Clinical trials: Insufficiency, Pulmonary
COPD, Respiratory Insufficiency
Use of Autologous Stem/Stromal Cells In Chronic Lung Disorders: Obstructive (COPD) & Restrictive (RLD)
Pulmonary Disorders are often categorized as Obstructive or Restrictive disorders. This study will establish two channels of investigation, one group within each type of pulmonary dysfunction.
- Trial name
- cSVF-Lung (NCT03909750)
- Testing
- Lipoaspiration, AD-cSVF, Normal Saline IV
- Where
- 2 sites in United States, Honduras
- Volunteers
- 50 people
- Sponsor
- Healeon Medical Inc
Sickle Cell Disease Vaso-occlusive Crisis
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
This is a phase 2, randomized, multiple-dose, placebo-controlled study designed to evaluate the safety, efficacy, and pharmacokinetics (PK) of CSL889 (human hemopexin) when given intravenously (IV) to adults and adolescents with…
- Trial name
- NCT06699849
- Testing
- CSL889
- Where
- 30 sites in United States, Turkey (Türkiye) and 1 more
- Volunteers
- 70 people
- Sponsor
- CSL Behring
Coronary; Ischemic, Arrhythmias, Cardiac
Influence of a Multi-parametric Optimization Strategy for General Anesthesia on Postoperative Morbidity and Mortality
With the increasing aging population demographics and life expectancies, the number of very elderly patients undergoing surgery is rising.
- Conditions
- Coronary; Ischemic, Arrhythmias, Cardiac, Heart Failure, Peripheral Vascular Diseases
- Trial name
- OPTI-AGED (NCT02668250)
- Testing
- OPTI-AGED, Usual Care
- Where
- 29 sites in France
- Volunteers
- 2,495 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
ARDS (Acute Respiratory Distress Syndrome), VILI (Ventilator-induced Lung Injury)
Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study)
The REALVENT trial is designed to evaluate whether a real-time, algorithm-driven ventilation feedback strategy can improve lung-protective ventilation (LPV) achievement rates in critically ill patients receiving invasive…
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), VILI (Ventilator-induced Lung Injury), Respiratory Failure, Critical Illness
- Trial name
- REALVENT (NCT07307066)
- Testing
- REal-time Algorithm-driven Ventilation feedback to improve lung-protective ventilation in critically, Standard ICU care
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Peking Union Medical College Hospital
Respiratory Failure
Comparison of Non-invasive Methods of Lung Ventilation in Patients With Respiratory Failure After Cardiac Surgery
Comparison of the effectiveness of three methods of non-invasive ventilation in patients with mild and moderate respiratory failure in the early postoperative period after cardiac surgery
- Trial name
- NCT04787666
- Testing
- Using of non-invasive mask ventilation, high-flow oxygen therapy through a nasal cannula (high-flow nasal oxygenation) and non-invasive ventilation with a helmet
- Where
- Russia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Petrovsky National Research Centre of Surgery
Respiratory Insufficiency, Chronic Obstructive Pulmonary Disease
Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure.
Non-invasive ventilation has become increasingly important in the management of patients with acute respiratory failure. One of its major goals is to prevent the need for invasive ventilation, which is associated with numerous…
- Conditions
- Respiratory Insufficiency, Chronic Obstructive Pulmonary Disease, Pneumonia, Pulmonary Edema
- Trial name
- NCT00331656
- Testing
- Non-invasive positive pressure mask ventilators, Extrathoracic biphasic cuirass ventilator (RTX, Hayek)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Venous Insufficiency
The Efficacy of Venavine Intensive® on the Quality of Life in Females With Chronic Venous Insufficiency
Chronic Venous Insufficiency (CVI) is impaired venous return which results in lower limbs symptoms that include pain, swelling and dermatologic changes.
- Trial name
- NCT02498327
- Testing
- Gelatine Capsule, Venavine Intensive®
- Where
- South Africa
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Johannesburg
Post Thrombotic Syndrome, Deep Vein Thrombosis
Long-term Outcome After Heparin and Edoxaban Versus Heparin Plus Vit K Antagonists for Acute DVT and PE
Centers that participated in the HOKUSAI VTE trial will be invited to collect follow of previously enrolled patients at least 2 years after the index VTE.
- Conditions
- Post Thrombotic Syndrome, Deep Vein Thrombosis, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT03757481
- Testing
- no intervention
- Where
- 11 sites in France
- Volunteers
- 156 people
- Sponsor
- University Hospital, Montpellier
Chronic Kidney Disease Stage 2, Chronic Kidney Disease Stage 3
Preserving Kidney Function in Children With Chronic Kidney Disease
Pediatric chronic kidney disease (CKD) results from health conditions that reduce kidney function for >3 months. It can progress to end-stage kidney disease (ESKD), which requires dialysis or kidney transplant.
