Clinical trials: Insulin Therapy
Type 2 Diabetes
Anti-Diabetic Effect of Gynostemma Pentaphyllum Tea as add-on Therapy With Sulfonylureas in Type 2 Diabetic Patients
The present study aimed at investigating effect of Gynostemma pentapyllum (GP) extract, administered as a "tea", as add-on therapy with Sulfonylurea (SU) in drug-naive patients with newly diagnosed type 2 diabetes.
- Trial name
- NCT00808860
- Testing
- GP group
- Where
- Vietnam
- Volunteers
- 25 people
- Sponsor
- Hanoi Medical University
Type 2 Diabetes
Closed-loop in Adults With T2D Not Requiring Dialysis
The main objective of this study is to determine the efficacy, safety and utility of fully automated closed-loop glucose control in the home setting over an 8 week period in adults with type 2 diabetes (T2D).
- Trial name
- AP-Renal (NCT04701424)
- Testing
- CamAPS HX Closed-loop, Multiple Daily Insulin Injections (Control)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Cambridge
Prediabetic State, Insulin Resistance
Effect of Empagliflozin + Linagliptin + Metformin + Lifestyle in Patients With Prediabetes
Type 2 diabetes is a worldwide epidemic disease, and preventive strategies are needed to face this health problem. The goal of this trial is to evaluate the effect of empagliflozin + linagliptin + metformin + lifestyle on…
- Trial name
- 4T (NCT04131582)
- Testing
- Linagliptin + metformin and Empagliflozin + metformin, Metformin
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- Universidad de Guanajuato
Type 2 Diabetes Mellitus
Therapeutic Effect of Dapagliflozin Combined With CSII on Newly Diagnosed Type 2 Diabetes Mellitus
To compare the effect of dapagliflozin combined with CSII and CSII alone on glucose profile in newly diagnosed type 2 diabetes mellitus by continuous glucose monitoring system.
- Trial name
- NCT04120623
- Testing
- Dapagliflozin 10 MG, Insulin Aspart
- Volunteers
- 100 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Diabetes, Self-Monitoring, Blood Glucose
Insulin Treatment Variation in Southwestern Diabetics
The purpose of this study is to better understand disparities in insulin dosing, hemoglobin A1c, and self-reported patient self-care behaviors among non-Hispanic white, Hispanic, and African American veterans with type 2 diabetes…
- Trial name
- NCT00148304
- Where
- 3 sites in United States
- Volunteers
- 1,248 people
- Sponsor
- VA Office of Research and Development
Cardiovascular Risk Factor, Diabetes Mellitus, Type 2
Evaluation of a Physical Activity Referral Scheme
The study will evaluate the effectiveness of a co-developed exercise referral scheme. Participants will be recruited to one of three groups 1. Co-developed exercise referral scheme, 2. Usual care exercise referral scheme, 3.
- Conditions
- Cardiovascular Risk Factor, Diabetes Mellitus, Type 2, Anxiety, Depression
- Trial name
- NCT03490747
- Testing
- Physical activity referral scheme, Usual care exercise referral scheme
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- Paula Watson
Type 1 Diabetes (T1D)
Introducing Biosimilar Insulin Glargine to the Treatment Regimen of Children and Youth with Type 1 Diabetes in Mali
This study aimed to evaluate the impact on blood glucose control and quality of life in children and youth with type 1 diabetes in Mali by switching the insulin regimen from human insulin via needle and syringe, to long-acting…
- Trial name
- NCT06624943
- Testing
- biosimilar insulin glargine
- Where
- Mali
- Volunteers
- 260 people
- Sponsor
- Life for a Child Program, Diabetes Australia
Type II Diabetes
Safety and Tolerability After Four Weeks of Treatment With AZD1656 in Patients With Type 2 Diabetes
The purpose of this study is to assess the 1 month safety and tolerability after multiple oral doses of AZD1656 in patients with Type 2 Diabetes Mellitus Treated with Insulin
- Trial name
- NCT00856908
- Testing
- AZD1656
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 1
Evaluation of Dose-titration of Pramlintide During Initiation of Therapy in Patients Trying to Improve Glucose Control
This is a randomized, triple-blind, placebo-controlled, multicenter study to investigate the safety of pramlintide treatment using pramlintide dose-titration coupled with insulin adjustments in subjects with type 1 diabetes who…
- Trial name
- NCT00042458
- Testing
- Pramlintide acetate
- Where
- 33 sites in United States
- Volunteers
- 296 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 1
A Study of a New Type of Insulin in Participants With Type 1 Diabetes on Insulin Injection Therapy
The study will be conducted in participants with type1 diabetes on insulin injection therapy to investigate how the body processes a test formulation of insulin lispro and the effect of the test formulation on blood sugar levels.
