Clinical trials: Insufficiency, Pulmonary
Renal Failure Chronic
Patients With Acute Renal Failure During Severe COVID-19
The occurrence of renal failure during severe forms of COVID-19 is common (20-35% of patients treated in intensive care) and associated with an unfavorable short-term prognosis, but the medium-term renal outcome is not is not…
- Trial name
- IR-EST-POSTCOV (NCT05077163)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Cerebrovascular Accident, Cancer
Multidisciplinary Inpatient Palliative Care Intervention
Palliative care is believed to improve care of patients with life-limiting illnesses. This study evaluated the impact of a multi-center randomized trial of a palliative care team intervention on the quality and cost of care of…
- Conditions
- Cerebrovascular Accident, Cancer, Coronary Arteriosclerosis, Heart Failure, Congestive
- Trial name
- NCT00325611
- Testing
- Multidisciplinary palliative care team met with patient
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Kaiser Permanente
COPD, COPD Exacerbation
Study of Sleep Quality in the Intensive Care Unit and Association with Weaning from Invasive Ventilation in Patients with Chronic Obstructive Bronchopneumopathy.
Patients admitted in ICU may require invasive mechanical ventilation, using a mechanical ventilator and an endotracheal tube. In ICU, a prolonged duration of invasive mechanical ventilation may be responsible for…
- Conditions
- COPD, COPD Exacerbation, Ventilated Patients, Ventilator-Associated Pneumonia (VAP)
- Trial name
- SLEECOP (NCT06653933)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Pulmonary Regurgitation
VenusP-Valve Pivotal Study (PROTEUS STUDY)
A prospective, multi-center, non-randomized interventional study to evaluate the safety and effectiveness of the VenusP-ValveTM System in patients with native right ventricular outflow tract (RVOT) dysfunction.
- Trial name
- PROTEUS (NCT06010563)
- Testing
- Transcatheter pulmonary valve implantation (TPVI), VenusP-ValveTM System
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Venus MedTech (HangZhou) Inc.
Respiratory Insufficiency, Diaphragm Injury
Feasibility of Reducing Respiratory Drive Using the Through-flow System
Mechanical ventilation can lead to diaphragm and lung injury. During mechanical ventilation, the diaphragm could be completely rested or it could be overworked, either of which may cause diaphragm injury.
- Conditions
- Respiratory Insufficiency, Diaphragm Injury, Lung Injury
- Trial name
- Throughflow (NCT05642832)
- Testing
- Throughflow titration phase
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Cardiac Diseases, Cardio-pulmonary Bypass
A Monitoring System Based on the Multifactorial Dynamic Perfusion Index to Predict and Prevent the Onset of Postoperative Acute Kidney Injury After Cardiac Surgery, Based on a Dynamic Collection of Hemodynamic and Clinical Parameters During Cardiopulmonary Bypass
This project is based on a predictive alghorithm (Multifactorial Dynamic Perfusion Index-MDPI) already published and covered by a patent.
- Conditions
- Cardiac Diseases, Cardio-pulmonary Bypass, Acute Kidney Injury, Adult Cardiac Surgery
- Trial name
- PEQUOD 2 (NCT06786416)
- Testing
- PEQUOD
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Policlinico S. Donato
Acute Respiratory Distress Syndrome, Infections
Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
BTI-203 is a randomized, double-blind, placebo-controlled, multicenter, Phase 2 proof-of-concept (POC) study to evaluate the efficacy and safety of rhu-pGSN plus standard of care (SOC) in subjects with moderate-to-severe ARDS…
- Trial name
- NCT05947955
- Testing
- Rhu-pGSN, normal saline
- Where
- 65 sites in United States, Belgium and 11 more
- Volunteers
- 600 people
- Sponsor
- BioAegis Therapeutics Inc.
Infant, Newborn, Infant, Low Birth Weight
Dexamethasone Therapy in VLBW Infants at Risk of CLD
Infants who are on breathing support are often treated with steroids (dexamethasone); however, the best timing of therapy is not known.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Dexamethasone (NCT00011362)
- Testing
- Dexamethasone Early, Dexamethasone Late
- Where
- 13 sites in United States
- Volunteers
- 371 people
- Sponsor
- NICHD Neonatal Research Network
Andes Hantavirus
Natural History of Andes Virus Infection
This is a longitudinal observational cohort study enrolling individuals with a defined exposure to Andes Virus (ANDV) who are confined or quarantined.
- Trial name
- NAVIS (NCT07703579)
- Where
- 3 sites in France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Surgery, Anaesthesia
Local Assessment of Ventilatory Management During General Anesthesia for Surgery
Objectives 1. To characterize mechanical ventilation practices during general anesthesia for surgery 2. To assess the dependence of intra-operative and post-operative pulmonary complications on intra-operative Mechanical…
- Conditions
- Surgery, Anaesthesia, Ventilator-Induced Lung Injury, Lung Injury
- Trial name
- LAS VEGAS (NCT01601223)
- Where
- 19 sites in United States, Estonia and 6 more
- Volunteers
- 10,690 people
- Sponsor
- European Society of Anaesthesiology
Cystic Fibrosis, Growth Failure
Baby Observational and Nutritional Study
Cystic fibrosis (CF) is a life-shortening disease that causes breathing and digestive problems, but can now be diagnosed at the time of birth. Lung function is very hard to measure in infants, but growth is not.
