Clinical trials: Insulin Dependent Diabetes
Diabetes Mellitus, Non-Insulin-Dependent, Hypertensive Disease
To Evaluate the Effect of Liraglutide on Ambulatory Blood Pressure-A Pilot Study
The investigators are conducting this research to study the effect of Liraglutide on blood pressure. Several studies have shown increased cardiovascular complications and deaths in diabetics with hypertension.
- Trial name
- NCT02299388
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Tulane University School of Medicine
Type 1 Diabetes
Regulatory T Cells in Type 1 Diabetes Patients Treated With IL-2
Type 1 diabetes is the most common severe chronic autoimmune disease worldwide and is caused by the autoimmune (loss of self tolerance) mediated destruction of the insulin producing pancreatic beta cells thus leading to insulin…
- Trial name
- DILT1D (NCT01827735)
- Testing
- Aldesleukin (Proleukin)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Ketosis Prone Diabetes
Modeling Ketosis-Prone Diabetes Remission Via Diverse Mechanisms of Glucotoxicity
The goal of this study is to quantify day-to-day changes in blood glucose during treatment towards remission in ketosis-prone diabetes (KPDM) and describe them using a mathematical model of KPDM pathogenesis and remission.
- Trial name
- NCT06699810
- Testing
- Continuous Glucose Monitoring, Insulin
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Emory University
T1D, Type 1 Diabetes (T1D)
Evaluation of a Biopsychosocial System
The goal of this observational study is to evaluate the feasibility of a biopsychosocial sensing system integrated into the Adhera Caring Digital Program® for caregivers of children with type 1 diabetes (T1D).
- Conditions
- T1D, Type 1 Diabetes (T1D), Type 1 Diabetes
- Trial name
- NCT07440108
- Testing
- Use of Biopsychosocial Sensing System
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Adhera Health, Inc.
Diabetes Mellitus, Type 1
Empagliflozin as Adjunctive to Insulin Therapy Over 26 Weeks in Patients With T1DM (EASE-3)
The study will investigate the efficacy, safety, tolerability and Pharmacokinetic(PK) of 3 doses of empagliflozin compared with placebo over 26 weeks in 960 patients with type 1 diabetes mellitus as adjunctive therapy to insulin
- Trial name
- NCT02580591
- Testing
- Empagliflozin
- Where
- 189 sites in United States, Australia and 22 more
- Volunteers
- 977 people
- Sponsor
- Boehringer Ingelheim
Type 1 Diabetes
Association Between Sarcopenia And Diabetic Neuropathy In Adults With Type 1 Diabetes, A Pilot Study
Monocentric interventional prospective study to evaluate the prevalence of sarcopenia in adults with type 1 diabetes (T1DM) and to evaluate the association between diabetic neuropathy and sarcopenia in subjects with T1DM; to…
- Trial name
- SARCO_DM1 (NCT06902597)
- Testing
- Dual energy X-ray absorptiometry
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Non-Insulin-dependent Diabetes Mellitus
Study of Metamucil on Blood Glucose and HbA1c in Type II NIDDM Subjects
A double-blind, randomized, placebo-controlled, multi-dose clinical study consisting of 2 phases; 1) an 8-week lead-in period during which patients followed a diet judged to be within the acceptable guidelines of the ADA, and 2)…
- Trial name
- NCT01582282
- Testing
- 3.4 g psyllium BID, 6.8g psyllium BID
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Procter and Gamble
Diabetes Mellitus, Type 1
Assessment of an iPhone Application on Glycemic Control in Type 1 Diabetes
The purpose of the study is to assess whether an electronic self-management tool, specifically an iPhone application entitled bant, can improve glycemic control in Adolescents who have Type 1 Diabetes Mellitus (T1DM).
- Trial name
- NCT01899274
- Testing
- bant iPhone application
- Where
- 2 sites in Canada
- Volunteers
- 92 people
- Sponsor
- The Hospital for Sick Children
Type 1 Diabetes
Encapsulated Faecal Microbiota Transplantation to Preserve Residual Beta Cell Function in Type 1 Diabetes Mellitus
In this single arm pilot study it will be investigated whether encapsulated autologous fecal microbiota transplantation may be used to halt the decline in residual beta cell function in individuals with recent onset Type 1…
- Trial name
- ENCAPSULATE (NCT05323162)
- Testing
- encapsulated autologous fecal microbiota transplantation
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Nordin Hanssen
Type 2 Diabetes Mellitus, Celiac Disease
Fiber-enriched Buckwheat Pasta and Glucose Variability in Patients With Type 1 Diabetes and Celiac Disease
The intervention was preceded by a 1-week run-in period during which participants underwent continuous glucose monitoring (CGM) and filled in a 7-day dietary record to optimize basal infusion rate and insulin-to-glycemic load…
- Trial name
- NCT03380988
- Testing
- Acute test meal with fiber-enriched buckwheat pasta, Acute test meal with corn pasta
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Federico II University
Diabetes Mellitus, Type 1
Therapeutic Effects of Plyometric Exercises in Children With Type 1 Diabetis
Despite the benefits of physical rehabilitation among adults and children with chronic illness such as Diabetes mellitus avoid engaging in different physical activities especially pediatric population.
