Clinical trials: Insulin Sensitivity/Resistance
Insulin Sensitivity
Insulin Signaling in Skeletal Muscle
The insulin sensitizing effects of metformin and pioglitazone in the skeletal muscle remain unknown. Our group aims to analyze molecular changes within the skeletal muscle of pre-diabetic patients through the use of a clinical…
- Trial name
- NCT03452267
- Testing
- Metformin, Pioglitazone
- Sponsor
- Wayne State University
Insulin Sensitivity, Glucose Intolerance
Effects of Progressive Negative Energy Balance on Glucose Tolerance, Insulin Sensitivity, and Beta-cell Function
Type 2 diabetes results from a combination of peripheral insulin resistance and beta-cell dysfunction, and manifests as fasting and postprandial hyperglycemia.
- Conditions
- Insulin Sensitivity, Glucose Intolerance, Insulin Resistance, Energy Supply; Deficiency
- Trial name
- NCT03264001
- Testing
- Negative energy balance
- Where
- Singapore
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Type2 Diabetes Mellitus
Adipose Tissue Expandability and Type 2 Diabetes
The goal of the study is to analyze deviations in adipogenic potential and metabolic properties of preadipocytes in subjects with genetic predisposition to type 2 diabetes, and thus identify factors that underlie hypertrophic…
- Trial name
- LIMEX (NCT03155412)
- Where
- Czechia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Insulin Sensitivity, Polycystic Ovarian Syndrome
Assessment of Cod Protein as an Insulin-sensitizing Agent in Women With Polycystic Ovary Syndrome.
The objective of our study is to determine the effects of fish protein on insulin sensitivity in PCOS women with insulin resistance, and its mechanism of action on glucose and endocrine metabolism.
- Trial name
- PCOS (NCT01766557)
- Testing
- Semi-controlled nutritional intervention with fish protein diet, Semi-controlled intervention with other animal proteins
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Laval University
Obesity, Insulin Resistance
Effects of Infliximab on Insulin Sensitivity and Beta Cell Function in Insulin Resistant Human Obesity
The aim of the study is to test whether neutralizing TNF-alpha with infliximab affects insulin resistance and phenotypical manifestations of the metabolic syndrome as fasting plasma insulin, total body fat, plasma lipid profile…
- Conditions
- Obesity, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT00636142
- Testing
- Infliximab
- Where
- Austria
- Volunteers
- 9 people
- Sponsor
- Medical University of Graz
Diabetes Mellitus, Type 2, Hypertension
Inspiratory Muscle Strength Training in Adults With Type 2 Diabetes
This clinical research study will investigate the effects of 6 weeks of inspiratory muscle strength training on metabolic and cardiovascular outcomes in adults with recent-onset type 2 diabetes.
- Trial name
- DIT (NCT05643768)
- Testing
- Inspiratory muscle strength training (IMST)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Arizona