Clinical trials: Insulin Resistance, Diabetes
Glucose Metabolism Disorder
Study of the Reversibility of Glucose Intolerance Caused by Chronic Aspartame Consumption
Experiments have shown that some artificial sweeteners like those in diet soda can cause changes in how the body responds to and uses sugar.
- Trial name
- NCT02520258
- Testing
- Oral glucose tolerance test (OGTT), Diet soda containing aspartame only
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Prediabetes, Vitamin D Deficiency
Effect of Vitamin D Deficiency and Vitamin D Supplementation on Glucose Metabolism
This study was intended to evaluate the effect of vitamin D supplementation on insulin sensitivity and pancreatic islet beta-cell function.
- Trial name
- NCT00749918
- Testing
- Cholecalciferol (vitamin D3)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Type II Diabetes
Supplementation of Brown Seaweed on Insulin Resistance of NAFLD Patients With Pre- or Type 2-Diabetes
Investigators research team conducted a previous human clinical trial of brown algae and conducted liver and metabolic indicators of brown algae to improve nonalcoholic fatty liver disease, and found brown algae extract…
- Trial name
- NCT04715776
- Testing
- Brown seaweed
- Where
- Taiwan
- Volunteers
- 106 people
- Sponsor
- Taipei Medical University WanFang Hospital
Metabolic Syndrome
The Effect of Protein Quality and Time-factor by Consumption of a Pre-meal on Postprandial Lipemia in Subjects With the Metabolic Syndrome.
Cardiovascular disease (CVD) is one of the most important and frequent causes of death. Postprandial lipidemia (PPL) is an independent risk factor for CVD, besides the traditional risk factors e.g.
- Trial name
- NCT02228252
- Testing
- Whey protein, Casein, Gluten protein
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Aarhus University Hospital
Insulin Resistance, Diabetes
Validation of a Novel Screening Test for Maternal Insulin Resistance
This will be a validation study of Quantose IR and Quantose IGT to predict insulin resistance and identify patients with prediabetes. This is a pilot study of 100 subjects.
- Trial name
- NCT03388697
- Testing
- Quantose IR and Quantose IGT analysis, HOMA IR the standard testing for insulin resistance
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Overweight, Insulin Resistance
Physical Activity for a Long and Healthy Life
The aim of the study is to 1) delineate the molecular mechanisms behind the large variation in insulin sensitivity among apparently healthy subjects and to 2) establish the dose-response relationship between physical training and…
- Conditions
- Overweight, Insulin Resistance, Diabetes Mellitus, Type 2
- Trial name
- FINE (NCT01430143)
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Type 2 Diabetes Mellitus, Obesity
Renal HEIR Study: Renal Hemodynamics, Energetics and Insulin Resistance in Youth Onset Type 2 Diabetes Study
Type 2 diabetes (T2D) in youth is increasing in prevalence in parallel with the obesity epidemic. In the US, almost half of patients with renal failure have DKD, and ≥80% have T2D.
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Nephropathy, Adolescent Obesity
- Trial name
- Renal-HEIR (NCT03584217)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 MG/ML, Renal Biopsy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1
Randomized Trial Comparing Sitagliptin to Placebo in Closed Loop
There are many recent advances in insulin treatment of type 1 Diabetes Mellitus (T1DM), however after a meal sugars are always a concern.
- Trial name
- NCT02328040
- Testing
- Sitagliptin and insulin/novolog via CL
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Albert Einstein College of Medicine
Prediabetes, Type 2 Diabetes
Effects of Dried Whole Fruits on Metabolism in Diabetes
Diabetes becomes epidemic in worldwide countries. Diabetes Canada indicated that 30% of adults in Manitoba are diabetes or prediabetes. Nine out of ten diabetic patients are type 2 diabetes (T2D).
- Trial name
- NCT07354386
- Testing
- Freeze dried whole Saskatoon berry, Freeze dried apple slice bulk
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- University of Manitoba
Alzheimer's Disease, Obesity
Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain Function
Background: Insulin removes sugar from the blood to use for energy. Insulin resistance means that cells may not respond to insulin normally. It can lead to serious diseases.
