Clinical trials: Insulin Dependent Diabetes
Diabetes Mellitus, Type 1
Accu-Chek® CONNECT at School (CATS) Pediatric Study
This interventional, 6-month post-marketing study is designed to evaluate the change in diabetes-related distress among parents/caregivers of school-age children and adolescents with type 1 diabetes (T1D) who are receiving…
- Trial name
- CATS (NCT02609633)
- Testing
- Accu-Chek® CONNECT DMS, DMS
- Where
- 13 sites in United States
- Volunteers
- 196 people
- Sponsor
- Hoffmann-La Roche
Type 1 Diabetes
The Impact of Continuous Glucose Monitoring Use on Sleep in Parents of Children With Type 1 Diabetes Mellitus
The purpose of this prospective exploratory study is to compare sleep quality and sleep-wake patterns in parents of children with type 1 diabetes (T1D) before and several weeks after initiating using real-time continuous glucose…
- Trial name
- NCT01425255
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Type1diabetes, Depressive Symptoms
Type 1 Diabetes and Depression: Role of Brain Glutamate
The goal of this study is to examine the effect of chronic and acute hyperglycemia in type 1 diabetes mellitus (T1DM) on brain glutamate levels using magnetic resonance spectroscopy (MRS), and associations of brain glutamate with…
- Conditions
- Type1diabetes, Depressive Symptoms, Major Depressive Disorder
- Trial name
- NCT05355285
- Testing
- Glucose Clamp
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Type 1 Diabetes
Incentives, Cognitive Training and Internet Therapy for Teens With Poorly Controlled Type 1 Diabetes
The overall goal of this project is to develop a novel family friendly intervention that will help teens with poor metabolic control of their type 1 diabetes increase and sustain daily self monitoring of blood glucose and lower…
- Trial name
- NCT01722643
- Testing
- MAxIM, Usual Care
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Type 1 Diabetes
Pancreatic Enzyme Replacement and Glucose Regulation in Type 1 Diabetes
Recent studies have demonstrated reduced pancreatic volume is present within months of T1D diagnosis in children, adolescents, and adults.
- Trial name
- CREON (NCT05266963)
- Testing
- CREON
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes
GLP-1 Receptor Targeting in Diabetic and Healthy Individuals
The purpose of the study is to determine whether there are differences in pancreatic uptake of the radiotracer between healthy individuals and patients with type 1 diabetes.
- Trial name
- GLP-1-CPOP (NCT01825148)
- Testing
- radiolabeled Exendin
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetic Neuropathies
Role of Synchronized Lifestyle Modification Program in Insulin Dependent Diabetic Peripheral Neuropathy Patients
This study aims to determine the role of Synchronized Lifestyle modification program along with Physiotherapy on the symptoms of DPN in patients on insulin therapy.
- Trial name
- NCT04813133
- Testing
- Synchronized Lifestyle Modification Program, Synchronized Lifestyle Modification Program and Physiotherapy, Physiotherapy
- Where
- Pakistan
- Volunteers
- 216 people
- Sponsor
- Riphah International University
Hypoglycemia, Diabetes Mellitus
Clinical Usability of Nasal Glucagon in Treatment of Hypoglycemia in Children and Adolescents
Up to fifty (50) children and adolescents with type 1 diabetes (T1D) aged 4 to ˂18 years at time of enrolment will be selected for inclusion in the study.
- Trial name
- NCT02402933
- Testing
- Nasal Glucagon
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus Type 1
Effects of XOMA 052 on Insulin Production in Type 1 Diabetes
To assess the effects of treatment with XOMA 052 on beta-cell function and insulin production in subjects with well-controlled Type 1 diabetes. The safety, tolerability, and pharmacokinetics (PK) of XOMA 052 will also be assessed.
- Trial name
- LATE STAGE (NCT01788033)
- Testing
- XOMA 052
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University of Zurich
Gestational Diabetes Mellitus
Study of Postprandial Incretin Response in Women With Gestational Diabetes
The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent…
- Trial name
- NCT01274052
- Testing
- Meal test
- Where
- Denmark
- Volunteers
- 19 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Type 1 Diabetes
Managing Insulin Pumps for Exercise (Study 2)
People with Type 1 Diabetes Mellitus (T1DM) like to take part in sport and exercise, but problems with metabolism and blood glucose control can make this difficult.
