Clinical trials: Insulin Resistance, Diabetes
Obesity, Type 2 Diabetes
Impacts of Intermittent Fasting on Energy Balance and Associated Health Outcomes
Obesity is a global concern with links to conditions such as diabetes. Historically, these conditions have been managed by reducing energy intake on a daily basis, which is often hampered by low adherence rates and compensatory…
- Trial name
- NCT02498002
- Testing
- Physical Activity Monitoring (Actiheart), Energy Intake Monitoring, Body Weight Monitoring
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Bath
Type 2 Diabetes Mellitus, Overweight
Effects of Low Versus High Carbohydrate Diet During Rehabilitation on Cardiovascular Function and Metabolism in Type 2 Diabetes
Compared to the traditional low fat diet for overweight patients with type 2 diabetes, recent evidence shows that low carbohydrate/high protein diets lower triglycerides and postprandial glucose levels more effectively.
- Trial name
- NCT01004757
- Testing
- LOGI diet, Low Fat diet
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- Munich Municipal Hospital
Type 1 Diabetes
Closed-loop Control of Overnight Glucose Levels (Artificial Pancreas) in Type 1 Diabètes Adults With Hypoglycemia Unawareness and Documented Nocturnal Hypoglycemia
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02282254
- Testing
- Overnight intervention
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type2 Diabetes, Obesity
Glucose Metabolism in Brown Adipose Tissue (BAT) in Young Healthy Men Evaluated by Deuterium Metabolic Imaging (DMI)
In this study the investigators wish to evaluate the glucose metabolism in brown adipose tissue (BAT) in young healthy men (aged 18-35).
- Conditions
- Type2 Diabetes, Obesity, Metabolic Syndrome
- Trial name
- NCT04060745
- Testing
- cooling using a water-perfused vest, thermoneutrality
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 2 Diabetes
Chromium and Insulin Action
The effect of Chromium to improve glucose levels in diabetes is controversial. The hypothesis of the study was to evaluate the effect of supplementing the diet of individuals with Type 2 diabetes with chromium picolinate and…
- Trial name
- NCT00283777
- Testing
- Chromium Picolinate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Pennington Biomedical Research Center
Diabetes, Obesity
Multi-Tracer PET Quantitation of Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus
The purpose of this research is to use a recently developed triple-tracer positron emission tomography (PET) method to study skeletal muscle insulin resistance.
- Trial name
- NCT00222781
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Obesity, Hypercholesterolemia
Improving the Management of Obesity in Primary Care Practice (The Power-UP Trial)
The purpose of the study is to compare three methods of achieving weight loss in primary care medical practice. The study will be conducted in six primary care practices.
- Conditions
- Obesity, Hypercholesterolemia, Metabolic Syndrome, Hypertension
- Trial name
- Power-UP (NCT00826774)
- Testing
- Usual Care, Brief Lifestyle Counseling, Enhanced Brief Lifestyle Counseling
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obesity, Hyperlipidemias
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population.
- Conditions
- Obesity, Hyperlipidemias, Polycystic Ovary Syndrome, Hypertension
- Trial name
- NCT06049420
- Testing
- Lifestyle counseling and coaching
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- West Virginia School of Osteopathic Medicine
Type 2 Diabetes Mellitus
The Effect of Resistant Starch Bagels on Risk Factors of Type 2 Diabetes and Colorectal Cancer
The purpose of this study is to determine if consumption of bagels made with resistant starch for 8 weeks can improve markers of type 2 diabetes, colon cancer and satiety in adults.
