Clinical trials: Insulin Resistance, Diabetes
Diabetes, Obesity
A Study to Evaluate the Effect of Lipid Infusion on Toll Like Receptor 4 (TLR4) Signaling
The purpose of this study is to determine whether a lipid infusion can up-regulate toll-like receptor 4 (TLR4) signaling in human subjects
- Trial name
- NCT01740817
- Testing
- Intralipid 20%, Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Insulin Resistance, Insulin Resistance and Type 2 Diabetes
The Muscle Monitor: Early Skeletal Muscle Indicators of Insulin Resistance and Cardiometabolic Risk
Insulin resistance is an early etiological factor in the development of type-2 diabetes (T2D), which constitutes a large societal health burden with an expected additional rise in the years to come.
- Conditions
- Insulin Resistance, Insulin Resistance and Type 2 Diabetes, Cardiometabolic Risk Factors, Physical Activity
- Trial name
- MUSCLE MONITOR (NCT07678736)
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- University Ghent
Type 2 Diabetes
How Glargine Insulin, Oral Diabetes Medications and Exenatide May Improve Blood Sugar Control and Weight Gain in Type 2 Diabetics
This study is designed to look at how using glargine insulin with oral diabetes medications and exenatide may improve control of blood sugar levels and weight gain in type 2 diabetics. The main study will last 32 weeks.
- Trial name
- MEXELIN (NCT00667732)
- Testing
- exenatide
- Where
- 3 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Prediabetes, Insulin Resistance
The Metabolic Effects of Almond Consumption in Adults With Pre-Diabetes
Study Hypothesis: Daily consumption of almonds over 16 weeks will produce a decrease in hemoglobin A1c (HbA1c) levels in adults with pre-diabetes.
- Conditions
- Prediabetes, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT00270985
- Testing
- Almonds in a calorie controlled diet, Nut free diet
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Obesity Adult Onset, Diabetes Mellitus Type 2
Effect of Citrus Flavonoids on Obesity.
The aim of this study is to evaluate whether the intake of a functional juice enriched in citrus polymethoxylated flavonoids is able to improve the glycaemic profile and insulin resistance of obese patients by reversing the…
- Trial name
- NCT06680635
- Testing
- Flavonoid-enriched juice and a low-calorie diet
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Celia Bañuls
Obesity, Obesity, Abdominal
Probiotic Lysate (Postbiotic and Metabiotic) Supplementation for Type 2 Diabetes Patients (DELI_Diab Study)
The current study aim was to conduct placebo-controlled randomize clinical trial to assess the short-term efficacy and safety of postbiotics as an adjunction to the standard anti-diabetic therapy on insulin resistance, glycemic…
- Conditions
- Obesity, Obesity, Abdominal, Insulin Resistance, Insulin Sensitivity
- Trial name
- NCT05770076
- Testing
- Probiotic lysate (postbiotic and metabiotic)
- Where
- 4 sites in Ukraine
- Volunteers
- 55 people
- Sponsor
- Bogomolets National Medical University
Hypoglycemia
Glucagon in the Treatment of Hypoglycemia in Newborn Infants of Diabetic Mothers
Thesis Infants of diabetic mothers are at high risk to develop hypoglycemia after birth. After birth, glucose and ketone bodies are the main substrates of brain energy.
- Trial name
- NCT00434772
- Testing
- glucagon
- Where
- Israel
- Sponsor
- Shaare Zedek Medical Center
Obesity, PreDiabetes
Network Meta-analysis of Intermittent Fasting and Cardiometabolic Risk
Intermittent fasting is a method of restricting calories over a defined period of time and includes regimens such as whole-day fasting, alternate-day fasting, and time-restricted feeding.
- Conditions
- Obesity, PreDiabetes, Diabetes, Hypertension
- Trial name
- NCT05309057
- Testing
- Intermittent Fasting
- Where
- 2 sites in Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes Mellitus
Clinical Usefulness of a Magnifier for Insulin Pen
Insulin treatment is crucial for glucose control. Many patients with type 2 diabetes exhibit inadequate glycemic control in spite of combination of oral antidiabetic drugs and eventually need insulin therapy.
- Trial name
- NCT01563419
- Testing
- Indicator magnifying window (Izumi Planning Co.)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Non-Alcoholic Fatty Liver Disease, Cardiovascular Diseases
NAFLD Primary Care
Non-alcoholic fatty liver disease (NAFLD) is with 25% the most prevalent liver disorder in Western society and is associated with overweight, obesity, metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), cardiovascular…
- Conditions
- Non-Alcoholic Fatty Liver Disease, Cardiovascular Diseases, Type2 Diabetes, Metabolic Syndrome
- Trial name
- NCT04918732
- Testing
- FibroScan
- Where
- Netherlands
- Volunteers
- 1,470 people
- Sponsor
- Maastricht University
MAFLD in Prediabetes and Diabetes
Effect of SGLT2 Inhibitor on Metabolic-Dysfunction-Associated Fatty Liver Disease in Patients With Insulin Resistance
Metabolic-dysfunction-associated fatty liver disease (MAFLD) has evolved as a major health problem recently. Discovering ways to prevent or delay the progression of MAFLD has become a global focus.
