Clinical trials: Insufficiency, Pulmonary
Respiratory Failure
The Effects of Sound Energy on Pulmonary Gas Exchange
Study of the effects of sonic pressure oscillations on pulmonary gas exchange with added dead space.
- Trial name
- NCT02447731
- Testing
- Induction of sound waves in lungs by "sonic oscillator"
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Pulmonary Atelectasis, Respiratory Insufficiency
Respiratory Complications After Laparoscopic Surgery
The purpose of this study is to describe the magnitude of respiratory complications after laparoscopic hysterectomy and cholecystectomy.
- Conditions
- Pulmonary Atelectasis, Respiratory Insufficiency, Pneumonia
- Trial name
- NCT01476254
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Herlev Hospital
Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure
Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning (TheraPPP) Pathway
Treatment of patients with Hypoxemic respiratory failure (HRF) and Acute Respiratory Distress Syndrome (ARDS) is complex. Therapies that have been shown to save the lives of patients with HRF and ARDS are available but they are…
- Conditions
- Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure, ARDS, Human
- Trial name
- TheraPPP (NCT04070053)
- Testing
- TheraPPP Pathway
- Where
- Canada
- Volunteers
- 920 people
- Sponsor
- University of Calgary
Respiratory Failure, Respiratory Distress Syndrome, Adult
Ventilation and Perfusion in the Respiratory System
Respiratory failure occurs when the lung fails to perform one or both of its roles in gas exchange; oxygenation and/or ventilation.
- Conditions
- Respiratory Failure, Respiratory Distress Syndrome, Adult, Critical Illness, Pulmonary Disease
- Trial name
- NCT05081895
- Testing
- Electrical Impedance tomography, Lung mechanics and gas exchange
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Diego
Coronavirus Infection, Pneumonia, Viral
COVID-19-associated ARDS Treated With Dexamethasone: Alliance Covid-19 Brasil III
The Severe Acute Respiratory Syndrome COronaVirus 2 (SARS-CoV2) is a new and recognized infectious disease of the respiratory tract. Most cases are mild or asymptomatic.
- Conditions
- Coronavirus Infection, Pneumonia, Viral, Acute Respiratory Distress Syndrome
- Trial name
- CoDEX (NCT04327401)
- Testing
- Dexamethasone
- Where
- 21 sites in Brazil
- Volunteers
- 299 people
- Sponsor
- Hospital Sirio-Libanes
Intensive Care Unit Syndrome, Intensive Care Neuropathy
Recovery From ICUAW Following Severe Respiratory and Cardiac Failure
To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO).
- Conditions
- Intensive Care Unit Syndrome, Intensive Care Neuropathy, Intensive Care (ICU) Myopathy, Acute Respiratory Distress Syndrome
- Trial name
- CLEVERER (NCT03753412)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Barts & The London NHS Trust
Acute Hypoxemic Respiratory Failure
Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure
This study is being conducted to evaluate if wearing a non-invasive breathing support device over the chest/abdomen improves markers of breathing in patients with lung injury requiring high-flow oxygen.
- Trial name
- NCT05675345
- Testing
- HFNC only, HFNC + CNEP10, HFNC + CNEP20
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Sars-CoV2, Acute Respiratory Distress Syndrome
Mesenchymal Stromal Cells for the Treatment of SARS-CoV-2 Induced Acute Respiratory Failure (COVID-19 Disease)
*At this time, we are only enrolling at Houston Methodist Hospital (HMH)/Baylor College of Medicine (BCM) and are not shipping cells outside of BCM/HMH.* This is a study for patients who have respiratory infection caused by…
- Conditions
- Sars-CoV2, Acute Respiratory Distress Syndrome, COVID-19
- Trial name
- NCT04345601
- Testing
- Mesenchymal Stromal Cells, Supportive Care
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Baylor College of Medicine
Hypercapnic Respiratory Failure, COPD
Treatment of Acute Hypercapnic Respiratory Failure With OptiflowTM or Optiflow+DuetTM Nasal Cannula in COPD-patients
Hypothesis Treatment with HFNC and OptiflowTM+Duet can significantly reduce PaCO2 and normalize pH in patients with COPD exacerbation and acute hypercapnic failure, compared to HFNC with OptiflowTM.
- Trial name
- DUACT (NCT06257667)
- Testing
- Respiratory Support
- Volunteers
- 138 people
- Sponsor
- Aalborg University Hospital
COPD
The Effect of Oxygen Therapy With Airvo High-flow Heated Humidification
The purpose of our study is to establish whether domiciliary use of the Airvo warm passover humidifier can reduce the number of exacerbations in patients with respiratory insufficiency.
