Clinical trials: Insulin Dependent Diabetes
Type 1 Diabetes Mellitus
Evaluation of Safety and Diabetes Status Upon Oral Treatment With GABA in Patients With Longstanding Type-1 Diabetes
The main goal of this study is to find a reasonably safe and tolerable treatment for adult patients with type 1-diabetes and that regain some of the endogenous insulin secretion, improve the patients' quality of life (QoL) and…
- Trial name
- NCT03635437
- Testing
- Gamma-Aminobutyric Acid (GABA), Alprazolam
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Per-Ola Carlsson
Squamous Cell Carcinoma of the Head and Neck
Personalized Immunotherapy in Patients With Recurrent /Metastatic SCCHN That Have Progressed on Prior Immunotherapy
In this Phase II trial of personalized immunotherapy in R/M HNSCC, gene expression of LAG3 and CTLA4 by RNA seq will be determined to select the appropriate agent (Ipilimumab or Relatlimab) to add to Nivolumab in patients with…
- Trial name
- NCT04326257
- Testing
- Nivolumab+Relatlimab, Nivolumab+Ipilimumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dan Zandberg
NAFLD, Type 1 Diabetes
Prevalence, Incidence and Characteristics of NAFLD/NASH in Type 1 Diabetes Mellitus
Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by intrahepatic fat accumulation. It is closely related to insulin resistance.
- Conditions
- NAFLD, Type 1 Diabetes, Cardiovascular Diseases
- Trial name
- NAFLDIA1 (NCT04664036)
- Testing
- ultrasound, elastography, controlled attenuation parameter (CAP)
- Where
- Belgium
- Volunteers
- 700 people
- Sponsor
- University Hospital, Antwerp
Diabetes Mellitus, Type 1, Fasting
Health Education During Ramadan Fasting in Type 1 Diabetes
Adult Muslims are obliged to start fasting during the month of Ramadan. Fasting entails refraining from all food, drink, tablets and injections(vitamins \& fluids) between sunrise and sunset; a period which varies by geographical…
- Trial name
- NCT03501511
- Testing
- IDF modules, Conversational Maps
- Where
- Egypt
- Volunteers
- 53 people
- Sponsor
- Ain Shams University
Type 1 Diabetes
Description of Patients With Type 1 Diabetes Treated With Teplizumab
Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease caused by the destruction of pancreatic β cells. T1D pathogenesis progresses through several stages: Stage 1 T1D includes the presence of β cell autoimmunity and thus…
- Trial name
- TEPLI-REAL (NCT06892002)
- Testing
- Teplizumab
- Where
- 27 sites in United States, Israel
- Volunteers
- 110 people
- Sponsor
- Sanofi
Type 1 Diabetes Mellitus
Mesenchymal Stem Cells to Intervene in the Development of Type 1 Diabetes: a Blinded Randomized Study
This project aims to evaluate the efficacy of autologous mesenchymal stem cell treatment to preserve insulin production and beta-cell mass in recently diagnosed patients with type 1 diabetes mellitus.
- Trial name
- NCT02057211
- Testing
- autologous mesenchymal stem cell transplantation
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Uppsala University Hospital
Type 1 Diabetes Mellitus, Physical Activity
Physical Activity in Children With Type 1 Diabetes Study
This study aims to test the feasibility of a physical activity intervention called the Steps To Active Kids (STAK) programme in children aged 9 - 11 years with Type 1 Diabetes Mellitus (T1DM).
- Trial name
- NCT02144337
- Testing
- Steps To Active Kids (STAK) programme
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Nottingham
Type 1 Diabetes Mellitus
Efficacy of Glucagon In the Prevention of Hypoglycemia During Mild Exercise
The study will consist of two study arms. Each arm will include a 24-96 hour outpatient run-in period prior to their exercise visit wearing the bi-hormonal bionic pancreas.
- Trial name
- NCT03217175
- Testing
- Bihormonal Bionic Pancreas, Insulin Only Bionic Pancreas, Glucagon
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Depression, Type 1 Diabetes
Cognitive Behavioral Therapy (CBT) for Adherence and Depression in Type 1 Diabetes
This study is a pilot behavioral intervention trial, designed to initially examine cognitive behavioral therapy for medical adherence and depression (CBT-AD) in patients with depression and poorly controlled type 1 diabetes.
