Clinical trials: Insulin Resistance, Diabetes
Hyperuricemia, Prediabetes
Effect of Allopurinol Treatment on Insulin Resistance
Several studies showed that hyperuricemia is an independent risk factor for development of diabetes mellitus. However none of the previous studies have investigated the effect of lowering serum uric acid levels on insulin…
- Conditions
- Hyperuricemia, Prediabetes, Insulin Resistance
- Trial name
- NCT02008968
- Testing
- allopurinol 300 mg./day, No intervention, Normouricemic
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Obesity & Overweight
The Effect of Liraglutide on Body Weight, Body Composition, Ectopic Lipid Accumulation and Insulin Sensitivity in Subjects With Overweight or Obesity Without Diabetes
The aim of the study is to evaluate the effect of a 12-week liraglutide treatment as an addition to dietary intervention in comparison to dietary intervention alone on body weight, body composition, ectopic lipid accumulation and…
- Trial name
- NCT07913685
- Testing
- liraglutide, Low-calorie diet with dietician's monitoring
- Where
- Poland
- Volunteers
- 83 people
- Sponsor
- Medical University of Bialystok
Coronary Artery Disease, Acute Coronary Syndrome
PAR Regulation of Platelet Function in Diabetic Patients
Thrombin is the most potent activator of platelets, and platelet activation is a hallmark of thrombosis. Coronary artery disease (CAD) is the major cause of mortality and morbidity in the United States and other industrialized…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Diabetes, Metabolic Syndrome
- Trial name
- NCT00855374
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Diabetes Mellitus
Effect of Fenugreek on Blood Sugar and Insulin in Diabetic Humans
The purpose of this study is to determine if bread containing fenugreek reduces blood sugar and insulin compared to identical bread without fenugreek.
- Trial name
- Fenugreek (NCT00597350)
- Testing
- Trigonella foenum-graecum (fenugreek)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Type 2 Diabetes
Pilot Trial of Chromium-Metformin Combination in Type 2 Diabetes
This pilot trial seeks to gather preliminary data on the combination of chromium picolinate, the most commonly used form of chromium, and metformin.
- Trial name
- NCT00332085
- Testing
- Chromium Picolinate
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Bastyr University
Obesity, Prediabetic State
The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity.
The study aims to investigate the effects of oral inositols on insulin-resistance and metabolic variables (triglycerides, total cholesterol, HDL cholesterol) in children aged 8-12 years with obesity and insulin-resistance.
- Conditions
- Obesity, Prediabetic State, Dyslipidemias, Insulin Resistance
- Trial name
- ONIRICO (NCT05701813)
- Testing
- INOSITOLS, CELLULOSE
- Volunteers
- 56 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Diabetes
Descriptive Analysis of Long- and Intermediate-Acting Insulin in Adult Diabetics
Over the past 40 years, new types of insulins have been marketed to mirror the effect of endogenous insulin. With the existing long-acting insulin product patents expiring and the FDA approval of new biosimilar and innovator…
- Trial name
- NCT02922179
- Testing
- Long- and intermediate- acting insulins
- Volunteers
- 103,951 people
- Sponsor
- Biologics & Biosimilars Collective Intelligence Consortium
Diabetes Mellitus, Type 2, Prediabetic State
Serum Sphingolipidomic Analyses in Healthy, Diabetic and Prediabetic Subjects
This study is designed to compare the serum sphingolipidomic analyses in healthy, pre-diabetic and diabetic subjects. age, sex and BMI are matched among these three groups.
- Trial name
- NCT02826759
- Testing
- diabetes
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Diabetes
Acute Impact of Intramuscular (IM) Aripiprazole and Olanzapine on Insulin Resistance in High Risk Prediabetics
Antipsychotic medicines used to treat mental illnesses have been associated with effects on blood sugar control. Laboratory studies have shown that certain medications in particular may alter how insulin works.
- Trial name
- NCT01411930
- Testing
- Intramuscular olanzapine, aripiprazole, Intramuscular aripiprazole, olanzapine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Veterans Medical Research Foundation
Diabetes Mellitus
Insulin Administration Skills of Nursing Students
Aim: The effects of training delivered to nursing students through the traditional method, the Six Thinking Hats method, and the video method were examined on insulin application skill.
- Trial name
- Skills (NCT06555341)
- Testing
- Experimental: Six Thinking Hats Group, Other: Video Group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Diabetes Mellitus
Pilot Study of Clinician-supported Patient Self-management of Hospital Insulin Therapy
This study will examine the feasibility of implementing a clinician-supported patient self-managed inpatient insulin intervention.
