Clinical trials: Insulin Dependent Diabetes
MASLD, Type 1 Diabetes
Study of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in Adults With Type 1 Diabetes
Type 1 diabetes (T1D) is a disease characterized by an absolute deficiency of insulin secondary to autoimmune destruction of pancreatic beta cells , historically individuals with T1D are not liable for metabolic complications.
- Trial name
- NCT07750210
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Sohag University
Type 1 Diabetes, Quality of Life
Randomized Crossover Study to Test the Impact of Using a Software for Smartphones and Tablets in Treating Type 1 Diabetes
The purpose of this study is to evaluate the impact of a software for smartphones and tablets on type 1 diabetes control and quality of life
- Conditions
- Type 1 Diabetes, Quality of Life, Hypoglycaemia
- Trial name
- NCT02107326
- Testing
- Webdia Software
- Where
- Switzerland
- Volunteers
- 55 people
- Sponsor
- Philippe Klee
Type1diabetes, Fatty Liver
Night Hyperglycemia and Fatty Liver in Type 1 Diabetes
This clinical trial aims to discover the relationship between hyperglycemia at night and early morning hours and the presence of fatty liver in patients with type 1 diabetes.
- Trial name
- NCT05933018
- Testing
- liver elastography
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- HaEmek Medical Center, Israel
Diabetes, Diabetes Mellitus, Type 1
Safety and Efficacy of Insulin Detemir Plus Insulin Aspart Against Insulin Glargine Plus Insulin Aspart as Mealtime Insulin in Type 1 Diabetes
This trial is conducted in Europe and the United States of America (USA). The purpose of this study is to test whether insulin detemir is a safe and at least as effective alternative to insulin glargine for the control of blood…
- Trial name
- NCT00095082
- Testing
- insulin detemir, insulin glargine, insulin aspart
- Where
- 81 sites in United States, Finland and 5 more
- Volunteers
- 447 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
A Study to Compare Pharmacokinetics and Pharmacodynamics of SAR342434 to Insulin Lispro in Subjects With Type 1 Diabetes
Primary Objective: To compare exposure and activity of SAR342434 to US-approved and EU-approved Humalog®. Secondary Objective: To assess the safety and tolerability of SAR342434.
- Trial name
- NCT02273258
- Testing
- SAR342434, Insulin Lispro
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Sanofi
Diabetes Mellitus
Optimising Health in Type 1 Diabetes
Type 1 diabetes is an autoimmune condition where circulating immune cells destroy the beta-cells in the pancreas that make insulin, resulting in a degree of insulin deficiency, whereby blood glucose levels rise and diabetes…
- Trial name
- NCT02903615
- Testing
- Novel diet, Standard diet
- Where
- 2 sites in Australia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Garvan Institute of Medical Research
Type 1 Diabetes
Comparison of a Twice Daily Versus a Three Times Daily Insulin Regimen in Children With Type 1 Diabetes
The purpose of this study is to determine whether there is a difference in blood sugar control (as measured by hemoglobin A1c (HA1c)), in children given twice daily insulin injections incorporating a new long acting insulin…
- Trial name
- NCT00522210
- Testing
- Detemir, Novolin NPH or Humulin N
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Calgary
Non Insulin Dependent Diabetes
Curcumin Supplementation and Patients With Type 2 Diabetes
Diabetes mellitus is the most common endocrine disorder, causes many complications such as micro- and macro-vascular diseases. Various kinds of antidiabetic drugs have been developed, but most of them have side effects.
- Trial name
- NCT02529982
- Testing
- Curcumin
- Where
- Iran
- Volunteers
- 44 people
- Sponsor
- National Nutrition and Food Technology Institute
Diabetes Mellitus, Type 1 Diabetes
The Insulin-Only Bionic Pancreas Pivotal Trial
This multi-center randomized control trial (RCT) will compare efficacy and safety endpoints using the insulin-only configuration of the iLet Bionic Pancreas (BP) System versus Usual Care (UC) during a 13-week study period.
- Conditions
- Diabetes Mellitus, Type 1 Diabetes, Diabetes Mellitus, Type 1
- Trial name
- NCT04200313
- Testing
- Bionic Pancreas (BP) with Aspart or Lispro, Bionic Pancreas with Fiasp (BPFiasp), Usual Care (UC)
- Where
- 16 sites in United States
- Volunteers
- 440 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes
Better Control in Pediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference (SWEET- Registry)
SWEET-REGISTRY is a multi center, investigator initiated registry in patients with diabetes. SWEET' is an acronym derived from 'Better control in Pediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference'.
