Clinical trials: Insulin Dependent Diabetes
Diabetes Mellitus Type 1
The Effect of Supplementation With Two Different Doses of Vitamin D on Bone Mineral Density, Vitamin D Levels and Hand Grip Strength in Children With Diabetes Mellitus Type 1
The aim of the study is to assess the effect of 12 month supplementation with two different doses of vitamin D ( 500 vs 1000) on bone mineral density, serum 25 hydroxyvitamin D levels and hand grip strength in preadolescents with…
- Trial name
- NCT01277913
- Testing
- Vitamin D3
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Warsaw
Diabetes Mellitus, Type 1
A Research Study to Compare a New Weekly Insulin, Insulin Icodec, and an Available Daily Insulin, Insulin Degludec, Both in Combination With Mealtime Insulin in People With Type 1 Diabetes (ONWARDS 6)
This study compares insulin icodec (a new insulin) to insulin degludec (an insulin already available on the market) in people with type 1 diabetes.
- Trial name
- ONWARDS 6 (NCT04848480)
- Testing
- insulin icodec, insulin degludec, insulin aspart
- Where
- 130 sites in United States, Austria and 10 more
- Volunteers
- 582 people
- Sponsor
- Novo Nordisk A/S
Coronary Disease, Cardiovascular Diseases
Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes
The BARI 2D trial is a multicenter study that uses a 2x2 factorial design, with 2400 patients being assigned at random to initial elective revascularization with aggressive medical therapy or aggressive medical therapy alone with…
- Conditions
- Coronary Disease, Cardiovascular Diseases, Heart Diseases, Insulin Resistance
- Trial name
- BARI2D (NCT00006305)
- Testing
- Angioplasty, Transluminal, Percutaneous Coronary, other catheter-based interventions, Coronary Artery Bypass, Biguanides, thiazolidinediones
- Volunteers
- 2,368 people
- Sponsor
- University of Pittsburgh
Type 1 Diabetes
Accuracy, Reliability and Safety of GlucoMen®Day, a New Generation Microdialysis Continuous Glucose Monitor
Monocenter single-arm, prospective clinical study in 20 type 1 diabetic subjects, equipped with the GlucoMen®Day system, over up to 100 hours observation after implantation of the microdialysis probe.
- Trial name
- NCT01407315
- Testing
- GlucoMenDay
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Ketosis Prone Diabetes, Diabetes Ketoacidosis
Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin Treatment
The study intends on enrolling 48 subjects with diabetes. Diabetic subjects that no longer need insulin will be randomly placed (like the flip of a coin) on a diabetes pill called metformin, a diabetes pill called sitagliptin or…
- Conditions
- Ketosis Prone Diabetes, Diabetes Ketoacidosis, Hyperglycemia
- Trial name
- NCT01099618
- Testing
- metformin, Sitagliptin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dawn Smiley MD
Diabetes Mellitus, Type 1
GABA and Beta-cell Regeneration
GABA(gamma-Aminobutyric acid) may be used for decreasing anti-gad antibodies and leads beta-cell regeneration.
- Trial name
- NCT04375020
- Testing
- GABA
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ministry of Health and Population, Egypt
Influenza-like Illness
Biobran/MGN-3 Increases Innate Resistance and Reduces the Incidence of Influenza-like Illnesses
Influenza is a seasonally-epidemic viral infection causing 3-5 million severe illnesses and up to approximately 500,000 annual deaths around the world.
- Trial name
- NCT04646980
- Testing
- Biobran/MGN-3
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Zagazig University
Type 1 Diabetes Mellitus
Comparison of SAR342434 to Humalog as the Rapid Acting Insulin in Adult Patients With Type 1 Diabetes Mellitus Also Using Insulin Glargine
Primary Objective: To demonstrate non-inferiority of SAR342434 versus Humalog in glycated haemoglobin A1c (HbA1c) change from baseline to Week 26 in participants with type 1 diabetes mellitus (T1DM) also using insulin glargine.
- Trial name
- SORELLA1 (NCT02273180)
- Testing
- SAR342434, Humalog, Insulin glargine HOE901
- Where
- 89 sites in United States, France and 6 more
- Volunteers
- 507 people
- Sponsor
- Sanofi
Type 1 Diabetes Mellitus
Cotransplantation of Islet and Mesenchymal Stem Cell in Type 1 Diabetic Patients
The study evaluates the safety and efficacy of Cotransplantation of Islet and Mesenchymal Stem Cell in Type 1 Diabetic Patients.
- Trial name
- NCT00646724
- Testing
- cotransplantation of islet and mesenchymal stem cell
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fuzhou General Hospital
Diabetes Mellitus Type 1
Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression
This study will test whether a new islet transplant procedure will enable patients with type 1 diabetes mellitus to stop insulin therapy. Islets are cell clusters in the pancreas that contain insulin-producing cells.
