Clinical trials: Insulin Resistance, Diabetes
Type 2 Diabetes Mellitus
Impact of Rutin and Vitamin C Combination on Oxidative Stress, Insulin Sensitivity and Lipid Profile in Type 2 Diabetic Patients
The objective of this study is to investigate the effect ofRutin and Vitamin C combination in comparison with vitamin C alone on the oxidative and antioxidative status , insulin resistance and lipid profile in type 2 diabetic…
- Trial name
- NCT03437902
- Testing
- Rutin in combination with Vitamin C, Vitamin C
- Where
- Egypt
- Volunteers
- 53 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type 2
Comparative Metabolomics in Diabetes Patients From Sri Lanka and Switzerland
This study is a case-control study, where the assumed different subtypes of type 2 diabetes in people of Tamil ethnicity and Swiss origin living in Bern, Switzerland will be examined by measuring the metabolite profiles and the…
- Trial name
- NCT05787457
- Testing
- Clinical examination, Blood testing, MRI
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes Mellitus, Type 1
A Study to Determine Iatrogenic Hyperinsulinemia's Contribution to Insulin Resistance and Endothelial Dysfunction in Type 1 Diabetes
The investigators will test the hypothesis that reducing insulin doses using a low carbohydrate diet (LCD) will be associated with with improved insulin sensitivity (Aim 1) and blood vessel health (Aim 2).
- Trial name
- NCT04118374
- Testing
- Standard Carb Diet, Low Carb Diet
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Vanderbilt University Medical Center
Metabolic Syndrome, Overweight and Obesity
The Soy Treatment Evaluation for Metabolic Health (STEM) Trial
Strategies to reduce sugar-sweetened beverages (SSB) have become one of the leading public health targets to address the epidemics of obesity and diabetes.
- Conditions
- Metabolic Syndrome, Overweight and Obesity, PreDiabetes, Diabetes
- Trial name
- NCT05191160
- Testing
- Soy Milk, Cow's Milk, Sugar Sweetened Beverages
- Where
- Canada
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Metabolic Syndrome, Non-Alcoholic Fatty Liver Disease
Healthy Liver - Healthy Brain
People with liver disease report difficulties with attention and problem-solving skills. Diet plays an important role in the development of liver disease and/or pre-diabetes.
- Conditions
- Metabolic Syndrome, Non-Alcoholic Fatty Liver Disease, NAFLD, Pre-diabetes
- Trial name
- NCT05216796
- Testing
- Diet Intervention
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease
Diabetes, Exercise and Liver Fat (DELIVER)
This randomised controlled trial will determine if exercise (150 - 200 min per week, 6 weeks) can beneficially modify liver fat quality in non alcohol fatty liver disease patients with type 2 diabetes mellitus (n = 26, 13 per…
- Conditions
- Type 2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, Obesity, Insulin Resistance
- Trial name
- (DELIVER) (NCT04004273)
- Testing
- Exercise
- Where
- 4 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- James King
Metabolic Syndrome
Mechanisms by Which Strength Training Ameliorates the Metabolic Syndrome
Prevention and treatment strategies for diabetes use exercise as the cornerstone. Even though endurance training and strength training both improve insulin resistance, strength training may be better suited for persons at risk…
- Trial name
- NCT00727779
- Testing
- strength training
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- East Tennessee State University
Type 1 Diabetes
Equivalence of A Stable Liquid Glucagon Formulation With Freshly Reconstituted Lyophilized Glucagon
This study will test the hypothesis that micro-doses of Xerisol Glucagon (Xeris Pharmaceuticals) will be non-inferior by pharmacokinetic and pharmacodynamic criteria vs. micro-doses of Glucagon for Injection (Eli Lilly).
- Trial name
- NCT02018627
- Testing
- Xeris glucagon, Lilly glucagon
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Steven J. Russell, MD, PhD
Overweight, Obesity
Correlation of Irisin and Adipokine Levels With Body Mass Index and Risk Factors for Metabolic Syndrome in Hispanic Children
Childhood obesity is one of the most serious global public health challenges of the 21st century (Daniels et al., 2009). Mexico has the highest prevalence of obesity, (Secretaría de Salud, 2009); 34.4% of children and 35% of…
- Conditions
- Overweight, Obesity, Thinness
- Trial name
- NCT02320110
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Tecnologico y de Estudios Superiores de Monterey
Type 1 Diabetes
The Summer Camp Study 2: Blood Glucose Control With a Bi-Hormonal Endocrine Pancreas
This study will test the hypothesis that a wearable automated bionic pancreas system that automatically delivers both insulin and glucagon can improve glycemic control vs.
