Clinical trials: Insulin Resistance, Diabetes
Hyperlipidemia, Diabetes Mellitus
Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders
The purpose of the present study is to conduct a thorough and relevant physiology study of carriers and non-carriers of the gene variant X in order to determine the effect of the genetic variant on various metabolic parameters.
- Conditions
- Hyperlipidemia, Diabetes Mellitus, Metabolic Syndrome, Arterial Hypertension
- Trial name
- NCT01571609
- Testing
- first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Prediabetes, Healthy (Controls)
Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?
Brief Summary The goal of this clinical trial is to learn whether older adults with prediabetes, but no diagnosed cognitive impairment, show early changes in brain energy use and thinking speed compared to older adults with…
- Trial name
- NCT07546409
- Testing
- Ketone Monoester (KE)
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obesity, Insulin Resistance
Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes (Vita-K 'n' Adults Study)
Given that glutamate carboxylation or decarboxylation is key to the metabolic role of osteocalcin (at least in mouse models) and that carboxylation is vitamin K dependent, it is critical to isolate the effect of vitamin K…
- Conditions
- Obesity, Insulin Resistance, Insulin Sensitivity, Beta-Cell Dysfunction
- Trial name
- NCT02366481
- Testing
- Low-Dose Vitamin K2 Supplement (menaquinone-7; 90-mcg/d), High-Dose Vitamin K2 Supplement (menaquinone-7; 180-mcg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Obesity, Metabolic Syndrome
CardioMetabolic Program Meets eHealth: Redesign and Evaluation for Optimal Reach and Impact
The eCMP Pilot aims to study the feasibility and potential effectiveness of an electronically-mediated CardioMetabolic Program (eCMP) for therapeutic lifestyle change among adults with or at high risk for type 2 diabetes, heart…
- Conditions
- Obesity, Metabolic Syndrome, Pre-diabetes, Type 2 Diabetes
- Trial name
- eCMP (NCT02246400)
- Testing
- eCMP
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Palo Alto Medical Foundation
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Influence of Prior Walking on Postprandial Metabolism in Centrally Obese Men
The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in centrally obese South Asian and White European men.
- Conditions
- Diabetes Mellitus, Type 2, Cardiovascular Diseases, Endothelial Dysfunction, Insulin Resistance
- Trial name
- NCT03952000
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Type 2 Diabetes, Cardiometabolic Syndrome
PDE3B in Metabolic Regulation
Phosphodiesterase 3B (PDE3B), an enzyme responsible for the degradation of cyclic AMP and GMP (two important second messengers used for intracellular signal transduction), has been associated with cardiometabolic outcomes.
- Conditions
- Type 2 Diabetes, Cardiometabolic Syndrome, Cardiovascular Diseases
- Trial name
- NCT06533007
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Diabetes Mellitus, Pre-Diabetes
Study to Evaluate Safety and Efficacy of PreCrea® on Subjects With Higher Than Normal Blood Sugar Levels
The purpose of the study is to evaluate the efficacy and safety of PreCrea® on subjects with higher than normal blood sugar levels.
- Conditions
- Diabetes Mellitus, Pre-Diabetes, Hyperglycemia, Metabolic Syndrome
- Trial name
- Precrea (NCT02189005)
- Testing
- Study dietary supplement (PreCrea 600 mg capsules)
- Where
- 6 sites in India
- Volunteers
- 210 people
- Sponsor
- Joe Fenn
Cardiovascular Disease, Chronic Kidney Disease
Vascular Risk After Kidney Transplantation
Hypothesis: Nontraditional risk factors, such as inflammation, vitamin D deficiency, elevated PTH, insulin resistance, homocysteine, or uric acid, contribute to cardiovascular disease progression after kidney transplant.
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease, Diabetes, Vitamin D Deficiency
- Trial name
- NCT00374595
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- University of Nebraska
Gestational Diabetes Mellitus
Inositol Stereoisomers to Treat Gestational Diabetes
The investigators aim to compare the effect of different inositol stereoisomers supplementation in lowering insulin resistance levels after 8 weeks of treatment in pregnant women with GDM and in preventing adverse obstetric…
- Trial name
- NCT02097069
- Testing
- Folic acid, Myo-inositol, D-Chiro-inositol
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Diabetes Mellitus, Type 2, Insulin Dependent Diabetes
Diabetes Toolkit at Discharge
The purpose of this randomized clinical trial is to implement the DM Discharge Toolkit into hospital discharge and assess the effect of the DM Discharge Toolkit on patients newly requiring insulin.
