Clinical trials: Insulin Resistance, Diabetes
Hypogonadism, Male, Diabetes Mellitus, Type 2
Study on Effects of Testosterone Replacement Therapy in Hypogonadal Type 2 Diabetic Patients" (SETH2)
Aim of the study was to investigate the effects of testosterone replacement therapy on components of metabolic syndrome, vascular function and morphology, grade of non-alcoholic fatty liver disease (NAFLD), bone mineral density…
- Conditions
- Hypogonadism, Male, Diabetes Mellitus, Type 2, Obesity
- Trial name
- SETH2 (NCT03792321)
- Testing
- Testosterone Undecanoate
- Volunteers
- 55 people
- Sponsor
- University Medical Centre Ljubljana
Gestational Diabetes Mellitus in Pregnancy, Vitamin D Deficiency
Effects of Vitamin D Supplementation on Glucose Metabolism in Women With Former Gestational Diabetes Mellitus
Gestational Diabetes Mellitus (GDM) and vitamin D deficiency are related to insulin resistance and impaired beta-cell function, with heightened risk for future development of diabetes.
- Trial name
- NCT01992133
- Testing
- Vitamin D3
- Where
- Malaysia
- Volunteers
- 26 people
- Sponsor
- RCSI & UCD Malaysia Campus
Prostate Cancer
Lifestyle Intervention to Improve Insulin Sensitivity and Markers of Cardiovascular Risk in Prostate Cancer Survivors
The purpose of this study is to discover if intensive lifestyle changes (such as diet and increased physical activity) improve the body's sensitivity to insulin, and therefore help prevent diabetes and other cardiovascular…
- Trial name
- NCT00738140
- Testing
- Diabetes Prevention Program
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus
Effect of Adiponectin Genetic Polymorphism on Rosiglitazone Response
The aims of the present study were to investigate the association between adiponectin gene polymorphisms and the response to rosiglitazone monotherapy in T2D patients.
- Trial name
- NCT00501488
- Testing
- rosiglitazone
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Central South University
Insulin Sensitivity, Type 2 Diabetes
Exercise and Diet in Type 2 Diabetic Women
The purpose of this study was to evaluate the effects of 12 weeks' increased daily physical activity versus diet restriction on regional fat distribution, insulin sensitivity and adipokines including retinol binding protein-4…
- Trial name
- NCT00763074
- Testing
- Standard life style modification for type 2 diabetes, Diet restriction, Exercise
- Volunteers
- 70 people
- Sponsor
- Eulji University Hospital
Diabetes Mellitus, Type 2
Evaluation of the Impact of Intensive Short-Term Drug Therapy in Patients With Type 2 Diabetes Mellitus
This phase IV study is a prospective open-label multi-center study to investigate the effect of a temporary individualized poly-pharmaceutical De-escalation treatment with the target to regenerate ß-cell function over 12 weeks on…
- Trial name
- NCT04027023
- Testing
- Diabetes mellitus Type 2 De-escalation treatment (DET)
- Where
- 2 sites in United States, Germany
- Volunteers
- 9 people
- Sponsor
- Sciema UG
Prediabetic State, Cardiovascular Diseases
Role of Aging and Individual Variation in Exercise Training Responsiveness
The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15…
- Conditions
- Prediabetic State, Cardiovascular Diseases, Insulin Resistance, Obesity
- Trial name
- STRRIDE IV (NCT06471569)
- Testing
- Low/Mod, High/Mod, High/Vig
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Duke University
Type 2 Diabetes Mellitus (T2DM)
Phase III Trial of SGLT2 Inhibitor and Thiazolidinedione Fixed-Dose Combination vs. Monotherapy in Type 2 Diabetes Patients on Metformin
This clinical trial is studying whether combining two commonly used diabetes medications into a single pill works better than taking them separately for people with type 2 diabetes who are already on metformin.
- Trial name
- CONTROL (NCT07057479)
- Testing
- Fixed-dose combination of SGLT2 inhibitor and thiazolidinedione, Control Group 1 Intervention - SGLT2 inhibitor monotherapy, Control Group 2 Intervention - Thiazolidinedione monotherapy
- Where
- Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Chronic Heart Failure, Coronary Artery Disease
The Influence of Metformin on Chronic Heart Failure Clinical Course in Patients With Prediabetes
It is well known fact, that prediabetes is a predictor of high cardiovascular mortality, increasing the risk of developing such adverse cardiovascular events as myocardial infarction, stroke and sudden cardiac death.
- Conditions
- Chronic Heart Failure, Coronary Artery Disease, PreDiabetes
- Trial name
- NCT04549415
- Testing
- Metformin Hydrochloride, lifestyle modification
- Where
- Kyrgyzstan
- Volunteers
- 97 people
- Sponsor
- National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Obesity, Body Weight
Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans
This study, at the Western Human Nutrition Research Center (WHNRC), will focus on whether or not achieving and maintaining a healthy body weight is the most important health promoting recommendation of the Dietary Guidelines for…
- Trial name
- DGA4ME (NCT04293224)
- Testing
- DGA Mediterranean diet pattern, energy balance, DGA Mediterranean diet pattern, negative energy balance, TAD diet pattern, negative energy balance
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Diabetes Mellitus Type 2
A Study in Type 2 Diabetes Patients Who Are Taking Moderate Dose Insulin, Looking at the Effects of the Medication Luseogliflozin on Risk of Ketoacidosis and Insulin Resistance.
