Clinical trials: Insulin Resistance, Diabetes
Type 2 Diabetes, Obesity
Resveratrol in Type2 Diabetes and Obesity
The main objective of this study is to investigate the effect of resveratrol (plant derived food supplement) on inflammatory mediators and insulin resistance at the cellular and molecular level in obese non diabetic and type 2…
- Conditions
- Type 2 Diabetes, Obesity, Insulin Resistance
- Trial name
- NCT01158417
- Testing
- Resveratrol 40 mg oral three times a day, Resveratrol 500 mg oral once daily.
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Diabetes Mellitus, Type 2, Metabolic Syndrome X
Effects of Cilostazol on Plasma Adipocytokine and Arterial Stiffness
Cilostazol is an antiplatelet agent used to reduce the symptoms of intermittent claudication. Cilostazol inhibits phosphodiesterase III (PDE III), which causes it to be a vasodilator and inhibitor of platelet aggregation.
- Trial name
- NCT00573950
- Testing
- cilostazol
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Korea University Anam Hospital
Major Depressive Disorder, Depression
Is Brain Insulin Resistance a Feature of the Biology of Depression in Adolescents
This study will examine if brain insulin resistance is a feature of depression in humans using magnetic resonance imaging (MRI) measures sensitive to brain insulin action.
- Trial name
- NCT05571878
- Testing
- Humalog, Saline nasal spray
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Type 2 Diabetes Mellitus, Steroids
Incretin Physiology Associated With Steroid Hormone Treatment
The purpose of this study is to evaluate whether the reduced incretin effect and the paradoxical glucagon responses during oral glucose ingestion and isoglycaemic iv glucose infusion observed in patients with type 2 diabetes are…
- Trial name
- NCT00713440
- Testing
- Oral glucose test (OGTT); isoglycaemic iv. clamp; liquid meal test; Gastric Emptying Rate; Prednisolone; Paracetamol
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Type 2 Diabetes
Effect of Rosiglitazone on Myocardial Blood Flow Regulation in Type 2 Diabetes
The overall hypothesis to be tested is that increased insulin resistance contributes to abnormal cardiac blood flow regulation in type 2 diabetic patients, which can be reversed by 6 months treatment with rosiglitazone.
- Trial name
- NCT00549874
- Testing
- Rosiglitazone, Glyburide
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- University of Michigan
Patients With Metabolic Syndrome
A Randomized, Double-Blind Trial Comparing the Efficacy and Safety of Fenofibrate, Metformin, Their Combination and Placebo in Patients With Metabolic Syndrome.
The purpose of this study was to study the effect of different combinations of fenofibrate and metformin on the cluster of metabolic syndrome (MetS) biochemical abnormalities, and to determine the dose combination allowing…
- Trial name
- NCT00703755
- Testing
- Fenofibrate /Metformin
- Where
- 101 sites in Canada, Finland and 7 more
- Volunteers
- 2,288 people
- Sponsor
- Solvay Pharmaceuticals
Cardiovascular Diseases, Coronary Disease
20 Year Changes in Fitness & Cardiovascular Disease Risk - Ancillary to CARDIA
To understand the complex, longitudinal relations between physical fitness, physical activity, body mass and composition and fat distribution, and genetic factors and their independent or interactive effects on the development of…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- NCT00106457
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes Mellitus, Type 2, Pre Diabetes
Prediabetes Intervention With Tea
The goal of this interventional study is investigating the effect of the daily consumption of olive leaves tea on glycemic control of individuals diagnosed with pre-diabetes.
- Trial name
- PREVENT (NCT05583045)
- Testing
- Olive Leaf Tea, Lifestyle behavior change program (LBC)
- Where
- Portugal
- Volunteers
- 140 people
- Sponsor
- Instituto Politécnico de Bragança
Atherosclerosis, Metabolic Syndrome
Cardiometabolic Risk Factors Registry
CARFARE (CARDIOMETABOLIC RISK FACTORS REGISTRY) is a registry done in the context of a cardiovascular primary prevention program of the Cardiometabolic Unit Officia of the Cardiology Department of the Austral University Hospital.
- Conditions
- Atherosclerosis, Metabolic Syndrome, Diabetes, Cardiovascular Risk Factor
- Trial name
- CARFARE (NCT04040777)
- Where
- Argentina
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Austral University, Argentina
Major Depressive Disorder (MDD)
tVNS, Motivation, and Insulin Sensitivity
Disturbances in energy metabolism significantly increase the risk of developing major depressive disorder (MDD), especially in individuals with type 2 diabetes.