- Trial name
- NCT01398995
- Testing
- Reduction of basal insulin infusion to 50% of normal
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Buckinghamshire Healthcare NHS Trust
Diabetes Mellitus, Type 1
Islet Transplantation in Type 1 Diabetic Kidney Allograft
The purpose of this study is to learn about the safety of islet transplantation when performed after kidney transplantation, which may provide more normal control of blood sugar without the need for insulin shots.
- Trial name
- NCT01241864
- Testing
- Allogenic islet cells (human, U. Chicago), Intraportal infusion of islet cells
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Diabetes Mellitus, Non-Insulin-Dependent
Acute Glycemic Effects of a Very Low Fat Diet in Type 2 Diabetes
There is some consensus that high fat diets can contribute to the development of obesity and type 2 diabetes in humans and animals.
- Trial name
- NCT00006432
- Testing
- very low fat diet
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
SARS-CoV2 Infection Common Pathogens, Diabetes Mellitus, Type 1
Characterisation of the Immune Response to SARS-CoV-2 Infection / COVID-19 in Type 1 Diabetes
Emerging clinical details of the current SARS-CoV-2 pandemic have illustrated that there are multiple clinical presentations and outcomes of this viral infection.
- Trial name
- TIRID (NCT05171998)
- Testing
- venous blood sample
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cwm Taf University Health Board (NHS)
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Telemedicine Continuous Remote Monitoring of Adults With Uncontrolled Diabetes Mellitus
The purpose of this single center observational study is to determine the effect of continuous remote continuous glucose monitor (CGM) reporting coupled with a telemedicine intervention (Tele-CGM program) on levels of HbA1C in…
- Trial name
- TELEMTRRDM (NCT05161793)
- Testing
- Tele-Monitor DM
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- University of Southern California
Diabetes Mellitus, Type 1
A Study in Participants With Type I Diabetes Mellitus
The purpose of this study is: To compare blood sugar control on LY2605541 with insulin glargine after 52 weeks of treatment. To compare the rate of nocturnal low blood sugar episodes on LY2605541 with insulin glargine during 52…
- Trial name
- IMAGINE 3 (NCT01454284)
- Testing
- Glargine, LY2605541, Insulin Lispro
- Where
- 119 sites in United States, Australia and 18 more
- Volunteers
- 1,114 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes, Type 1 Diabetes Mellitus
Evaluating Glucose Control Using a Next-Generation AID Algorithm in Individuals With T1D
Feasibility study to evaluate the safety and feasibility of Omnipod automated insulin delivery algorithms in individuals with type 1 diabetes.
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus, Diabetes (DM)
- Trial name
- EVOLUTIONT1D (NCT07593625)
- Testing
- Omnipod M System, Omnipod S
- Where
- New Zealand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Insulet Corporation
Type 1 Diabetes, Hypoglycemia
Brain Ketone Metabolism in Type 1 Diabetes
This study is designed to examine the value of infusing BHB in type 1 diabetic subjects during experimentally induced hypoglycemic episode in conjunction with testing of cognitive function.
- Trial name
- NCT02471040
- Testing
- Beta-hydroxybutyrate, Normal Saline
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetes Mellitus, Type I
The Effectiveness of Continuous Glucose Monitoring in Diabetes Treatment for Infants and Young Children
The purpose of this study is to see if the use of a real-time glucose sensor improves diabetes control in young children (less than 4 years old) with Type I diabetes when they are initiated on insulin pump therapy.
- Trial name
- Gerber RTSA (NCT00875290)
- Testing
- Real-time glucose sensor
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Seattle Children's Hospital
Type I Diabetes
A Multiple Ascending Dose Trial Investigating Safety, Tolerability and Pharmacokinetics of NNC0361-0041
The trial is a placebo-controlled, double-blinded within cohorts, randomized, multiple ascending dose trial with a sequential trial design.
- Trial name
- TOPPLE T1D (NCT04279613)
- Testing
- NNC0361-0041
- Where
- 16 sites in United States
- Volunteers
- 47 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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