Clinical trials: Insufficiency, Pulmonary
Covid19, Corticosteroids
Low or High Dose of Dexamethasone in Patients With Respiratory Failure by COVID-19
After RECOVERY trial publication, low dose (6 mg dexamethasone for 10 days) was recommended as the usual care treatment in hospitalized patients with respiratory failure by COVID-19 needing oxygen therapy.
- Trial name
- HIGHLOWDEXA (NCT04726098)
- Testing
- Dexamethasone high dose, Dexamethasone low dose
- Where
- Spain
- Volunteers
- 198 people
- Sponsor
- Manuel Taboada Muñiz
Acute Kidney Injury
UltraSound Evaluation of Fluid tOleRanCE for Acute Kidney Injury
Fluid expansion with isotonic crystalloids is a first-line intervention in the treatment of patients with acute kidney injury (AKI).
- Trial name
- USE-the-FORCE (NCT06411080)
- Testing
- Ultrasound evaluation of fluid tolerance
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Congenital Disorders
Constrictive Pericarditis in the Adult Congenital Cardiac Population
The primary aim of this study is to determine the clinical and radiographic findings with constrictive pericarditis in the adult congenital population and determine the degree of right heart failure and dilation from pulmonary…
- Trial name
- NCT00268086
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Healthcare of Atlanta
Respiratory Failure, Respiratory Insufficiency
Comparison of High-flow Oxygen vs. BiPAP in Type II (Hypercapnic) Respiratory Failure
A retrospective cohort study of all patients treated for type II (hypercapnic) respiratory failure with either High-Flow Oxygen Therapy or Non-Invasive Ventilation in a general adult hospital.
- Conditions
- Respiratory Failure, Respiratory Insufficiency, Respiratory Tract Diseases, COPD
- Trial name
- NCT03443479
- Testing
- Non-Invasive Ventilation, High-Flow Nasal Cannula
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- Hôpital de Verdun
Exocrine Pancreatic Insufficiency, Cystic Fibrosis
Control of Steatorrhea in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency
This study by Aptalis (formerly Axcan) assesses the efficacy and safety of Panzytrat® 25,000 compared to Kreon® 25,000 in the control of steatorrhea in participants with cystic fibrosis (CF) and exocrine pancreatic insufficiency…
- Trial name
- NCT01327703
- Testing
- Panzytrat® 25,000, Kreon® 25,000
- Where
- 13 sites in Germany, Poland
- Volunteers
- 87 people
- Sponsor
- Forest Laboratories
Infection, Heart Failure
Rural Home Hospital: Proof of Concept
This study examines the implications of providing hospital-level care in rural homes.
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04531280
- Testing
- Home hospital care
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Brigham and Women's Hospital
Diaphragm Injury, Lung Injury
Lung and Diaphragm-Protective Ventilation by Means of Assessing Respiratory Work
This study is designed to test a proposed strategy for lung- and diaphragm-protective ventilation (LDPV) in patients with acute hypoxemic respiratory failure.
- Conditions
- Diaphragm Injury, Lung Injury, Respiratory Insufficiency, Mechanical Ventilation Complication
- Trial name
- LANDMARK (NCT03612583)
- Testing
- Lung- and Diaphragm-Protective Ventilation
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- University Health Network, Toronto
Multi-organ Failure After Severe Trauma
Metabolic Reprogramming in Renal Tubular Cells in Acute Kidney Injury Following Severe Trauma
Severe trauma remains the leading cause of death in people under 50, and is associated with high morbidity, including severe disability, with a substantial socio-economic impact.
- Trial name
- METAKIT (NCT06167512)
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease, Cerebral Vascular Disease
Pilot Study: Cardiovascular Events in High Risk Orthopedic Surgical Patients
This is a non-randomized, non-interventional pilot observational study designed to follow high-risk patients through their surgical and hospital stay.
- Conditions
- Coronary Artery Disease, Cerebral Vascular Disease, Peripheral Artery Disease, Renal Insufficiency
- Trial name
- NCT01809730
- Where
- United States
- Sponsor
- NYU Langone Health
Acute Respiratory Distress Syndrome, Acute Lung Injury
Airway Pressure Release Ventilation as a Preventative Strategy
The early initiation of Airway Pressure Release Ventilation in multi-system trauma patients decreases the incidence and severity of acute lung injury and Acute Respiratory Distress Syndrome and allows faster recovery of lung…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Respiratory Failure, Trauma
- Trial name
- NCT00813371
- Testing
- Airway Pressure Release Ventilation, ARDSnet protocol
- Sponsor
- Texas Tech University Health Sciences Center
Healthy Adults, Pulmonary Hypertension
A Multicenter Study on the Normal Reference Range and Clinical Significance of the Right Atrioventricular Coupling Index Assessed by Artificial Intelligence-Based Three-Dimensional Echocardiography
This multicenter study aims to establish the normal reference range of the Right Atrioventricular Coupling Index (RACI) in healthy Chinese adults using AI-based 3DE technology.
