Clinical trials: Insulin Dependent Diabetes
Diabetes Mellitus
Evaluation of the Accuracy of an Implanted Glucose Sensor
The purpose of this clinical investigation is to evaluate the accuracy of the Senseonics Continuous Glucose Monitoring System (Senseonics CGM System) measurements when compared with reference standard measurements The…
- Trial name
- PRECISEII (NCT02647905)
- Testing
- Continuous Glucose Monitoring System
- Where
- 9 sites in United States
- Volunteers
- 90 people
- Sponsor
- Senseonics, Inc.
Type 1 Diabetes
Closing the Loop for 36 Hours in Adolescents With Type 1 Diabetes: Evaluation of Reduced Meal Bolusing
The main focus of our research is the development of a closed-loop system for glucose control in people with type 1 diabetes. After having demonstrated the safety and efficacy of overnight closed-loop insulin delivery, we are…
- Trial name
- NCT01629251
- Testing
- Closed-loop insulin delivery
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- University of Cambridge
Diabetes Mellitus, Type 1
Assessing Closed-loop Insulin Delivery in Children With Type 1 Diabetes.
The objective of this clinical trial is to assess the safety of our insulin dosing algorithm in children with type 1 diabetes in a free-living study.
- Trial name
- NCT04612257
- Testing
- Insulin-alone closed-loop
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McGill University
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Evaluation of Blood Volume and Perceived Pain During Fingerstick Monitoring of Blood Glucose
The procurement of blood for SMBG, usually via a finger stick, is considered by many patients to be the most painful portion of diabetes therapy.
- Trial name
- NCT00741390
- Testing
- BD/33G, OTM / 33G, OTU/28G
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- Becton, Dickinson and Company
Type I Diabetes
Ladarixin as Adjunctive Therapy to Improve Insulin Sensitivity and Glucometabolic Outcomes in Type 1 Diabetes
Objectives Primary study objective: To determine whether orally-administered ladarixin versus placebo adjunctive therapy improves insulin sensitivity in overweight, insulin-resistant (IR) type 1 Diabetic (T1D) adult subjects.
- Trial name
- NCT05035368
- Testing
- Ladarixin
- Where
- United States
- Sponsor
- Dompé Farmaceutici S.p.A
Obesity, Hypertension
Methods for Measuring Insulin Sensitivity
Patients with high blood pressure, diabetes, and who are overweight are known to have defects in the way their body responds to insulin.
- Conditions
- Obesity, Hypertension, Diabetes-Mellitus, Non-Insulin Dependent
- Trial name
- NCT00001625
- Where
- United States
- Volunteers
- 480 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Type 1 Diabetes
Use of Exenatide and Pramlintide to Decrease Post-prandial Hyperglycemia
The main purpose of the study is to determine the effects of 16 weeks of adjunctive pramlintide or exenatide use on glycemic control in Type 1 Diabetes.
- Trial name
- NCT01269047
- Testing
- Pramlintide, Exenatide, Insulin
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Albert Einstein College of Medicine
Diabetes Mellitus, Diabetes Mellitus, Type 1
An Open-Label, FIH Study Evaluating the Safety, Tolerability, and Efficacy of VCTX211 Combination Product in Subjects With T1D
This is an open-label, multicenter, Phase 1 study evaluating the Safety, Tolerability, and Efficacy of VCTX211 Combination Product in Subjects with T1D
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- NCT05565248
- Testing
- VCTX211
- Where
- 2 sites in Canada
- Volunteers
- 5 people
- Sponsor
- CRISPR Therapeutics AG
Type 1 Diabetes
Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families
This R01 is in response to RFA-DK-19-021, Treating Diabetes Distress to Improve Glycemic Outcomes in Type 1 Diabetes. The objective is to test the feasibility and acceptability of a novel, practical, and potentially scalable…
- Trial name
- R2D2 (NCT05268250)
- Testing
- R2D2 mHealth intervention
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes Mellitus
Pharmacodynamics, Pharmacokinetics, and Safety of ASP1941 in Patients With Type 1 Diabetes Mellitus
The objective of this study is to assess pharmacodynamics, pharmacokinetics, and safety of ASP1941 in patients with type 1 diabetes mellitus when administered once daily (q.d.) for 2 weeks.
- Trial name
- NCT02529449
- Testing
- ASP1941
- Where
- 11 sites in Japan
- Volunteers
- 43 people
- Sponsor
- Astellas Pharma Inc
Type 1 Diabetes, Diabetes Distress
Behavioral Approaches to Reducing Diabetes Distress and Improving Glycemic Control
This study is comparing three programs to reduce Diabetes Distress (the worries and concerns that people with diabetes may experience as they struggle to keep blood glucose levels in range) in adults with type 1 diabetes.
