Clinical trials: Insufficiency Fractures, active
Breast Cancer
Observational Study of Bone Complications in People With Post-menopausal Breast Cancer Who Have Stopped Treatment With Denosumab and Aromatase Inhibitors
The purpose of this study to gather information about changes in the bones after stopping treatment with aromatase inhibitor/AI and denosumab.
- Trial name
- NCT05590949
- Testing
- Physical Evaluation, Dual-energy X-ray absorptiometry scans, Trabecular Bone Score
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pulmonary Edema, Pneumonia
Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second.
- Conditions
- Pulmonary Edema, Pneumonia, Atelectasis, Pleural Effusion
- Trial name
- NCT06538376
- Testing
- Portable Dynamic Digital Radiography (DDR)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Brigham and Women's Hospital
Fracture; Pelvic, Insufficiency Fractures
Real World Evidence of SI-BONE's iFuse TORQ TNT Advancing Treatment of Pelvic Ring Fractures
The purpose of this study is to evaluate outcomes in patients treated with iFuse TORQ TNT for pelvic fragility fractures.
- Conditions
- Fracture; Pelvic, Insufficiency Fractures, Fragility Fracture, Sacroiliac; Fusion
- Trial name
- REBAR (NCT07530497)
- Testing
- iFuse TORQ TNT Implant System
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- SI-BONE, Inc.
Pelvic Fracture, Insufficiency Fractures
Titanium Fusion Implant in Combination With Trans-iliac Screws for Insufficiency Fractures of the Pelvis
Many approaches to the surgical treatment of OF-P have been tried, but no one method has stood out as particularly successful. The placement of three implants, including implants that could minimise motion in the sacroiliac joint…
- Conditions
- Pelvic Fracture, Insufficiency Fractures, Mobility Limitation
- Trial name
- TIKTIS (NCT05367505)
- Testing
- iFuse-3D implant
- Where
- 3 sites in Germany
- Volunteers
- 50 people
- Sponsor
- University of Witten/Herdecke
Cervix Cancer
Alendronate to Reduce Pelvic Insufficiency Fractures in Cervical Cancer Patients Undergoing Chemoradiation
Primary Objective Proof of concept: To evaluate the efficacy of alendronate in preventing pelvic insufficiency fractures (PIFs) in cervical cancer patients treated with chemo-radiotherapy over the short and long term.
- Trial name
- NCT07245381
- Testing
- Alendronate 70mg weekly
- Volunteers
- 65 people
- Sponsor
- Dr. Itay GoorAryeh
Subchondral Insufficiency Fracture
Bio-Integrative, Fiber-Reinforced Kneebar for Treating Subchondral Insufficiency of the Knee
The OSSIOfiber® Trimmable Fixation Nails are indicated for maintenance of alignment and fixation of bone fractures, osteotomies, arthrodesis and bone grafts in the presence of appropriate additional immobilization (e.g., rigid…
- Trial name
- NCT06138548
- Testing
- Ossiofiber® Trimmable Fixation Nail
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Subchondral Insufficiency Fracture
Bio-Integrative, Fiber-Reinforced Kneebar for Treating Subchondral Insufficiency of the Knee
The OSSIOfiber® Trimmable Fixation Nails are indicated for maintenance of alignment and fixation of bone fractures, osteotomies, arthrodesis and bone grafts in the presence of appropriate additional immobilization (e.g., rigid…
- Trial name
- NCT06423378
- Testing
- OSSIOfiber® Trimmable Fixation Nails
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Trauma (Including Fractures), Trauma Patients
Renal and Hepatic Abnormal Doppler Patterns in Trauma
The goal of this observational study is to learn about renal and hepatic blood flow abnormalities detected by bedside ultrasound in adult patients admitted to the intensive care unit (ICU) following major trauma.
- Conditions
- Trauma (Including Fractures), Trauma Patients, Kidney Disease, Hypovolemia
- Trial name
- RECREANT (NCT07492511)
- Testing
- Point of care ultrasound
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Azienda Usl di Bologna
Adynamic Bone Disease, Chronic Kidney Diseases
Treatment of Adynamic Bone Disorder With Parathyroid Hormone in Chronic Kidney Disease
This study is a 1:1 randomized controlled trial with an intervention for 18 months and a follow up period of 12 months. The purpose of the study is to assess the safety and efficacy of recombinant human parathyroid hormone for…
- Conditions
- Adynamic Bone Disease, Chronic Kidney Diseases, Cardiac Disease, Chronic Kidney Disease-Mineral and Bone Disorder
- Trial name
- NCT04522622
- Testing
- Teriparatide, DXA,VFA, X-ray, HR-pQCT, 18-F NAF PET/CT, Bone biopsy
- Where
- 4 sites in Denmark
- Volunteers
- 48 people
- Sponsor
- Ditte Hansen
Sacral Fracture, Osteoporotic Fracture
Sacroplasty for Sacral Insufficiency Fractures.
This study is designed to determine whether sacroplasty, a minimally invasive procedure to stabilize sacral fractures, improves quality of life and functional recovery in adults aged 50 years or older with sacral or posterior…
- Trial name
- SACRA (NCT07493564)
- Testing
- Percutaneous Sacroplasty, Standard conservative management
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Chronic Kidney Disease Mineral and Bone Disorder, Chronic Kidney Disease (CKD)
The CPH-MBD Cohort
Persons with chronic kidney disease (CKD) have a 3-fold increased risk of bone fracture and a 10-fold increased risk of cardiovascular disease than the general population.
- Conditions
- Chronic Kidney Disease Mineral and Bone Disorder, Chronic Kidney Disease (CKD), Bone Markers
- Trial name
- NCT07193056
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Herlev Hospital
HIV, Hepatitis B
EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV
The EuroSIDA study is a prospective observational cohort study of 23,000+ patients followed in 100+ clinics in 35 European countries, Israel and Argentina.
- Conditions
- HIV, Hepatitis B, Hepatitis C, AIDS
- Trial name
- EuroSIDA (NCT02699736)
- Where
- 110 sites in Argentina, Austria and 34 more
- Volunteers
- 23,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Trauma, Rib Fractures
Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures
The goal of this double blinded randomized control trial is to learn if percutaneous cryoablation of traumatic rib fractures improves outcomes.
- Conditions
- Trauma, Rib Fractures, Chest Wall Disorder, Respiratory Insufficiency
- Trial name
- NCT06533904
- Testing
- Percutaneous Cryoablation of Intercostal Nerves, Multi-modal pain regimen
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loma Linda University