Clinical trials: Insulin Resistance, Diabetes
Essential Hypertension Complicated by Type 2 Diabetes Mellitus
A Study to Explore the Effects of Azilsartan Compared to Telmisartan on Insulin Resistance of Patients With Essential Hypertension on Type 2 Diabetes Mellitus by HOMA-R
Multicenter, randomized, open-label, parallel-group exploratory study to explore the effects of azilsartan (Azirva), compared with telmisartan, on insulin resistance in participants with essential hypertension complicated by type…
- Trial name
- NCT02079805
- Testing
- Azilsartan, Telmisartan
- Where
- Japan
- Volunteers
- 33 people
- Sponsor
- Takeda
Diabetes Mellitus, Type 2
Treatment Differences Between Canagliflozin and Placebo in Insulin Secretion in Subjects With Type 2 Diabetes Mellitus (T2DM)
The purpose of this study is to assess changes from baseline in insulin sensitivity, hepatic fat content and beta cell function after approximately 24-25 weeks of treatment with canagliflozin compared to placebo in participants…
- Trial name
- NCT02009488
- Testing
- Canagliflozin, 100 mg, Canagliflozin, 300 mg
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Janssen Research & Development, LLC
Impaired Glucose Tolerance, Insulin Sensitivity
Effects of Glucose Lowering Agents in South Asian Women With Impaired Glucose Tolerance or Impaired Fasting Glucose
This study will test the effect of four common oral anti-diabetic agents on hepatic insulin sensitivity in South Asian women with impaired glucose tolerance or impaired fasting glucose.
- Conditions
- Impaired Glucose Tolerance, Insulin Sensitivity, Glucose Metabolism Disorders
- Trial name
- DIASA3 (NCT04662866)
- Testing
- Metformin capsule 500 mg, Empagliflozin encapsulated tablet 10 mg, Pioglitazone encapsulated tablet 30 mg, Linagliptin encapsulated tablet 5 mg
- Where
- Norway
- Volunteers
- 64 people
- Sponsor
- Oslo University Hospital
New Onset Diabetes Mellitus After Renal Transplantation
Improving Secretion of Insulin in New Onset Diabetes After Renal Transplantation
New onset diabetes after transplantation (NODAT) is a frequent and feared complication after kidney transplantation and leads to an increase in cardiovascular complications as well as in the rate of graft loss.
- Trial name
- ISINODAT (NCT01268995)
- Testing
- Cyclosporine A, Tacrolimus
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Medical University of Vienna
Psoriasis, Metabolic Syndrome
Effects of TNF-alpha Antagonism (Etanercept) in Patients With the Metabolic Syndrome and Psoriasis
People with psoriasis have significantly higher rates of obesity, diabetes, heart failure and high blood pressure than the general public.
- Conditions
- Psoriasis, Metabolic Syndrome, Hyperlipidemia, Obesity
- Trial name
- NCT00477191
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Massachusetts General Hospital
Type 2 Diabetes Mellitus
The Verona Newly Diagnosed Type 2 Diabetes Study
Type 2 diabetes mellitus is a complex disease whose clinical phenotype results from the variable combination of genetic and nongenetic factors.
- Trial name
- VNDS (NCT01526720)
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Left Ventricular Hypertrophy, Insulin Resistance
MetfoRmin and Its Effects on Left Ventricular Hypertrophy in Normotensive Patients With Coronary Artery Disease
Thickening of the heart muscle (left ventricle) known medically as Left Ventricular Hypertrophy (LVH) is very common in patients with heart disease. This increases risk of cerebrovascular/cardiovascular event.
- Conditions
- Left Ventricular Hypertrophy, Insulin Resistance, Coronary Artery Disease, PreDiabetes
- Trial name
- MET-REMODEL (NCT02226510)
- Testing
- Metformin XL
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- University of Dundee
Diabetes Mellitus, Type 2, Diabetes Mellitus
A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 Diabetes
The purpose of this study is to investigate the effectiveness and safety of 12 weeks of treatment with R256918 in patients with Type 2 Diabetes Mellitus who are taking metformin.
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Endocrine System Diseases, Nutritional and Metabolic Diseases
- Trial name
- NCT00672386
- Testing
- JNJ16269110, Metformin, Dietary Counseling
- Where
- 62 sites in Belgium, Denmark and 9 more
- Volunteers
- 352 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Metabolic Syndrome
Relation Between Serum Uric Acid and Metabolic Syndrome in Type 2 DM
This study will be undertaken to evaluate the association of serum uric acid (SUA) level with metabolic risk factors in patients with type 2 diabetes and their relation to eGFR status
- Trial name
- NCT04575389
- Testing
- Serum uric acid levels ,HBA1C , fasting plasma glucose ,lipid profile , creatinine level
- Volunteers
- 100 people
- Sponsor
- Assiut University
Diabetes, Gestational, Insulin Resistance
Metformin in Gestational Diabetes Mellitus
Gestational diabetes (GDM) is a condition that manifests as high blood sugar levels (hyperglycemia) during pregnancy in previously healthy women.
