Clinical trials: Insufficiency, Pulmonary
Inadequate or Impaired Respiratory Function
The Differential Pattern of Deposition of Nano Particles in the Airways of Exposed Workers
Investigation of the differences between the levels of extracellular and intracellular nano-particles in workers exposed to environmental particles during their employment to enhance understanding the process of penetration of…
- Trial name
- Nanoexposure (NCT01599845)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Hypoxemic Acute Respiratory Failure
Effects of Nasal Ventilation on Cerebral and Pulmonary Function in Orally Intubated Patients
The passage of air through the nasal cavity generates rhythmic oscillations transmitted by the olfactory bulb to the brain, which induces cerebral activation in functional areas and is associated with better cognitive performance…
- Trial name
- VENTINA (NCT06438302)
- Testing
- EEG activity measurement
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Automated Oxygen Titration During Walking in Patients With COPD
Purpose: to evaluate the immediate effect of automated oxygen titration compared to usual fixed-dose oxygen treatment during exercise in patients with COPD on long-term oxygen treatment.
- Trial name
- NCT04123730
- Testing
- Fixed-dose compared to variable oxygen flow supplementation during walking
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Hvidovre University Hospital
Respiratory Distress Syndrome, Adult, Hypoxemic Respiratory Failure
Utility of Defining ARDS and Past and Current Definitions of ARDS
Acute Respiratory Distress Syndrome (ARDS), marked by acute hypoxemia and bilateral pulmonary infiltrates, has undergone multiple definitions over the years.
- Conditions
- Respiratory Distress Syndrome, Adult, Hypoxemic Respiratory Failure, Respiratory Failure, Phenotypic Abnormality
- Trial name
- Delphi_ARDS (NCT06159465)
- Where
- United Arab Emirates
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NMC Specialty Hospital
Bone Marrow Failure Syndrome, Severe Aplastic Anemia
CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation
This study's goal is to determine the frequency and severity of acute graft versus host disease, to evaluate incidence of primary and secondary graft rejection, to assess event free survival and overall survival, to determine the…
- Conditions
- Bone Marrow Failure Syndrome, Severe Aplastic Anemia, Severe Congenital Neutropenia, Amegakaryocytic Thrombocytopenia
- Trial name
- NCT01966367
- Testing
- CD34 Stem Cell Selection Therapy
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Diane George
Covid19, Respiratory Failure
Furosemide as Supportive Therapy for COVID-19 Respiratory Failure
This double-blind, placebo-controlled, randomized, parallel-group phase 2/3 study will study the utility of nebulized furosemide for pulmonary inflammation in Intubated, mechanically ventilated Patients with COVID-19.
- Trial name
- FaST-1 (NCT04588792)
- Testing
- Nebulized Furosemide, Nebulized Saline
- Where
- 4 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Dr. John Muscedere
Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF)
A Study to Evaluate Safety and Explore Efficacy of New Lipase NHS7108 in Adult Participants With Exocrine Pancreatic Insufficiency.
The purpose of this study is to measure the safety and explore the efficacy of 4 different doses of the new lipase NHS7108 in participants with EPI.
- Conditions
- Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF), Pancreatic Enzyme Abnormality, Pancreatic Diseases
- Trial name
- EPIC (NCT07559175)
- Testing
- NHS7108, Zenpep®
- Where
- 39 sites in United States, Bulgaria and 5 more
- Volunteers
- 66 people
- Sponsor
- Aimmune Nestlé Health Science US R&D, LLC
Acute Disease, Sepsis
Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
Research in acute care faces many challenges, including enrollment challenges, legal limitations in data sharing, limited funding, and lack of singular ownership of the domain of acute care.
- Conditions
- Acute Disease, Sepsis, Pneumonia, Frailty
- Trial name
- Acutelines (NCT04615065)
- Where
- Netherlands
- Volunteers
- 35,000 people
- Sponsor
- University Medical Center Groningen
Aortic Insufficiency, Aortic Stenosis
Automated Phonocardiography Analysis in Adults
Background: Computer aided auscultation in the differentiation of pathologic (AHA class I) from no- or innocent murmurs (AHA class III) via artificial intelligence algorithms could be a useful tool to assist healthcare providers…
- Conditions
- Aortic Insufficiency, Aortic Stenosis, Mitral Insufficiency, Mitral Insufficiency and Aortic Stenosis
- Trial name
- NCT03600051
- Testing
- Automated Heart Murmur Detection AI
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- CSD Labs GmbH
High Altitude Polycythemia
Treatment of High Altitude Polycythemia by Acetazolamide
The prevalence of High Altitude Polycythemia (or Chronic Mountain Sickness) is between 8 and 15% in the high altitude regions of South America. There is no pharmacological treatment available.