- Conditions
- Healthy Adults, Pulmonary Hypertension, Tricuspid Regurgitation, Heart Failure
- Trial name
- NCT07292896
- Where
- 25 sites in China
- Volunteers
- 2,640 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Pneumocystis Pneumonia
Effects and Safety of Caspofungin and Corticosteroids in Pneumocystis Pneumonia in Non-HIV Patients
Pneumocystis Pneumonia is increasing in Immunocompromised Non-HIV Infected Patients. The effects and safety of caspofungin and corticosteroids is not certain in this population.
- Trial name
- NCT02603575
- Testing
- caspofungin, corticosteroids, Sulfanilamides
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Chao Yang Hospital
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Sedation vs No Sedation in Mechanically Ventilated COPD Patients
This study aims to evaluate the safety and efficacy of no-sedation compared to daily interruption of sedation (DIS) in mechanically ventilated patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- SEDvsNO-COPD (NCT07620912)
- Testing
- Midalozam
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Cystic Fibrosis, Exocrine Pancreatic Insufficiency
Study of Pancreatic Enzyme Product in Pediatric Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency
This is an open-label study to evaluate the efficacy and safety of Aptalis' (formerly Eurand) pancreatic enzyme product (PEP) microtabs in pediatric participants under age 7 with cystic fibrosis (CF) and exocrine pancreatic…
- Trial name
- NCT00981214
- Testing
- EUR-1008 (APT-1008)
- Where
- 14 sites in United States
- Volunteers
- 19 people
- Sponsor
- Forest Laboratories
Diaphragm Ultrasonography, Lung Ultrasound
The Role of Lung and Diaphragm Ultrasonography in Predicting Clinical Progression in Hypoxemic Respiratory Failure
The goal of this observational study is to evaluate whether the risk of intubation in patients with hypoxemic respiratory failure who were monitored in the intensive care unit and received non-invasive mechanical ventilation and…
- Conditions
- Diaphragm Ultrasonography, Lung Ultrasound, Hypoxemic Respiratory Failure
- Trial name
- NCT06706830
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 91 people
- Sponsor
- Simge Evren
SARS-CoV-2, Covid-19
Immunological Profiling of Patients With COVID-19 in Respiratory Distress
The study investigators hypothesize that the pneumonia arising in patients with COVID-19 is largely of immunopathological origin.
- Trial name
- ACTICOV-2 (NCT04351711)
- Testing
- Immunological profiling
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Diabetes Mellitus, Respiratory Failure
The Effect of Aromatherapy Massage on Sleep Quality
Sleep disturbance is one of the most common complaints of patients admitted to ICU. Insufficient sleep in intensive care units may be associated with environmental reasons such as excessive light at night, loud warning sounds and…
- Conditions
- Diabetes Mellitus, Respiratory Failure, Pneumonia, Respiratory Disease
- Trial name
- NCT06295900
- Testing
- Intervention 1 Group, Intervention 2 Group
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Nilgün Erdoğan
COVID-19 Severe Respiratory Failure
Combination of Inhaled DNase, Baricitinib and Tocilizumab in Severe COVID-19
In patients with COVID-19, severe hypoxemic respiratory failure (SRF) leading to invasive mechanical ventilation (IMV), raises the mortality rate substantially.
- Trial name
- NCT05279391
- Testing
- Dexamethasone, Low molecular weight heparin, Anakinra 100Mg/0.67Ml Inj Syringe
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Democritus University of Thrace
COVID-19, Respiratory Failure With Hypoxia
Elmo Respiratory Support Project - COVID-19
The number of COVID-19 cases has been growing exponentially, so that the industrialized economies are facing a significant shortage in the number of ventilators available to meet the demands imposed by the disease.
- Trial name
- NCT04470258
- Testing
- ELMO PROJECT AT COVID-19: STUDY IN HUMANS, ELMO PROJECT AT COVID-19: PROOF OF CONCEPT AND USABILITY
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Escola de Saúde Pública do Ceará
Chronic Renal Disease, Renal Dialysis
Impact of the Cycle Ergometer in Muscle Strength and Pulmonary Function in Patients in Hemodialysis
Muscle strength can be measured by dynamometry, but the investigators did not find in the literature the study of this technique in the quadriceps of patients with chronic kidney disease on hemodialysis.
- Trial name
- NCT02834026
- Testing
- Cicloergometry training, No Cicloergometry training
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
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