Clinical trials: Insulin Resistant Diabetes (Mellitus)
Diabetes, Diabetes Type 2
ACUTE EFFECT OF CONSUMPTION OF GROUND OR WHOLE FLAXSEEDS ON BLOOD GLUCOSE IN PEOPLE WITH TYPE 2 DIABETES
This study aimed to evaluate the effect of consuming a portion of French bread combined with whole or ground flaxseed on the glycemia of people with DM 2 in a randomized, crossover clinical trial conducted with 16 people with DM…
- Conditions
- Diabetes, Diabetes Type 2, Insulin Resistance
- Trial name
- DM2 (NCT06912542)
- Testing
- Whole flaxseed bread, Ground flaxseed bread, French bread
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- Universidade Francisca
Diabetes Mellitus, Type 2, Diabetes Mellitus
A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 Diabetes
The purpose of this study is to investigate the effectiveness and safety of 12 weeks of treatment with R256918 in patients with Type 2 Diabetes Mellitus who are taking metformin.
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Endocrine System Diseases, Nutritional and Metabolic Diseases
- Trial name
- NCT00672386
- Testing
- JNJ16269110, Metformin, Dietary Counseling
- Where
- 62 sites in Belgium, Denmark and 9 more
- Volunteers
- 352 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Obesity, Insulin Resistance
Endothelial Function in Hispanic Children/Adolescents at Risk for Type 2 Diabetes
Type 2 diabetes is now more frequent in children/adolescents, especially in those from minority populations, including Hispanic Americans (HA).
- Trial name
- NCT01926925
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Healthy, Metabolic Syndrome X
Investigation of Genetic Risk of Metabolic Syndrome in Company Employee (NGK Study)
The metabolic syndrome is a highly prevalent disorder, which causes atherosclerotic cardiovascular disease and is closely associated with insulin resistance.
- Conditions
- Healthy, Metabolic Syndrome X, Hyperlipidemia, Hypertension
- Trial name
- NCT00408824
- Where
- Japan
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Nagoya University
Type1 Diabetes Mellitus, Adiposity
Effect of Adiposity on Hepatic and Peripheral Insulin Resistance in Type 1 Diabetes
The purpose of this study is to assess the effects of adiposity on resistance to insulin's ability to suppress hepatic glucose production and to stimulate peripheral glucose metabolism in adolescents with type 1 diabetes.
- Trial name
- T1D (NCT03582956)
- Testing
- Euglycemic hyperinsulinemic clamp with tracer enhancement
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yale University
Dyslipidemia, Diabetes
Meta-analyses of Dietary Pulses and Cardiometabolic Risk
Dietary pulses, more commonly known as "legumes", are generally recognized as healthy components of the diet. Canada's Food Guide encourages consumptions of meat alternatives, such as beans "more often"; and the dietary…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT01594567
- Testing
- Dietary pulses
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Atherosclerosis, Metabolic Syndrome
Cardiometabolic Risk Factors Registry
CARFARE (CARDIOMETABOLIC RISK FACTORS REGISTRY) is a registry done in the context of a cardiovascular primary prevention program of the Cardiometabolic Unit Officia of the Cardiology Department of the Austral University Hospital.
- Conditions
- Atherosclerosis, Metabolic Syndrome, Diabetes, Cardiovascular Risk Factor
- Trial name
- CARFARE (NCT04040777)
- Where
- Argentina
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Austral University, Argentina
Type 2 Diabetes
The Effect of LINAGLIPTIN on Inflammation, Oxidative Stress and Insulin Resistance in Obese Type 2 Diabetes Subjects
This is a single center, prospective randomized double blind, parallel and placebo controlled study to evaluate oxidative stress and inflammation before and after treatment with linagliptin for 12 weeks.
- Trial name
- 1971 (NCT02372630)
- Testing
- Linagliptin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University at Buffalo
Intra-abdominal Fat, Metabolic Syndrome
Habitual Diet and Avocado Trial
The Habitual Diet and Avocado Trial will evaluate the effects of providing one avocado per day for recommended consumption over a 6 month period in a cohort of approximately 1000 free-living participants with increased waist…
- Conditions
- Intra-abdominal Fat, Metabolic Syndrome, High Cholesterol, Triglycerides High
- Trial name
- HAT (NCT03528031)
- Testing
- Intervention Daily Avocado
- Where
- 4 sites in United States
- Volunteers
- 1,008 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes Mellitus
The Verona Newly Diagnosed Type 2 Diabetes Study
Type 2 diabetes mellitus is a complex disease whose clinical phenotype results from the variable combination of genetic and nongenetic factors.
