Clinical trials: Insulin Sensitivity
Type 2 Diabetes
Pharmacogenomics of Thiazolidinediones
The purpose of this study is to determine predictors of response to pioglitazone, an anti-diabetic medication. The investigators know from randomized clinical trials that some 30% of patients do not respond to this type of…
- Trial name
- PPAR (NCT01135394)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Insulin Resistance, Obesity
The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adolescents
The purpose of this study is to investigate the effects of dietary exposure to artificial sweeteners on taste sensitivity, preference and brain response in adolescents using fMRI, psychophysical measures, and questionnaires.
- Trial name
- NCT02499705
- Testing
- Sucralose, Sucrose, Sucralose + maltodextrin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Yale University
Insulin Sensitivity
Physical Training Per se
The investigators aimed to evaluate the health benefits of physical training per se, weight loss per se and exercise-induced weight loss in young, overweight men.
- Trial name
- TPS (NCT01090869)
- Testing
- 12 weeks of lifestyle change
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Diabetes Mellitus, Type 2
Comprehensive Postpartum Screening Strategies for Women With Gestational Diabetes Mellitus (GDM)
Previous gestational diabetes (GDM) predisposes affected women to diabetes. Pregnancy, in essence, serves as a metabolic stress test and uncovers underlying insulin resistance and ß-cell dysfunction.
- Trial name
- COPSS-GDM (NCT00849849)
- Where
- United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Woman's
Insulin Sensitivity/Resistance
Type 2 Diabetes Affect Exercise Induced Improvement in Insulin Sensitivity
This study investigates whether: (i) a family history of type 2 diabetes affects exercise induced improvements in insulin sensitivity. (ii) being prediabetic affects exercise induced improvements in glycemic control.
- Trial name
- HIT (NCT02745613)
- Testing
- 8 weeks of combined exercise intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Morbid Obesity
Glucose Homeostasis Pre and Post Bariatric Surgery
The investigators wish to study the effects of three forms of bariatric surgery: Roux-en-Y gastric bypass, Sleeve Gastrectomy, and Gastric Banding. The surgery is not part of the clinical trial.
- Trial name
- RB (NCT00981500)
- Testing
- gastric bypass, gastric banding, sleeve gastrectomy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes Mellitus
BFR Walking for Insulin and Aerobic Improvement in Type 2 Diabetes
This clinical trial examines the impact of Blood-Flow Restriction Walk Training (BFRw) on insulin sensitivity and aerobic capacity in individuals with Type 2 Diabetes (T2D).
- Trial name
- BRAID (NCT06290947)
- Testing
- BFR Cuffs for Intervention Group, Standard Walking Training Program
- Where
- Palestinian Territories
- Volunteers
- 60 people
- Sponsor
- Arab American University (Palestine)
Glucocorticoid Effect
Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals
In a randomized, cross-over study, 20 healthy volunteers will receive a block and replace therapy that mimics physiological GC rhythm (metyrapone plus hydrocortisone) or placebo.
