Clinical trials: Insufficiency, Pulmonary
Premature Baby 26 to 32 Weeks, Bronchopulmonary Dysplasia
Respiratory Outcome at Adolescence of Very Low Birthweight Infants
EPIPAGEADO is an observational study. Respiratory symptoms and lung function will be evaluated in very low birth weight and term infants, born in 1997 and included in the French EPIPAGE cohort.
- Trial name
- EPIPAGEADO (NCT01424553)
- Testing
- Prevention and follow-up of the patients pulmonary parameters
- Where
- France
- Volunteers
- 355 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Diseases, Chronic Kidney Diseases
NAVIGATE Kidney: A Multi-level Intervention to Reduce Kidney Health Disparities
The overarching goal of this project is to refine and adapt previous work on the NAVIGATE-Kidney project for individuals with CKD.
- Trial name
- NAV-Kidney (NCT06810622)
- Testing
- Community health worker intervention, Standard Care (in control arm)
- Where
- 2 sites in United States
- Volunteers
- 448 people
- Sponsor
- University of Colorado, Denver
COVID-19, Acute Kidney Injury
Applying Artificial Intelligence to Identify Subphenotypes of Acute Kidney Injury in Mexican Patients With Severe COVID-19
The goal of this observational study was to identify subphenotypes of acute kidney injury patients with COVID-19, and the investigators analyzed their impact on mortality.
- Trial name
- IA-COVAKI (NCT06471101)
- Testing
- clusters
- Where
- Mexico
- Volunteers
- 2,934 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
COVID-19 Pneumonia, Sequelae of; Infection
Assessment of Long-term Sequelae of Coronavirus Disease 2019 (COVID-19) Pneumonia With Chest CT and Pulmonary Function Tests
The goal of this prospective multicentric study is to evaluate the presence of long-term pulmonary sequelae in patients who had required hospitalization for treating COVID-19 pneumonia, trough chest CT and pulmonary function…
- Conditions
- COVID-19 Pneumonia, Sequelae of; Infection, Respiratory Function Impaired, SARS CoV 2 Infection
- Trial name
- NCT05835128
- Where
- 2 sites in Portugal
- Volunteers
- 250 people
- Sponsor
- Centro Hospitalar Universitario do Algarve
COVID-19
Relation Between COVID-19 Pts and Hyponatremia in Adreno Ortical Insufficient Patients.
Hyponatremia in COVID-19 patients with adrenal insufficiency
- Trial name
- NCT05408481
- Testing
- Serum cortisol level
- Volunteers
- 50 people
- Sponsor
- Assiut University
Nursing Home Residents
Feasibility of Risk Sign Displays to Prevent Falls, Dehydration and Pulmonary Aspiration in Nursing Homes
BACKGROUND: Prior research has shown a relationship between dehydration, falls and pulmonary aspiration among older adults in nursing and health care facilities, which contributes to its loss of independence and quality-of-life.
- Trial name
- NCT03123601
- Testing
- Risk sign displays
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- Campus Neurológico Sénior
Work of Breathing
Gas Mask and Chronic Obstructive Pulmonary Disease (COPD): New Understanding on the Respiratory Index Impact?
Background: The gas mask is used to protect the aiways against respiratory hazards (CBRN agents). Within the CBRNE committee, speculations are that unprotected lungs would look like to those of COPD patients in post-exposure of…
- Trial name
- COPD (NCT02809807)
- Testing
- measurement of the work of breathing, Gas Mask
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Laval University
Smoking, Airway Obstruction
Effect of the Salbutamol on Mechanical Properties of Respiratory System
The aim of this study is to assess the bronchodilator response of salbutamol on respiratory mechanics of healthy individuals, smokers and COPD with varying degrees of airway obstruction.
- Trial name
- NCT01521572
- Testing
- Salbutamol sulphate
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML)
CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant
The purpose of this study is to learn more about the effects of (classification determinant) CD34+ stem cell selection on graft versus host disease (GVHD) in children, adolescents, and young adults.
- Conditions
- Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML), Myelodysplastic Syndrome (MDS), Juvenile Myelomonocytic Leukemia (JMML)
- Trial name
- NCT02061800
- Testing
- CliniMACS CD34+ Reagent System, Thiotepa, Cyclophosphamide
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Diane George
Primary Ovarian Insufficiency, Cardiovascular Diseases
Associations of Combinations of Single-nucleotide Polymorphisms in Women With Premature Ovarian Failure
Research objective. To study the associations between combinations of single nucleotide polymorphisms and behavioural risk factors with non-communicable diseases and adverse outcomes in women with premature ovarian failure.
- Conditions
- Primary Ovarian Insufficiency, Cardiovascular Diseases, Menopause, Premature, Coronary Disease
- Trial name
- NCT04943354
- Testing
- Taking a person's venous blood
- Where
- Russia
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Ryazan State Medical University
ARDS (Acute Respiratory Distress Syndrome), Respiratory Acidosis
Clinical Study to Determine the Optimal Operation Parameters During CO2 Removal With the Abylcap® System
This prospective study includes 5 patients with ARDS (Acute Respiratory Distress Syndrome) treated by mechanical ventilation. In case of respiratory acidosis, extracorporeal CO2 (carbon dioxide)removal might be necessary.