- Trial name
- VNDS (NCT01526720)
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Shift Work Schedule, Circadian Rhythm
Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance
The purpose of this study is to examine the impact of timed cortisol release or differently timed cortisol rhythms on insulin resistance in both men and women undergoing sleep restriction.
- Conditions
- Shift Work Schedule, Circadian Rhythm, Insulin Resistance, Circadian Misalignment
- Trial name
- NCT07494084
- Testing
- Metyrapone And Hydrocortisone, Dextrose, insulin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington State University
Diabetes, Insulin Resistance
Changes in Inflammatory State in Asian Americans Changing From Traditional Asian Diets to American Diet - a Pilot Study
We hypothesize that Asian Americans compared to Caucasians, will be at higher risk of developing a pro-inflammatory state that may contribute to the development of heart disease and diabetes when they change from a traditional…
- Conditions
- Diabetes, Insulin Resistance, Inflammation, Cardiovascular Disease
- Trial name
- NCT00379548
- Testing
- 2 groups of population responding to 2 types of diets
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Obesity, Diabetes Mellitus, Type 2
CCK1R Function in Patient Leukocytes
The type 1 cholecystokinin receptor (CCK1R) is a potential target for the treatment of obesity, due to the ability of this GI hormone to elicit satiety.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Metabolic Syndrome
- Trial name
- NCT03121755
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Metabolic Syndrome, Diabetes Mellitus
Biomarkers Derived From Adipose Tissue Useful for Diagnosis and Prognosis of Cardiovascular Risk (CVR) in Obese Patient
This study evaluates the relationship between the adipose tissue, as an active component, which can define metabolic phenotypes linked to cardiovascular risk modification post bariatric surgery.
- Conditions
- Metabolic Syndrome, Diabetes Mellitus, Inflammatory Response
- Trial name
- CROP (NCT03561987)
- Testing
- Bariatric surgery
- Volunteers
- 70 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
ST-Elevation Myocardial Infarction
PraSugrel vs TicagrElor in ST-Elevation Myocardial Infarction paTients With Diabetes Mellitus
Dual antiplatelet therapy is essential in patients following ST-Elevation myocardial infarction (STEMI) with percutaneous coronary intervention (PCI) and drug eluting stent implantation.
- Trial name
- RESET 2D (NCT01531114)
- Testing
- ticagrelor, prasugrel
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Gennaro Sardella
Diabetes Mellitus Type 2, Insulin Resistance
OatMeal and Insulin Resistance: OMA-IR
Insulin resistance is a central feature of Diabetes mellitus type 2 (Stumvoll et al. 2005). Hypo- and hyperglycemic states are associated with adverse inpatient outcomes (ADA et al.
- Trial name
- NCT00401453
- Testing
- Diet: carbohydrate days. (Name: oatmeal.)
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Universitätsmedizin Mannheim
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Stem Cell Educator Therapy in Diabetes
Stem Cell Educator (SCE) therapy circulates a patient's blood through a blood cell separator, briefly cocultures the patient's immune cells with adherent Cord Blood Stem Cells (CB-SCs) in vitro, and returns only the "educated"…
- Trial name
- NCT03390231
- Testing
- Stem Cell Educator therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Throne Biotechnologies Inc.
Type 2 Diabetes Mellitus
A Study to Evaluate Pharmacokinetics of LY3209590 in Pediatric Participants With Type 2 Diabetes Mellitus
The main purpose of this study is to evaluate how much of LY3209590 gets into the blood stream after a single dose and how long it takes the body to remove it in pediatric participants with Type 2 Diabetes Mellitus (T2DM).
- Trial name
- NCT06362265
- Testing
- LY3209590
- Where
- 10 sites in United States
- Volunteers
- 15 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes, Insulin Resistance
Effect of Neuromuscular Electrostimulation on Sympathetic Nerve Activity in Patients With Type 2 Diabetes (ELECTROSYMP2)
Physical activity (PA) is recommended for the treatment of subjects with type 2 diabetes to increase insulin sensitivity and improve metabolic control.
- Trial name
- ELECTROSYMP2 (NCT02171351)
- Testing
- effect of neuromuscular electrostimulation (NMES), effect of neuro electrostimulation (NES), effect of voluntary contractions (VC)
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Diabetes Mellitus, Type 2
Effect Of Rosiglitazone On Carotid Intima Media Thickness In Patients With Insulin Resistance Syndrome And/Or Type 2 Diabetes
The study investigated the effect of rosiglitazone and placebo on carotid intima media thickness in patients with insulin resistance syndrome and/or type 2 diabetes.
- Trial name
- NCT00306644
- Testing
- Rosiglitazone
- Where
- Sweden
- Volunteers
- 556 people
- Sponsor
- GlaxoSmithKline
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