- Trial name
- NCT07198100
- Testing
- Transcutaneous non-invasive vagus nerve stimulation (tVNS), Oral glucose tolerance test (oGTT)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Gestational Diabetes Mellitus (GDM)
Gestational Diabetes and Human Milk Composition Study
This study aims to compare hormone levels and milk composition in women with and without gestational diabetes through postpartum human milk and blood samples.
- Trial name
- NCT07051681
- Testing
- Individualized Medical Nutrition Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Marmara University
Type 2 Diabetes
GIP: Glucose-dependent Insulinotropic Peptide
The purpose of this study is to test the safety of glucose-dependent insulinotropic peptide (GIP)/GIP Analog on people with Type 2 Diabetes.
- Trial name
- NCT00239707
- Testing
- GIP, Modified GIP, Normal Saline
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- National Institute on Aging (NIA)
Type 1 Diabetes Mellitus
Umbilical Cord Blood Infusion to Treat Type 1 Diabetes
While this study is now completely enrolled, we do hope to develop a "next generation" cord blood based study sometime in early 2009.
- Trial name
- NCT00305344
- Testing
- Autologous Umbilical Cord Blood Transfusion, Cord blood
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Florida
Insulin Resistance, Diabetes
Insulin Resistance And End Stage Renal Disease: The Role Of Retinol Binding Protein 4
The purpose of this study is to determine whether Retinol binding protein 4 has a role in insulin resistance development in patients suffering from end stage renal disease on hemodialysis.
- Conditions
- Insulin Resistance, Diabetes, End Stage Renal Disease
- Trial name
- NCT00910130
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Prediabetic State, Insulin Resistance
Effect of Low Dose Combination of Linagliptin + Metformin to Prevent Diabetes
Type 2 diabetes is a chronic disease that has reached global epidemic proportions due to the growing number of patients in all countries; It has become the disease that causes more chronic and acute complications to patients…
- Trial name
- NCT04134650
- Testing
- Linagliptin + metformin, Metformin
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- Universidad de Guanajuato
Healthy, Diabetes
Meta-analysis of Oats for Diabetes Prevention and Management
Oats are a commonly consumed source of viscous soluble fibre, which has an established role in cardiovascular disease risk management including in cholesterol and glycemic control.
- Conditions
- Healthy, Diabetes, Metabolic Syndrome, Overweight and Obesity
- Trial name
- NCT04631913
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes Mellitus Type 2 in Obese, Type 2 Diabetes Mellitus With Features of Insulin Resistance
Percutaneous Electric Neurostimulation of Dermatome T7 Improves Glycemic Profile in Obese and Typo 2 Diabetic Patients
Percutaneous neurostimulation of dermatome T7 increases Insulin segregation by the apancreas and improves glycemic profile in diabetic patients
- Trial name
- NCT02122874
- Testing
- Percutaneous Neurostimulation (PENS) of dermatome T7, 1200 Kcal diet
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario Elche
Adverse Drug Event, Effect of Drug
Research on Human Insulin rDNA Safety and Efficacy in Patients With Type 2 Diabetes Mellitus
Objective: To evaluate the safety and efficacy of Human Insulin rDNA (Insuget) in patients with Type II Diabetes Mellitus. Study Design: Open-label, prospective, observational, single arm, multi-center, post-marketing…
- Conditions
- Adverse Drug Event, Effect of Drug, Type 2 Diabetes Treated With Insulin
- Trial name
- RISE (NCT05161741)
- Testing
- Insulin
- Where
- Pakistan
- Volunteers
- 238 people
- Sponsor
- Getz Pharma
Obesity, Insulin Resistance
Mitochondrial Function in Pediatric Obesity
The prevalence of pediatric obesity is increasing at an unprecedented rate. Obese children are at risk for the development of insulin resistance, relative insulin deficiency and type 2 diabetes mellitus.
- Trial name
- NCT00577174
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type 2 DM
Safety and Efficacy Assessment of Unani Formulation 'Dolabi' in Management of Diabetes Mellitus Type II
Diabetes is a chronic health condition that affects millions of people worldwide. In recent years, Pakistan has witnessed a significant increase in the prevalence of diabetes, making it a major public health concern.
- Trial name
- NCT06841497
- Testing
- Dolabi
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Hamdard University
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