- Conditions
- Alzheimer's Disease, Obesity, Diabetes Mellitus
- Trial name
- NCT02460783
- Testing
- Boost (R) 5-2 diet, Healthy Living Diet
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Diabetes Type 2, Diabetes Type 1
Disentangling the Effect of Brain Insulin Resistance on Brain Health
People with diabetes are at increased risk of developing dementia, including Alzheimer's disease and vascular dementia. In addition, persons with diabetes have more pronounced age-related brain atrophy and cognitive difficulties…
- Trial name
- BIR 1 (NCT07374705)
- Where
- 3 sites in Denmark, Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henrik Bo Wiberg Larsson
Diabetes
Effect of Nesiritide Infusion on Insulin Sensitivity in Healthy Obese Insulin Resistant Subjects
The purpose of the study is to compare the effects of nesiritide to placebo administered by a continuous IV infusion over 48 hours for the treatment of insulin resistance in healthy, obese, insulin resistant individuals.
- Trial name
- BNP3 (NCT03234751)
- Testing
- Continous IV infusion of Nesiritide, Hyperinsulinemic euglycemic clamp
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Hypogonadism, Metabolic Syndrome
Androgen Deprivation Therapy Study
The purpose of this study is to examine the link between low testosterone and insulin resistance/diabetes in men undergoing androgen deprivation therapy for prostate cancer.
- Conditions
- Hypogonadism, Metabolic Syndrome, Diabetes, Inflammation
- Trial name
- ADT (NCT00743327)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Institute on Aging (NIA)
Type 1 Diabetes
Closed-Loop Glucagon Administration For Hypoglycemia Treatment
This study will test the hypothesis that a wearable automated bionic pancreas system that automatically delivers glucagon only can prevent or treat hypoglycemia vs. usual care for people with type 1 diabetes > 21 years old.
- Trial name
- NCT02181127
- Testing
- Glucagon-only Bionic Pancreas
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes, Insulin Sensitivity/Resistance
Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes
GLP-1 increases skeletal and cardiac microvascular perfusion and improves insulin's microvascular responses in human subjects with T1DM, leading to improved metabolic insulin responses, endothelial function, and increased muscle…
- Trial name
- KML001 (NCT04133922)
- Testing
- GLP-1, Insulin, Dextrose 20 % in Water
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Type 2 Diabetes, Healthy
Type 2 Diabetes and the Effect of Probiotics
Insulin-resistance in type 2 diabetes is associated with chronic inflammation. Anti-inflammatory actions might increase sensitivity to insulin.
- Conditions
- Type 2 Diabetes, Healthy, Endotoxemia
- Trial name
- NCT00413348
- Testing
- Lactobacillus acidophilus NCFM
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Insulin Resistance, Type 2 Diabetes
Endothelial Function in Patients With Type 2 Diabetes Versus Healthy Subjects
The aim of the study is to evaluate the effect of hyperinsulinemia and postprandial changes in plasma glucose and lipids concentrations on the endothelial function together with other metabolic parameters in patients with type 2…
- Trial name
- EndoPat (NCT01946347)
- Testing
- mixed meal, Acute in vivo induced hyperinsulinemia
- Where
- Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute for Clinical and Experimental Medicine
Obesity, Pre-diabetes
Chromium Effects on Insulin and Vascular Function in People at Risk for Diabetes
The purpose of this study is to investigate the effects of Chromium on glucose tolerance and endothelial function in people at risk for type II diabetes.
- Conditions
- Obesity, Pre-diabetes, Insulin Resistance, Impaired Glucose Tolerance
- Trial name
- NCT00067626
- Testing
- Chromium
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Griffin Hospital
Type 2 Diabetes
Diabetes Prevention in Clinical Practice.
We randomize individuals with impaired glucose tolerance to one of three arms for degree of physical activity: 1. Continue with your current life style; 2. Ordinary life activities for increased physical activity; 3.
- Trial name
- DIAVIP (NCT01834378)
- Testing
- Low intensity intervention, High intensity intervention.
- Volunteers
- 96 people
- Sponsor
- Göteborg University
Type 2 Diabetes Mellitus
Remission Evaluation of a Metabolic Intervention for Type 2 Diabetes With IGlarLixi
The purpose of the study is to determine whether in patients with early type 2 diabetes, a short-term intensive metabolic intervention comprising iGlarLixi, metformin, and lifestyle approaches will be superior to standard…
- Trial name
- REMIT-iGL (NCT03130426)
- Testing
- iGlarLixi, Insulin Glargine, Metformin
- Where
- 8 sites in Canada
- Volunteers
- 161 people
- Sponsor
- Population Health Research Institute
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