- Trial name
- NCT05663931
- Testing
- DM Discharge Toolkit
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Northwestern University
Pain, Diabetes Mellitus
Cold Spray for Insulin-Injection Pain in the Emergency Department
This randomized, double-blind, placebo-controlled, within-patient crossover trial evaluated whether a vapocoolant (cold) spray applied before subcutaneous insulin injection reduces injection pain compared with a placebo…
- Trial name
- NCT07728162
- Testing
- Cold (vapocoolant) spray
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Abant Izzet Baysal University
Metabolic Syndrome
Composition & Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome
The investigators previous research has suggested that lipid (fatty) composition in the muscle cells of mice plays a key role in their insulin sensitivity.
- Trial name
- COMP-SR (NCT02122666)
- Testing
- muscle biopsy
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Metabolic Syndrome (MetS)
Isoleucine Addition Treatment Effects in a Controlled Diet Study
The primary purpose of this study is to determine whether isoleucine repletion attenuates increases in insulin sensitivity typically observed when people with obesity follow a healthy, low-isoleucine diet.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Metabolic Syndrome (MetS), Obesity & Overweight
- Trial name
- ISOLATE (NCT07329088)
- Testing
- L-Isoleucine, Low-isoleucine diet
- Where
- United States
- Sponsor
- Jean L. Fry
PreDiabetes, NAFLD
Effects of Almonds in Glucose-intolerant Adults (AGAMEMNON)
Tree nuts - such as almonds - contribute to beneficial effects of the Mediterranean diet on risk for cardiovascular events, type 2 diabetes, dyslipidemia, hypertension, inflammation and non-alcoholic fatty liver disease.
- Trial name
- AGAMEMNON (NCT06413069)
- Testing
- Raw whole almonds
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Charite University, Berlin, Germany
Diabetes Mellitus, Type 2, Overweight and Obesity
Cut Down on Carbohydrate Usage in the Diet of Type 2 Diabetes. The Hypo-energetic Study
Scientific evidence for the dietary treatment of type 2 diabetes (T2D) is insufficient, which is why the investigators aim to reform dietary recommendation to the overweight or obese patient with type 2 diabetes.
- Trial name
- CutDM-Hypo (NCT03814694)
- Testing
- CRHP Diet, CD Diet
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Bispebjerg Hospital
Type 2 Diabetes, Obesity
Metabolomic Analysis of Hepatic Insulin Resistance
This is a pilot study to show that it is possible to identify the specific types of fats in blood, adipose tissue, and liver tissue.
- Trial name
- NCT01833403
- Testing
- Hyperinsulinemic-euglycemic clamp
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Insulin Sensitivity
The Effect of Blueberries on Enhancing Insulin Sensitivity in Humans: A Pilot Study
The purpose of this study is to evaluate the effect of blueberry powder on insulin sensitivity in obese, non-diabetic, and insulin resistant subjects.
- Trial name
- BLUEBERRY (NCT01005420)
- Testing
- Blueberry Powder
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Type2diabetes, Type 2 Diabetes Treated With Insulin
The CARING Study: Creating and Restoring Health Through Nutrition Guidance
The CARING study assesses the health benefits of nutrition education for Blue Cross Blue Shield subscribers, as well as potential healthcare cost savings to subscribers and the insurance company.
- Trial name
- NCT05795439
- Testing
- Low-fat, vegan diet
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Physicians Committee for Responsible Medicine
Diabetes Mellitus, Type II, Insulin Resistance
Rosiglitazone to Reverse Metabolic Defects in Diabetes
This study will examine whether the anti-diabetes medicine rosiglitazone can safely and effectively reverse the early problems of type 2 diabetes and delay the onset of disease in people with pre-diabetes.
- Trial name
- NCT00094796
- Testing
- Exercise cardiopulmonary metabolic testing, Skeletal muscle biopsy, Brachial artery reactivity testing
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Insulin Sensitivity, Lipid Metabolism
Effects of Potato Resistant Starch Intake on Insulin Sensitivity, Related Metabolic Markers and Satiety
The objective of this study is to assess whether intake of baked and then chilled potatoes over a 24-h period, compared to intake of isocaloric, carbohydrate (CHO)-matched foods low in fiber and resistant starch (RS), will…
- Conditions
- Insulin Sensitivity, Lipid Metabolism, Resistant Starch, Potato
- Trial name
- NCT03689738
- Testing
- Potato (Resistant Starch), CHO-matched (Low-fiber, RS-free)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research