- Trial name
- NCT05577286
- Testing
- regular care, plyometric training
- Volunteers
- 30 people
- Sponsor
- Cairo University
Diabetes Mellitus, Type 1
Pharmacology of Insulin Injected With Jet-Injection
The purpose of this study is to compare the pharmacological profile of insulin administered with jet-injection with that of insulin injected with a conventional insulin pen.
- Trial name
- NCT00983775
- Testing
- jet injector (SQ pen/Novopen III)
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM)
Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring.
The goal of this clinical trial is to develop and evaluate a novel diabetes ketoacidosis risk mitigation strategy to support the safe use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) therapy in participants with type 1…
- Conditions
- Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), Chronic Kidney Disease, Diabetic Ketoacidosis
- Trial name
- SCOUT-CKD (NCT07325201)
- Testing
- Sotagliflozin initiation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- HealthPartners Institute
Type 1 Diabetes
Evaluation of a Treatment and Education Programme for Type 1 Diabetic Patients (PRIMAS)
This study is a randomized prospective trial with 6-month follow up. A non-inferiority hypothesis is tested. A new developed treatment and education programme for type 1 diabetic patients (PRIMAS) will be tested compared to an…
- Trial name
- PRIMAS (NCT01220557)
- Testing
- PRIMAS, DTTP
- Volunteers
- 160 people
- Sponsor
- Forschungsinstitut der Diabetes Akademie Mergentheim
Patients With Type 1 Diabetes
Allogeneic Islet Transplantation for the Treatment of Type 1 Diabetes
It is a multicentre, sequential, phase II clinical trial, aiming at evaluating the allogeneic islet transplantation for the treatment of type 1 diabetes.
- Trial name
- GRIIF (NCT01974674)
- Testing
- Allogeneic transplantation of intrahepatic islet
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes
Transdermal Basal Insulin Patch Study in Type 1 Diabetes
This study is designed to evaluate the pharmacokinetics/pharmacodynamics of an investigational basal insulin patch in type 1 diabetes patients.
- Trial name
- NCT00519623
- Testing
- PassPort(R) Transdermal Insulin Delivery System
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Altea Therapeutics
Type 1 Diabetes (Juvenile Onset), Continuous Glucose Monitoring System
Mediterranean Diet and Oxidative Stress in Type 1 Diabetes (MEDOX-T1D)
Achieving optimal glycemic control in type 1 diabetes requires a holistic approach that includes individualized medical nutrition therapy in addition to appropriate insulin therapy.
- Conditions
- Type 1 Diabetes (Juvenile Onset), Continuous Glucose Monitoring System, Oxidative Stress
- Trial name
- MEDOX-T1D (NCT07544368)
- Testing
- Mediterranean Diet Intervention
- Volunteers
- 54 people
- Sponsor
- Istanbul University
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Fit-One: A Trial Evaluating the Effect of One Drop and Fitbit on Diabetes and Pre-diabetes Outcomes
The Fit-One trial involves three prospective, randomized waitlist-controlled studies. These studies evaluate the effects of One Drop's digital therapeutics solution with and without Fitbit devices on the social cognitive…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, PreDiabetes
- Trial name
- Fit-One (NCT03459573)
- Testing
- One Drop | Experts On Track, One Drop | Experts On Call, One Drop | Experts Revive
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Chandra Osborn, PhD, MPH
Diabetes Type 1
French Version of the Scales of Fear of Hypoglycaemia in Children With Type 1 Diabetes and Their Parents
Type 1 diabetes usually appears brutally in children or young adults. While many factors of poor glycemic balance have been identified in the literature (age, socio-cultural and socio-economic level, family structure, adherence…
- Trial name
- FHS (NCT03529188)
- Where
- 3 sites in France
- Volunteers
- 194 people
- Sponsor
- University Hospital, Brest
Diabetes type1, Hypoglycemia
Hypoglycemia and Cardiac Arrhythmias in Type 1 Diabetes
The investigators hypothesise that following episodes of hypoglycemia, rebound hyperglycemia may result in a prolonged period of increased QTc and, thereby, increased susceptibility to serious cardiac arrhythmias in patients with…
- Conditions
- Diabetes type1, Hypoglycemia, Arrhythmias, Cardiac
- Trial name
- Hypo-Heart-1 (NCT03956173)
- Testing
- Hypoglycemic combined with either normo or hyperglycemic clamp.
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Steno Diabetes Center Copenhagen