Clinical trials: Insulin Resistance, Diabetes
Type 2 Diabetes
24 Hour Plasma Glucose Profiles Comparing Lispro Mix 75/25 vs. Glargine
The purpose of this study is to determine if twice-daily Lispro low mixture (75/25) will result in lower post prandial blood glucose readings versus once-daily glargine plus oral diabetic medications.
- Trial name
- NCT00551538
- Testing
- Lispro mix 75/25, Glargine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Eli Lilly and Company
Metabolic Syndrome, PreDiabetes
Lean Beef Consumption and Insulin Sensitivity in Men and Women With Risk Factors for Diabetes
The objective of this trial is to compare the effects of a healthy, lean beef diet and an average American, United States Department of Agriculture (USDA) style diet, that is low in saturated fatty acids (SFA), on insulin…
- Trial name
- NCT03202680
- Testing
- USDA Style Diet, Lean Beef Diet
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Insulin Sensitivity, Type2 Diabetes
Dairy Products, Diabetes and Genetics
This study will investigate the in-depth the benefits of dairy consumption on glucose metabolism in patients at risk of type 2 diabetes using novel genomics methodology.To do so, 33 individuals at risk of type 2 diabetes will be…
- Trial name
- PRODIGE (NCT02961179)
- Testing
- Increased dairy product, Dietary counselling
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- CHU de Quebec-Universite Laval
Hyperglycemia, Diabetes
Basal Bolus Versus Human Insulin in Hospitalized Patients With Diabetes in Paraguay
Few randomized studies have focused on the optimal management of non-ICU patients with type 2 diabetes in Latin America. Objective: Compare safety and efficacy of a basal bolus regimen with analogs and human insulins in general…
- Trial name
- NCT02278913
- Testing
- Basal Bolus (Glargine and Glulisine), Human Insulin
- Where
- Paraguay
- Volunteers
- 134 people
- Sponsor
- Universidad Nacional de Asunción
Type 1 Diabetes
Outpatient Automated Blood Glucose Control With a Bi-hormonal Bionic Endocrine Pancreas
This study will test the hypothesis that a wearable automated bionic pancreas system that automatically delivers both insulin and glucagon can improved glycemic control vs. usual in the outpatient environment.
- Trial name
- NCT01762059
- Testing
- Bi-homonal Bionic Pancreas, Usual care
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes Mellitus
An Open Label, Multi-Center, Randomized, Parallel Group Study Comparing the Efficacy and Safety of Insulin VIAject™ and Regular Human Insulin in Patients With Type 1 Diabetes Mellitus
The purpose of this study is to demonstrate equivalent blood glucose control in patients with type 1 diabetes mellitus with insulin VIAject™ and regular human insulin as prandial insulin and to demonstrate an equivalent safety…
- Trial name
- NCT00542724
- Testing
- VIAject™, Regular Human Insulin
- Volunteers
- 462 people
- Sponsor
- Biodel
Obesity, Diabetes Mellitus
The Bialystok Bariatric Surgery Study
The Bialystok Bariatric Surgery Study (BBSS) is a prospective observational cohort study of patients undergoing bariatric surgery at the First Clinical Department of General and Endocrine Surgery at the Medical University of…
- Conditions
- Obesity, Diabetes Mellitus, Metabolic Syndrome, Dyslipidemias
- Trial name
- BBSS (NCT04634591)
- Testing
- Bariatric surgery
- Where
- Poland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Diabete Mellitus, MASLD
RESET-INSPIRE Study: Insulin Sensitivity & Population Intervention With Real-time Evaluation Using CGM
The RESET-INSPIRE study is designed to investigate individual variability in glucose response and insulin sensitivity, a key mechanism underlying metabolic-associated steatotic liver disease (MASLD) and cardiometabolic disorders.
- Trial name
- RESET-INSPIRE (NCT07861191)
- Where
- Singapore
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National University Health System, Singapore
Type 2 Diabetes
Evaluating the Effects of a Study Medication on Exercise Function in Type 2 Diabetes
People who are overweight or who have type 2 diabetes mellitus (T2DM) have higher levels of certain fats in their blood. The blood vessels and heart of most of these individuals do not work normally and people with T2DM also have…
- Trial name
- AcT2 (NCT01580813)
- Testing
- Acipimox
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes Mellitus, Insulin Resistance
Effects of Six Months of Moderate Resistance- Versus Endurance-Training on Muscle ATP Synthesis in First-Degree Relatives of Patients With Type 2 Diabetes
Life style intervention including diet and exercise is the recommended strategy for prevention of type 2 diabetes mellitus (T2DM).
