Clinical trials: Insulin Response
Sedentary Lifestyle
Cardiovascular Risk in Sedentary Elderly During Prolonged Sitting Time Versus Intermittent Sitting Time
In adults, the sedentary behavior was related to cardiovascular risk markers, regardless of the level of physical activity (PA).
- Trial name
- NCT02894099
- Testing
- Prolonged sitting time, PST+Light intensity Short bouts PA, PST+Moderate intensity Short bouts PA
- Where
- Brazil
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Diabetes, Diabetes Mellitus, Type 1
Comparison of Hypoglycaemic Response Between NN1250 and Insulin Glargine in Type 1 Diabetics
This trial iss conducted in Europe. The aim of this clinical trial is to evaluate the hypoglycaemic response (the response to low blood sugar) to NN1250 (insulin degludec) in subjects with type 1 diabetes.
- Trial name
- NCT01002768
- Testing
- insulin degludec, insulin glargine
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Novo Nordisk A/S
Insulin Resistance
Gastric Emptying and Insulin Response to Test Drink
Surgery is a stress on the body and recovering well after surgery is very important to patients and their doctors. It is therefore important to prepare patient's bodies for the stress of surgery, and one way to do this is to…
- Trial name
- NCT01971229
- Testing
- Carbohydrate based drink, Whey protein based drink
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Franco Carli
Metabolic Syndrome
Acute Effects of Dietary Fats and Carbohydrate in Subjects With Metabolic Syndrome
There is increasing evidence suggests that elevated levels of postprandial triacylglycerol (TAG)-rich lipoproteins may promote the development of cardiovascular diseases (CVD).
- Trial name
- NCT01571947
- Testing
- Acute Effects of Fats and Carbohydrate
- Where
- 2 sites in Malaysia
- Volunteers
- 30 people
- Sponsor
- Malaysia Palm Oil Board
Metabolic Syndrome, Diabetes
Glycaemic Control Effect of BSG and Underlying Gut - Related Mechanism in Singapore Adults With Metabolic Syndrome
The purpose of this research project is to assess the glycaemic controlling effects of consuming BSG and bio-transformed BSG-containing biscuits and its underlying gut - related mechanism in adults with MetS using in-vivo setting.
- Trial name
- NCT05529108
- Testing
- control biscuits, autoclaved BSG-containing biscuits, bio-transformed BSG-containing biscuits
- Where
- Singapore
- Volunteers
- 38 people
- Sponsor
- National University of Singapore
Glycemic Control, Satiety Response
Postprandial Glycemia and Satiety of Meals With Potatoes, With and Without Protein
The proposed study aims to simulate a meal eaten at home, where meals will provide a fixed amount of protein from beef or vegetarian substitute "meat" balls with ad libitum access to one of mashed potatoes, full-fat fries, or…
- Conditions
- Glycemic Control, Satiety Response, Appetite Regulation, Diabetes
- Trial name
- NCT05610124
- Testing
- Ad libitum full-fat French fries with beef meatballs, Ad libitum instant mashed potatoes with beef meatballs, Ad libitum macaroni pasta with beef meatballs
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Growth Failure, X-linked Severe Combined Immunodeficiency (XSCID)
Treatment for Growth Failure in Patients With X-Linked Severe Combined Immunodeficiency: Phase 2 Study of Insulin-Like Growth Factor-1
This study will evaluate the safety and effectiveness of insulin-like growth factor-1 (IGF-1) to treat patients with X-linked severe combined immunodeficiency (XSCID).
- Conditions
- Growth Failure, X-linked Severe Combined Immunodeficiency (XSCID), Growth Hormone Resistence
- Trial name
- NCT00490100
- Testing
- Increlex
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes
Vildagliptin and the Glucagon Response to Hypoglycemia in Insulin-Treated Patients With Type 2 Diabetes
The purpose of this study is to explore whether the novel therapy of type 2 diabetes, vildagliptin, which inhibits dipeptidyl peptidase-4 (DPP-4), affects glucagon counterregulation during hypoglycemia in insulin-treated patients…
- Trial name
- NCT01219400
- Testing
- Vildagliptin
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Lund University
High Intensity Interval Training, Diet, Healthy
Insulin Sensitivity Response to High-Intensity Training in Insulin Resistance During Pregnancy
Insulin Resistance is one of the common complications that occur during pregnancy. Early intervention is essential to prevent the development of the diseaseThere is evidence that physical inactivity increases the risk of a lot of…
- Trial name
- NCT04830995
- Testing
- moderate restricted diet (1800-2000 kcal/day) for four weeks
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Cardiovascular Diseases
Effects of the Mediterranean Diet on Cardiovascular Risk Profile in Men and Women
The purpose of this study is to document differences between men and women in changes in metabolic variables associated with cardiovascular risk in response to a 4 weeks isocaloric controlled nutritional intervention based on the…
- Trial name
- ALIMED (NCT01293344)
- Testing
- Controlled nutritional intervention based on the Mediterranean diet
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Laval University
Metabolic Syndrome
Acute Effects of Tocotrienols on Insulin Sensitivity and Metabolic Risk Markers in Individuals at Risk for Metabolic Syndrome
Objectives: To compare the acute effects of gamma delta rich tocotrienol fractions (gd-TRF) on insulin sensitivity, metabolic risk markers and postprandial lipemia in individuals at risk for metabolic syndrome.
