Clinical trials: Insulin Sensitivity/Resistance
Schizophrenia, Diabetes
Effect of Atypical Antipsychotic Drugs Olanzapine and Amisulpride on Glucose Metabolism
Patients suffering from schizophrenia have a high risk to become obese and develop diabetes. Risk of obesity is particularly high with some newer schizophrenia drugs, such as clozapine or olanzapine.
- Conditions
- Schizophrenia, Diabetes, Insulin Resistance
- Trial name
- NCT01160991
- Testing
- Glucose clamp technique, Amisulpride, Olanzapine
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Overweight, Obesity
SIT LESS 3: The Effect of Low Intensity Physical Activity on Insulin Sensitivity, Mood and Cognitive Performance
Background of the study: A sedentary lifestyle and obesity are well known risk factors of type 2 diabetes. The major focus of current guidelines for type 2 diabetes prevention is on energy balance.
- Trial name
- SIT LESS 3 (NCT02394249)
- Testing
- Physical activity regime
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
HIV, Insulin Sensitivity
Study of HIV-Infected and Uninfected Pregnant Woman/Child Dyads in Gaborone, Botswana
The purpose of this study is to assess the early longitudinal metabolic effects including insulin sensitivity in HIV-exposed uninfected (HEU) children compared to HIV-unexposed uninfected (HUU) children; as well as to determine…
- Conditions
- HIV, Insulin Sensitivity, Diabetes Mellitus
- Trial name
- NCT03088410
- Testing
- Zidovudine, Nevirapine
- Where
- Botswana
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Obesity, Drug Effect
Effect of Triticum Aestivum vs Placebo on Metabolic Profile Components and Insulin Sensitivity in Patients With Obesity
Obesity is a metabolic disease which has been declared as the most prevalent chronic health problem in adults; according to the World Health Organization (WHO), it is defined as an increase in Body Mass Index (BMI) greater than…
- Conditions
- Obesity, Drug Effect, Insulin Sensitivity
- Trial name
- NCT06501248
- Testing
- Triticum Aestivum
- Where
- Mexico
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Obesity, Abdominal
The Impact Of An Intermittent Energy Restricted Diet On Insulin Sensitivity In Men and Women With Central Obesity
An intermittent energy restricted (IER) diet may modify cardio-metabolic disease risk factors compared to an energy-matched continuous energy restricted (CER) diet.
- Trial name
- Met-IER (NCT02679989)
- Testing
- Intermittent Energy Restriction, Continuous Energy Restriction
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- King's College London
Insulin Resistance
Effects of Hi-maize Resistant Starch on Insulin Sensitivity
The purpose of this study is to determine the effects of a dietary fiber, resistant starch, on insulin sensitivity. Low insulin sensitivity is a risk factor for some diseases including type 2 diabetes and heart disease.
- Trial name
- NCT01058135
- Testing
- Hi-maize starch (Low dose), Hi-maize starch (High-dose), Control (starch)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ingredion Incorporated
Obesity, Impaired Glucose Tolerance
Effects of Rosiglitazone on the Metabolic Phenotype of Impaired Glucose Tolerance in Youth
The purpose of the study is to determine whether treatment of children and adolescents with Impaired Glucose Tolerance (IGT) with rosiglitazone will lead to improvements in insulin sensitivity and glucose tolerance.
- Conditions
- Obesity, Impaired Glucose Tolerance, Type 2 Diabetes Mellitus
- Trial name
- NCT00413335
- Testing
- Rosiglitazone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Dry Eye, Insulin Sensitivity
Topical Insulin for Ocular Surface Interface in Dry Eye Disease
This is a parallel randomized controlled trial for the treatment of dry eye disease. The main objective is to investigate the efficacy and safety of the use of insulin eye drops in the control of moderate-severe dry eye disease.
- Trial name
- NCT06939959
- Testing
- Artificial tear, insulin human
- Where
- Pakistan
- Volunteers
- 128 people
- Sponsor
- Khyber Teaching Hospital
Borderline Hypokalemia
The Effects of Potassium on Glucose Metabolism in African Americans
African Americans suffer a disproportionately high risk of diabetes compared to other Americans. Reasons for race disparities in diabetes incidence are not completely understood.