- Trial name
- NCT02105324
- Testing
- Bionic Pancreas, Usual Care
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type 2, Diabetes Mellitus
A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 Diabetes
The purpose of this study is to investigate the effectiveness and safety of 12 weeks of treatment with R256918 in patients with Type 2 Diabetes Mellitus who are taking metformin.
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Endocrine System Diseases, Nutritional and Metabolic Diseases
- Trial name
- NCT00672386
- Testing
- JNJ16269110, Metformin, Dietary Counseling
- Where
- 62 sites in Belgium, Denmark and 9 more
- Volunteers
- 352 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Diabetes Mellitus
Effects of Exercise Behavior Modification on Plasma Adiponectin and Insulin Resistance in High Risk Subjects of Diabetes
Investigators hypothesized home-based exercise intervention was beneficial to those who have had diabetic risk factor for type 2 diabetes mellitus
- Trial name
- NCT01136096
- Testing
- Physical activity promoting intervention, General instruction and education
- Where
- Taiwan
- Volunteers
- 216 people
- Sponsor
- National Taiwan University Hospital
Obesity
Vestibular Stimulation to Trigger Adipose Loss (VeSTAL) Clinical Trial
A randomized, double blind sham controlled clinical trial to evaluate the efficacy of vestibular nerve stimulation (VeNS), combined with a lifestyle modification program, compared to a sham control and a lifestyle modification…
- Trial name
- VeSTAL (NCT03640286)
- Testing
- VeSTAL
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Neurovalens Ltd.
Type 1 Diabetes
A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500
The goal of this clinical trial is to assess the safety of a new U500 insulin formulation and to determine how rapidly it is absorbed and how long it takes to act when administered intraperitoneally.
- Trial name
- NCT07341373
- Testing
- Portal Insulin U-500, Humulin R U-500, Lyumjev U-100 Insulin
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Portal Diabetes, Inc.
Diabete Mellitus, Type 2 Diabetes
Mangosteen Supplement as Adjuvant Therapy With Sitagliptin/Metformin in Iraqi Patients With Type 2 Diabetes
This clinical trial was conducted at the National Diabetes Center for Treatment and Research, Mustansiriyah University, Baghdad (Sept 2024-May 2025).
- Conditions
- Diabete Mellitus, Type 2 Diabetes, Obesity Type 2 Diabetes Mellitus, Dyslipidemia in Patients With Diabetes Mellitus
- Trial name
- NCT07172269
- Testing
- Sitagliptin + Metformin, mangosteen supplement, Lifestyle Management
- Where
- Iraq
- Volunteers
- 58 people
- Sponsor
- Mais Qais Hbeeb
PreDiabetes, Impaired Glucose Tolerance
Effect of Probiotics Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes.
Pre diabetes (PD) is a term that refers to alterations in blood glucose levels, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both, and increase in glycated hemoglobin (HbA1c), all this factors…
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Hyperglycemia, Resistance, Insulin
- Trial name
- NCT04341571
- Testing
- Probiotics, Metformin
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- University of Guadalajara
Type 2 Diabetes Mellitus
Severe Insulin Resistance in Patients With Type 2 Diabetes
The purpose of the study is to investigate some of the mechanisms behind severe insulin resistance and to determine the dose response to insulin in patients with type 2 diabetes mellitus.
- Trial name
- NCT00654056
- Testing
- Actrapid (human insulin)
- Volunteers
- 8 people
- Sponsor
- University of Aarhus
Type 1 Diabetes
Pharmacokinetic Comparison of Intradermal Versus Sub-cutaneous Insulin and Glucagon Delivery in Type 1 Diabetes
The investigators are doing this research study to find out if the type of needle used to administer them affects the speed with which insulin and glucagon get into the blood.
- Trial name
- NCT01684956
- Testing
- Intradermal injection, Subcutaneous injection
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus Type 2, Insulin Resistance
OatMeal and Insulin Resistance: OMA-IR
Insulin resistance is a central feature of Diabetes mellitus type 2 (Stumvoll et al. 2005). Hypo- and hyperglycemic states are associated with adverse inpatient outcomes (ADA et al.
- Trial name
- NCT00401453
- Testing
- Diet: carbohydrate days. (Name: oatmeal.)
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Universitätsmedizin Mannheim
Gestational Diabetes, Pregnancy Related
Strict Versus Permissive Thresholds for Initiation of Pharmacotherapy in Gestational Diabetes
The aim of our study is to compare neonatal and maternal outcomes using different thresholds for the initiation and titration of pharmacotherapy for gestational diabetes (GDM).
- Trial name
- START 1 (NCT06419777)
- Testing
- Insulin
- Where
- 2 sites in United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
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