- Trial name
- NCT01626430
- Testing
- Gamma delta TRF
- Where
- 2 sites in Malaysia
- Volunteers
- 30 people
- Sponsor
- Malaysia Palm Oil Board
Colon Cancer
Insulin Therapy Reduce Post-Operative Inflammatory Response After Curative Colorectal Cancer Resection: Randomization Controlled Trial
Research Problem: Surgical stress induces inflammation and postoperative immuno-suppression, which are risk. factors for both post-operative complication and possible disease recurrence.
- Trial name
- NCT02746432
- Testing
- Hyper insulinemic euglycemic clamp
- Where
- Saudi Arabia
- Volunteers
- 144 people
- Sponsor
- King Saud University
Sedentary Behavior, Insulin Sensitivity
The Effect of Sitting and Moderate Exercise on Plasma Insulin and Glucose Responses to an Oral Glucose Tolerance Test
The investigators hypothesize that cycling for 1 hour of exercise at 65% peak oxygen consumption (VO2peak) after sitting >13 hr/day (SIT+EX) will not be different in postprandial plasma insulin responses compared to the control…
- Conditions
- Sedentary Behavior, Insulin Sensitivity, Sedentary Lifestyle
- Trial name
- NCT04195165
- Testing
- SIT, ACTIVE, EX
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Insulin Resistance
Study In Patients With Insulin Resistance
Fluid management study in patients with insulin resistance.
- Trial name
- NCT00197132
- Testing
- Avandia
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- GlaxoSmithKline
Healthy, Glucose Metabolism
Protein Concentrations in Yogurt and Satiety, Food Intake and Glycemia in Healthy Men
This study compared the effects of dairy products, including milk and yogurt, with different amounts of proteins on responses of appetite, glucose and insulin and on food intake at a meal served 120 minutes later in healthy adult…
- Trial name
- NCT01673321
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Metabolic Syndrome, Hypertension
Effect of Sitagliptin and an ACE Inhibitor on Blood Pressure in Metabolic Syndrome
This study will measure the effect of the anti-diabetic agent sitagliptin on blood pressure in individuals with the metabolic syndrome.
- Trial name
- NCT00666848
- Testing
- Enalapril 5mg, Enalapril 10mg, Sitagliptin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Vanderbilt University
Blood Glucose, Blood Insulin
Postprandial Response to Fruit Juice
The goal of this clinical trial is to determine postprandial responses to fruit juices.
- Trial name
- NCT07103083
- Testing
- Beverage 1, Beverage 2, Beverage 3
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ocean Spray Cranberries, Inc.
Obesity, Diabetes
Acute Effects of Dietary Fiber on Postprandial Responses in Lean and Overweight Subjects
It has been suggested that obesity occurs because the colonic microbes in obese individuals, compared to those who are lean, produce more short chain fatty acids during the fermentation of dietary fiber; this means that obese…
- Trial name
- NCT02795559
- Testing
- Glucose, Inulin, Resistant starch
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 2 Diabetes
Characteristics of Glargine in Type 2 Diabetics
The study is to determine the dose response relationship of insulin glargine in type 2 diabetes over a 24-hour period and measuring the differences in glucose production among the differing doses of glargine.
- Trial name
- NCT00574912
- Testing
- Insulin Glargine 0.5 u/kg body wt SC, Insulin Glargine 1.0 u/kg body wt SC, Insulin Glargine 1.5 u/kg body wt SC
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes, Diabetes Mellitus, Type 1
Insulin and Abatacept in Recently-diagnosed Type 1 Diabetes
The goal of this clinical trial is to test whether the combination of two safe immune therapies called abatacept and nasal insulin can preserve pancreas function in recently-diagnosed type 1 diabetes.
- Trial name
- IAA (NCT05742243)
- Testing
- Abatacept (CTLA4-Ig) and nasal insulin (Humulin R®)
- Where
- 6 sites in Australia
- Volunteers
- 68 people
- Sponsor
- Melbourne Health