- Trial name
- SGLT2 (NCT07891234)
- Testing
- Dapagliflozin 5Mg Tab, Metfomin 500 mg, Dapagliflozin (10mg Tab)
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Sherihan AboElyazed Mohamed Khalil
Diabetes Mellitus, Type 2
Effect Of Rosiglitazone On Carotid Intima Media Thickness In Patients With Insulin Resistance Syndrome And/Or Type 2 Diabetes
The study investigated the effect of rosiglitazone and placebo on carotid intima media thickness in patients with insulin resistance syndrome and/or type 2 diabetes.
- Trial name
- NCT00306644
- Testing
- Rosiglitazone
- Where
- Sweden
- Volunteers
- 556 people
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Type 2, Insulin Resistance
Low Dose Fat-Induced Insulin Resistance
The primary goal of this study is to determine the dose of fatty acids that acutely induces mild insulin resistance in healthy volunteers.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Insulin Sensitivity
- Trial name
- BCAA (NCT03479671)
- Testing
- Intralipid, 20% Intravenous Emulsion
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Type 2 Diabetes, Overweight and Obesity
Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and…
- Trial name
- REACH (NCT04791371)
- Testing
- Cardiovascular exercise
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 2, Glucose, High Blood
Use of Functional MRI to Assess Functional Hypothalamic Activation in Response to Diazoxide
The goal of this study is to determine whether metabolic control centers in the brain can be activated in patients with type 2 diabetes (T2D) as compared to non-diabetic individuals.
- Conditions
- Diabetes Mellitus, Type 2, Glucose, High Blood, Glucose Metabolism Disorders (Including Diabetes Mellitus)
- Trial name
- NCT03566511
- Testing
- Diazoxide
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Meredith Hawkins
Vitamin D Deficiency, Insulin Resistance
Vitamin D, Insulin Resistance, and Cardiovascular Disease
In recent years, vitamin D has been shown not only to be important for bone and calcium metabolism but also for homeostasis of critical tissues involved in vascular disease in patients with diabetes.
- Conditions
- Vitamin D Deficiency, Insulin Resistance, Type 2 Diabetes Mellitus, Cardiovascular Disease
- Trial name
- NCT00736632
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Washington University School of Medicine
Metabolic Syndrome, Impaired Glucose Tolerance
Prevention of Type 2 Diabetes Mellitus by L-Arginine in Patients With Metabolic Syndrome
Aim The principal objective of this project is: To evaluate the efficacy of long term (18 months) L-Arginine therapy in preventing or delaying clinical onset of type 2 diabetes mellitus in subjects with impaired glucose tolerance…
- Conditions
- Metabolic Syndrome, Impaired Glucose Tolerance, Insulin Resistance, Endothelial Dysfunction
- Trial name
- L-arginine (NCT00917449)
- Testing
- L-arginine
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- IRCCS San Raffaele
Type 2 Diabetes, Liver Cirrhosis
Various Insulin Regimens for Diabetic Inpatients With Cirrhosis Trial
Liver disease is an important cause of death in type 2 diabetes. In the population-based Verona Diabetes Study cirrhosis was the fourth leading cause of death and accounted for 4.4% of diabetes-related deaths.
- Trial name
- VIRDICT (NCT01143948)
- Testing
- Glargine & Glulisine, Regular insulin, NPH & regular insulin
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Hypovitaminosis D, Insulin Resistance
Comparative Effectiveness of Vitamin D and Repletion Strategies
The importance of vitamin D (VitD) in the prevention and treatment of human health conditions has gained increased attention in recent years.
- Conditions
- Hypovitaminosis D, Insulin Resistance, Diabetes
- Trial name
- CEDARS (NCT01524874)
- Testing
- Vitamin D3
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Bastyr University
Gestational Diabetes Mellitus, Pregnancy, High Risk
Continuous Glucose Monitoring (CGM) Substudy of the DECIDE RCT
This is a nested multicenter prospective cohort conducted concurrently and in conjunction with the DECIDE two-arm, pragmatic non-inferiority comparative effectiveness Randomized Controlled Trial (RCT) (NCT06445946) of metformin…
- Trial name
- DECIDE CGM (NCT06490874)
- Testing
- CGM device - Metformin group, CGM device - Insulin group
- Where
- 4 sites in United States
- Sponsor
- Ohio State University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.