- Trial name
- HHCOPD (NCT02731872)
- Testing
- Airvo humidifier
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Birgitte Schantz Laursen
Palliative Care, Primary Palliative Care
Primary Palliative Care - a Feasibility Cluster Trial
This feasibility cluster-controlled randomized trial (RCT) evaluates a complex intervention for the delivery of primary palliative care in Family Health Units (FHUs).
- Conditions
- Palliative Care, Primary Palliative Care, Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- PrimPal (NCT07737899)
- Testing
- Primary Palliative Care Complex Intervention (PrimPal)
- Where
- 2 sites in Portugal
- Volunteers
- 30 people
- Sponsor
- University of Coimbra
Comorbidities and Coexisting Conditions, Alzheimer Disease
An Integrated Solution for Sustainable Care for Multimorbid Elderly Patients With Dementia
The CAREPATH will conduct Technical Validation and Usability (TVU) study by involving ≥ 45 target end users (16 patients with MCI or mild dementia with their informal caregivers and 16 healthcare professionals from various…
- Conditions
- Comorbidities and Coexisting Conditions, Alzheimer Disease, Dementia, Malnutrition
- Trial name
- CAREPATH (NCT05104593)
- Testing
- Intervention tested (CAREPATH)
- Where
- Spain
- Volunteers
- 204 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
Alpha 1-antitrypsin Deficiency (AATD)
Screening for Alpha-1 Antitrypsin Deficiency in Patients With Airway Obstruction
Brief Summary: This study aims to find out if a genetic condition called Alpha-1 Antitrypsin Deficiency (AATD) is more common in people who have shortness of breath and signs of airway obstruction on their breathing tests.
- Trial name
- AATD-SAO (NCT07152834)
- Testing
- Blood Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 734 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Cardiovascular, Comorbidity
Improving Patient-Centered Care for Underserved Older African American Patients With Cardiovascular Comorbidities
This is formative evaluation trial guided by the Values Clarification Theory25 and the Cultural Values Theory26, with specific aims to: Aim 1.
- Conditions
- Cardiovascular, Comorbidity, Diabetes, Inflammatory Joint Diseases
- Trial name
- PPC Heart (NCT07748858)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Alabama at Birmingham
Respiratory Failure, Covid19
Apparatus and Method for Moving Patients
A novel device and process to move patients has been developed, particularly useful for patients with severe respiratory failure (ie COVID 19) who require prone ventilation (moving from their back onto the stomach and then onto…
- Trial name
- AMMP (NCT04882865)
- Testing
- assist
- Where
- Canada
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Calciphylaxis, Renal Insufficiency, Chronic
The Early Administration of Sodium Thiosulfate Should Help to Reduce the Mortality of Dialysis Patients With Calciphylaxis, From a National Cohort
The national drug safety agency authorizes nominatively the use of sodium thiosulfate in dialysis patients with calciphylaxis. To date, it is the largest global cohort (more 600 patients from 2012 to 2016).
- Trial name
- NCT03146793
- Testing
- Sodium Thiosulfate
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier St Esprit
End Stage Renal Disease
Less Frequency Hemodialysis and COVID-19
Facing the unusual situation imposed by the coronavirus disease, the aim of this study is to evaluate the risk and effects of less frequent hemodialysis on prevalent patients
- Trial name
- NCT04374058
- Testing
- less-frequency hemodialysis
- Where
- Argentina
- Volunteers
- 50 people
- Sponsor
- Dialisis Madariaga
Respiratory Failure
Chronic Obstructive Pulmonary Disease and Weaning From Mechanical Ventilation in Difficult to Wean Patients
To evaluate and compare two methods of weaning from mechanical ventilation in patients with chronic obstructive pulmonary disease (COPD) where the extubation failed.
- Trial name
- NCT00355732
- Testing
- Weaning from mechanical ventilation
- Where
- 2 sites in Croatia
- Sponsor
- Dr. Josip Benčević General Hospital
Anemia, Iron-Deficiency, Kidney Failure, Chronic
Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients
This study compares the effect of Ferrlecit® (a form of intravenous iron) to ferrous sulfate (a form of oral iron) in treating anemia and iron deficiency in chronic kidney disease patients who are not receiving erythropoietic…
- Trial name
- NCT00224055
- Testing
- Sodium Ferric Gluconate Complex in Sucrose Injection, Ferrous sulfate tablets
- Where
- 24 sites in United States, Puerto Rico
- Volunteers
- 89 people
- Sponsor
- Watson Pharmaceuticals
Hypercapnic Respiratory Failure, COPD
Feasibility Study of the Hemolung Respiratory Assist System
The purpose of this study is to evaluate the safety and efficacy of the Hemolung Respiratory Assist System in patients with hypercapnic respiratory failure associated with acute exacerbation of chronic obstructive pulmonary…
- Trial name
- NCT00987740
- Testing
- Hemolung Respiratory Assist System
- Where
- India
- Volunteers
- 2 people
- Sponsor
- Alung Technologies