- Trial name
- NCT02144441
- Testing
- glargine and aspart
- Where
- United States
- Sponsor
- University of Pennsylvania
Vitamin D Deficiency, Obesity
Vitamin D and Adipose Tissue Inflammation
Chronic, low-grade adipose tissue inflammation is a major risk factor for type 2 diabetes mellitus. The cause of adipose tissue inflammation has remained largely unclear.
- Conditions
- Vitamin D Deficiency, Obesity, Type 2 Diabetes Mellitus, Intestinal Permeability
- Trial name
- NCT01477034
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Prostate Cancer, Metabolic Syndrome
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
The overriding objectives of this study are: 1. Primary outcomes: 1. To confirm that administration of oral acetate increases the proportion of A.
- Conditions
- Prostate Cancer, Metabolic Syndrome, Obesity, Cardiovascular Morbidity
- Trial name
- NCT05802121
- Testing
- Apple Cider Vinegar
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Western University
Diabetes Mellitus, Diabetic Foot
Identification of Biomarkers for the Study of the Diabetic Foot and Evolution.
The European Working Group on Sarcopenia in the Elderly1 defines sarcopenia as a disorder of the progressive and generalized musculoskeletal system [1], which is associated with the increase and probability of adverse outcomes…
- Conditions
- Diabetes Mellitus, Diabetic Foot, Sarcopenia, Neuropathy, Diabetic
- Trial name
- SCFOOT (NCT05783700)
- Testing
- BIOIMPEDANCEMETRY
- Volunteers
- 300 people
- Sponsor
- Esther Soler
CARDIOMETABOLIC CONDITIONS, Obesity
The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older
This is a multisite clinical trial of healthy lifestyle programs for middle-to-older-aged adults (50 -74 years) to improve their weight and, therefore, reduce risk for chronic disease.
- Conditions
- CARDIOMETABOLIC CONDITIONS, Obesity, Pre-diabetes, Metabolic Syndrome
- Trial name
- PIVOT (NCT05654142)
- Testing
- Base intervention, Augmented Intervention
- Where
- 3 sites in United States
- Volunteers
- 1,029 people
- Sponsor
- University of Illinois Chicago
Diabetes Mellitus
Effect of Anakinra on Insulin Sensitivity in Type 1 Diabetes Mellitus
The purpose of this study is to test whether anakinra is able to reduce insulin resistance. This will be tested in overweighted type I diabetes mellitus patients, which have no residual beta-cell function.
- Trial name
- NCT01285245
- Testing
- kineret
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Obesity in Diabetes, Obesity/Therapy
Semaglutide Treatment in Type 1 Diabetes
The goal of this clinical trial is to investigate the efficacy of semaglutide on body weight, insulin dose requirements and improvements in glucose control and safety aspects in regards to risk of hypoglycemia and diabetic…
- Conditions
- Obesity in Diabetes, Obesity/Therapy, Type 1 Diabetes Mellitus (T1DM), Insulin Sensitivity/Resistance
- Trial name
- OBES1TY (NCT06909006)
- Testing
- Semaglutide 2.4mg
- Where
- Denmark
- Volunteers
- 122 people
- Sponsor
- Nordsjaellands Hospital
Diabetes Mellitus
Clinical Usefulness of a Magnifier for Insulin Pen
Insulin treatment is crucial for glucose control. Many patients with type 2 diabetes exhibit inadequate glycemic control in spite of combination of oral antidiabetic drugs and eventually need insulin therapy.
- Trial name
- NCT01563419
- Testing
- Indicator magnifying window (Izumi Planning Co.)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Diabetes Mellitus, Type 2
Glycemic Evaluation of Okra Seed Noodles
In Singapore, the Ministry of Health has declared a "War on Diabetes" and major efforts will be made to develop and deploy programs to prevent diabetes.
- Trial name
- NCT03990844
- Testing
- Okra seed
- Where
- Singapore
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Type 1 Diabetes
Closed-loop Control of Postprandial Glucose Levels in Children and Adults With Type 1 Diabetes
Current intensive insulin therapy in T1D involves prandial insulin boluses depending on the carbohydrate content of each ingested meal.
- Trial name
- NCT02490098
- Testing
- 6-day intervention with sensor-augmented pump therapy, 6-day intervention with single-hormone closed-loop strategy, 6-day intervention with dual-hormone closed-loop strategy
- Where
- Canada
- Sponsor
- Institut de Recherches Cliniques de Montreal
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