Clinical trials: Insulin Resistance, Diabetes
Diabetes, Obese
PGC-1 and Mitochondrial Dysfunction in Diabetes
The purpose of this study is determine if you have too much fat in your body that it will decrease the conversion of food energy into energy that your body can use.
- Trial name
- NCT01724515
- Testing
- Lipid infusion and muscle biopsies
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes, Gestational, Insulin Resistance
Metformin in Gestational Diabetes Mellitus
Gestational diabetes (GDM) is a condition that manifests as high blood sugar levels (hyperglycemia) during pregnancy in previously healthy women.
- Trial name
- MetGDM (NCT00681460)
- Testing
- human recombined insulin, metformin
- Where
- Poland
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- K. Marcinkowski University of Medical Sciences
Diabetes Mellitus
Metformin as Adjuvant to Insulin Therapy in Insulin-resistant Diabetes Mellitus With Pregnancy
Adding metformin to insulin therapy in pregnant women with diabetes mellitus who show insulin resistance may be equivalently effective to further raising the insulin dose
- Trial name
- NCT01915550
- Testing
- Metformin, Humulin Insulin Mixtard
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Diabetes Type 2, Metabolic Syndrome
Regulating Efficacy and Wellness in Diabetes
The propose of the study is to test the hypothesis that an eight week program consisting of walking exercise and social cognitive theory based group workshops will increase physical activity adherence six months later in older…
- Trial name
- REWinD (NCT01790724)
- Testing
- Walking exercise
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Hyperglycemia
Effect of Resistant Starch Type 4 on Glycemia and Insulin Sensitivity in Young Adults
This study tested the effects of resistant starch type 4 on blood sugar and hunger in young adults with Type 2 diabetes.
- Trial name
- NCT00687960
- Testing
- Resistant starch type 4 - raw, Resistant Starch Type 4 - Cooked, Dextrose
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Morbid Obesity, Metabolic Syndrome
FMT in Obesity: RYGB vs. LEAN vs. Autologous FMT
This double-blinded proof-of-concept study is proposed to explore the effects of fecal microbiota transfer (FMT) in human subjects.
- Conditions
- Morbid Obesity, Metabolic Syndrome, Diabetes, PreDiabetes
- Trial name
- DACH (NCT06268990)
- Testing
- Fecal microbiota transplantation
- Where
- Austria
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Wiebke Kristin Fenske
Insulin Resistance, Polycystic Ovary Syndrome
Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
The study aims to investigate the relationship between fasting insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) across various demographic factors, including age, sex, race/ethnicity, BMI, and polycystic…
- Conditions
- Insulin Resistance, Polycystic Ovary Syndrome, Hyperinsulinism, Obesity
- Trial name
- DAISY (NCT05950282)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ali Chappell
Insulin Resistance
Effect of Polyphenol-rich Dark Chocolate on Insulin Sensitivity in Normal Weight and Overweight Adults
The purpose of the study is to determine the effect of polyphenol-rich dark chocolate on insulin sensitivity in normal weight and overweight adults.
- Trial name
- NCT01749020
- Testing
- Polyphenol-rich Dark chocolate
- Where
- United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Type 1 Diabetes
Faster Aspart on Insulin-pump Treated T1DM Patients
Observational retrospective study about effectiveness and safety of insulin Faster Aspart on continuous subcutaneous insulin infusion treated adult Type 1 Diabetes Mellitus (T1DM) patients in routine clinical practice.
- Trial name
- realFACI (NCT04233203)
- Testing
- Insulin Faster Aspart, Insulin pump
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Jesús Moreno Fernández
Gestational Diabetes, Insulin Resistance
Pregnancy Outcomes: Effects of Metformin Study (POEM Study)
One approach to prevent the rising burden of diabetes is to address the issue of gestational diabetes mellitus (GDM). GDM has a growing prevalence up to 5-10% (and even higher in specific subgroups), with a pregnant population…
- Trial name
- POEM (NCT02947503)
- Testing
- Metformin TEVA 850 mg
- Where
- 4 sites in Netherlands
- Volunteers
- 500 people
- Sponsor
- Bethesda Diabetes Research Center
Diabetes, HIV Infections
The Study of HIV Protease Inhibitors and Their Effects on Glucose Metabolism
The purpose of this study is to determine the mechanisms by which HIV protease inhibitors contribute to the development of diabetes in HIV-infected patients.
