Clinical trials: Insulin Resistance, Diabetes
Obesity, Metabolic Syndrome
Effect of Resvida, a Comparison With Calorie Restriction Regimen
The purpose of this study is to compare the effects of the antioxidant "resveratrol" to a diet intervention (Calorie Restriction) to determine how each of them affects the following: gene expression profile, cholesterol (lipids)…
- Conditions
- Obesity, Metabolic Syndrome, Diabetes, Aging
- Trial name
- Resvida (NCT00823381)
- Testing
- resveratrol, Calorie Restriction
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Diabetes Mellitus, Type 2
Insulin Therapy in the Hospital Comparing Two Protocols
The purpose of this study is to determine if by using insulin analog (Glargine and lispro insulin) with an insulin pen the investigators are able to obtain a higher rate of correct timing of insulin and food administration as…
- Trial name
- NCT00841919
- Testing
- Glargine insulin, NPH insulin and regular insulin, lispro insulin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cook County Health
Obesity, Diabetes
Semaglutide 2.4 mg in Patients With Poor Weight-loss
A double-blinded, randomised, placebo-controlled trial of semaglutide 3.0 mg/ml in patients with poor weight-loss following bariatric surgery.
- Conditions
- Obesity, Diabetes, Metabolic Syndrome
- Trial name
- BARI-STEP (NCT05073835)
- Testing
- Semaglutide 3 mg
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Cardiovascular Diseases, Heart Diseases
Central Obesity and Disease Risk in Japanese Americans
To conduct a longitudinal study of central obesity and related risk factors found to be associated with hypertension and atherosclerotic cardiovascular disease (ASCVD) in a previously-examined cross-sectional cohort of…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Hypertension
- Trial name
- NCT00005365
- Sponsor
- University of Washington
Diabetes Mellitus, Type 2, Obesity
Epigenetics of Muscle Insulin Resistance
The investigators are trying to understand the role of DNA (deoxyribonucleic acid) methylation in insulin resistance in skeletal muscle and blood tissues.
- Trial name
- NCT03259984
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Obesity, Diabetes
Treatment of Morbidly Obese Adolescent With a Duodena-jejunal Liner
Obesity and its complications have a significant effect on morbidity and mortality in these subjects. Especially at risk are subjects with extremely increased BMI (above 99th percentile for age and gender in adolescents).
- Conditions
- Obesity, Diabetes, Metabolic Syndrome
- Trial name
- NCT02183935
- Testing
- Duodena-jejunal liner
- Where
- Slovenia
- Volunteers
- 22 people
- Sponsor
- University Medical Centre Ljubljana
Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus
Combined Liraglutide and Metformin Therapy in Women With Previous Gestational Diabetes Mellitus (GDM)
A diagnosis of gestational diabetes mellitus (GDM)has significant implications for the future health of the mother. GDM is often the culmination of years of unrecognized and unmodified diabetes risk factors that lead to overt and…
- Conditions
- Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus, Metabolic Syndrome, Impaired Glucose Tolerance
- Trial name
- NCT01234649
- Testing
- Metformin XR plus liraglutide
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Woman's
Diabetes Mellitus, Type 2
Exercise Training and Type 2 Diabetes
The purpose of this study is to assess whether 4-months of interval-walking exercise training improves glycemic control in individuals with type 2 diabetes mellitus.
- Trial name
- NCT01234155
- Testing
- Exercise Training - Interval Walking, Exercise - Continuous Walking
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pre-diabetes
Reducing Risk of Type 2 Diabetes: Hydroxychloroquine Use in Pre-Diabetes
The purpose of this study is to determine the short-term effects of the antimalarial medication, hydroxychloroquine (HCQ), compared with placebo using frequently sampled intravenous glucose tolerance testing (FSIGTT) methodology…
- Trial name
- NCT01326533
- Testing
- hydroxychloroquine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Diabetes Mellitus, Steroid Diabetes
Sitagliptin Prophylaxis for Glucocorticoid-Induced Impairment of Glucose Metabolism in Males With the Metabolic Syndrome
The investigators will assess whether the DPP-inhibitor sitagliptin will ameliorate glucocorticoid-induced impairment of glucose metabolism and beta-cell dysfunction and thus could be used as a prophylaxis for…
- Conditions
- Diabetes Mellitus, Steroid Diabetes, Glucocorticoid-induced Diabetes, Beta-cell Function
- Trial name
- SPHINX (NCT00721552)
- Testing
- Sitagliptin 100 mg, Prednisolone 30 mg
- Where
- Netherlands
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Asthma
Effect of Inhaled Steroids on Glucose Regulation in Asthma Patients
Inhaled steroid has been the cornerstone in the treatment of asthma, which carries a huge patient population worldwide including Hong Kong. In general, the safety of long-term use of inhaled steroid has been well documented.