- Trial name
- NCT01913977
- Testing
- Abylcap® System: blood flow (QB): 200mL/min; gas flow (QG):7L/min, Abylcap® System: blood flow (QB): 300mL/min; gas flow (QG):7L/min, Abylcap® System: blood flow (QB): 400mL/min; gas flow (QG):7L/min
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- University Hospital, Ghent
Acute Respiratory Distress Syndrome
Estimation of Intrinsic Positive End-Expiratory Pressure (PEEP) in Acute Respiratory Distress Syndrome (ARDS)
ARDS (Acute Respiratory Distress Syndrome) is a condition of severe inflammation and excess fluids in the lungs that impairs their function of oxygen uptake to the point of needing a ventilator (breathing machine) to help them…
- Trial name
- NCT00446706
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Anemia, Kidney Failure
Dynepo Infrequent Dosing Study
The purpose of this study is to demonstrate non-inferiority of efficacy between twice weekly and once weekly dose schedule of Dynepo in previously erythropoietin (EPO)-naive patients, as measured by haemoglobin at week 24 and…
- Trial name
- NCT00450333
- Testing
- Dynepo (Epoetin delta), Dynepo
- Where
- 53 sites in Austria, Belgium and 5 more
- Volunteers
- 407 people
- Sponsor
- Shire
COVID-19, Renal Insufficiency, Chronic
Efficiency and Safety of Paxlovid for COVID-19 Patients With Severe Chronic Kidney Disease
This is a prospective, single-center, open and self-controlled study.The purpose of this study is to evaluate the efficacy and safety of Paxlovid for the treatment of COVID-19 patients with severe chronic kidney disease.
- Trial name
- ESPTCSCKD (NCT05938140)
- Testing
- Nirmatrelvir/ritonavir
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis
Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis
The purpose of this study is to determine whether nasal high flow is non inferior to non invasive ventilation (NIV) in the early treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and…
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis, Respiratory Failure With Hypercapnia
- Trial name
- HiCOPD (NCT06114667)
- Testing
- Ventilatory support via nasal high flow, Ventilatory support via NIV
- Where
- 3 sites in France
- Volunteers
- 174 people
- Sponsor
- University Hospital, Montpellier
Infant, Newborn, Hypertension, Pulmonary
Inhaled Nitric Oxide Study for Respiratory Failure in Newborns
Respiratory failure in term newborns is associated with increased rates of death and long-term neurodevelopmental problems. This large international multicenter trial randomized newborns who had failed to respond to intensive…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- NINOS (NCT00005776)
- Testing
- Inhaled nitric oxide
- Where
- 20 sites in United States, Canada
- Volunteers
- 235 people
- Sponsor
- NICHD Neonatal Research Network
COPD, Interstitial Pneumonia
Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study
This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results.
- Conditions
- COPD, Interstitial Pneumonia, Bronchiectasis, Respiratory Failure
- Trial name
- NCT06922916
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Zhejiang University
Chronic Kidney Disease, Unspecified
Paricalcitol on Albuminuria, Inflammation and Fibrosis on Proteinuric Chronic Renal Diseases (PALIFE Study)
The purpose of this study is to estimate the differences between albuminuria values determined as Urine Albumin-to-Creatinine Ratio (UACR)(log transformed) from baseline to last observation caused by paricalcitol between the…
- Trial name
- PALIFE (NCT01820078)
- Testing
- Experimental arm, Comparator Arm
- Where
- 25 sites in Spain
- Volunteers
- 127 people
- Sponsor
- Fundación Renal Iñigo Alvarez De Toledo
Preterm Infant, Respiratory Insufficiency Syndrome of Newborn
Non-invasive Respiratory Support in Preterm Infants
Lungs of babies born early are not fully developed and they often need a machine to help them breathe. The traditional approach to provide this support is with a breathing tube passed into the windpipe.
- Conditions
- Preterm Infant, Respiratory Insufficiency Syndrome of Newborn, Bronchopulmonary Dysplasia
- Trial name
- NOVEL (NCT03512158)
- Testing
- Non-invasive respiratory support mode
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster Children's Hospital
Early Onset Scoliosis, Congenital Spinal Deformities
The Treatment of Progressive Early Onset Spinal Deformities: A Multi-Center Outcome Study
The purpose of this study is to examine the treatment, both surgical and non-surgical, of patients with any form of early onset scoliosis.
- Conditions
- Early Onset Scoliosis, Congenital Spinal Deformities, Infantile Idiopathic Scoliosis, Neuromuscular Spinal Deformity
- Trial name
- GSSG (NCT02299362)
- Where
- 27 sites in United States, Canada and 5 more
- Volunteers
- 2,602 people
- Sponsor
- Growing Spine Study Group