Clinical trials: Insufficiency, Pulmonary
Heart Transplantation, Kidney Transplantation
Effects of Donor and Recipient Genetic Expression on Heart, Lung, Liver, or Kidney Transplant Survival
Activity of genes in donor tissues that are involved in inflammation are thought to be involved with early organ dysfunction, increased immune responses in transplant recipients, and organ rejection.
- Conditions
- Heart Transplantation, Kidney Transplantation, Liver Transplantation, Lung Transplantation
- Trial name
- NCT00531921
- Where
- 5 sites in United States
- Volunteers
- 313 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Kidney Injury, Acute Kidney Failure
AKI After Pulmonary Endarterectomy
This retrospective, single-centre observational study evaluates perioperative determinants and clinical outcomes of postoperative acute kidney injury (AKI) in patients undergoing pulmonary endarterectomy (PEA) between 2018 and…
- Conditions
- Acute Kidney Injury, Acute Kidney Failure, Pulmonary Thromboembolisms, Hypothermic Circulatory Arrest Time
- Trial name
- NCT07132619
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ebru Girgin Dinc
COVID-19
Clinical and Electronic Record for Patients With COVID-19 Treated With the Assisted Breathing Helmet - ELMO in Ceará
Continuous positive airway pressure (CPAP) with a helmet-like interface has been described as a safe strategy, with minimal contamination of the environment, improving the oxygenation of patients with acute respiratory failure…
- Trial name
- COVID-19 (NCT05375799)
- Testing
- Clinical Observation
- Where
- Brazil
- Volunteers
- 2,000 people
- Sponsor
- Escola de Saúde Pública do Ceará
Infections, Heart Failure
Advancing Health Information Exchange (HIE) During Inter-hospital Transfer (IHT) to Improve Patient Outcomes
Sub-optimal transfer of clinical information during inter-hospital transfer (IHT, the transfer of patients between acute care hospitals) is common and can lead to patient harm.
- Conditions
- Infections, Heart Failure, COPD Exacerbation, Asthma
- Trial name
- NCT05443321
- Testing
- Health Information Exchange (HIE) platform
- Where
- United States
- Volunteers
- 1,006 people
- Sponsor
- Brigham and Women's Hospital
Coronavirus Infections, Respiratory Failure
Acute Respiratory Failure and COVID-19 in Real Life
In December 2019 a new kind of virus was identified in China as the responsible of severe acute respiratory syndrome (SARS) and interstitial pneumonia.
- Conditions
- Coronavirus Infections, Respiratory Failure, Ventilator Lung
- Trial name
- NCT04307459
- Testing
- standard operating procedures
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- University of Milan
Urinary Bladder Neoplasm, Triple Negative Breast Neoplasms
Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies
This study is a Phase I/II, multicenter, first-in-human, open-label dose-escalation study of BT8009 given as a single agent and in combination with pembrolizumab in participants with advanced solid tumors associated with Nectin-4…
- Conditions
- Urinary Bladder Neoplasm, Triple Negative Breast Neoplasms, Hormone Receptor Positive, HER2-negative Neoplasms, Hormone Receptor Positive, HER2-low Neoplasms
- Trial name
- NCT04561362
- Testing
- BT8009, Pembrolizumab
- Where
- 24 sites in United States, Canada and 4 more
- Volunteers
- 329 people
- Sponsor
- BicycleTx Limited
Pulmonary Arterial Hypertension, Erectile Dysfunction
A Study to Evaluate the Pharmacokinetics and Safety of TPN171H Tablets in Patients with Renal Insufficiency and Healthy Subjects
To evaluate the effect of renal insufficiency on the pharmacokinetics of TPN171H tablets after single dose oral administration, so as to provide basis for formulating clinical medication plan for patients with renal…
- Trial name
- NCT05208814
- Testing
- TPN171H single dose
- Where
- 2 sites in China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
COPD, ESRD
Randomized Evaluation of Default Access to Palliative Services
This is a large pragmatic, randomized controlled trial to test the real-world effectiveness of inpatient palliative care consultative services in improving a number of patient- and family-centered processes and outcomes of care…
- Conditions
- COPD, ESRD, Dementia
- Trial name
- REDAPS (NCT02505035)
- Testing
- Default ordering of palliative consult
- Where
- 11 sites in United States
- Volunteers
- 34,239 people
- Sponsor
- University of Pennsylvania
Covid19, Hypoxemic Respiratory Failure
Automatic Oxygen Titration With O2matic® to Patients Admitted With COVID-19 and Hypoxemic Respiratory Failure
Patients with coronavirus disease (COVID-19) and pneumonitis often have hypoxemic respiratory failure and a need of supplementary oxygen.
