Clinical trials: Insulin Resistance, Diabetes
Obesity, Overweight
The Effect of Mashed Potato Composition on Food Intake, Satiety and Blood Glucose
Potato is one of the world's most popular foods and is widely accepted as a staple food. The objective of this study is to determine the effect of consuming instant mashed potatoes with and without fat on glycemic response…
- Conditions
- Obesity, Overweight, Diabetes, Metabolic Syndrome
- Trial name
- NCT02009254
- Testing
- Dietary treatment
- Sponsor
- University of Toronto
Diabetes Mellitus, Type 2
Effect of Meal Frequency on Insulin Resistance in Subjects With Type 2 Diabetes
Aims and priorities of the project The purpose of this study is to 1. test the effect of frequency of meals (six vs. two meals daily with the same daily caloric restriction of -500 kcal/day) on insulin sensitivity, insulin…
- Trial name
- Frequency (NCT01277471)
- Testing
- Meal frequency (6 meals vs. 2 meals/day), 6 meals/day followed by 2 meals/day
- Where
- Czechia
- Volunteers
- 54 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Type 1 Diabetes Mellitus, Glycemic Variability
Impact of Dietary Fat and Menstrual Cycle Phases in Type 1 Diabetes
This clinical trial aims to evaluate how variations in dietary fat content and hormonal status influence postprandial glycemic response in individuals with type 1 diabetes (T1D), with a special focus on women.
- Conditions
- Type 1 Diabetes Mellitus, Glycemic Variability, Sex Characteristics, Menstrual Cycle
- Trial name
- DIABETEXX/3 (NCT07278063)
- Testing
- Low Fat Mixed Meal, High Fat Mixed Meal
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Type2 Diabetes, Insulin Resistance
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes
Type 2 diabetes are characterized by insulin resistance in skeletal muscle. Insulin resistance plays a major role for the increased risk of heart disease seen in type 2 diabetes.
- Trial name
- NCT03500016
- Testing
- High intensity interval training
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Diabetes, Prediabetes
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
Vegetarian diets have been associated with a reduced risk of preventable diseases such as type 2 diabetes and cardiovascular disease. These effects may be mediated through direct or indirect pathways.
- Conditions
- Diabetes, Prediabetes, Metabolic Syndrome, Dysglycemia
- Trial name
- NCT02037321
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Gestational Diabetes, Inflammation
Effect of Very Low Carbohydrate Diet on Glycemic, Metabolic, Glycated and Inflammatory Markers in Gestational Diabetes Mellitus
Uncontrolled Gestational Diabetes Mellitus may leads to maternal and fetal complications. These complications can be avoided by adopting the dietary modifications along with medications.
- Conditions
- Gestational Diabetes, Inflammation, Metabolic Syndrome, Glucose Intolerance During Pregnancy
- Trial name
- NCT05305352
- Testing
- Very low carbohydrate dietary intervention
- Where
- Pakistan
- Sponsor
- Khyber Medical University Peshawar
Type 2 Diabetes, Obesity
Relationship Between Changes in Gut Hormones After Gastric Bypass and Gastric Banding and Improvements in Diabetes
The purpose of this study is to see how hormones that control blood sugar change in response to two different weight loss surgeries (gastric bypass and gastric banding).
- Conditions
- Type 2 Diabetes, Obesity, Bariatric Surgery
- Trial name
- NCT01153438
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Healthy
Various Serving Sizes of Lentils on Blood Glucose and Insulin
The purpose of this study is to assess the effects of consuming either 1/2 or 1/4 cup servings of lentils on post-prandial blood glucose and insulin as compared to 4 types of starchy foods (corn, macaroni, white potato, white…
- Trial name
- NCT02940158
- Testing
- 1/4 cup- Small red lentil, 1/4 cup- Small green lentil, 1/4 cup- corn
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Heart Diseases, Type 2 Diabetes
Effectiveness of Tele-exercise Training on Cardiorespiratory Fitness in Patients With Cardiometabolic Multimorbidity
This trial aimed to assess whether assumed increase in physical activity after tele-exercise training can improve cardiorespiratory fitness of patients with cardiometabolic multimorbidity.
