Clinical trials: Insulin Resistance, Diabetes
Diabetes, Hypothyroidism
Thyroid Study Type 2 Diabetes Mellitus (T2DM)
Background of the study: Thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are known to promote weight loss, which could be beneficial for treating obesity, and type 2 diabetes.
- Trial name
- NCT01379170
- Testing
- Euthyrox (levothyroxine)
- Where
- Netherlands
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Type 2, Autoimmune Diabetes
Metabolic and Immunoinflammatory Profiles in Adults With Newly Diagnosed Diabetes
The goal of this observational study is to better understand how diabetes develops in adults at the time of diagnosis. The study focuses on adults with newly diagnosed diabetes in the Kazakh population.
- Trial name
- AD-HET-KZ (NCT07522502)
- Where
- Kazakhstan
- Volunteers
- 240 people
- Sponsor
- West Kazakhstan Marat Ospanov Medical University
Gestational Diabetes, Diabetes, Gestational
Metabolic Analysis for Treatment Choice in Gestational Diabetes Mellitus
Gestational diabetes (GDM) is a significant clinical and public health burden, affecting over 400,000 pregnant women in the United States each year.
- Conditions
- Gestational Diabetes, Diabetes, Gestational, Pregnancy in Diabetes
- Trial name
- MATCh-GDM (NCT03029702)
- Testing
- Insulin, Glyburide, Metformin
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Maisa N. Feghali, MD
Insulin Resistance, Cardiovascular Disease
Processing Responses of Grains (PRO-Grains) Study
The primary objective of this pilot study will be to examine the effects of consuming whole grains, differing in the degree of processing, on insulin sensitivity and other cardiometabolic risk factors.
- Conditions
- Insulin Resistance, Cardiovascular Disease, Diabetes
- Trial name
- NCT02186353
- Testing
- Partial feeding study
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Type 2 Diabetes Mellitus
Effects of Dapagliflozin on Insulin Resistance and Insulin Secretion in Subjects With Type 2 Diabetes
The purpose of this study is to evaluate the effects of dapagliflozin on insulin sensitivity
- Trial name
- NCT00831779
- Testing
- Dapagliflozin
- Where
- 3 sites in United States
- Volunteers
- 116 people
- Sponsor
- AstraZeneca
Diabetes, Low-intensity Chronic Inflammation
Vitamin D, C-reactive Protein and Insulin Resistance
Randomized, double blind, placebo-controlled clinical trial of vitamin D supplementation (cholecalciferol, 4,000 IU/day for 6 months, in 104 postmenopausal women with type 2 diabetes mellitus.
- Conditions
- Diabetes, Low-intensity Chronic Inflammation, Insulin Resistance
- Trial name
- NCT01019642
- Testing
- cholecalciferol
- Where
- Mexico
- Volunteers
- 104 people
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Insulin Resistance, Depression
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group…
- Conditions
- Insulin Resistance, Depression, Depressive Disorder, Mood Disorders
- Trial name
- CBTeX (NCT05543083)
- Testing
- Cognitive-Behavioral Therapy followed by Exercise Training, Exercise Training followed by Cognitive-Behavioral Therapy, Cognitive-Behavioral Therapy Only
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Obesity, Metabolic Syndrome
Effects of Human Leptin Replacement
This study will test the hypothesis that leptin contributes to the regulation of the dynamics of human endocrine function.
- Conditions
- Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT00657605
- Testing
- Recombinant methionyl human leptin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Miami
Type 1 Diabetes
Transdermal Basal Insulin Patch Study in Type 1 Diabetes
This study is designed to evaluate the pharmacokinetics/pharmacodynamics of an investigational basal insulin patch in type 1 diabetes patients.
- Trial name
- NCT00519623
- Testing
- PassPort(R) Transdermal Insulin Delivery System
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Altea Therapeutics
Diabetes, Psoriasis
Diabetes and Psoriasis
Patients with psoriasis will be evaluated. The investigators will collect personal history, concomitant diseases and in particular the presence of type 2 diabetes mellitus, impaired fasting glucose and impaired glucose…
- Trial name
- NCT02366273
- Testing
- PASI and HOMA index
- Where
- Italy
- Volunteers
- 425 people
- Sponsor
- University of Pavia
Type 2 Diabetes, NAFLD
Nutraceutical Improvement of Glucose Metabolism, NAFLD and Insulin Resistance by Oat-fiber Supplementation in Type 2 Diabetes Mellitus Patients
Cohort studies show an association between increased intake of insoluble (cereal) fiber and decreased risk for cardiovascular disease, type 2 diabetes (T2DM), non-alcoholic fatty liver disease (NAFLD), cancer, infectious and…
- Trial name
- NIMROD (NCT05654805)
- Testing
- Drinking powder supplement
- Where
- Germany
- Volunteers
- 92 people
- Sponsor
- Charite University, Berlin, Germany
Chronic Kidney Disease, Pre Diabetes
What is the Role of Triglyceride-glucose Index as a Predictive Marker for Insulin Resistance in Pre Diabetic Chronic Kidney Disease Patients?