- Trial name
- NCT00006505
- Testing
- Islet Transplantation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Type 1, Diabetes Type 2 on Insulin
Performance and Safety Evaluation of the EkiYou V2 Application in Patients With Diabetes Using Multiple Daily Insulin Injections (EkiYou-Study1)
EkiYou-Study-1 is an interventional before/after clinical investigation according to EU 2017/745. It is conducted in 21 adults with diabetes and treated by multiple daily insulin injections.
- Conditions
- Diabetes Type 1, Diabetes Type 2 on Insulin, Pancreatogenous Diabetes
- Trial name
- NCT06529705
- Testing
- EkiYou V2
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes Mellitus
To Evaluate the Effect on Post-prandial Glycemia Safety, and Tolerability of Viaject 7 vs. Lispro Insulin During Subcutaneous Insulin Pump Therapy
The purpose of this study is to evaluate the Effect on Post-prandial Glycemia Safety, and Tolerability of Viaject 7 vs. Lispro Insulin during SC Insulin Pump Therapy.
- Trial name
- NCT01110746
- Testing
- Viaject 7, LISPRO
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Biodel
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Managing Type 1 and High Risk Type 2 Diabetes in the Hospital Setting: Glucose as a Vital Sign
This program will provide patients with type 1 and high risk type 2 diabetes the safest hospitalization by using wireless continuous glucose monitoring devices (CGM) to track their glucose parameters in real-time similar to other…
- Trial name
- CGM (NCT03068273)
- Testing
- Real-time CGM data
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Scripps Whittier Diabetes Institute
Type 1 Diabetes Mellitus
BMI and Its Relationship to Hypoglycemic Seizures in Children With Insulin-requiring Diabetes
The landmark study Diabetes Control and Complication Trial (DCCT) clearly showed that intensive insulin management delays the onset and progression of longterm complications in adolescents with type 1 diabetes mellitus (T1DM).
- Trial name
- NCT00717483
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- Baylor College of Medicine
Type 1 Diabetes Mellitus
A Safety, Tolerability, and Efficacy Study of VC-01™ Combination Product in Subjects With Type I Diabetes Mellitus
The purpose of this trial is to test if VC-01™ combination product can be implanted subcutaneously in subjects with Type 1 Diabetes and maintained safely for two years.
- Trial name
- NCT02239354
- Testing
- VC-01™ Combination Product
- Where
- 2 sites in United States, Canada
- Volunteers
- 19 people
- Sponsor
- ViaCyte
Type 1 Diabetes, Pregnancy
Pancreatic Islet Mass in Pregnancy in Type 1 Diabetes
Type 1 diabetic women have a decrease in insulin requirements during early pregnancy. Preliminary evidence suggests this decrease may be secondary to the regeneration of pancreatic B-cells during pregnancy During the second and…
- Trial name
- NCT00548522
- Where
- 2 sites in Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta
Diabetes Mellitus, Type 1
Verapamil SR in Adults With Type 1 Diabetes
This study has been set up within the framework of the INNODIA network. INNODIA is a global partnership between 31 academic institutions, 6 industrial partners, a small sized enterprise and 2 patient organizations, bringing their…
- Trial name
- Ver-A-T1D (NCT04545151)
- Testing
- Verapamil SR 120 mg
- Where
- 22 sites in Austria, Belgium and 4 more
- Volunteers
- 136 people
- Sponsor
- Medical University of Graz
Type 1 Diabetes
Clinical Trial on Ladarixin Adjunctive Therapy to Improve Glycemic Control in Type 1 Diabetes.
Primary objective To determine whether oral ladarixin versus placebo adjunctive therapy improves glycemic control in overweight, insulin resistant (IR) adult subjects with type 1 diabetes (T1D).
- Trial name
- CONSERVA (NCT05368402)
- Testing
- Ladarixin
- Where
- 2 sites in Italy
- Volunteers
- 3 people
- Sponsor
- Dompé Farmaceutici S.p.A
Type 1 Diabetes Mellitus
Constructed Intervention by Home and School Diabetes Nurse Visits on Diabetic Control of Children With Type I Diabetes
The investigators assume that an intervention program that includes home visits and trainings of diabetes' nurse and dietitian will lead to an improvement of the patients' metabolic balance, a decrease in complications' rate, a…
- Trial name
- NCT01382459
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Type 1 Diabetes, Type 2 Diabetes
Automated Insulin Delivery for Inpatients With Dysglycemia
This randomized controlled trial will test the efficacy and safety of automated insulin delivery (AID) in hospitalized patients with diabetes (type 1 or type 2) requiring insulin therapy who are admitted to general…
- Trial name
- AIDING (NCT06418880)
- Testing
- AID system with Remote Real-Time CGM, Standard of Care Insulin Therapy + CGM
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- Emory University
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