The goal of this clinical trial is to learn if the drug Luseogliflozin works to treat people with diabetes who are taking moderate dose insulin treatment. It will also learn about the safety of the drug Luseogliflozin.
- Trial name
- LUSIRES (NCT07876258)
- Testing
- Luseogliflozin
- Where
- Malaysia
- Volunteers
- 40 people
- Sponsor
- Aimi Fadilah Mohamad
Gestational Diabetes Mellitus, Pregnancy, High Risk
Continuous Glucose Monitoring (CGM) Substudy of the DECIDE RCT
This is a nested multicenter prospective cohort conducted concurrently and in conjunction with the DECIDE two-arm, pragmatic non-inferiority comparative effectiveness Randomized Controlled Trial (RCT) (NCT06445946) of metformin…
- Trial name
- DECIDE CGM (NCT06490874)
- Testing
- CGM device - Metformin group, CGM device - Insulin group
- Where
- 4 sites in United States
- Sponsor
- Ohio State University
Obesity & Overweight
The Effect of Liraglutide on Body Weight, Body Composition, Ectopic Lipid Accumulation and Insulin Sensitivity in Subjects With Overweight or Obesity Without Diabetes
The aim of the study is to evaluate the effect of a 12-week liraglutide treatment as an addition to dietary intervention in comparison to dietary intervention alone on body weight, body composition, ectopic lipid accumulation and…
- Trial name
- NCT07913685
- Testing
- liraglutide, Low-calorie diet with dietician's monitoring
- Where
- Poland
- Volunteers
- 83 people
- Sponsor
- Medical University of Bialystok
Metabolic Syndrome, Diabetes
Post-prandial Glycaemic Controlling Effects of BSG in Singapore Adults With Metabolic Syndrome
The purpose of this study is to assess the glycaemic controlling effects of BSG and bio-transformed BSG-containing biscuits in Singapore adults with MetS.
- Conditions
- Metabolic Syndrome, Diabetes, Diet Modification
- Trial name
- NCT05421780
- Testing
- autoclaved BSG-containing biscuits, bio-transformed BSG-containing biscuits, control biscuits
- Where
- Singapore
- Volunteers
- 16 people
- Sponsor
- National University of Singapore
Obesity & Overweight, Type 2 Diabetes Mellitus (T2DM)
MRI Assessment of Pancreatic Fat Changes and Islet Function Recovery After Bariatric Surgery in Obese Patients
This study evaluates changes in pancreatic fat and recovery of pancreatic function in obese patients undergoing laparoscopic sleeve gastrectomy (LSG), a weight-loss surgery.
- Conditions
- Obesity & Overweight, Type 2 Diabetes Mellitus (T2DM), Pancreatic Steatosis, Insulin Resistance
- Trial name
- PANFAT-BS (NCT07464223)
- Testing
- Laparoscopic Sleeve Gastrectomy (LSG)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- yu li，MD
Diabetes Mellitus Type 1
A Multicenter Study of Outpatient Automated Blood Glucose Control With a Bihormonal Bionic Pancreas
This study will test the hypothesis that a wearable bionic pancreas system that automatically delivers insulin and glucagon can provide superior regulation of glycemia versus usual care for adults with type 1 diabetes.
- Trial name
- NCT02092220
- Testing
- Bionic Pancreas, Insulin pump with or without CGM
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type 2
Screening for Undiagnosed Type 2 Diabetes in New Classes of Subjects at High Risk
The study aims to evaluate IFG, IGT or unknown type 2 diabetes mellitus in new classes at high risk to develop alterations of glucose metabolism and definition of new pathogenic mechanisms of insulin resistance and…
- Trial name
- NCT00520962
- Where
- Italy
- Volunteers
- 1,997 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Cardiovascular Diseases, Diabetes
The Cork and Kerry Diabetes and Heart Disease Study (Phase II) Mitchelstown Cohort
The aim of the Cork and Kerry Study Phase II (Mitchelstown cohort recruited 2010-11) is to provide an updated profile of glucose tolerance status, cardiovascular health and their related factors in an Irish adult general…
- Conditions
- Cardiovascular Diseases, Diabetes, Obesity, Hypertension
- Trial name
- Mitchelstown (NCT03191227)
- Volunteers
- 2,047 people, healthy volunteers welcome
- Sponsor
- University College Cork
Diabetic Ketoacidosis, Insulin
Relapse Among Diabetic Ketoacidosis Patients Maintained Basal Bolus Insulin Administration in Combination With Continuous Intravenous Insulin Infusion VS Non Maintaining Basal Insulin Patients
This study aimed to assess intensive care unit stay and relapse among patients of Diabetic ketoacidosis (type 1 diabetes mellitus) maintained basal bolus insulin and patients non maintaining along with intervenors insulin…
- Conditions
- Diabetic Ketoacidosis, Insulin, Intensive Care Unit Stay
- Trial name
- NCT07423559
- Testing
- insulin infusion without basal insulin, insulin infusion with basal insulin, Insulin infusion with basal insulin and bolus
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia
Pilot Study Evaluating Safety of ExOlin® in Patients With Poorly Controlled Type 1 Diabetes
First in Human, pilot investigation An Open Label, Monocentric, Pilot Study Evaluating Safety of ExOlin® in Patients with Poorly Controlled Type 1 Diabetes with High Glucose Fluctuations, Prone to Severe Hypoglycemia
- Trial name
- Pilot'Ex (NCT05221359)
- Testing
- ExOlin®, Insulin aspart
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Defymed
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