- Trial name
- NCT00959348
- Where
- 4 sites in Hong Kong
- Volunteers
- 1,394 people
- Sponsor
- The University of Hong Kong
IDDM
A Pilot Study of Continuous Subcutaneous Pramlintide Infusion Therapy in Patients With Type 1 Diabetes
This research project will investigate the effects of pramlintide (Symlin) given by continuous subcutaneous (under the skin) infusion throughout the day and night, along with meal doses similar to those injected during…
- Trial name
- NCT00502138
- Testing
- Continuous Pramlintide infusion
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University Diabetes & Endocrine Consultants
Hyperostosis, Diffuse Idiopathic Skeletal, Metabolic Syndrome
Magnetic Resonance Imaging in High Risk Patients for the Development of Diffuse Idiopathic Skeletal Hyperostosis (DISH)
Diffuse idiopathic skeletal hyperostosis (DISH) is a poorly understood, systemic condition characterized by progressive calcification and ossification of ligaments and entheses.
- Conditions
- Hyperostosis, Diffuse Idiopathic Skeletal, Metabolic Syndrome, Diabetes Mellitus
- Trial name
- NCT03237455
- Testing
- Thoracic spine x-rays+whole spine MRI, blood tests, constitutional and demographic data collection
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Obesity
The Study of Inflammation on Blood Glucose Levels in Obese People
Chronic subaccute inflammation may underlie the development of diabetes cardiovascular disease and other components of the metabolic syndrome.
- Trial name
- NCT00258115
- Testing
- salsalate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Arterial Hypertension, Heart Rhythm Disorders
Screening for Cardiac and Cardiac-associated Pathology Using Single-channel Electrocardiogram
It is a prospective, controlled, single-center, observational, non-randomized study. The study is planned to include at least 4000 patients 18 years old and older in the training sample and 1000 patients over 18 years old in the…
- Conditions
- Arterial Hypertension, Heart Rhythm Disorders, Valvular Heart Diseases, Heart Failure
- Trial name
- NCT07396792
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Diabetes Mellitus, Type 2, Gestational Diabetes
Mechanisms Behind Severe Insulin Resistance During Pregnancy in Women With Glucose Metabolic Disorders (SIR-MET)
The aim of this study is to describe the metabolic changes during pregnancy in women with type 2 diabetes or gestational diabetes in order to detect the pathophysiological mechanisms behind severe insulin resistance during…
- Conditions
- Diabetes Mellitus, Type 2, Gestational Diabetes, Overweight and Obesity, Pregnancy in Diabetic
- Trial name
- NCT04924504
- Testing
- No interventions
- Where
- 2 sites in Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Insulin Resistance, Diabetes
Regulation of Endogenous Glucose Production by Brain Insulin Action
It is well known that the hormone insulin lowers blood glucose in part by acting directly on the liver and reducing hepatic glucose production.
- Trial name
- Nasal insulin (NCT02131948)
- Testing
- Intranasal insulin
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Obesity, Insulin Resistance
Endothelial Function in Young Hispanic Adults at Risk for Type 2 Diabetes
Diabetes is a major public health problem. Hispanics/Latinos are known to be at higher risk for type 2 diabetes. The function of the endothelium has played a key role in the understanding of vascular complications in people with…
- Trial name
- NCT01926938
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Schizophrenia, Prediabetic State
Home-based Intervention With Semaglutide Treatment Of Neuroleptica-Related Prediabetes
To investigate whether the Glucagon Like Peptide 1 (GLP-1) Semaglutide (1.34 mg/ml) has preventive effect compared to placebo in the development of diabetes and Metabolic Syndrome in people with pre-diabetes, overweight and…
- Trial name
- HISTORI (NCT05193578)
- Testing
- Semaglutide, 1.34 mg/mL
- Where
- Denmark
- Volunteers
- 154 people
- Sponsor
- Jan Frystyk
Type 2 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 24 Hours in Adults With Type 2 Diabetes Under Intensive Insulin Therapy
The introduction of insulin pump therapy in patients with type 2 diabetes using multiple daily injections and poorly controlled can be considered in order to improve glycemic control.
- Trial name
- NCT02490085
- Testing
- 24-hour intervention with multiple daily injections, 24-hour intervention with closed-loop strategy, Insulin
- Where
- 2 sites in Canada
- Volunteers
- 15 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
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