- Conditions
- Diabetes, HIV Infections, Insulin Resistance
- Trial name
- NCT00259727
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Insulin Resistance, Hyperinsulinemia
Diazoxide Suppression Test P&F Study
The goal of this study is to learn about how the hormone insulin controls blood sugar. The main question it aims to answer is about how much insulin the body actually needs to maintain a normal blood sugar level.
- Conditions
- Insulin Resistance, Hyperinsulinemia, Obesity
- Trial name
- DzST (NCT06606327)
- Testing
- Diazoxide, 3 mg/kg per dose
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Columbia University
Obesity, Type 2 Diabetes
The Effects of Weight Loss on Neuroadrenergic Function
Elevated subconscious nervous system activity is a characteristic of the obese state and contributes importantly to the risk of heart disease and diabetes.
- Conditions
- Obesity, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- NCT01771042
- Testing
- Dietary weight loss at 25% energy deficit
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- Baker Heart Research Institute
Diabetes Mellitus, Non-Insulin-Dependent, Obesity
A Trial to Study the Effect of Vitamin D Supplementation on Glucose and Insulin Metabolism in Centrally Obese Men
The purpose of the study is to evaluate the change in glucose and insulin metabolism(early markers for development of diabetes) after 6 weeks of weekly Vitamin D supplementation.
- Trial name
- NCT00347542
- Testing
- Vitamin D
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sitaram Bhartia Institute of Science and Research
Cardiovascular Diseases, Metabolic Syndrome
Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.
DOVE-MET-COME-100 is a single site prescreening survey study designed to identify adults who may be eligible for future industry-sponsored clinical trials.
- Conditions
- Cardiovascular Diseases, Metabolic Syndrome, Obesity, Prediabetes
- Trial name
- NCT07106879
- Testing
- Blood Work
- Where
- United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Clindove Research LLC
Prediabetic State, Obesity
Pancreatic Islet Function, Insulin Sensitivity, and Chronic Complications in Pre-Diabetes
We, the investigators at National Taiwan University Hospital, want to compare patients' islet cell function, insulin sensitivity and risk of chronic complications with normal subjects.
- Conditions
- Prediabetic State, Obesity, Metabolic Syndrome X
- Trial name
- NCT00172796
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Diabetes Mellitus
PK/PD Biosimilarity Study of Gan & Lee Insulin Lispro Injection vs. EU and US Humalog® in Healthy Males
Primary objective: To demonstrate pharmacokinetic (PK) and pharmacodynamic (PD) equivalence of Gan \& Lee Insulin Lispro Injection with both EU - approved Humalog® and US - licensed Humalog® (Reference Products) in healthy male…
- Trial name
- NCT04235439
- Testing
- Gan & Lee Insulin Lispro Injection
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Gan and Lee Pharmaceuticals, USA
Aneurysmal Subarachnoid Hemorrhage
Efficacy and Safety Study of a Low-carbohydrate Tube Feed in Critically Ill Patients Under Insulin Therapy
The purpose of this study is to determine the efficacy and safety of a diabetes-specific tube feed in comparison to an isocaloric, isonitrogenous standard enteral formula in critically ill patients receiving insulin treatment for…
- Trial name
- NCT02503527
- Testing
- Diben 1.5 kcal HP, Fresubin HP Energy Fibre (1.5 kcal)
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Fresenius Kabi
Metabolic Syndrome
Assessment of Therapeutic Potential of Stigma Maydis (Cornsilk) on Metabolic Syndrome
Over the past two decades, there has been an increase in the number of people with nutrition related maladies due to changes in their dietary habits and lifestyle.
- Trial name
- cornsilk (NCT06240273)
- Testing
- Corn silk powder
- Volunteers
- 50 people
- Sponsor
- University of Veterinary and Animal Sciences, Lahore - Pakistan
Type 2 Diabetes Mellitus (T2DM), Sarcopenia
The Simplified Total-body Resistance Exercise for Muscular Hypertrophy for Diabetic Population (D-STORM)
Type 2 diabetes is associated with progressive loss of muscle mass, which worsens blood sugar control and increases the risk of heart disease and disability.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Sarcopenia, Insulin Resistance
- Trial name
- D-STORM (NCT07664501)
- Testing
- D-STORM Resistance Training Programme, usual care
- Where
- Malaysia
- Volunteers
- 56 people
- Sponsor
- Universiti Teknologi Mara
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