- Trial name
- NCT01527981
- Testing
- Cognitive behavioral therapy for adherence and depression
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes
Adaptive Biobehavioral Control (ABC) in a Closed-Loop System
This study is intended to test a Web-based Information Tool (WIT) software providing additional information regarding time in range, GMI, hypo- and hyperglycemia risks, variability tracker, daily glycemic profiles, and potential…
- Trial name
- ABC-WIT (NCT05610111)
- Testing
- CLC + BAM, CLC + ABC
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Sue Brown
Type 1 Diabetes
PREVENTKD (Prevent Risks by Early interVEntion at Nighttime in Type 1 Diabetes for Kidney Disease)
The purpose of this study is to determine if the early treatment with a blood pressure medication (an ACE Inhibitor) can prevent or delay the development of kidney disease (microalbuminuria) in patients with Type 1 diabetes who…
- Trial name
- PREVENTKD (NCT00729365)
- Testing
- Ramipril
- Where
- 6 sites in United States
- Volunteers
- 65 people
- Sponsor
- Northwestern University
Diabetes
SKAMo-2: the Real-life Test of Continuous Photoacoustic Signal by Neogly in Patients With Type I Diabetes
Diabetes is one of the very common and chronic diseases in the present world, which affects children and adults. Diabetes is characterized by hyperglycemia.
- Trial name
- NCT06035367
- Testing
- Non-invasive continuous monitoring device to record photoacoustic signal
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Eclypia
Diabetes Mellitus
A Clinical Trial Assessing the Impact of Inhaled Insulin on Glucose Disposition
To assess the impact of inhalation of insulin on glucose disposition in patients with type 1 diabetes
- Trial name
- NCT00287066
- Testing
- Inhaled Human Insulin, Regular Human Insulin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Pfizer
Diabetes Mellitus Type 2, Diabetes Mellitus Type 1
A Study Evaluating the Perception of Insertion Pain With Accu-Chek FlexLink and FlexLink Plus Insulin Pump Devices Under Real Life Conditions in Diabetic Patients.
German Multi-centered, randomized, crossover study in diabetic patients evaluating two infusion sets under real life conditions at home.
- Trial name
- NCT02103595
- Testing
- Accu-Chek FlexLink, Accu-Chek FlexLink Plus
- Where
- 5 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Hoffmann-La Roche
Diabetes Mellitus Type 1
Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study
Physiology studies will be performed in patients with type 1 diabetes to define during a standardized mixed meal test: 1. The relationship between fast insulin analogue administration by i.v.
- Trial name
- NCT01800734
- Testing
- Clamp-Mixed Meal Arm
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Diabetes Mellitus, Type 2, Non-Insulin-Dependent Diabetes Mellitus
GSK189075, GW869682 Or Placebo In Type 2 Diabetic Patients
This is a study to compare the safety, blood concentrations, and effects of GSK189075, GW869682, and placebo when dosed for 2-weeks by mouth to patients with type 2 diabetes.
- Trial name
- NCT00291356
- Testing
- GSK189075 oral tablets, GW869682 oral tablets
- Where
- 3 sites in United States, Germany
- Volunteers
- 45 people
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Type 1
Safety and Efficacy of RT-CGMS in Patients With Type 1 Diabetes Mellitus Treated With an Implantable Pump
To investigate the effectiveness and safety of a Real Time Continuous Glucose Monitoring System (RT-CGMS in a population of patients with type 1 diabetes mellitus treated with insulin through an implanted pump.
- Trial name
- IP_RT-CGMS (NCT00501072)
- Testing
- Real-Time Continuous Glucose monitoring System (RT-CGMS)
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Medical Research Foundation, The Netherlands
Lupus Erythematosus, Rheumatoid Arthritis
Analysis of B Cells From Autoimmune Individuals
This observational study aims at finding out if individual with autoimmunity exhibit increased numbers of B cells that express two types (instead of one type) of antibodies, and if B cells of individuals genetically susceptible…
- Conditions
- Lupus Erythematosus, Rheumatoid Arthritis, Type 1 Diabetes
- Trial name
- NCT02747277
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1
Model Driven Diabetes Care
Patients with Diabetes Mellitus Type 1 using electronic self-help tools typically registers a large amount of data on their disease.
- Trial name
- MDDC (NCT01774149)
- Testing
- Few Touch Application, Diastat
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- University Hospital of North Norway
Anxiety, Depression
Mindfulness-based Cognitive Therapy to Improve Emotional Wellbeing and Glycaemic Control in Diabetes
Type 1 and 2 diabetes are challenging conditions to manage. Anxiety and depression are common among this group and are associated with poorer diabetes control.
- Conditions
- Anxiety, Depression, Diabetes
- Trial name
- MILESTONE (NCT02600091)
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Aberdeen