Clinical trials: Insulin Sensitivity
Diabetes Mellitus, Asthma
Safety and Efficacy of Inhaled Insulin in Patients With Diabetes and Asthma or COPD
Phase 3 , open-label, randomized study to evaluate the safety and efficacy of the Lilly/Alkermes inhaled insulin system compared to injected insulin in type 1 and type 2 diabetes patients with asthma or COPD.
- Conditions
- Diabetes Mellitus, Asthma, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT00157339
- Testing
- Human Insulin Inhalation Powder, injected insulin
- Where
- 101 sites in United States, Argentina and 14 more
- Volunteers
- 299 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 2
A Study to Assess the Effects of DPP-4 Inhibition on Insulin Sensitivity in Type 2 Diabetes
Type 2 diabetes results when the body does not produce enough insulin and/or is unable to properly use the insulin it makes (insulin resistance).
- Trial name
- NCT00351546
- Testing
- Vildagliptin
- Volunteers
- 12 people
- Sponsor
- Novartis
Safety and Tolerability
PK and PD Profile of Dance 501 in Healthy, Non-diabetic Subjects With Mild to Moderate Asthma or COPD
This will be a randomized, open-label, active-controlled, single dose crossover study with either three or four treatment periods.
- Trial name
- NCT03307512
- Testing
- inhaled human insulin, Insulin Lispro (Humalog U-100)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dance Biopharm Inc.
Diabetes Mellitus, Type 2
Treatment Differences Between Canagliflozin and Placebo in Insulin Secretion in Subjects With Type 2 Diabetes Mellitus (T2DM)
The purpose of this study is to assess changes from baseline in insulin sensitivity, hepatic fat content and beta cell function after approximately 24-25 weeks of treatment with canagliflozin compared to placebo in participants…
- Trial name
- NCT02009488
- Testing
- Canagliflozin, 100 mg, Canagliflozin, 300 mg
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Janssen Research & Development, LLC
Diabetes Mellitus, Type 2, Obesity
Pharmacodynamic Study of the Effect of INCB013739 on Insulin Sensitivity in Obese, Type 2 Diabetic Subjects
Purpose: A 28-day US study in patients with type 2 diabetes mellitus to assess the safety and tolerability as well as the effects of treatment with an investigational drug.
- Trial name
- NCT00478322
- Testing
- INCB013739
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Incyte Corporation
Insulin Sensitivity
The Effect of Gemcabene on Insulin Sensitivity in Nondiabetic Subjects
The purpose of this study is to determine the effect of gemcabene on insulin sensitivity as defined by average glucose disposal rate.
- Trial name
- NCT02586168
- Testing
- Gemcabene 900 mg
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- NeuroBo Pharmaceuticals Inc.
Hypertension, Insulin Resistance
A Comparison of the Effect of Olmesartan Medoxomil, Losartan Potassium, and Atenolol on the Ability of Overweight Patients With High Blood Pressure to Respond to Insulin
To examine the effect of three different blood pressure medications on the insulin sensitivity in overweight patients with high blood pressure.
- Conditions
- Hypertension, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT00185094
- Testing
- Olmesartan medoxomil, Losartan potassium, Atenolol
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Daiichi Sankyo
Diabetes, Diabetes Mellitus, Type 1
Safety of Inhaled Preprandial Human Insulin in Subjects With Diabetes and Asthma
This trial is conducted in Europe, Asia, Oceania and the United States of America (USA). This is a one-year clinical trial to compare the safety of inhaled preprandial human insulin to subcutaneous insulin aspart in subjects with…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Asthma
- Trial name
- iINHALE 9 (NCT00523042)
- Testing
- insulin aspart, inhaled human insulin
- Where
- 32 sites in United States, Australia and 4 more
- Volunteers
- 10 people
- Sponsor
- Novo Nordisk A/S
Prediabetes, Insulin Resistance
MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity
This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity.
- Conditions
- Prediabetes, Insulin Resistance, Overweight/Obesity
- Trial name
- MOTS-MET (NCT07505745)
- Testing
- MOTS-c (MDP), Route Subcutaneous injection, Regimen
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hudson Biotech
Hypertension, Impaired Glucose Tolerance
Clinical Trial To Evaluate The Effect Of Valsartan On Insulin Sensitivity In Subjects With Impaired Glucose Tolerance
THE PURPOSE OF THIS STUDY IS TO DETERMINE IF 24 WEEKS OF TREATMENT WITH VALSARTAN (80 MG - 320 MG) IMPROVES INSULIN SENSITIVITY IN SUBJECTS WITH HIGHER THAN NORMAL GLUCOSE LEVELS USING A TEST CALLED THE EUGLYCEMIC CLAMP.