- Conditions
- Cystic Fibrosis, Growth Failure, Exocrine Pancreatic Insufficiency
- Trial name
- BONUS (NCT01424696)
- Where
- 28 sites in United States
- Volunteers
- 231 people
- Sponsor
- Seattle Children's Hospital
Pneumonia, Viral, Covid19
Diaphragmatic Echography in COVID-19 Pneumonia
We hypothesized that diaphragm thickness is concerned in acute respiratory failure of COVID19 patients and its ultrasound measure at the begining of hospitalisation is a good predictor of poor outcome.
- Conditions
- Pneumonia, Viral, Covid19, Respiratory Failure
- Trial name
- COVIDUSDIAP (NCT05805579)
- Testing
- Diaphragmatic echography
- Where
- Spain
- Volunteers
- 171 people
- Sponsor
- Javier Lázaro
Cancer, Heart Failure
Study to Determine Therapeutic Massage Dosing to Improve Quality of Life in Hospitalized Patients Receiving Palliative Care
Therapeutic massage is the most common non-traditional treatment option offered to improve quality of life, provide comfort and decrease pain in hospice and palliative care settings outside the hospital.
- Conditions
- Cancer, Heart Failure, COPD, Sepsis
- Trial name
- NCT04916223
- Testing
- Therapeutic massage
- Where
- United States
- Volunteers
- 405 people
- Sponsor
- Medstar Health Research Institute
Essential Hypertension, Liver Cancer
A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
The human gut microbiome has been associated with many health factors but variability between studies limits the exploration of effects between them.
- Conditions
- Essential Hypertension, Liver Cancer, Nasopharyngeal Cancer, Pancreatic Cancer
- Trial name
- NCT05638269
- Testing
- no intervention
- Where
- 50 sites in China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Multiple Myeloma, Myelodysplastic Syndromes
A Study of Special Use Results Surveillance of Revlimid 5mg Capsules
To understand the safety and efficacy of Revlimid® 5 mg Capsules (hereinafter referred to as Revlimid) in all patients who are treated with it under the actual condition of use pursuant to the conditions of approval. 1.
- Trial name
- NCT02921802
- Where
- Japan
- Volunteers
- 4,626 people
- Sponsor
- Celgene
Respiratory Failure (Pediatric Patients), Pneumonia
AI-Assisted Bronchoscopy Navigation and Diagnostic System for Severe Pneumonia: A Multicenter Prospective Study
This study will evaluate an embodied-intelligence-assisted bronchoscopy navigation and diagnostic system for patients with severe pneumonia who require clinically indicated bronchoscopy.
- Trial name
- EIBRONCH (NCT07230431)
- Testing
- Embodied-Intelligence-Assisted Bronchoscopy Navigation and Diagnostic System (EIBRONCH), Conventional Bronchoscopy (Standard of Care)
- Volunteers
- 100 people
- Sponsor
- Chinese Medical Association
Cystic Fibrosis, Pancreatic Insufficiency
GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance
Diabetes is a major co-morbidity in pancreatic insufficient cystic fibrosis (PI-CF) and associated with worse outcomes. While reduced β-cell mass contributes to the insulin secretory defects that characterizes cystic…
- Conditions
- Cystic Fibrosis, Pancreatic Insufficiency, Abnormal Glucose Tolerance, Diabetes
- Trial name
- NCT04731272
- Testing
- Dulaglutide 0.75Mg/0.5Ml Inj Pen
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Cystic Fibrosis, Exocrine Pancreatic Insufficiency
Efficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic Insufficiency
The purpose of this study is to evaluate the efficacy in patients with cystic fibrosis and pancreatic insufficiency following treatment with BSSL
- Trial name
- NCT00743483
- Testing
- rhBSSL
- Where
- 4 sites in Netherlands, Poland
- Volunteers
- 15 people
- Sponsor
- Swedish Orphan Biovitrum
Covid19, Cardiopulmonary Disease
Physiological Studies in Post-COVID-19 Syndrome, and the Association With DNA Methylation
The physiological derangements in subjects suffering from long-term symptoms following a Covid-19 infection (Post-COVID-19 Syndrome) are poorly understood and evaluated.
- Conditions
- Covid19, Cardiopulmonary Disease, Dyspnea, Lung Function Decreased
- Trial name
- NCT04859894
- Testing
- Physiological testing
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Linkoeping University
Covid19, Vaccine Reaction
Protective Antibody Level After COVID-19 Vaccination Among Patients Under Hemodialysis
The aim of the study is to evaluate the level of neutralizing antibody against SARS-CoV-2 after COVID-19 vaccination in patients under hemodialysis.
- Conditions
- Covid19, Vaccine Reaction, Hemolysis, End-stage Renal Disease
- Trial name
- NCT04871945
- Testing
- Elecsys Anti-SARS-CoV-2 S (Roche Diagnostics GmbH, Mannheim, Germany), 2) ACCESS SARS-CoV-2 IgG II (Beckman Coulter, Inc. USA)
- Where
- South Korea
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Hanyang University Seoul Hospital
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