- Trial name
- NCT02129946
- Testing
- Resistant Starch
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Type 2 Diabetes, Obesity
The Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity in Type 2 Diabetes
Gastric bypass surgery induces remission of diabetes within days after surgery, before significant weight loss. The aim of the study is to examine whether improved insulin sensitivity of muscle and liver contributes to the…
- Trial name
- NCT01202526
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Diabetic Peripheral Neuropathy
Safety Study of Intranasal Insulin in Type 1 Diabetes and Diabetic Peripheral Neuropathy
The aim of this study is to evaluate the safety and tolerability of intranasal insulin in people with type 1 diabetes and diabetic peripheral neuropathy and to determine whether intranasal insulin is effective in slowing the…
- Trial name
- IIDPN (NCT01469559)
- Testing
- Novolin Toronto insulin, Normal saline
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Calgary
Prediabetes, Metabolic Syndrome
Evaluation of Group Lifestyle Balance DVD in Primary Care Practice
The purpose of this study is to examine different methods of delivering the Group Lifestyle Balance (GLB) intervention (1). The GLB is a 12-week lifestyle change program based on the highly successful lifestyle program that was…
- Trial name
- STEPUP (NCT00480779)
- Testing
- GLB Group, GLB DVD
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Pittsburgh
Metabolic Disease, Insulin Sensitivity
Metabolic Effects of Melatonin Treatment
Modern living is associated with an epidemic of type 2 diabetes mellitus (T2DM). Sleep disturbances such as insomnia or frequent awakenings are strong risk factors for T2DM with several studies indicating a central role of…
- Conditions
- Metabolic Disease, Insulin Sensitivity, Glucose Metabolism Disorders (Including Diabetes Mellitus), Type 2 Diabetes Mellitus
- Trial name
- NCT03859934
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 17 people
- Sponsor
- University of Aarhus
Pre Diabetes, Insulin Resistance
Exenatide and Weight Loss for Diabetes Prevention
Exenatide, a GLP-1 agonist approved for lowering blood glucose concentrations in patients with type 2 diabetes, has been associated with restoration of the first-phase insulin response when administered intravenously to patients…
- Trial name
- NCT02084654
- Testing
- Exenatide 5 and 10 mcg 2 times a day
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Stanford University
Diabetes Mellitus, Type 2
Glycemic Index in Subjects With Diabetes Mellitus Insulin Requesting
To evaluate the acute effect of a low and high glycemic index breakfast on the glycemic response and satiety in subjects with type 2 diabetes mellitus under intensive insulin therapy.
- Trial name
- GIDMIR (NCT02881164)
- Testing
- Low glycemic index, High glycemic index
- Volunteers
- 10 people
- Sponsor
- Universidad de Valparaiso
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH), Metabolic Syndrome
ENDOCARE-SCREEN: Metabolic Liver Dysfunction Screening Study
The ENDOCARE-SCREEN study is a single-center, observational, cross-sectional screening study designed to assess the prevalence, phenotypes, and determinants of metabolic dysfunction-associated steatotic liver disease…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH), Metabolic Syndrome, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus
- Trial name
- ENDOCARE-SCREE (NCT07336563)
- Where
- Poland
- Volunteers
- 10,000 people
- Sponsor
- Jarosław Drobnik
Diabetes Mellitus, Type 2
An Observational Study to Understand Challenges Associated With Progression of Insulin Therapy in Type 2 Diabetes
The purpose of this study is to identify specific patient, physician, and health system related factors associated with the progression to a more intensive regimen from initial insulin therapy for patients with type 2 diabetes.
- Trial name
- MOSAIc (NCT01400971)
- Where
- 153 sites in United States, Argentina and 17 more
- Volunteers
- 4,299 people
- Sponsor
- Eli Lilly and Company
Blood Glucose, High, Metabolic Disease
Functional and Value-Added Dairy Products and Blood Glucose Control
Milk proteins possess multiple biological activities including their effect on blood glucose control, satiety and energy intake.
- Conditions
- Blood Glucose, High, Metabolic Disease, Overweight and Obesity
- Trial name
- NCT05400694
- Testing
- Food
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mount Saint Vincent University
Sleep, Diabetes Mellitus, Type 2
Improving Insulin Resistance and Energy Metabolism Through Sleep Extension in Adolescents
The investigators propose to deliver a 4-week sleep extension intervention to adolescents to evaluate feasibility of the protocol and obtain preliminary data on intra-individual changes in metabolic parameters induced by sleep…
- Trial name
- REM (NCT03814512)
- Testing
- Extended Sleep Intervention
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Insulin-Dependent
Insulin Pump Therapy in Adolescents With Newly Diagnosed Type 1 Diabetes (T1D)
Within 4 weeks after diagnosis of type 1 diabetes, 10 subjects (pubertal males, 12-17 years old) will be randomized to either receive multiple daily injection (MDI) using Lantus insulin, or continuous subcutaneous insulin…
- Trial name
- NCT00357890
- Testing
- Insulin pump therapy, Multiple daily injections using insulin glargine + rapid acting analog
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nemours Children's Clinic
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