- Trial name
- SWEET (NCT04427189)
- Where
- Germany
- Volunteers
- 100,000 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Type 1 Diabetes
Oral Galactose as a Substrate for Post-Exercise Skeletal Muscle Glycogen Repletion in Individuals With Type 1 Diabetes
This Ph.D. project investigates whether orally ingested galactose can be taken up by skeletal muscle and the heart in response to exercise or hyperinsulinemia, and whether it may serve as a viable nutritional strategy for…
- Trial name
- NCT07774780
- Testing
- galactose
- Where
- 2 sites in Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 1 Diabetes Mellitus
Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy
This Phase 3 study was intended to demonstrate superiority of either sotagliflozin high dose or low dose versus placebo on glycosylated hemoglobin A1C (A1C) reduction at Week 24 when used as an adjunct in adult participants with…
- Trial name
- inTandem1 (NCT02384941)
- Testing
- Sotagliflozin
- Where
- 75 sites in United States, Canada
- Volunteers
- 793 people
- Sponsor
- Lexicon Pharmaceuticals
Diabetes Mellitus, Diabetes Mellitus, Type 1
Turkish Version of The Diabetes Quality of Life Brief Clinical Inventory Validity and Reliability
This study aims to develop Turkish version of the Diabetes Quality of Life Brief Clinical Inventory (DQL-BCI) and to perform validity and reliability evaluations.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetes
- Trial name
- NCT05407454
- Testing
- Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- İlke KARA, PT
Diabetic Neuropathies, Diabetes Mellitus, Insulin-Dependent
Treatment for Symptomatic Peripheral Neuropathy in Patients With Diabetes
The purpose of this protocol is to determine if an investigational drug is effective in treating nerve malfunction in diabetes.
- Conditions
- Diabetic Neuropathies, Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent
- Trial name
- NCT00044395
- Testing
- Ruboxistaurin mesylate
- Where
- 39 sites in United States, Australia and 7 more
- Volunteers
- 200 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 1
Evaluation of a Booster Administration of GAD-alum (Diamyd®) in Individuals With Type 1 Diabetes
The objective of the study is to evaluate the feasibility and safety of administering a 4th or 5th intralymphatic booster dose of GAD-alum (Diamyd®) to T1D patients carrying HLA DR3-DQ2, who have earlier been treated with three…
- Trial name
- NCT05351879
- Testing
- GAD-alum (Diamyd) 40 μg/mL
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Linkoeping University
Type 1 Diabetes (Juvenile Onset), Type 1 Diabetes
Type 1 Diabetes Autonomic and Vascular Function
The goal of this clinical trial is to investigate the autonomic and vascular function in men and women with Type 1 diabetes. The main questions it aims to answer are: 1.
- Conditions
- Type 1 Diabetes (Juvenile Onset), Type 1 Diabetes, Diabetes, Autoimmune
- Trial name
- NCT06786546
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Type 1 Diabetes, Diabetes Mellitus
Safety and Pharmacokinetics of CBX129801 in Patients With Type 1 Diabetes
The purpose of this study is to assess safety and tolerability and determine the pharmacokinetics of subcutaneous single and multiple (up to 12) dose administration of CBX129801 (long-acting synthetic C-peptide) in type 1…
- Conditions
- Type 1 Diabetes, Diabetes Mellitus, Peripheral Diabetic Neuropathy
- Trial name
- NCT01293461
- Testing
- CBX129801
- Where
- 8 sites in United States
- Volunteers
- 72 people
- Sponsor
- Cebix Incorporated
Insulin-dependent Gestational Diabetes
PINGUIN (Postpartum Intervention in Women With Gestational Diabetes Using Insulin)
The aim of the study is to prove the efficacy of the oral intake of vildagliptin in a daily dose of 100 mg in scope of the development of type 2 diabetes in women with insulin dependent gestational diabetes in their last…
- Trial name
- NCT01018602
- Testing
- vildagliptin, inactive pill
- Where
- Germany
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Institut fur Diabetesforschung, Munich, Germany
Type 1 Diabetes, Heart Disease
Haptoglobin Phenotype, Vitamin E and High-density Lipoprotein (HDL) Function in Type 1 Diabetes
The purpose of the study is to determine whether the function of the good cholesterol (HDL cholesterol) as well as its subfractions (via NMR spectroscopy) is altered among people with type 1 diabetes and a variation in the…
- Trial name
- HAP-E (NCT01098994)
- Testing
- Vitamin E, Dummy pills
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Pittsburgh
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Afrezza® Dosing Optimization Study
MKC-TI-191 is a Phase 4, single-arm, multicenter, proof-of-concept clinical trial evaluating the efficacy and safety of Afrezza, administered according to the current Afrezza prescribing information (PI) compared to a titrated…
- Trial name
- DOS (NCT04849845)
- Testing
- Afrezza Dose 1, Afrezza Dose 2
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Mannkind Corporation
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