronic Respiratory Diseases, Bronchiectasis
- Trial name
- NCT07631507
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Respiratory Failure
Lung Volume Change Between Noninvasive Positive Pressure Ventilation by Nasal Pillow and High Flow Nasal Cannula
The difference of lung volume change will be monitored by electrical impedance tomography before and after use of noninvasive positive pressure ventilation by nasal pillow and high flow nasal cannula in post-extubation patients.
- Trial name
- NCT02292992
- Testing
- Nasal Pillow CPAP
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Mackay Memorial Hospital
Complication of Surgical Procedure, Acute Respiratory Failure, Adult
Prospective Evaluation of a RIsk Score for Postoperative Pulmonary COmPlications in Europe
Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe (PERISCOPE) is a multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric…
- Conditions
- Complication of Surgical Procedure, Acute Respiratory Failure, Adult, Postoperative Respiratory Complications, Pulmonary Failure
- Trial name
- PERISCOPE (NCT01346709)
- Where
- 63 sites in Albania, Belgium and 19 more
- Volunteers
- 5,450 people
- Sponsor
- European Society of Anaesthesiology
Heart Failure, Community Acquired Pneumonia
Collaborative Healthcare Professionals Approach in Monitoring of Patient Centered Outcomes Through Pathways
The aim of this study is to determine if by providing a collaborative, integrated pathway-based healthcare compared to the usual healthcare, whether or not this would be superior in reducing the length of hospital stay across…
- Conditions
- Heart Failure, Community Acquired Pneumonia, Venous Thromboembolism, Acute Kidney Injury
- Trial name
- CHAMP-Path (NCT01561885)
- Testing
- Pathway-Based Care
- Where
- Saudi Arabia
- Volunteers
- 341 people
- Sponsor
- Majed Aljeraisy
Lung Neoplasms, Airway Obstruction
RejuvenAir™ System Lobectomy Safety and Histology Study
Cryotherapy has a long history of safe use in various medical procedures. RejuvenAir System radial spray cryotherapy is a novel procedure being developed as a treatment for conditions associated with abnormal bronchial function…
- Conditions
- Lung Neoplasms, Airway Obstruction, Lung Cancer
- Trial name
- Lobectomy (NCT02106143)
- Testing
- RejuvenAir™ Radial Spray Cryotherapy
- Where
- 3 sites in Ireland, Netherlands and 1 more
- Volunteers
- 11 people
- Sponsor
- CSA Medical, Inc.
Obesity Hypoventilation Syndrome, Obstructive Sleep Apnea
Simplus and Eson Non-Invasive Ventilation (NIV) Evaluation - Germany
This investigation is designed to evaluate the performance, comfort and ease of use of the Simplus and Eson masks amongst NIV patients who are currently on Bi-level therapy
- Conditions
- Obesity Hypoventilation Syndrome, Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Neuromuscular Disease
- Trial name
- NCT02726048
- Testing
- Simplus/Eson
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- Fisher and Paykel Healthcare
Inadequate or Impaired Respiratory Function
Positive Airway Pressure Versus Breathing Exercises With Load Inspiratory in Patients Undergoing Bariatric Surgery
Obesity, due to excess fat in the thoracoabdominal region, can promote changes in respiratory function and lung function, leading to reduction in lung volume and capacity.
- Trial name
- NCT02682771
- Testing
- Bilevel positive airway pressure, PowerBreathe, Conventional Respiratory Physiotherapy (CRP)
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF)
Phase 2 Study to Assess the Safety and Efficacy of ANG003
In this study, ANG003, a pancreatic enzyme replacement therapy (PERT; commonly called "enzymes"), is being investigated as a potential treatment for exocrine pancreatic insufficiency (EPI).
- Trial name
- NCT07450547
- Testing
- ANG003 Dose A, ANG003 Dose B, Creon
- Where
- 28 sites in United States
- Volunteers
- 113 people
- Sponsor
- Anagram Therapeutics, Inc.
Covid19
Pronation in COVID-19 Patients Undergoing Non Invasive Respiratory Support
Pronation seems feasible and effective in improving blood oxygenation in patients with COVID-19 pneumonia. Data are lacking on the effects of pronation on clinical outcome in this subset of patients.
- Trial name
- PRINCESS (NCT04649658)
- Testing
- Prone position
- Where
- Italy
- Volunteers
- 93 people
- Sponsor
- University of Modena and Reggio Emilia
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Validation of Chinese SRI Questionnaire
Assessment of health-related quality of life in COPD patients with severe chronic respiratory failure requires appropriate and highly specific measurement tools.
- Trial name
- VCSRI (NCT02240225)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Respiratory Failure
Evaluation of the Effectiveness of Vibroacoustic Therapy in the Complex Treatment of Acute Respiratory Failure
Evaluation of the effectiveness of vibroacoustic therapy in the complex treatment of acute respiratory failure
- Trial name
- NCT03911947
- Testing
- Vibrolung
- Where
- 5 sites in Kazakhstan
- Volunteers
- 113 people
- Sponsor
- Astana Medical University
Wheezy Bronchitis, Asthmatic Bronchitis
Efficacy of Intermittent Tiotropium in Early Childhood Wheezing
This study evaluates the effect of intermittent tiotropium bromide and salbutamol as needed versus intermittent fluticasone propionate and salbutamol as needed, or solely, salbutamol as needed on episode-free days in infants and…
- Conditions
- Wheezy Bronchitis, Asthmatic Bronchitis, Wheezing, Obstruction Airway
- Trial name
- NCT03199976
- Testing
- Tiotropium Bromide, Fluticasone Propionate, Salbutamol
- Where
- Finland
- Volunteers
- 80 people
- Sponsor
- Helsinki University Central Hospital
Cystic Fibrosis, Exocrine Pancreatic Insufficiency
Safety and Efficacy Study of ULTRASE® MT20 in Participants With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (PI)
The purpose of this study is to assess the safety and efficacy of Ultrase® MT20 compared to placebo for the correction of fat and protein malabsorption in participants with cystic fibrosis (CF) and exocrine pancreatic…
- Trial name
- NCT00408317
- Testing
- Ultrase® MT20
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- Forest Laboratories
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