- Conditions
- Heart Diseases, Type 2 Diabetes, Metabolic Syndrome, Coronary Artery Disease
- Trial name
- NCT05245110
- Testing
- tele-exercise training
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Coronary Artery Disease, Diabetes Mellitus, Type 2
CArdioMetabolism and Atherosclerotic PlaqUe progreSsion
Systematic metabolic diseases are closely related to prevalence and progression of atherosclerosis. This prospective cohort consecutively enrolls patients with coronary artery disease compliacted with metabolic abnormalities such…
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Dyslipidemias, Obesity
- Trial name
- CAMPUS (NCT05117424)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Ruijin Hospital
Insulin Resistance, Chronic Heart Failure
Cardioprotective and Metabolic Effects of Metformin in Patients With Heart Failure and Diabetes
The aim of the study is to evaluate the effect of metformin on myocardial function, insulin resistance and selected metabolic markers in patients with type 2 diabetes and heart failure (HF+DM+) in a cross-over, randomized…
- Trial name
- CARMET (NCT01690091)
- Testing
- Metformini hydrochloridum (Siofor 1000 tbl, Berlin)
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Diabetes Mellitus, Type II
Comparison of Apidra to Regular Insulin in Hospitalized Patients
The purpose of this study is to compare Apidra (a rapid acting insulin analogue) with Regular insulin (fast acting) in addition to the use of long acting insulin Glargine in hospitalized patients in terms of efficacy and safety…
- Trial name
- Apidra (NCT00528918)
- Testing
- Glulisine (Apidra)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Carl T. Hayden VA Medical Center
Diabetes
Double-Blind Comparison Between Mitiglinide and Nateglinide in Type 2 Diabetic Patients
The purpose of this study is to evaluate the efficacy and safety of Mitiglinide compared to Nateglinide for the treatment of type 2 diabetes.
- Trial name
- NCT00461617
- Testing
- Mitiglinide
- Volunteers
- 291 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Diabetes Mellitus, Type 1, Type 1 Diabetes Mellitus
Subcutaneous Pharmacokinetic Evaluation of Monomeric Insulin and Lyumjev in Adults With Type 1 Diabetes
The SPEED study is a randomized, crossover pilot study evaluating the pharmacokinetics of novel insulin formulations in adults with type 1 diabetes.
- Trial name
- SPEED (NCT07090824)
- Testing
- Diluted Humalog U-200 Insulin, Diluted U-500 Humulin Insulin, Lyumjev U-100 Insulin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia
Pilot Study Evaluating Safety of ExOlin® in Patients With Poorly Controlled Type 1 Diabetes
First in Human, pilot investigation An Open Label, Monocentric, Pilot Study Evaluating Safety of ExOlin® in Patients with Poorly Controlled Type 1 Diabetes with High Glucose Fluctuations, Prone to Severe Hypoglycemia
- Trial name
- Pilot'Ex (NCT05221359)
- Testing
- ExOlin®, Insulin aspart
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Defymed
Prediabetes / Type 2 Diabetes, Obesity and Overweight
An Integrative Study of the Role of Microbiome, Metabolome, Transcriptome and Chronobiology in the Context of Type 2 Diabetes.
The goal of this descriptive clinical study is to investigate daily oscillations in glycaemic control between healthy adults and adults with excess weight and who have early-stage prediabetes or T2D and are not taking medications…
- Conditions
- Prediabetes / Type 2 Diabetes, Obesity and Overweight, Insulin Resistance
- Trial name
- KRONODIABET (NCT06783218)
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Hypertension, Cardiovascular Disease
Meta-analyses of the Effect of Legumes on Blood Pressure
Legumes are generally recognized as healthy dietary components, and although beans and legumes are recommended in food guidelines in North America, guidelines vary in regards to how much and how often these foods should be…
- Conditions
- Hypertension, Cardiovascular Disease, Dyslipidemia, Diabetes
- Trial name
- NCT02600338
- Testing
- Legumes
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
COVID-19, Diabete Mellitus
Long-Term Sequelae of SARS-COV-2 Infection: Diabetes Mellitus
Hospitalized patients with severe COVID-19 have an increased incidence of insulin resistance, impaired beta cell function, glucose intolerance (prediabetes), and overt type 2 diabetes (T2D) compared to non-hospitalized patients…
- Trial name
- NCT05867017
- Testing
- Measure of physiologic parameters
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Obesity
Glycemic Index and CVD: a Crossover Feeding Study
This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese adults in a 10-day crossover feeding trial.
- Trial name
- NCT00141076
- Testing
- low vs high glycemic index diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Schizophrenia, Metabolic Syndrome X
Ziprasidone for Improving Insulin Sensitivity in People With Schizophrenia Who Are at Risk for Diabetes
This study will evaluate the effectiveness of ziprasidone treatment versus treatment with a standard atypical antipsychotic drug in improving insulin sensitivity and reducing excess abdominal fat storage in people with…
- Conditions
- Schizophrenia, Metabolic Syndrome X, Insulin Resistance
- Trial name
- NCT00338949
- Testing
- Switch, Control
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Veterans Medical Research Foundation
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