- Trial name
- EMBARK (NCT04016558)
- Testing
- StreamLine, TunedIn, FixIt
- Where
- United States
- Volunteers
- 296 people
- Sponsor
- University of California, San Francisco
Hypoglycemia, Diabetes Mellitus, Type 1
A Pilot Study of Nocturnal Hypoglycemia Prevention in Type 1 Diabetes Using the Vigilant Diabetes Management Companion
A single center pilot study assessing the Vigilant Diabetes Management Companion for the prevention of recurrent nocturnal hypoglycemia in type I diabetes patients.
- Trial name
- NCT02906891
- Testing
- Vigilant Diabetes Management Application
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- InSpark Technologies, Inc.
Type 1 Diabetes
Intervention for Children With Type 1 Diabetes Targeting Gut Microbes
The goal of this clinical study is to evaluate the effect of nutritional intervention program based on dietary products in the clinical treatment of newly diagnosed children with type 1 diabetes.
- Trial name
- TRIM1 (NCT06198725)
- Testing
- Trimtab
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Children's Hospital of Fudan University
Diabetes Mellitus, Type 1
EDCR Study - Etanercept Diamyd Combination Regimen -Open Trial to Evaluate Safety in Children With Type 1 Diabetes
The objectives of this study is to: Evaluate the tolerability of a combination therapy with Diamyd, vitamin D and etanercept Evaluate how the above mentioned treatments influence the immune system and endogenous insulin secretion
- Trial name
- NCT02464033
- Testing
- GAD-Alum, Vitamin D, Etanercept
- Where
- 8 sites in Sweden
- Volunteers
- 20 people
- Sponsor
- Johnny Ludvigsson
Diabetes
A Comparison Study of Prototype Continuous Glucose Sensors in the Intradermal and Subcutaneous Spaces
The purpose of this study is to compare two continuous glucose sensors, one placed subcutaneous (under the skin) and one placed intradermal (in the skin) over 12-14 hours.
- Trial name
- NCT01093833
- Testing
- BD Continuous glucose monitor (BD CGM), YSI Glucose Analyzer, Medtronic Guardian CGM
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Becton, Dickinson and Company
Diabetes Mellitus, Type 1
Ketone Monitoring in T1D: Effect of SGLT2i During Usual Care and With Insulin Deficiency
This proposed study will test whether measurement of breath acetone (BrAce) can be used for the purpose of identifying ketosis (elevated ketones) in persons with type 1 diabetes (T1D).
- Trial name
- NCT05541484
- Testing
- SGLT2 inhibitor, Biosense Breath Ketone Analyzer
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Diabetes, Diabetes Mellitus, Type 1
Human Insulin NPH and Insulin Aspart in Type 1 Diabetes
This trial is conducted in South America. This aim of this trial is to evaluate the comparative prandial blood glucose lowering profile in subjects with type 1 diabetes.
- Trial name
- NCT00597233
- Testing
- insulin aspart, soluble human insulin, insulin NPH
- Where
- Argentina
- Volunteers
- 91 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Efficacy of Coenzyme q10 in Pediatrics With Type 1 Diabetes Mellitus
The purpose of this study is to determine wether coenzyme Q10 is effective in reducing markers of endothelial dysfunction in pediatric patients with type 1 diabetes mellitus and aslo to investigate its effect on glycemic control…
- Trial name
- NCT03111433
- Testing
- Coenzyme Q10, Insulin
- Where
- Egypt
- Volunteers
- 49 people
- Sponsor
- Ain Shams University
Type1diabetes
Safety of Closed-loop Hybrid Insulin Administration During Ramadan Fasting in People Living With Type 1 Diabetes
Fasting in Ramadan is not recommended for people with type 1 diabetes. The main risk associated with fasting is dysglycemia (hypoglycemia, hyperglycemia, diabetic ketosis) and dehydration.
- Trial name
- RAMDAM (NCT05747352)
- Testing
- closed-loop hybrid insulin administration
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Sud Francilien
Type 1 Diabetes, Hyperglycemia Stress
Competition Induced Hyperglycemia in Athletes With Type 1 Diabetes
Design and methods 12 athletes with T1D and 12 healthy athletes are included in a prospective experimental randomized, cross-over study.
- Trial name
- EXCITE-1 (NCT05561517)
- Testing
- 5 K running
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
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