- Trial name
- Gluco-Feed (NCT05167084)
- Testing
- Metyrapone 250 mg Oral Tablets, Hydrocortisone 19,9mg s.c., pulsatile with a flow rate of 10μl/s
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Non-Alcoholic Fatty Liver Disease
Effects of TOTUM-448 on Liver Fat Content, Cardiometabolic Risk Factors and Gut Microbiota Among Participants with MASLD
This clinical trial aims to investigate the effects of TOTUM-448, a mix of 5 plant extracts and choline, consumed at the daily regimen of two times per day, on liver fat content, cardiometabolic risk factors and gut microbiota…
- Trial name
- CARDIO-LIVER (NCT06704321)
- Testing
- TOTUM-448
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Insulin Sensitivity
Pulse-based Foods for Alleviation of Negative Consequences of Sedentary Behaviour
The hypothesis is that consumption of pulse-based foods (i.e. containing chickpeas, lentils, and split peas) during the workday will improve insulin sensitivity, glucose tolerance, blood lipids, body composition, and blood…
- Trial name
- NCT03941704
- Testing
- Pulse-based diet, Regular diet
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Obesity; Familial
Assessment of the Health Improvement of Obese Patients After Fecal Microbiota Transplantation (FMT)
Search for mechanisms of the effect of fecal microbiota transplantation on patients with obesity
- Trial name
- NCT04579263
- Testing
- Fecal microbiota
- Where
- 2 sites in Russia
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Federal Research and Clinical Center of Physical-Chemical Medicine
Type 2 Diabetes Mellitus
Role of Allopurinol on Oxidative Stress and Mitochondrial Alterations in Skeletal Muscle of Diabetic Patients
Our recent data in mice have demonstrated a key role of xanthine oxidase in hyperglycemia-induced by Reactive oxygen species production, and a preventive role of allopurinol (inhibitor of xanthine oxidase) on the keeping of…
- Trial name
- DIAXO (NCT02533648)
- Testing
- 2 capsules of allopurinol 150 mg daily for 3 month, 2 capsules of lactose daily for 3 month
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Hospices Civils de Lyon
PreDiabetes, Insulin Sensitivity
Exercise Intervention for the Prevention of Prediabetes in Overweight Chinese
Overweight/obese Chinese and prediabetes will be recruited and divided into three age-matched groups including high intensity exercise, moderate intensity exercise, and non-exercise groups.
- Trial name
- NCT03240978
- Testing
- exercise intervention
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Pre-diabetes, Metabolic Syndrome
Replacing Refined Carbohydrates With Healthy Fats on Cardio-metabolic Markers
The primary goal is to to characterize the effects of consuming 1 avocado fruit 7 days / week (5-7 days is acceptable) compared to a no avocado relatively low fat, carbohydrate control treatment over a 12 week period on insulin…
- Trial name
- AV2 (NCT02695433)
- Testing
- Active, Control
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Diabetes Mellitus, Type 2, Skeletal Muscle Insulin Sensitivity
Effects of 5 Weeks Treatment With Dapagliflozin in Type 2 Diabetes Patients on How the Hormone Insulin Acts on Sugar Uptake in Muscles.
The purpose of this study is to investigate the effects of 5 weeks treatment with dapagliflozin in type 2 diabetes patients on how the hormone insulin acts on sugar uptake in muscles.
- Trial name
- DAPAMAAST (NCT03338855)
- Testing
- Dapagliflozin
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- AstraZeneca
Insulin Resistance, Type 2 Diabetes
Aerobic Plus Resistance Training and Insulin Sensitivity in African American Men
The purpose of this study is to investigate the effect of an exercise training intervention on the ability of African American males to use insulin properly. Insulin is a hormone that helps the body use glucose.
- Trial name
- ARTIIS (NCT01787617)
- Testing
- Aerobic Plus Resistance Training Group, Control Group
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Diabetes Mellitus Type 2, Hypovitaminosis D
Diabetes Intervention Trial With Vitamin D in Subjects of Nordic and Sub-Indian Ethnicity
The aim of this 6 months study is to evaluate the metabolic effects of 400.000-600.000 IU of vitamin D supplementation in subjects with type 2 diabetes and hypovitaminosis D.
- Trial name
- DIVINE (NCT00992797)
- Testing
- Cholecalciferol, Orange juice
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital, Aker
Metabolic Syndrome, Obesity
Genistein Stimulates Insulin Sensitivity Through Gut Microbiota
There is evidence that genistein present in soy can improve insulin resistance in rodents and humans with metabolic syndrome (MetS). However, it is not known if this improvement is associated with changes in the gut microbiota.
- Trial name
- GENISTEIN (NCT04105023)
- Testing
- genistein
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Type 2 Diabetes
Surgery Or Lifestyle Intervention for Type 2 Diabetes (SOLID)
This research study will investigate the safety and effectiveness of weight loss surgery for overweight persons with type 2 diabetes.
- Trial name
- SOLID (NCT01040468)
- Testing
- Roux-en-Y Gastric Bypass surgery, Laparoscopic Adjustable Gastric Banding surgery, Intensive Lifestyle Modification
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Pennsylvania
Type 2 Diabetes
Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Type 2 Diabetes Mellitus
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT01663220
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Foundation for the National Institutes of Health