- Trial name
- NCT02236598
- Testing
- K+ supplement
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Duke University
Glucose Homeostasis
Comparison of the Effects of a 12-Week Consumption of Two Carbonated Beverages on Insulin Sensitivity
The purpose of this study is to determine whether consumption of carbonated drinks containing sweeteners affect insulin sensitivity.
- Trial name
- SEDULC (NCT02031497)
- Testing
- Drink with sweeteners, Drink without sweeteners
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute For European Expertise in Physiology
Type 2 Diabetes
Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Type 2 Diabetes Mellitus
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT01663220
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Foundation for the National Institutes of Health
Insulin Sensitivity, Physical Activity
METAPREDICT: Developing Predictors of the Health Benefits of Exercise for Individuals
Physical activity is a powerful lifestyle factor that on average reduces risk for development of diabetes and cardiovascular disease.
- Trial name
- METAPREDICT (NCT01920659)
- Testing
- High Intensity Training (HIT), REHIT
- Where
- United Kingdom
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Metabolic Syndrome X
Comparison of Two Different Diets on Health Outcomes
The purpose of this study is to compare the effects of a low-carbohydrate diet and a high-carbohydrate, high-fiber diet, on insulin sensitivity and blood chemicals considered risk markers for heart disease, in persons with the…
- Trial name
- NCT00269646
- Testing
- Low-carbohydrate and high-carbohydrate diets
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome, Insulin Resistance
The Effect of Acupuncture on Insulin Sensitivity Polycystic Ovary Syndrome
Hyperinsulinemia and insulin resistance play a key role in the pathogenesis of polycystic ovary syndrome (PCOS). Insulin resistance is significantly associated with the long-term risks of metabolic syndrome and cardiovascular…
- Trial name
- NCT02026323
- Testing
- acupuncture
- Where
- China
- Volunteers
- 112 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Cystic Fibrosis-related Diabetes
β-cell Function and Insulin Sensitivity in Patients With Cystic Fibrosis
Cystic fibrosis is a genetic disorder caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, leading to pulmonary infections, sinus disease, pancreatic insufficiency, hepatobiliary disease and…
- Trial name
- NCT04379726
- Testing
- therapeutic optimization
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Metabolic Syndrome
Effect of Fasting With Two Meals on Insulin Resistance Indices of Metabolic Syndrome
this study was conducted to assess the insulin resistance indices in the subjects undergoing Ramadan fasting (diet which consisted of two meals at 12 hours intervals)for a thirty days period.
- Trial name
- NCT00429390
- Testing
- Ramadan Fasting
- Volunteers
- 55 people
- Sponsor
- Free Islamic University of Medical Sciences
Aging, Obesity
Biologic Effects of Dehydroepiandrosterone (DHEA) in Humans
The purpose of this study is to determine whether DHEA replacement therapy decreases abdominal fat and improves insulin sensitivity.
- Conditions
- Aging, Obesity, Insulin Resistance
- Trial name
- NCT00099697
- Testing
- DHEA
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Type 2 Diabetes, Diabetic Nephropathy
Effects of Losartan on Insulin Sensitivity and Secretion in Type 2 Diabetes and Nephropathy
Angiotensin type-1 receptor (AT1R) blockers (ARBs) have been recognized recently as regulators of glucose and lipid metabolism in adipocytes and adipose tissue.Moreover telmisartan and irbesartan have been recognized recently as…
- Trial name
- NCT00361023
- Testing
- losartan
- Volunteers
- 25 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Type 1 Diabetes, Chronic Inflammation
The Effect of Colchicine, on Insulin Sensitivity in Individuals With Type 1 Diabetes and Systemic Low-grade Inflammation
The aim for this clinical trial is to evaluate if colchicine in addition to standard of care improves insulin sensitivity in individuals with type 1 diabetes, systemic low-grade inflammaiton and reduced insulin sensitivity.
- Conditions
- Type 1 Diabetes, Chronic Inflammation, Insulin Sensitivity
- Trial name
- INS1GHT (NCT07247734)
- Testing
- Colchicin 0.5 mg once daily for two weeks, then twice daily for two weeks, Colchicine tablet 0.5 mg once-daily for two weeks, then twice daily for two weeks
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Asger Lund, MD
Obesity, Pre-diabetes
The Effect of Time-Restricted Eating in Cardiometabolic Health
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no energy intake the rest of the day.
- Trial name
- NCT04484987
- Testing
- 9 hours daily eating window, 15 hours daily eating window
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of California, Davis