- Trial name
- MetGDM (NCT00681460)
- Testing
- human recombined insulin, metformin
- Where
- Poland
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- K. Marcinkowski University of Medical Sciences
Insulin Resistance, Hyperinsulinemia
Diazoxide Suppression Test P&F Study
The goal of this study is to learn about how the hormone insulin controls blood sugar. The main question it aims to answer is about how much insulin the body actually needs to maintain a normal blood sugar level.
- Conditions
- Insulin Resistance, Hyperinsulinemia, Obesity
- Trial name
- DzST (NCT06606327)
- Testing
- Diazoxide, 3 mg/kg per dose
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Columbia University
Diabetes Mellitus, Type 2
Effects of KDT501 on Metabolic Features in Insulin Resistant Subjects
KDT501 is an orally administered product designed to help control impaired glucose and insulin regulation in patients with insulin resistance.
- Trial name
- NCT02444910
- Testing
- KDT501
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- KinDex Pharmaceuticals, Inc.
Diabetic Pregnancy, Insulin Resistance
Metformin Use to Improve Pregnancy Outcome in Women With Type 1 Diabetes.
The study investigates whether additional metformin medication in combination with regular insulin treatment will decrease the need of insulin for women with diabetes mellitus type 1 during pregnancy.
- Conditions
- Diabetic Pregnancy, Insulin Resistance, Type1diabetes
- Trial name
- NCT03765359
- Testing
- metforminhydrochloride
- Where
- 5 sites in Finland
- Volunteers
- 101 people
- Sponsor
- Tampere University Hospital
Gestational Diabetes Mellitus in Pregnancy
The Effect of E-Health Management on Gestational Diabetes Control
The purpose of this study was to develop an e-heath management platform(eHMP) for women with high risk of gestational diabetes mellitus (GDM) and to evaluate the longitudinal effects between groups of eHMP intervention.
- Trial name
- NCT03726983
- Testing
- Experimental group
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- Chang Gung Memorial Hospital
Insulin Resistance, Diabetes
Diabetes, Insulin Resistance and Body Composition
The goal of this retrospective study is to learn about the correlation between diabetes, insulin resistance and body compositions.
- Trial name
- NCT06724068
- Testing
- Diabetes，Insulin resistance，Control
- Where
- China
- Volunteers
- 515 people, healthy volunteers welcome
- Sponsor
- Xuan Song
Diabetes Mellitus
Integration of Continuous Glucose Monitoring Into a BiHormonal Closed-Loop Artificial Pancreas
The investigators hypothesize that our closed-loop glucose-control system can provide BG control in subjects with type 1 diabetes using the estimated BG signal from a CGM as the input signal to the controller.
- Trial name
- CL2 (NCT01161862)
- Testing
- Bi-hormonal (insulin and glucagon) artificial pancreas
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Boston University Charles River Campus
Type 2 Diabetes Mellitus
A Study to Assess Insulin Delivery With PaQ® in Patients With Type 2 Diabetes Mellitus
The purpose of the study is to obtain an assessment (efficacy, safety, and patient reported outcomes) of basal bolus insulin delivery with PaQ in insulin-using patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT02419859
- Testing
- PaQ® Insulin Delivery Device, Insulin, Asp(B28)-
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- CeQur Corporation
Pre-Diabetes, Major Lung or Abdominal Surgery
Attenuating The Post-Operative Insulin Resistance And Promoting Protein Anabolism
Major surgery results in a stress- induced catabolic response, marked by post-operative insulin resistance, hyperglycemia and loss of body protein, which is associated with increased morbidity, mortality and adverse outcomes.
- Conditions
- Pre-Diabetes, Major Lung or Abdominal Surgery, Insulin Resistance
- Trial name
- NCT02393573
- Testing
- Metformin
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Metabolic Syndrome, Triglycerides
Therapeutic Lifestyle Modifications to Reduce Burden of Chronic Disease
The investigators previously established that there was a high burden of disease among all categories of staff at the University of the West Indies, St.
- Conditions
- Metabolic Syndrome, Triglycerides, Blood Pressure, Diabetes
- Trial name
- NCT01277614
- Testing
- Therapeutic lifestyle
- Where
- Trinidad and Tobago
- Volunteers
- 144 people
- Sponsor
- The University of The West Indies
Type 2 Diabetes Mellitus, Insulin Resistance
Metabolic Effects of Pioglitazone in Type II Diabetic Patients Previously Treated With Insulin
The goal of the study is to demonstrate whether a switch from insulin therapy to an oral therapy with pioglitazone/glimepiride will lead to a deterioration of glycemic control (increase in HbA1c by more than 0.5 %) within a 6…
- Trial name
- PIOswitch (NCT00576784)
- Testing
- pioglitazone and glimepiride
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- IKFE Institute for Clinical Research and Development