Clinical trials: Insulin Resistance, Diabetes
Type 2 Diabetes Mellitus (T2DM), Obesity (Disorder)
Digital Dietary Intervention for Patients Receiving GLP-1 Receptor Agonist Therapy
The goal of this clinical trial is to learn whether adding the NutriSteppe digital dietary intervention to routine medical care improves metabolic health in adults aged 21 to 65 years with type 2 diabetes mellitus, obesity, or…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Obesity (Disorder), Overweight, Metabolic Syndrome
- Trial name
- NutriSteppe (NCT07728669)
- Testing
- NutriSteppe Digital Dietary Intervention
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- Kazakh Academy of Nutrition
Coronary Artery Disease, Non-significant Coronary Artery Disease
TweeSteden Mild Stenosis Study
Psychosocial factors have been found to be associated with an increased risk for coronary artery disease incidence, progression and worse clinical outcomes.
- Conditions
- Coronary Artery Disease, Non-significant Coronary Artery Disease, Mild Stenosis, Vascular Irregularities
- Trial name
- TWIST (NCT01788241)
- Where
- Netherlands
- Volunteers
- 547 people
- Sponsor
- Tilburg University
Obesity, Diabetes Mellitus, Type 2
The Potential of Dapagliflozin Plus Exenatide in Obese Insulin-resistant Patients
This is a 28-week, multi-center, randomized, double-blind, placebo-controlled trial to study a potential synergistic effect of Dapagliflozin plus Exenatide once-weekly in combination with high-dose intensive insulin therapy…
- Trial name
- NCT03419624
- Testing
- Dapagliflozin 10mg, Exenatide 2 mg [Bydureon], Insulin
- Where
- 4 sites in Germany
- Volunteers
- 13 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
PreDiabetes, Insulin Resistance
Brown Seaweed Extract on Glycemic Control and Body Weight
The overall goal of this study is to investigate the effects of a daily dietary supplement of brown seaweed (2 capsules of InSea2®) on body weight, glycemic control and insulin secretion in overweight prediabetic men and women in…
- Trial name
- Algues (NCT03075943)
- Testing
- InSea2
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Laval University
Insulin Resistance, Diabetes Mellitus
Thyroid Hormone to Induce Non-Insulin Mediated Glucose Disposal in People With Insulin Receptor Mutations
Background: Insulin receptor mutation causes high blood sugars and sometimes diabetes complications. Researchers want to see if thyroid hormone helps.
- Conditions
- Insulin Resistance, Diabetes Mellitus, Abnormal Glucose Metabolism
- Trial name
- NCT02457897
- Testing
- Liothyronine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type 2, Insulin Resistance
Circadian Misalignment and Insulin Sensitivity
This study will evaluate the effect of circadian misalignment on insulin sensitivity in healthy lean subjects in a randomized cross-over design.
- Trial name
- NCT02580513
- Testing
- Circadian Misalignment
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Type 2
Investigation for Health Efficacy of Infrared-C Radiation on Diabetes Patients in Senior's Activity Center
Hyperglycemia caused by diabetes will bring us the long-term damage，it causes glycation. The combination of sugar molecules and protein molecules will transform to advanced glycation end products (AGEs) and produce a lot of free…
- Trial name
- NCT04177420
- Testing
- FIR-C mattress, FIR-C abdominal pad, fake FIR-C mattress
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- Nanhua University
Obesity, Type II Diabetes Mellitus
Yellow Pea Fractions and Short-term Food Intake, Subjective Appetite and Glycemic Response
It is hypothesized that yellow pea protein and fiber will reduce short-term food intake, subjective appetite and glycemic response.
- Conditions
- Obesity, Type II Diabetes Mellitus, Metabolic Syndrome
- Trial name
- NCT01242059
- Testing
- yellow pea protein, yellow pea fiber, Control
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Metabolic Syndrome, Pre-diabetes
Effect of Pasteurized Akkermansia Muciniphila on Insulin Resistance in Otherwise Healthy Subjects With Dysglycaemia
The purpose of this study is to demonstrate the efficacy of pasteurized Akkermansia muciniphila (pAKK) in improving insulin sensitivity in hyperglycaemic, but otherwise healthy persons with metabolic syndrome.
- Conditions
- Metabolic Syndrome, Pre-diabetes, Overweight and Obesity
- Trial name
- NCT05114018
- Testing
- Pasteurized A. muciniphila
- Where
- 2 sites in Germany, Ireland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- A-Mansia Biotech S.A.
Diabetes Prevention, Obesity Prevention
The Effect of Whey Protein and Its Hydrolysate on Pre- and Post-Fixed Meal Glycemia and Insulin in Young Adults
The purpose of this study is to describe relationships among whey protein and its hydrolysate when consumed before a meal on pre- and post-fixed meal satiety, blood glucose and insulin in healthy young adults.