- Trial name
- NCT00241072
- Testing
- valsartan
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Novartis
Type 2 Diabetes Mellitus
Study to Assess the Effect of 24 Weeks of Treatment With Vildagliptin in Patients With Type 2 Diabetes
The study will demonstrate the effect of 24 weeks of treatment with vildagliptin compared to placebo on insulin sensitivity in patients with type 2 diabetes mellitus (T2DM) treated with metformin, assessed as glucose Rd (rate of…
- Trial name
- NCT01356381
- Testing
- Vildagliptin
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Novartis Pharmaceuticals
Asthma, Diabetes Mellitus
A Study Designed to Determine if the Pharmacokinetic Disposition of Inhaled Insulin Exposure is the Same for Asthmatics and Non-asthmatics
This study will compare the rate and extent of absorption of TI Inhalation Powder in subjects with asthma and subjects with normal lung function. 24 eligible subjects will be enrolled into the treatment phase of the trial.
- Trial name
- NCT00673621
- Testing
- Technosphere Insulin Inhalation Powder, Salbutamol (Albuterol), Methacholine chloride
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mannkind Corporation
Infant, Small for Gestational Age
Safety Study In Patients Who Were Born Small And Short And Were Treated With Growth Hormone To Achieve Normal Height
The purpose of this study is to demonstrate that insulin sensitivity is not different between growth hormone - treated subjects who are small for gestational age (SGA) and an SGA cohort of subjects matched by gender and body mass…
- Trial name
- NCT00396474
- Testing
- post GH treatment observational study
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Insulin Resistance
A Study of the Safety, Tolerance and Assessment of HE3286 on Insulin Sensitivity and Hepatic Glucose Production
The objectives of this study are to evaluate the safety and tolerance of 20 mg (10 mg BID) of HE3286 when administered orally over 28 days to obese insulin-resistant adult subjects and, to assess the activity of HE3286 on insulin…
- Trial name
- NCT00991107
- Testing
- HE3286
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Harbor Therapeutics
Schizophrenia, Schizoaffective Disorder
Safety Study of Olanzapine and a Comparator in Patients With Schizophrenia and Schizoaffective Disorder
This study will assess whether olanzapine and/or risperidone affect the way the human body uses sugar in the blood.
- Trial name
- NCT00190749
- Testing
- olanzapine, risperidone
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Eli Lilly and Company
Obesity
Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscle Health)
The purpose of this clinical study is to look into how study medicines CagriSema (cagrilintide and semaglutide), cagrilintide, and semaglutide affects muscle health in people with excess body weight and slightly higher than…
- Trial name
- RASMUS (NCT07527195)
- Testing
- Cagrilintide, Semaglutide
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Novo Nordisk A/S
Overweight, Obesity
Effects of Obex in Overweight and Obese Patients
Obesity is an important and growing public health worldwide Obesity is highly related to the development of metabolic syndrome, diabetes, cardiovascular diseases and cancer An extensive body of evidence from efficacy trials has…
- Trial name
- NCT02145442
- Testing
- Obex
- Where
- Cuba
- Volunteers
- 40 people
- Sponsor
- Catalysis SL
Metabolic Cardiovascular Syndrome
Hyperinsulinemic Euglycemic Clamp Protocol
The purpose of the study is to determine the safety and efficacy of TRC150094 in male patients with cardiometabolic risk. Cardiometabolic risk which is the overall risk of cardiovascular disease (CVD) and diabetes resulting from…
- Trial name
- NCT01408667
- Testing
- TRC150094
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Torrent Pharmaceuticals Limited
Focus of the Study is Insulin Sensitivity
Effects of Dietary Fiber on Insulin Sensitivity
This study will examine the effects of a dietary fiber on insulin sensitivity in overweight and obese women. The fiber will be added to snack foods and women will consume the foods for four weeks.
- Trial name
- NCT01521806
- Testing
- Dietary Fiber
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ingredion Incorporated
Asthma, Diabetes Mellitus
A One Year Clinical Trial Assessing the Usefulness and Safety of Inhaled Insulin in Diabetics With Asthma
A One Year Clinical Trial Assessing the Usefulness and Safety of Inhaled Insulin in Diabetics with Asthma
- Trial name
- NCT00139659
- Testing
- Inhaled Insulin, Subcutaneous Insulin
- Where
- 102 sites in United States, Brazil and 3 more
- Volunteers
- 288 people
- Sponsor
- Pfizer