- Conditions
- Chronic Kidney Disease Stage 2, Chronic Kidney Disease Stage 3, Pediatric Kidney Disease
- Trial name
- PRESERVE (NCT05169411)
- Testing
- Blood pressure, Urine protein
- Where
- United States
- Volunteers
- 20,240 people
- Sponsor
- Children's Hospital of Philadelphia
Pulmonary Edema, Respiratory Insufficiency
Mortality and Risk Factors in Patients With Acute Cardiogenic Pulmonary Edema: a Multicentric, Observational, Prospective Study
The purpose of this study is to define the current treatment of patients ospitalized with acute cardiogenic pulmonary edema. Clinical and laboratory data collected in the Emergency Department will used to investigate the primary…
- Trial name
- ACPE (NCT01269177)
- Testing
- Non invasive ventilation
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Milan
Infections, Heart Failure
Rural Hospital-Level Care at Home for Acutely Ill Adults
This study examines the implications of providing hospital-level care in rural homes.
- Conditions
- Infections, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT05256303
- Testing
- Home Hospital care, Traditional Hospital care
- Where
- 3 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- Brigham and Women's Hospital
Respiratory Distress Syndrome, Adult
Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Patients Having Acute Respiratory Distress Syndrome (ARDS)
In this study effectiveness and safety of a new drug FP-1201-lyo (recombinant human interferon beta-1a) is compared to placebo. Investigation is conducted with patients who have acute respiratory distress syndrome (ARDS).
- Trial name
- INTEREST (NCT02622724)
- Testing
- Interferon beta-1a
- Where
- 71 sites in Belgium, Czechia and 6 more
- Volunteers
- 301 people
- Sponsor
- Faron Pharmaceuticals Ltd
Acute Respiratory Failure, Lung Diseases
Extracorporeal Support for Respiratory Insufficiency (ECMO)
To evaluate indications for the use and efficacy of extracorporeal membrane oxygenators (ECMO's) for the support of patients with potentially reversible acute respiratory failure.
- Trial name
- NCT00000562
- Testing
- extracorporeal membrane oxygenation
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Critical COVID-19 With Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure
Novel Corona Virus (SARS-CoV-2) is known to cause Respiratory Failure, which is the hallmark of Acute COVID-19, as defined by the new NIH/FDA classification.
- Conditions
- Critical COVID-19 With Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Corona Virus Infection, Acute Lung Injury
- Trial name
- COVID-AIV (NCT04311697)
- Testing
- Aviptadil by intravenous infusion + standard of care, Normal Saline Infusion + standard of care
- Where
- 10 sites in United States
- Volunteers
- 203 people
- Sponsor
- APR Applied Pharma Research s.a.
End Stage Liver Disease, Lung Cancer
Antinociceptive Modalities on Ischemia Reperfusion Injury
Postoperative pain caused by surgery-associated tissue injury is a major concern for all the clinical practitioners. Because it affects multiple systems and induces physiological, immunological and psychological changes.
- Trial name
- NCT01932918
- Testing
- Patient controlled analgesia
- Where
- Taiwan
- Volunteers
- 142 people
- Sponsor
- National Taiwan University Hospital
Acute Respiratory Failure, Acute Respiratory Distress Syndrome
Closed-loop syncHronization vErsuS convenTional Synchronization in sPontaneously Breathing Adult Nonivasive ventilationPatients
The study is a multicentric prospective randomised cross-over study. It evaluates the compatibility of patients with the device without altering the routine treatment applied.
- Conditions
- Acute Respiratory Failure, Acute Respiratory Distress Syndrome, Chronic Respiratory Failure
- Trial name
- CHESTSPAN (NCT06357780)
- Testing
- close-loop synchronization controller with spontaneous mode, Conventional
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Respiratory Insufficiency in Children, Newborn Rds
Diaphragmatic Work During HFNC and CPAP Support
The goal of this randomised controlled, cross-over clinical trial is to compare High Flow Nasal Cannulas (HFNC) and Continuous Positive Airways Pressure (CPAP) in neonates over 34 weeks' amenorrhoea (SA) up to children weighing…
- Conditions
- Respiratory Insufficiency in Children, Newborn Rds, Nasal Cannula, CPAP Ventilation
- Trial name
- DiaWorkHFNC (NCT06249009)
- Testing
- Non invasive ventilation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Lung Function Decreased
Effect of Respiratory Muscle Training on Lung Function on Quarry Workers in Minia Government Egypt
forty quarry workers participated in the study with age range (40-60 years), body mass index (BMI) from 25 to 34.9 kg/m2 (over weight and class 1 obesity). The patients divided into two groups randomly.
- Trial name
- NCT06070584
- Testing
- aerobic exercises with electrical treadmill for 30 min and inspiratory muscle training for 10 minutes.,
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Deraya University
Pulmonary Hypertension
Effect of Nasal Highflow on Right Heart Function
In this study effect of NHF on pulmonary thermodynamic parameters will studied.
- Trial name
- HÄMOFLOW (NCT02885116)
- Testing
- Nasal high flow (NHF) supplementation, oxygen supplementation
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Leipzig
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study B, RCT
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT04790617)
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 183 people
- Sponsor
- University of Calgary
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