The aim of this study is to evaluate the role of the triglyceride-glucose (TyG) index as a predictive marker for insulin resistance in pre-diabetic patients with chronic kidney disease (CKD), and to investigate its potential…
- Trial name
- NCT07279922
- Testing
- Triglyceride-glucose index
- Volunteers
- 60 people
- Sponsor
- Assiut University
Diabetes, Schizophrenia
Pioglitazone as a Treatment for Lipid and Glucose Abnormalities In Patients With Schizophrenia
This is a study with an approved drug for treating type 2 diabetes, for its effects on treating glucose and lipid abnormalities in patients being treated with first or second-generation antipsychotics, and comparison of effects…
- Conditions
- Diabetes, Schizophrenia, Insulin Resistance, Cognitive Impairment
- Trial name
- NCT00231894
- Testing
- Pioglitazone, Life style diet group
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Diabetes Mellitus, Type 1
Joint Application of Human Insulin and Rapid Insulin Analogue in Control of Postprandial Glycemia
Postprandial glycemic control is essential for diabetes compensation. Insulin pump therapy control blood glucose released in response to both high and low glycemic index carbohydrates in a mixed diet using normal, square and…
- Trial name
- CPIT (NCT01088451)
- Testing
- Combined prandial insulin therapy (CPIT)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- University Hospital Hradec Kralove
Cardiometabolic Syndrome, Physical Inactivity
Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention
Lower attainment of cardiovascular health (CVH), indicated by the American Heart Association's Life's Simple 7 (LS7; physical activity, diet, cholesterol, blood pressure, body mass index, smoking, glycemia) and Life's Essential 8…
- Conditions
- Cardiometabolic Syndrome, Physical Inactivity, Hypertension, Type 2 Diabetes
- Trial name
- NCT06055036
- Testing
- Black Impact Intervention
- Where
- United States
- Volunteers
- 348 people
- Sponsor
- Ohio State University
Type 1 Diabetes (T1D)
Effects of Long Duration Cycling in People With Type 1 Diabetes
The goal of this interventional study is to build a high quality, real world multimodal dataset that combines continuous glucose monitoring (CGM), wearable and fitness data, performance metrics, and saliva and urine omics…
- Trial name
- PEDAL-T1D (NCT07286019)
- Testing
- Prolonged moderate-intensity cycling session
- Where
- Spain
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Universitat de Girona
Diabetes Mellitus, Type 2, Erectile Dysfunction
Exploratory CSII Trial on Erectile Dysfunction in T2DM Patients
Erectile dysfunction (ED) is a common form of organic sexual dysfunction in males with diabetes, with estimated incidence rates between 35 and 75%.
- Trial name
- ECSIITED (NCT01468519)
- Testing
- Insulin
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Jothydev's Diabetes and Research Centre
Insulin Resistance, Chronic Heart Failure
The Role of Insulin Resistance in Patients With Heart Failure and Type 2 Diabetes
The purpose of this cross-sectional comparative 2x2 trial study is to compare the degree of insulin resistance, myocardial function and selected metabolic parameters and to explore the pathophysiological mechanisms by which…
- Trial name
- CARMET2 (NCT02559128)
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institute for Clinical and Experimental Medicine
Weight Gain, Overweight
Cross-Sectional and Longitudinal Studies of "Pre-Diabetes" in the Pima Indians
Insulin resistance and a defect in early insulin secretion are risk factors for the development of type 2 diabetes mellitus. A recent longitudinal analysis which tracked the development of diabetes demonstrated that both insulin…
- Conditions
- Weight Gain, Overweight, Insulin Resistance, Obesity
- Trial name
- NCT00340132
- Where
- United States
- Volunteers
- 1,759 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes, Obesity
EndoBarrier in Obese Subjects With Type 2 Diabetes Mellitus
The aim of the study is to explore short and longer-term effects of the Endobarrier™ implantation on insulin resistance and beta-cell function assessed by repeated Botnia clamps.
- Trial name
- NCT02769728
- Testing
- EndoBarrier
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Graz
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