- Trial name
- RECO2 (NCT01145092)
- Testing
- exercise training, endurance training
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Landsteiner Institut
Type 1 Diabetes, Type 2 Diabetes Treated With Insulin
Inpatient Closed Loop Glucose Control With the Gen 2 GlucoSTAT
The goal of this study is to perform a first-in-humans trial of a fully integrated, automated, closed-loop blood glucose control system designed for inpatient use.
- Trial name
- NCT04227626
- Testing
- GlucoSTAT
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Gestational Diabetes Mellitus
Fibroblast Growth Factors 19 and 21 in Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) is the most common complication in pregnancy. Both mother and offspring have a significantly increased future risk for metabolic and cardiovascular disease as a consequence of GDM.
- Trial name
- NCT01858597
- Testing
- biachemical detection
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hepatocellular Carcinoma, Type 2 Diabetes
Role of LncRNA H19 in The Regulation of IGF-1R Expression
Hepatocellular carcinoma (HCC) is a common cancer that poses a heavy economic burden on the healthcare system. In Egypt, it is the most common cause of mortality and morbidity-related cancer.
- Conditions
- Hepatocellular Carcinoma, Type 2 Diabetes, Cancer
- Trial name
- NCT04767750
- Testing
- Blood sample collection
- Where
- 2 sites in Egypt
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Insulin Sensitivity
Association Between Vitamin D and Inflammation and Diabetes Risk in Morbidly Obese Pre-Menopausal Women
Obesity is associated with low-grade inflammation, insulin resistance and low vitamin D status. Vitamin D has traditionally been known to involve in calcium homeostasis and prevent rickets; however, recently it has been…
- Trial name
- VitD2014 (NCT02169050)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Illinois Chicago
Diabetes Mellitus
Advancing Insulin Prescribing in General Practice
Family Physicians, the subjects of this trial are reluctant to initiate insulin in patients with type 2 diabetes due to a lack of familiarity and comfort with this clinical strategy.
- Trial name
- AIM@GP (NCT00593489)
- Testing
- Basal Insulin Initiation Strategy
- Where
- Canada
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Diabetes Mellitus, Endocrine System Diseases
Soluble Epoxide Hydrolase Inhibition and Insulin Resistance
The purpose of this study is to test how soluble epoxide hydrolase (sEH) inhibition with GSK2256294 affects tissue sEH activity and insulin sensitivity.
- Conditions
- Diabetes Mellitus, Endocrine System Diseases, Glucose Metabolism Disorders, PreDiabetes
- Trial name
- NCT03486223
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus Type 2 in Obese, Obesity
Epigenetics and the Origin of Muscle Insulin Resistance in Humans
The investigators are trying to understand the role of DNA (deoxyribonucleic acid) methylation in insulin resistance in skeletal muscle and blood tissues.
- Trial name
- NCT01726491
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Type 2 Diabetes
Sitagliptin in the Elderly
Diabetes is common in the elderly; by the age of 70, approximately 25% of the population will have diabetes. Unfortunately, currently available medications are often not as effective or not well tolerated in older adults.
- Trial name
- NCT00451113
- Testing
- Sitagliptin 100 mg
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of British Columbia
Metabolism, Insulin Resistance
The Effect of Pharmacological Antilipolysis on the Metabolic Effects of Ghrelin
This study will investigate the non-growth-hormone-dependent metabolic effects of the hormone Ghrelin in growth hormone deficient subjects by examining the insulin tolerance as well as signal proteins in fat and muscle biopsies.
- Conditions
- Metabolism, Insulin Resistance, Hypopituitarism
- Trial name
- NCT01209416
- Testing
- Acipimox, Ghrelin
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- University of Aarhus
Spinal Cord Injuries, Insulin Resistance
Once Weekly GLP-1 in Persons With Spinal Cord Injury
Chronic spinal cord injury (SCI) results in adverse soft tissue body composition changes and an extremely sedentary lifestyle. These abrupt changes often lead to a high prevalence of cardiometabolic diseases, such as impaired…
- Conditions
- Spinal Cord Injuries, Insulin Resistance, Pre Diabetes, Obesity
- Trial name
- NCT03292315
- Testing
- Semaglutide 1MG Injection [Ozempic], No Intervention
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
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