- Conditions
- Covid19, Hypoxemic Respiratory Failure, Hypoxemia
- Trial name
- O2matic-COVI (NCT04565106)
- Testing
- Closed-loop control of oxygen supplementation by O2matic
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Hvidovre University Hospital
Interstitial Fibrosis, Kidney Transplant; Complications
Fingolimod for the Abrogation of Interstitial Fibrosis and Tubular Atrophy Following Kidney Transplantation
This is a randomized, double-blind, placebo-controlled trial in de novo kidney transplant patients to determine if the addition of fingolimod (brand name Gilenya®, candidate name- FTY720) on the background of standard…
- Conditions
- Interstitial Fibrosis, Kidney Transplant; Complications, Kidney Transplant Rejection, Kidney Transplant Failure and Rejection
- Trial name
- NCT05285878
- Testing
- Fingolimod
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Methodist Hospital Research Institute
Respiratory Failure
Safety and Efficacy of Endotracheal Intubation Using Glidescope Video-Laryngoscope
The safety and efficacy of a video-laryngoscope as a primary intubation tool in urgent endotracheal intubation of critically-ill patients has not been well-described in the literature.
- Trial name
- NCT01683526
- Testing
- Direct laryngoscopy, Video laryngoscopy (Glidescope)
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Beth Israel Medical Center
Prematurity, Respiratory Insufficiency
Inhaled Prostaglandin E1 (IPGE1) for Hypoxemic Respiratory Failure (NHRF)
This is a randomized controlled trial (RCT) on the use of Inhaled prostaglandin E1 (IPGE1) in Neonatal Hypoxemic Respiratory Failure (NHRF).
- Conditions
- Prematurity, Respiratory Insufficiency, Pulmonary Hypertension, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT01467076
- Testing
- Aerosolized Normal Saline, Inhaled PGE1
- Where
- 11 sites in United States
- Volunteers
- 7 people
- Sponsor
- NICHD Neonatal Research Network
Cancer, COPD
SELF-BREATHE RCT for Chronic Breathlessness
A feasibility RCT comprising two groups: 1. Intervention (SELF-BREATHE in addition to standard NHS care) 2. Control group (standard / currently available NHS care)
- Conditions
- Cancer, COPD, Asthma, Bronchiectasis Adult
- Trial name
- NCT04574050
- Testing
- SELF-BREATHE
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- King's College Hospital NHS Trust
Gastrointestinal Stromal Tumors, Advanced Systemic Mastocytosis
A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies
This is a Phase 1, open-label, first-in-human (FIH) dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antitumor activity of DCC-2618, administered…
- Conditions
- Gastrointestinal Stromal Tumors, Advanced Systemic Mastocytosis, Advanced Cancers
- Trial name
- NCT02571036
- Testing
- DCC-2618
- Where
- 26 sites in United States, Canada and 4 more
- Volunteers
- 282 people
- Sponsor
- Deciphera Pharmaceuticals, LLC
Congestive Heart Failure, Diabetes
Study of the Effect on Clinical Outcomes Using Secure Text Messaging
In this study, the investigators will conduct a randomized, controlled trial to evaluate the impact of offering mobile secure text messaging on clinical outcomes.
- Conditions
- Congestive Heart Failure, Diabetes, Renal Failure, Copd
- Trial name
- NCT02568514
- Testing
- Secure text messaging
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Exocrine Pancreatic Insufficiency, Cystic Fibrosis
EASY: Extended Access to Sollpura Over Years
Liprotamase consists of 3 soluble, non-porcine digestive enzymes, lipase, protease, and amylase, combined in a fixed ratio. Liprotamase is stable in the stomach and can be formulated without enteric coating for administration…
- Trial name
- NCT02823964
- Testing
- Liprotamase
- Where
- 15 sites in United States, Czechia and 4 more
- Volunteers
- 25 people
- Sponsor
- Anthera Pharmaceuticals
Premature Birth, Respiration Failure
Predictors of Prolonged Mechanical Ventilation in Preterm Infants
This prospective cohort study aims to identify the independent predictors of prolonged mechanical ventilation in preterm infants admitted to the Neonatal Intensive Care Unit of Assiut University Children Hospital.
- Conditions
- Premature Birth, Respiration Failure, Bronchopulmonary Dysplasia
- Trial name
- NCT07821632
- Volunteers
- 100 people
- Sponsor
- Assiut University
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
COPD, Chronic Obstructive Pulmonary Disease
The Efficacy of the AIRVO Warm Humidifier as an Add on to Oxygen Therapy
The primary purpose of this study is to show whether at home usage of the AIRVO warm humidifier can potentially reduce the number of exacerbations in patients with significant respiratory insufficiency.
- Trial name
- NCT03081650
- Testing
- Airvo Humidifier
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lutheran Hospital, Indiana
Respiratory Insufficiency
Influence Positive End-expiratory Pressure on Autoregulation in Patients With Respiratory Insufficiency
The aim of the present study is to characterize the influence of an elevated positive end-expiratory pressure in patients with acute respiratory distress syndrome or acute lung injury on the cerebrovascular autoregulation.
- Trial name
- dARICUPEEP (NCT01376518)
- Testing
- positive end-expiratory pressure
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Johannes Gutenberg University Mainz
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