- Trial name
- NCT00988182
- Testing
- dietary intervention, water control
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes Mellitus, Type 1, Type 1 Diabetes
Human Versus Analogue Insulin for Youth With Type 1 Diabetes in Low-Resource Settings
The primary objective of this trial is to determine whether insulin glargine reduces the risk of serious hypoglycemia or improves Time in Range at 6 months when compared against standard of care human insulin (e.g.
- Trial name
- HumAn-1 (NCT05614089)
- Testing
- Insulin Glargine, NPH or premixed 70/30 (human insulin)
- Where
- 3 sites in Bangladesh, Tanzania
- Volunteers
- 400 people
- Sponsor
- Jing Luo
Obesity, Overweight
The Food Intake, Satiety and Blood Glucose After Ingestion of Potato Chips Produced From Three Potato Cultivars
Potato is one of the world's most popular foods and is widely accepted as a staple food. The objective of this study is to determine the effect of consuming potato chips from different cultivars on blood glucose, subjective…
- Conditions
- Obesity, Overweight, Diabetes, Metabolic Syndrome
- Trial name
- NCT02014220
- Testing
- dietary treatment
- Where
- Canada
- Sponsor
- University of Toronto
Type 2 Diabetes Treated With Insulin
Characteristics of Type 2 Diabetes Patients, Treated With Insulin and Their Follow up Care in Guadeloupe
Type 2 diabetes is a major problem of public health in the French West Indies, with an estimated prevalence of 8%, twice more than in France.
- Trial name
- DT2IT (NCT03362762)
- Testing
- Description of plans insuliniques used in Guadeloupe in the type 2 diabetes and the characteristics of the handled patients:
- Where
- Guadeloupe
- Volunteers
- 205 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Diabetes Mellitus, Cardiac Event
Intraoperative Insulin Administration at Cardiac Surgery for Diabetic Patients
The primary objective of the study was to explore which insulin-based regimen is better, infusion or bolus regimen, for intraoperative management of glucose level for the diabetic patient at cardiac surgery.
- Trial name
- NCT04824586
- Testing
- Fast-acting human insulin
- Where
- Jordan
- Volunteers
- 70 people
- Sponsor
- The Hashemite University
Diabetes Mellitus, Type 2
A Clinical Trial Comparing the Efficacy and Safety of Exubera® and Lantus®
To compare efficacy and safety of Exubera® vs Lantus® in patients with type 2 diabetes mellitus.
- Trial name
- NCT00391027
- Testing
- Insulin Glargine (Lantus®), Inhaled Human Insulin (Exubera®)
- Where
- 62 sites in Belgium, Finland and 8 more
- Volunteers
- 261 people
- Sponsor
- Pfizer
Type 2 Diabetes
Investigating the Insulin Resistance in Individuals With Type 2 Diabetes
Numerous studies have provided evidence of a correlation between Type 2 Diabetes Mellitus (T2DM) and cognitive dysfunction, specifically in the realms of complex attention, information processing, and executive function.
- Trial name
- NCT06428968
- Testing
- 160 units nasal insulin spray
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central South University
Cardiovascular Disease
Effect of Pulse Fractions on Indices on Cardiovascular Disease and Diabetes Risk Factors
The purpose of this study is to determine if whole and fractionated yellow pea flour, administered at USDA recommended dosages (50 g/day), improve risk factors associated with cardiovascular disease and diabetes.
- Trial name
- NCT00839774
- Testing
- Whole yellow pea flour, Fractionated pea flour, White wheat flour
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- University of Manitoba
Type 1 Diabetes
Safety of Overestimation of a Meal Insulin Bolus in the Context of Dual-hormone Closed-loop Operation - Part 2
In previous studies, investigators have studied if a pre-meal insulin bolus based on estimated carbohydrate meal size would alleviate the burden of carbohydrate counting without a significant degradation in postprandial glucose…
- Trial name
- NCT02798250
- Testing
- Dual-hormone closed-loop, Insulin, Glucagon
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Inflammation, Obesity and Type 2 Diabetes
Inflammation's Impact on Heart Disease and Diabetes
The goal of this observational study is to evaluate the inflammatory response associated with cardiometabolic diseases, and whether these can be reduced by ex vivo treatment with therapeutic agents.
- Conditions
- Inflammation, Obesity and Type 2 Diabetes, Obesity, Metabolic Syndrome
- Trial name
- INFO (NCT06752018)
- Testing
- Gastric bypass
- Where
- Denmark
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cardiovascular Diseases, Coronary Disease
Genetics of the Metabolic Syndrome in Japanese Americans
To investigate the genetic influence of candidate gene polymorphisms on risk factors for the metabolic insulin resistance syndrome in Japanese American sibships and kindreds.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Insulin Resistance
- Trial name
- NCT00005374
- Sponsor
- University of Washington
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