Clinical trials: Insufficiency, Pulmonary
Covid19, COVID-19 Respiratory Infection
Post COVID-19 Pulmonary Rehabilitation Program
Coronavirus-2019 disease (COVID-19) is a highly infectious respiratory disease that causes respiratory, physical and psychological dysfunction in patients.
- Conditions
- Covid19, COVID-19 Respiratory Infection, Lung Diseases, Respiratory Insufficiency
- Trial name
- COVID19REHAB (NCT04982042)
- Testing
- Pulmonary Rehabilitation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Centro Universitário de Anapolis
Acute Respiratory Distress Syndrome, Respiratory Failure
Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome
The goal of this interventional study is to compare standard mechanical ventilation to a lung-stress oriented ventilation strategy in patients with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- PREVENT VILI (NCT06066502)
- Testing
- Precision ventilation, Guided usual care ventilation
- Where
- 33 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Beth Israel Deaconess Medical Center
COVID-19, End Stage Renal Disease
The Danish Pre-HCQ COVID Dialysis Study
Hydroxychloroquine has been shown to inhibit replication of SARS-CoV-2 in vitro. The presented multicenter parallel-group open-label randomized clinical trial aims to investigate the efficacy of prophylactic hydroxychloroquine on…
- Trial name
- NCT05110651
- Testing
- Hydroxychloroquine
- Where
- 3 sites in Denmark
- Sponsor
- Nicholas Carlson
Acute Kidney Failure Stage 3
Venous Excess and Lung Ultrasound During Continuous Kidney Replacement Therapy in Critically Ill Patients
Hemodynamic management of critically ill patients has long been focused on the arterial side of the vasculature by assessing adequate perfusion pressure. However, the venous pressure is also of critical importance.
- Trial name
- VExLUS-KRT (NCT06254703)
- Testing
- VExUS (venous excess ultrasound), modified VExUS (modified venous excess ultrasound)
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Chulalongkorn University
Pulmonary Valve Insufficiency
Feasibility Study to Evaluate the Safety of the Autologous GrOwnValve Transcatheter Pulmonary Heart Valve
Aim of this study is to investigate the clinical safety of a novel pediatric heart valve.
- Trial name
- GECT (NCT05809856)
- Testing
- GrOwnValve - novel heart valve replacement approach
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Charite University, Berlin, Germany
Acute Kidney Injury, ARDS, Human
Renal Doppler to Predict Acute Kidney Injury (AKI) in ARDS Patients. (RED-AKI Study)
This is a multicenter international observational prospective cohort study. The main questions it aims to answer are: PRIMARY AIM: To describe the capability of IRVF demodulation at diagnosis of ARDS to predict development of AKI…
- Trial name
- RED-AKI (NCT06302192)
- Testing
- ARDS+AKI
- Volunteers
- 164 people
- Sponsor
- Policlinico Hospital
Airway Obstruction
Accurate Recognition of Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
It has been observed that COPD exacerbations are under-reported in China. One of the reasons for this is Chinese subjects with COPD cannot describe the symptoms of exacerbation mentioned in English.
- Trial name
- NCT03170999
- Testing
- Focus group interview, Draft item set, Candidate item set
- Where
- 3 sites in China
- Volunteers
- 199 people
- Sponsor
- GlaxoSmithKline
Coronavirus, COVID-19
Cytokine Adsorption in Severe COVID-19 Pneumonia Requiring Extracorporeal Membrane Oxygenation
In December 2019 in the city of Wuhan in China, a series of patients with unclear pneumonia was noticed, some of whom have died of it.
- Conditions
- Coronavirus, COVID-19, SARS-CoV Infection, Respiratory Failure
- Trial name
- CYCOV (NCT04324528)
- Testing
- vv-ECMO + cytokine adsorption (Cytosorb adsorber), vv-ECMO only (no cytokine adsorption)
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Dr. Alexander Supady
Congestive Heart Failure, Ischemic Cardiomyopathy
Cardiac Output Pulmonary Arterial Catheter Compared to FloWave™ 1000
The purpose of this study is to compare cardiac output results obtained using the thermodilution push technique with the Pulmonary Arterial Catheter (PAC) to the predicted cardiac output results obtained from the non-invasive…
- Conditions
- Congestive Heart Failure, Ischemic Cardiomyopathy, Mitral Valve Prolapse, Mitral Regurgitation
- Trial name
- NCT00665301
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- Woolsthorpe Technologies, LLC
COVID, Corona Virus Infection
Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms
The study is a prospective, randomized, controlled investigation designed for comparison of two groups for the reduction of respiratory distress in a CoViD-19 population, using gammaCore Sapphire (nVNS) plus standard of care…
- Conditions
- COVID, Corona Virus Infection, Respiratory Failure, Respiratory Distress Syndrome, Adult
- Trial name
- SAVIORII (NCT04382391)
- Testing
- gammaCore® Sapphire (non-invasive vagus nerve stimulator), Standard of care therapies
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Respiratory Distress Syndrome, Adult, Respiratory Insufficiency
Personalised Simulation Technologies for Optimising Treatment in the Intensive Care Unit
This project aims to develop software models describing how critically ill patients respond to changes in their treatment whilst admitted to an Intensive Care Unit (ICU).
