Clinical trials: Insufficiency, Pulmonary
Respiratory Distress Syndrome, Respiratory Insufficiency
Recruitment Manoeuvres in Critically Ill Patients
Diseases of the lungs can be life-threatening. When these organs fail to adequately work, treatments to support their function are offered, often in Intensive Care Units (ICU).
- Conditions
- Respiratory Distress Syndrome, Respiratory Insufficiency, Respiratory Failure, Shock Lung
- Trial name
- RMCIP (NCT05508724)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Oxford
Hernia, Ventral, Hernia Incisional
Renal- and Pulmonary Function in Relation to Abdominal Hypertension After Abdominal Reconstruction
An incisional hernia is technically challenging to operate and is the most frequent long-term complication after open surgery, resulting in impaired quality of life and reduced physical ability.
- Conditions
- Hernia, Ventral, Hernia Incisional, Acute Kidney Injury, Restrictive Lung Disease
- Trial name
- REPARE (NCT04143776)
- Testing
- Abdominal reconstruction
- Where
- Denmark
- Sponsor
- Bispebjerg Hospital
Congenital Heart Disease, Tetrology of Fallot
Harmony TPV Post-Approval Study
The purpose of this study is to characterize the functionality of transcatheter implantation of the Medtronic Harmony Transcatheter Pulmonary Valve (TPV) achieved by real-world implanters.
- Conditions
- Congenital Heart Disease, Tetrology of Fallot, RVOT Anomaly, Pulmonary Regurgitation
- Trial name
- NCT05077774
- Testing
- Harmony TPV System
- Where
- 20 sites in United States, Canada
- Volunteers
- 174 people
- Sponsor
- Medtronic Cardiovascular
Pulmonary Hypertension
Idiopathic Pre-capillary Pulmonary Hypertension in ESKD Patients
This study investigates the prevalence and prognosis of idiopathic pre-capillary pulmonary hypertension (PH) in patients with end-stage kidney disease (ESKD).
- Trial name
- NCT02743091
- Volunteers
- 1,988 people
- Sponsor
- Toujinkai Hospital
Respiratory Failure, ICU
Retrospective Cohort Study of Low-Flow Extracorporeal Carbon Dioxide Removal (ECCO2R) System: Evaluating ECCO2R's Efficacy and Safety in Participants With Respiratory Failure
This is an observational study performed by retrospective review of data routinely collected for patients receiving low-flow extracorporeal carbon dioxide removal (ECCO2R) therapy in intensive care units (ICUs).
- Conditions
- Respiratory Failure, ICU, Asthma (Diagnosis), ARDS
- Trial name
- NCT07161271
- Where
- Hong Kong
- Volunteers
- 59 people
- Sponsor
- Hong Kong University
Deep Vein Thrombosis, Thromboses, Venous
Ongoing Registry of Treatment of Venous Thromboembolism
Ongoing registration of patients with venous thromboembolism treated by means of antithrombotic therapy, thrombolisys, open surgery, endovenous desobstruction and stenting.
- Conditions
- Deep Vein Thrombosis, Thromboses, Venous, Thrombosis Embolism, Postthrombotic Syndrome
- Trial name
- RRT VTE (NCT03881345)
- Testing
- Anticoagulants, Open surgery, Thrombolysis
- Where
- Russia
- Volunteers
- 5,000 people
- Sponsor
- Medalp Private Surgery Clinic
ARDS, Respiratory Failure
PEEP Titration and Lung Recruitment Potential Assessed by 3D EIT
In a population of ARDS patients, we explore the influence of different PEEP levels on regional ventilation distribution, ventilation homogeneity, and the center of ventilation, optimal PEEP and lung recruitment potential as well…
- Trial name
- NCT06594601
- Testing
- lung recruitment potential assessed by 3D EIT, PEEP titration by 3D eit
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Postoperative Pulmonary Atelectasis, Pneumothorax
Cardiopulmonary Bypass on Mechanical Power and Postoperative Pulmonary Complications
During cardiopulmonary bypass (CPB), oxygenation of the patient on the pump can be left completely under pump control, or the lungs can be ventilated with low tidal volume to reduce atelectasis.
- Conditions
- Postoperative Pulmonary Atelectasis, Pneumothorax, Pneumonia, Ards
- Trial name
- NCT06292767
- Testing
- mechanical power calculation
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- TC Erciyes University
Respiratory Failure, Circulatory Failure
Influence of Fluid Challenge on End-Expiratory Lung Impedance in Mechanically Ventilated Patients Monitored With Electrical Impedance Tomography
The study investigates the influence of a clinically indicated fluid challenge on end-expiratory lung impedance, assessed by electrical impedance tomography (EIT).
- Conditions
- Respiratory Failure, Circulatory Failure, Fluid Responsiveness, Fluid Overload
- Trial name
- NCT02992002
- Testing
- Fluid Challenge
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- University Hospital Schleswig-Holstein
Pulmonary Disease, Respiratory System Abnormalities
Distribution of Ventilation, Respiratory Drive and Gas Exchange: Measurements and Monitoring
Respiratory physiology involves a complex interplay of elements including control of breathing, respiratory drive, pulmonary mechanics, distribution of ventilation and gas exchange.