- Trial name
- NCT00424970
- Testing
- acetazolamide
- Where
- Peru
- Volunteers
- 55 people
- Sponsor
- Association pour la Recherche en Physiologie de l'Environnement
Acute Respiratory Distress Syndrome, Acute Renal Failure
Pulmonary And Renal Support During Acute Respiratory Distress Syndrome
In patients presenting with the acute respiratory distress syndrome (ARDS), mechanical ventilation with low tidal volume (6 ml/kg predicted body weight) is the current gold standard for supportive care.
- Trial name
- PARSA (NCT01239966)
- Testing
- Combined ECCOR and RRT
- Where
- 2 sites in France
- Volunteers
- 11 people
- Sponsor
- Hôpital Européen Marseille
Hypercapnic Respiratory Failure, Pulmonary Disease, Chronic Obstructive
Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor
The study is an open, prospective, single center clinical observational pilot investigation. The aim is to compare the carbon dioxide values measured by the IscAlert sensor, which is inserted in proximity to the nasal mucosa.
- Conditions
- Hypercapnic Respiratory Failure, Pulmonary Disease, Chronic Obstructive, Neuromuscular Diseases, Obesity Hypoventilation Syndrome (OHS)
- Trial name
- DISCO (NCT06367686)
- Testing
- IscAlert sensor
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- The Hospital of Vestfold
COVID-19, Respiratory Failure
Photobiomodulation Therapy Combined With Static Magnetic Field in Patients With COVID-19
Coronavirus disease 2019 (COVID-19) is a disease caused by a novel coronavirus called SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2).
- Trial name
- NCT04386694
- Testing
- Active PBMT/sMF
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Nove de Julho
Pulmonary Hypertension (PH), End Stage Kidney Disease (ESRD)
Euvolemia-Based Assessment of Pulmonary Hypertension in Stable Hemodialysis Patients
Pulmonary hypertension (PH) is a frequent and clinically significant complication in patients with end-stage kidney disease (ESKD) undergoing maintenance hemodialysis (HD).
- Conditions
- Pulmonary Hypertension (PH), End Stage Kidney Disease (ESRD), Hemodialysis Patients, Volume Overload
- Trial name
- EU-PHASE-HD (NCT07676786)
- Testing
- Observational Assessment
- Where
- 2 sites in Romania
- Volunteers
- 30 people
- Sponsor
- Stefan Lujinschi
Lung Transplant; Complications, Acute Kidney Injury
Association Between Renal Regional Oxygen Saturation Measured by Near-InfraRed Spectroscopy and Postoperative Renal Failure After Lung Transplantation Surgery: A Pilot Study
Complications after lung transplantation are almost ubiquitous, among which postoperative acute renal failure may represent more than 50% of lung transplant patients and require extrarenal purification in 5 to 13% of cases.
- Trial name
- SO-AKI-TP (NCT05836922)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Infection, Heart Failure
Prediction of Expected Length of Hospital Stay Using Machine Learning
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04784351
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Respiratory Infection, Fluid Overload
Fluid Restriction Keeps Children Dry
Rationale: Fluid overload is a common complication in children who are admitted to the pediatric intensive care for mechanical ventilation.
- Conditions
- Respiratory Infection, Fluid Overload, Critical Illness, Respiratory Insufficiency
- Trial name
- LESSER (NCT02989051)
- Testing
- Restrictive fluid regimen, Liberal fluid regimen
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diabetes, Hypertension
Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence
Socioeconomically disadvantaged populations with multiple chronic conditions have high rates of nonadherence to essential chronic disease medications after hospital discharge.
- Conditions
- Diabetes, Hypertension, High Cholesterol/Hyperlipidemia, Coronary Artery Disease
- Trial name
- MedAAAction (NCT06374277)
- Testing
- Med AAAction intervention
- Where
- 2 sites in United States
- Volunteers
- 388 people
- Sponsor
- University of Tennessee
Lung Cancer, Adrenal Insufficiency
Adrenal Function in Patients With Newly Diagnosed Lung Cancer
Patients with newly diagnosed lung cancer may have hypofunction of the adrenal cortex either from tumour metastasis or other mechanisms.
- Trial name
- NCT00364624
- Where
- China
- Volunteers
- 133 people
- Sponsor
- Princess Margaret Hospital, Hong Kong
Drug Use, Alcohol Use
Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions
This study will assess Specialized Community Disease Management (SCDM), an intervention which employs various evidence-based strategies to engage substance using co-morbid patients while in the hospital and follow them into the…
- Conditions
- Drug Use, Alcohol Use, Congestive Heart Failure, Pneumonia
- Trial name
- NCT02059005
- Testing
- Specialized Community Disease Management, Treatment As Usual
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Treatment Research Institute
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