Clinical trials: Insulin Resistance, Diabetes
Postprandial Lipid Metabolism, Type 1 Diabetes (T1D)
The TiMeD-T1D Project
The aim of the proposed study is to investigate the metabolic consequences of varying the timing of meal insulin boluses and skipping boluses altogether in individuals with type 1 diabetes.
- Trial name
- NCT07172672
- Testing
- 400 mL Fresubin Energy Drink and 100 mL heavy cream with the addition of the 18F-FTHA radiotracer
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Advanced Solid Tumor, Metastatic Solid Tumor
A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and therapeutic activity of GI-102 as a single agent and in combination with conventional anti-cancer drugs, pembrolizumab or trastuzumab…
- Conditions
- Advanced Solid Tumor, Metastatic Solid Tumor, Soft Tissue Sarcoma (STS), Platinum-resistant Ovarian Cancer (PROC)
- Trial name
- NCT05824975
- Testing
- GI-102 subcutaneous (SC), GI-102, doxorubicin
- Where
- 11 sites in United States, South Korea
- Volunteers
- 358 people
- Sponsor
- GI Innovation, Inc.
Diabetes Mellitus Type 2
Lispro Mix 25 vs. Glargine in Type 2 Diabetics
In patients with type 2 diabetes who have not been on insulin therapy before the study will achieve better glycemic control by the treatment regiment consisting of two times daily insulin lispro mix 25 than by the treatment…
- Trial name
- IOOL (NCT00551356)
- Testing
- Insulin lispro mix 25, Glargine
- Where
- Mexico
- Volunteers
- 53 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 60 Hours in Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT01966393
- Testing
- 60-hours intervention
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Pre-diabetes
Vitamin D in Minorities With Prediabetes
Vitamin D supplementation in minority subjects with both pre-diabetes and low vitamin D levels will delay the development of diabetes.
- Trial name
- NCT00876928
- Testing
- vitamin D
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Charles Drew University of Medicine and Science
Prediabetes, Obesity / Overweight
Very-Low-Carbohydrate Diet for Prediabetes and Obesity
Prediabetes is a condition where blood sugar is higher than normal but not yet high enough to be called type 2 diabetes. It is common in adults who are overweight or obese, and without treatment it often progresses to diabetes…
- Conditions
- Prediabetes, Obesity / Overweight, VERY LOW CARBOHYDRATE DIET
- Trial name
- VLCBD (NCT07830121)
- Testing
- Standard Dietary Advice, Very-Low-Carbohydrate Diet (VLCBD)
- Where
- Malaysia
- Volunteers
- 33 people
- Sponsor
- Universiti Teknologi Mara
Diabetes, Insulin Resistance
Physiologic and Functional Adaptations of Insulin Sensitive Tissues
The long-term goal is to understand the mechanisms of intestinal nutrient sensing and signal relays to insulin sensitive tissues (adipose, skeletal muscle, liver) in humans.
- Conditions
- Diabetes, Insulin Resistance, Obesity, Bariatric Surgery Candidate
- Trial name
- NCT03407833
- Testing
- Endoscopy biopsy, Surgical biopsy, Mixed-meal tolerance test
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Polycystic Ovary Syndrome, Abnormal Weight Gain
Go Girls! Fitness Support Group Intervention Effectiveness Study
The main purpose of this study is to determine if the Go Girls! program to take place at the Kluge Children's Rehabilitation Center Therapeutic Recreation Gymnasium, intended to introduce girls to a fun, non-threatening…
- Conditions
- Polycystic Ovary Syndrome, Abnormal Weight Gain, Excess Weight, Insulin Resistance
- Trial name
- CBS002 (NCT02117063)
- Testing
- Go Girls! Fitness Support Group
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Virginia
Gestational Diabetes
Metformin Versus Insulin in Gestational Diabetes
Gestational diabetes is traditionally treated with insulin. Metformin is a peroral drug used worldwide in the treatment of type 2 diabetes and also in a few studies on patients with gestational diabetes.
- Trial name
- NCT01240785
- Testing
- metformin, insulin
- Volunteers
- 221 people
- Sponsor
- Turku University Hospital
Insulin Resistance, Diabetes Mellitus
A Crossover Study of the Acute Effects of Olanzapine in Healthy Volunteers
The purpose of this clinical research study is to examine the acute hormonal and metabolic effects of the drug olanzapine, as well as appetite effects, in healthy volunteers.
- Trial name
- NCT00741026
- Testing
- Olanzapine 10 mg po qhs for 3 days
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Gestational Diabetes, Type 2 Diabetes
Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country
The study hypothesis was In women with gestational diabetes and type 2 diabetes in pregnancy metformin treatment compared with insulin will result in better perinatal and maternal outcome and improved treatment acceptability with…
- Conditions
- Gestational Diabetes, Type 2 Diabetes, Pregnancy
- Trial name
- migdm&t2dm (NCT01855763)
- Testing
- Metformin, Insulin
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Insulin Resistance
Chromium and Insulin Resistance
Chromium is an essential nutrient for the maintenance of normal glucose tolerance and its deficiency causes insulin resistance. Chromium administration has also been shown in several studies to lower glucose and insulin levels in…
- Trial name
- NCT00846248
- Testing
- Chromium
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Diabetes Mellitus
Metabolic Effects of Stevia in Type 2 Diabetic Patients
The main aim of the study is to assess the short term and 1-month metabolic effects of Stevia rebaudiana bertoni in patients with type 2 diabetes.