- Conditions
- Pulmonary Disease, Respiratory System Abnormalities, OSA, Respiratory Failure
- Trial name
- NCT05462600
- Testing
- Position change
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Chronic Pancreatitis, Respiratory Insufficiency
Is There an Association Between Chronic Pancreatitis and Pulmonary Function
To evaluate pulmonary function in chronic pancreatitis compared with healthy volunteers and patients with cirrhosis.
- Conditions
- Chronic Pancreatitis, Respiratory Insufficiency, Cirrhosis, Liver, Lung Function Decreased
- Trial name
- RespPanc (NCT03850977)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Pulmonary Disease, Postoperative Respiratory Complications
Screening of Postoperative Pulmonary Complications by Electrical Impedance Tomography
The purpose of this study is to determine whether Electrical Impedance Tomography can be used as sensitive and specific predictor in the detection of postoperative pulmonary complications (e.g.
- Conditions
- Pulmonary Disease, Postoperative Respiratory Complications, Malignant Neoplasm of Stomach, Liver Diseases
- Trial name
- NCT02337673
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Johannes Gutenberg University Mainz
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Respiratory Failure
Effects of mTOR Inhibition With Sirolimus (RAPA) in Patients With COVID-19 to Moderate the Progression of ARDS
This study assesses the clinical effectiveness of mammalian target of rapamycin (mTOR) inhibition with rapamycin in minimizing or decreasing the severity of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in…
- Conditions
- Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Respiratory Failure, Sars-CoV2
- Trial name
- RAPA-CARDS (NCT04482712)
- Testing
- Rapamycin
- Where
- 2 sites in United States
- Sponsor
- The University of Texas Health Science Center at San Antonio
Heart Failure, Chronic Obstructive Pulmonary Disease (COPD)
Epidemiological Cluster Evaluation in Patients Admitted to Internal Medicine, With at Least One of the Following Diagnoses: Heart Failure, COPD, Renal Failure. The FADOI IN-CluDiMI Study
Improved medical care has led to an increase in both the age and clinical complexity of patients admitted to Internal Medicine wards, characterized by multiple chronic diseases.
- Conditions
- Heart Failure, Chronic Obstructive Pulmonary Disease (COPD), Chronic Kidney Disease (CKD)
- Trial name
- IN-CluDiMI (NCT07660757)
- Where
- Italy
- Volunteers
- 4,500 people
- Sponsor
- Fadoi Foundation, Italy
Pulmonary Regurgitation
Implantation of the Venus P-Valve™ in the Pulmonic Position in Patients With Native Outflow Tracts
A prospective, non-randomized multi-center clinical investigation of the Venus P-Valve™ for the treatment of pulmonary regurgitation with or without stenosis in patient with native outflow tracts.
- Trial name
- NCT02846753
- Testing
- trans catheter heart valve replacement
- Volunteers
- 84 people
- Sponsor
- Venus MedTech (HangZhou) Inc.
Respiratory Insufficiency, Respiratory Distress Syndrome, Adult
Inflammatory Effects of a Lung Recruitment Manoeuvre
Recruitment manoeuvres, consisting of sustained inflations at high airway pressures, have been advocated as an adjunct to mechanical ventilation in lung protective ventilation strategies to prevent the collapse of the lung.
- Trial name
- NCT01070654
- Testing
- 40/30 recruitment manoeuvre, continuous positive airway pressure (CPAP)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Hypercapnic Respiratory Failure, COPD, ARDS
Feasibility Study of the Hemolung Respiratory Assist System (Germany)
The purpose of this study is to evaluate the safety and efficacy of the Hemolung Respiratory Assist System (RAS) in patients with hypercapnic respiratory failure.
- Trial name
- NCT01021605
- Testing
- Hemolung Respiratory Assist System
- Where
- 7 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Alung Technologies
Infant, Newborn, Hypertension, Pulmonary
Early Inhaled Nitric Oxide for Respiratory Failure in Newborns
This prospective, randomized controlled trial tested whether initiating iNO therapy earlier would reduce death and reduce the use of extracorporeal membrane oxygenation (ECMO) -- temporary lung bypass -- therapy compared with the…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- Early iNO (NCT00005773)
- Testing
- Inhaled Nitric Oxide, Standard iNO therapy
- Where
- 18 sites in United States
- Volunteers
- 302 people
- Sponsor
- NICHD Neonatal Research Network
COPD (Chronic Obstructive Pulmonary Disease), Obesity Hypoventilation Syndrome (OHS)
Assessment of Breathing Pattern During NIV
COPD and OHS are respiratory conditions that disrupt normal breathing. Positive airway pressure, specifically Non-Invasive Ventilation (NIV), has been shown to improve breathing and reduce symptoms in patients with these…
- Trial name
- NCT06682286
- Testing
- NIV mask A, NIV mask B
- Where
- New Zealand
- Volunteers
- 40 people
- Sponsor
- Fisher and Paykel Healthcare
Lung Function Decreased
Pulmonary Ventilation Heterogeneity Determined by EIT During PFT in Subjects With Normal One-second Rates
To evaluate the demographic characteristics of normal one-second rates population in patients with pulmonary function tests recommended by outpatient physicians.
- Trial name
- NCT06407986
- Testing
- pulmonary function test
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sir Run Run Shaw Hospital
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