Clinical trials: Insulin Resistance, Diabetes
Diabetes Mellitus, Type 2, Metabolic Syndrome
Randomized Control Trial for Overweight Employees in Worksites
Impact of lifestyle intervention in at-risk Asian Indians at worksite remains largely unexplored. The aim of this study was to assess impact of the multi-component interventions on body weight, body fat patterning and…
- Conditions
- Diabetes Mellitus, Type 2, Metabolic Syndrome, Lifestyle Risk Reduction
- Trial name
- NCT03249610
- Testing
- Lifestyle intervention
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Glucose Intolerance, Insulin Resistance
Diagnosis of Insulin Resistance: 13C-Glucose Breath Test Vs HOMA Index.
The prevalence of type 2 diabetes is rising in the population for many years. It is now recognized that a period of glucose intolerance precedes the clinical symptoms appearance.
- Conditions
- Glucose Intolerance, Insulin Resistance, Diabetes Mellitus, Type 2
- Trial name
- NCT00264940
- Sponsor
- Tel-Aviv Sourasky Medical Center
Obesity
Assessment of Changes in Abdominal Fat
In this study, we propose to determine the effect of weight loss on amount of body fat, and on body fat distribution, in severely obese patients.
- Trial name
- NCT00228579
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
Type 2 Diabetes Mellitus
Effectiveness of V-Go™ for Patients With Diabetes in a Real-world Setting
The aim of the present study is to observe glycemic control, dose requirements, hypoglycemia risk, other possible adverse effects and weight changes, as well as to compare these parameters to prior treatment when patients with…
- Trial name
- SIMPLE (NCT01326598)
- Testing
- V-Go™
- Where
- 25 sites in United States
- Volunteers
- 270 people
- Sponsor
- Valeritas, Inc.
Metabolic Syndrome
Testosterone Therapy in Men With Low Testosterone Levels and Metabolic Syndrome or Early Stages of Type 2 Diabetes
Men with metabolic syndrome often have lower than normal testosterone levels and low testosterone levels have been suggested to predispose for development of type2 diabetes.
- Trial name
- NCT00479609
- Testing
- Transdermal testosterone therapy
- Where
- Sweden
- Volunteers
- 176 people
- Sponsor
- Karolinska Institutet
Cardiovascular Diseases, Heart Diseases
Diet, Insulin Resistance, and Cardiovascular Risk
To elucidate dietary factors that elevate risk for cardiovascular disease (CVD) in conjunction with insulin resistance.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Insulin Resistance, Hyperinsulinism
- Trial name
- NCT00005530
- Sponsor
- University of South Carolina
Diabetes, Hypertension
The Effect of Dietary Nitrate on Blood Pressure, Insulin Sensitivity, and Vascular Function in Type 2 Diabetes
Dietary nitrate supplementation has previously been shown to reduce blood pressure in healthy volunteers. The investigators wished to see whether this would be replicated in subjects with type 2 diabetes and age matched healthy…
- Trial name
- NCT04076007
- Testing
- Beetroot juice, Nitrate depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Type 1 Diabetes
Assessment of the Efficacy of the Artificial Pancreas Combined With a Qualitative Meal Size Estimation to Control Postprandial Glucose Levels
Postprandial glycemic excursions are major determinants of overall glycemic control in type 1 diabetes. Carbohydrate content of ingested meals is the main determinant of post-meal glucose excursion.
- Trial name
- NCT04031599
- Testing
- Single-hormone closed-loop system, Insulin pump, Continuous glucose monitoring system
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Cardiovascular Diseases, Hypertension
Influence of Insulin on BP Change During Adolescence
To define the relation of insulin resistance during childhood and adolescence to the development of the insulin resistance syndrome in young adulthood.
- Conditions
- Cardiovascular Diseases, Hypertension, Obesity, Insulin Resistance
- Trial name
- NCT00007098
- Volunteers
- 2 people
- Sponsor
- University of Minnesota
Alzheimer's Disease, Mild Cognitive Impairment
A Pilot Clinical Trial of Exendin-4 in Alzheimer's Disease
Background: Exendin-4 (or Exenatide) is a medication currently used to treat diabetes that has shown promising results in animal and cellular models of Alzheimer's disease.
- Trial name
- NCT01255163
- Testing
- Exendin-4 SC
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Institute on Aging (NIA)
NAFLD, TYPE 2 DIABETES
Resveratrol for the Treatment of Non Alcoholic Fatty Liver Disease and Insulin Resistance in Overweight Adolescents
The current project is designed as a 30-day pilot trial to demonstrate the safety and tolerability of resveratrol therapy in overweight adolescents to decrease liver fat, and improve insulin sensitivity to prevent type 2 diabetes.