- Trial name
- STEDIA1 (NCT02834715)
- Testing
- Stevia rebaudiana liquid extract
- Where
- Cameroon
- Volunteers
- 22 people
- Sponsor
- Yaounde Central Hospital
Hypertension, Type 2 Diabetes
Project WHADE: A Partner-Based Physical Activity Program for Women
This study is designed to test the feasibility and acceptability of a new method for supporting physical activity among women ages 40-65 who have risk factors for cardiovascular disease.
- Conditions
- Hypertension, Type 2 Diabetes, Metabolic Syndrome, Smoking
- Trial name
- NCT06350604
- Testing
- Project WHADE: A Partner-Based Physical Activity Program for Women
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Rowan University
Metabolic Syndrome, Dyslipidemias
The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters.
The current study will test the central hypothesis that Glycine supplementation in humans improves Lipid profile and therefore reduces the risk of Atherosclerosis.
- Conditions
- Metabolic Syndrome, Dyslipidemias, Diabetes Mellitus, Obesity
- Trial name
- NCT03850314
- Testing
- Glycine
- Volunteers
- 50 people
- Sponsor
- Prof. Tony hayek MD
Gestational Diabetes Mellitus (GDM), Oxidative Stress
Impact of Chromium Supplementation on Glucido-lipidic Metabolism, Oxidative Stress and Inflammatory State in Patients with Gestational Diabetes
Our study aims to explore the influence of dietary chromium supplementation in the form of chromium picolinate, at different doses (200 µg and 400 µg per day), on the health of pregnant women with gestational diabetes.
- Conditions
- Gestational Diabetes Mellitus (GDM), Oxidative Stress, Inflammatory Status, Insulin Resistance
- Trial name
- Cr and GDM (NCT06860087)
- Testing
- Oral chromium supplementation during gestational diabetes mellitus through the administration of chromium picolinate tablets (200 µg/d), Dietary Supplement: Oral chromium supplementation during gestational diabetes mellitus through the administration of chromium picolinate tablets (400 µg/d)
- Where
- Algeria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Kasdi Merbah
Diabetes Mellitus, Metabolic Syndrome X
Effect of Statins on Oxidative Stress and Endothelial Progenitor Cells
Thirty-six subjects with hyperlipidemia and metabolic syndrome and/or diabetes were randomized in a double-blind manner to either pravastatin 80 mg or atorvastatin 10 mg daily.
- Conditions
- Diabetes Mellitus, Metabolic Syndrome X, Hypercholesterolemia
- Trial name
- STOPCAP (NCT00166036)
- Testing
- Atorvastatin, Pravastatin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Emory University
Type 1 Diabetes, Chronic Inflammation
The Effect of Colchicine, on Insulin Sensitivity in Individuals With Type 1 Diabetes and Systemic Low-grade Inflammation
The aim for this clinical trial is to evaluate if colchicine in addition to standard of care improves insulin sensitivity in individuals with type 1 diabetes, systemic low-grade inflammaiton and reduced insulin sensitivity.
- Conditions
- Type 1 Diabetes, Chronic Inflammation, Insulin Sensitivity
- Trial name
- INS1GHT (NCT07247734)
- Testing
- Colchicin 0.5 mg once daily for two weeks, then twice daily for two weeks, Colchicine tablet 0.5 mg once-daily for two weeks, then twice daily for two weeks
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Asger Lund, MD
Type 2 Diabetes Mellitus
Glycemic Control and Complications in Diabetes Mellitus Type 2 (VADT)
This study is a prospective, 2-arm, randomized controlled trial to determine whether glycemic control, achieved through intensification of treatment, is effective in preventing clinical macrovascular complications in patients…
- Trial name
- VADT (NCT00032487)
- Testing
- Insulin, Glimepiride, Rosiglitazone
- Where
- 21 sites in United States, Puerto Rico
- Volunteers
- 1,791 people
- Sponsor
- VA Office of Research and Development
Type 2 Diabetes Mellitus
Short Term Effect of Liraglutide Versus Vildagliptine on Insulin Secretion and Insulin Sensitivity in Type 2 Diabetes
This is a single blind randomised controlled clinical trial in uncontrolled type 2 Diabetes mellitus patients on oral glucose lowering agents, and naive to incretinomimetic.
- Trial name
- LIRAVIS (NCT02832999)
- Testing
- sub cutaneous liraglutide, Oral Vildagliptin
- Where
- Cameroon
- Volunteers
- 14 people
- Sponsor
- Yaounde Central Hospital
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