- Trial name
- PSTOTICU (NCT04297397)
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Non-invasive Positive Pressure (NPPV ) for Severe Stable Chronic Obstructive Pulmonary Disease
Assessment of the effect and safety of noninvasive positive pressure ventilation for severe stable chronic obstructive pulmonary disease
- Trial name
- NCT02499718
- Testing
- BiPAP mode
- Where
- China
- Volunteers
- 368 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Home Non-invasive Ventilation for Chronic Obstructive Pulmonary Disease Patients
Chronic Obstructive Pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure are more likely to develop exacerbations.
- Trial name
- NIVOLD (NCT01526642)
- Testing
- Non Invasive Ventilation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Rouen
COVID-19, Vaccination
COVID-19 Vaccination AZV 2021-2023
The study is aimed at the clinical and laboratory characteristics of patients with completed vaccination against SARS-CoV-2 admitted to the hospital in the standard ward and intensive care unit due to the severe course of…
- Conditions
- COVID-19, Vaccination, Immunity, Respiratory Failure
- Trial name
- NCT05589233
- Testing
- Vaccionation eighter started or full course
- Where
- Czechia
- Volunteers
- 3,000 people
- Sponsor
- University Hospital Hradec Kralove
Respiratory Distress Syndrome, Newborn, Infant, Newborn
Feasibility of Uninterrupted Infant Respiratory Support Treatment
Feasibility study of a simplified respiratory support system for newborn infants
- Conditions
- Respiratory Distress Syndrome, Newborn, Infant, Newborn, Respiratory Insufficiency Syndrome of Newborn
- Trial name
- FUIRST (NCT04244890)
- Testing
- Uninterrupted CPAP for the first hours of life
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Karolinska Institutet
Chronic Kidney Diseases, Hypertension
Real Clinical Practice Register of AlbUminuRia Detection in Patients With Previously undiAgnosed Chronic Kidney Disease
Real clinical practice register of Albuminuria detection in patients with previously undiagnosed chronic kidney disease
- Conditions
- Chronic Kidney Diseases, Hypertension, Chronic Heart Failure, Ischemic Heart Disease
- Trial name
- AURA (NCT05690009)
- Where
- Russia
- Volunteers
- 4,580 people
- Sponsor
- Eurasian Association of Therapists
Cystic Fibrosis, Pancreatic Insufficiency
Study of LYM-X-SORB™ to Improve Fatty Acid and Choline Status in Children With CF and PI
The purpose of this phase II research study is to evaluate the effectiveness of the next generation LYM-X-SORB™ in improving the essential fatty acid (EFA) and choline status for children and adolescents with Cystic Fibrosis (CF)…
- Trial name
- NCT00406536
- Testing
- Lym-X-Sorb powder
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Avanti Polar Lipids, Inc.
End Stage Renal Disease (ESRD), Chronic Kidney Disease on Hemodialysis
Expanded Hemodialysis Versus High-Volume Online Hemodiafiltration for Uremic Toxin Removal
People with advanced kidney disease need dialysis to remove waste products from the blood. Some of these waste products, called uremic toxins, are small, while others are medium-sized and more difficult to remove.
- Conditions
- End Stage Renal Disease (ESRD), Chronic Kidney Disease on Hemodialysis, Renal Dialysis, Uremia; Chronic
- Trial name
- REMOV-HDx (NCT07348536)
- Testing
- Expanded Hemodialysis With Medium Cut-Off Membrane, High-Volume Online Hemodiafiltration
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Respiratory Failure, Acute Respiratory Distress Syndrome
Cross-section Survey of Mechanical Ventilation and Acute Respiratory Distress Syndrome in China
The characteristics and outcomes of a mixed group of critically ill patients who received mechanical ventilation are not known in China.
- Trial name
- NCT01666834
- Where
- China
- Volunteers
- 555 people
- Sponsor
- Southeast University, China
Organic, Including Symptomatic, Mental Disorders, Substance Use
Exploring the Comorbidity Between Mental Disorders and General Medical Conditions
Mental disorders have been shown to be associated with a number of general medical conditions (also referred to as somatic or physical conditions).
- Conditions
- Organic, Including Symptomatic, Mental Disorders, Substance Use, Schizophrenia, Mood [Affective] Disorders
- Trial name
- COMO-GMC (NCT03847753)
- Testing
- Organic Disorders, Substance Use Disorders, Schizophrenia Disorders
- Volunteers
- 5,940,299 people
- Sponsor
- University of Aarhus
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