- Conditions
- NAFLD, TYPE 2 DIABETES, METABOLIC SYNDROME
- Trial name
- NCT02216552
- Testing
- Resveratrol
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Manitoba
Type 2 Diabetes
24 Hour Plasma Glucose Profiles Comparing Lispro Mix 75/25 vs. Glargine
The purpose of this study is to determine if twice-daily Lispro low mixture (75/25) will result in lower post prandial blood glucose readings versus once-daily glargine plus oral diabetic medications.
- Trial name
- NCT00551538
- Testing
- Lispro mix 75/25, Glargine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Metabolic Syndrome
Evaluating the Navajo Community Outreach and Patient Empowerment (COPE) Program
Since 2009, a programmatic community-based strategy (COPE) has been implemented to address health disparities among Navajo individuals living with multiple chronic conditions.
- Conditions
- Diabetes Mellitus, Metabolic Syndrome, Hypertension, Chronic Disease
- Trial name
- NCT03326206
- Where
- 6 sites in United States
- Volunteers
- 28,813 people
- Sponsor
- Brigham and Women's Hospital
Gestational Diabetes Mellitus
Study of Postprandial Incretin Response in Women With Gestational Diabetes
The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent…
- Trial name
- NCT01274052
- Testing
- Meal test
- Where
- Denmark
- Volunteers
- 19 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Non-Alcoholic Fatty Liver Disease, Cardiovascular Diseases
NAFLD Primary Care
Non-alcoholic fatty liver disease (NAFLD) is with 25% the most prevalent liver disorder in Western society and is associated with overweight, obesity, metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), cardiovascular…
- Conditions
- Non-Alcoholic Fatty Liver Disease, Cardiovascular Diseases, Type2 Diabetes, Metabolic Syndrome
- Trial name
- NCT04918732
- Testing
- FibroScan
- Where
- Netherlands
- Volunteers
- 1,470 people
- Sponsor
- Maastricht University
Metabolic Syndrome, Insulin Resistance
Effects of Fish Oils on Inflammation and Insulin Resistance
The purpose of this study is to determine whether improvement in fat and muscle metabolism after the treatment with Omacor (fish oils) provides insight into the link between obesity, fat and muscle function leading to metabolic…
- Trial name
- NCT00579436
- Testing
- omega-3 fatty acid
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Diabetes Mellitus, Type 2, Insulin Resistance
The Effect of a Nutritional Supplement in Individuals With Type 2 Diabetes Mellitus: a Pilot Study
Diabetes Mellitus (DM) is a major risk factor for cardiovascular disease, with 50% of diabetes-associated deaths being attributed to cardiovascular complications.
- Trial name
- NCT01505803
- Testing
- Zinc supplements, Omega 3 supplements
- Where
- Australia
- Volunteers
- 48 people
- Sponsor
- University of Sydney
Diabetes Mellitus, Type 2
Efficacy of DLBS-32 in Subjects With Type-II Diabetes Mellitus
The purpose of this study is to investigate clinical efficacy and safety of DLBS 32 in the management of subjects with type-II-diabetes mellitus and to determine the minimal effective dose of DLBS 32 for subjects with…
- Trial name
- NCT01005069
- Testing
- DLBS-32
- Where
- 2 sites in Indonesia
- Volunteers
- 72 people
- Sponsor
- Dexa Medica Group
Diabetes, Prediabetes
Meta-analyses of the Effect of Tree Nuts on Glycemic Control and Features of the Metabolic Syndrome
Tree nuts (almonds, Brazil nuts, cashews, hazelnuts, macadamia nuts, pecans, pine nuts, pistachios and walnuts) are an important source of unsaturated fatty acids, vegetable protein, and fibre, as well as minerals, vitamins, and…
- Conditions
- Diabetes, Prediabetes, Dysglycemia, Overweight
- Trial name
- NCT01630980
- Testing
- Tree nuts
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Chronic Kidney Diseases, Diabetes Mellitus
Automated Insulin Delivery in Adults With Advanced Kidney Disease
Diabetes is the leading cause of kidney failure in the UK. Many people with diabetes and advanced kidney failure inject themselves with insulin and do finger-prick blood glucose tests.
- Trial name
- AIDkidney (NCT06463483)
- Testing
- Medtronic 780G System, Continuous Glucose Monitoring
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Imperial College London
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