- Trial name
- NCT02623452
- Testing
- Insulin Lispro
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes Mellitus
The Exploreration of the Management for the Positive IAA in Patients With Type 2 Diabetes After Premix Insulin Therapy
Premix insulin is widely used, with high proportion of positive insulin autoimmune antibody in patients with type 2 diabetes. The positive insulin autoimmune antibody may affect blood glucose control.
- Trial name
- NCT05578352
- Testing
- Add oral hyppoglycemia drug, Add GLP-1 receptor agonist, Change insulin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Type 2 Diabetes Mellitus, Postprandial Hyperglycemia
Effects of Insulin Treatment on Postprandial Platelet Activation in Patients With Non-insulin-dependent Diabetes Mellitus (NIDDM)
The postprandial phase in diabetic patients is characterized by a rapid increase in blood glucose levels, increase in platelet aggregation, LDL oxidation and over production of thrombin.
- Trial name
- NCT00771693
- Testing
- Insulin aspart (Novorapid®)
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Karolinska Institutet
Type 2 Diabets Mellitus
Combination of Glinides With Premixed Insulin
Combination therapy of glinides with premixed insulin provides better glycemic control than premixed insulin alone.
- Trial name
- NCT00369148
- Testing
- nateglinide(drug) mitiglinide(drug)
- Where
- 6 sites in Japan
- Volunteers
- 60 people
- Sponsor
- Keio University
Hypertension, Metabolic Syndrome
Jiangzhuo Qinggan Prescription and Irbesartan in the Treatment of Essential Hypertension(Hepatogastric Damp-heat)Clinical Study
Jangzhuo Qinggan prescription and irbesartan in the treatment of essential hypertension(Hepatogastric Damp-heat), randomized, parallel-controlled, multi-center clinical study.
- Trial name
- JZQG (NCT01082835)
- Where
- 5 sites in China
- Volunteers
- 240 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Diabetes Mellitus, Type 2, Insulin Resistance
Treatment of Type 2 Diabetes Mellitus by Duodenal Exclusion Associated With Omentectomy: Clinical and Hormonal Study
Based in a surgery technique studied in a non-obese diabetic mouse model by Rubino and Marescaux(2004), wich reversed diabetes in those animals, we have performed a previous study in human volunteers with type 2 diabetes and…
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Obesity
- Trial name
- NCT00566215
- Testing
- Duodenal exclusion plus omentectomy, Duodenal exclusion without omentectomy
- Where
- Brazil
- Volunteers
- 6 people
- Sponsor
- University of Campinas, Brazil
Diabetes, Blood Sugar; High
The Effect of Meal Replacement on the Time to Reach the Blood Glucose Target in Patients With Type 2 Diabetes Mellitus
This study was designed as a randomized controlled study. It was planned to include 100 patients with type 2 diabetes who received short-term intensive insulin therapy and randomly divided them into a meal replacement…
- Trial name
- NCT05365152
- Testing
- Meal Replacement
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Metabolic Syndrome (MetS)
Use of a Mobile Application for Tracking Physical Activity in the Management of Metabolic Syndrome in Primary Care
This study will explore whether integrating a mobile app to track physical activity-recommended by family doctors during routine primary care visits-can help individuals with metabolic syndrome become more active.
- Trial name
- IMAFIL (NCT07236450)
- Testing
- Mobile Application and Wearable Device for Physical Activity Monitoring
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Andreia Lobo
HIV Infections
Raltegravir Insulin Sensitivity Study
The purpose of the study is to look at the effects of two different HIV medications on the body's response to insulin (a hormone that regulates blood sugar levels).
- Trial name
- NCT00531999
- Testing
- Raltegravir then lopinavir/ritonavir, Lopinavir/ritonavir then raltegravir
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- St Stephens Aids Trust
Type 2 Diabetes Treated With Insulin
A Randomized Trial Evaluating Control-IQ+ Technology in Adults With Type 2 Diabetes
A randomized controlled trial (RCT) to assess the safety and efficacy of use of Control-IQ+ technology in adults with type 2 diabetes using basal-bolus insulin therapy.
- Trial name
- 2IQP (NCT05785832)
- Testing
- t:slim X2 insulin pump with Control-IQ+ technology and Dexcom G6 CGM, Standard Therapy plus continuous glucose monitoring (CGM)
- Where
- 21 sites in United States, Canada
- Volunteers
- 319 people
- Sponsor
- Tandem Diabetes Care, Inc.
Type 1 Diabetes
Glycaemic Load and Pre-meal Insulin Doses in Type 1 Diabetes Patients
The aim of this study is to compare the feasibility and the efficacy on short-term glucose control of pre-meal insulin doses adjustment made on the bases of the glycemic load or of the carbohydrates content of the meal in…
- Trial name
- GLUT (NCT01978704)
- Testing
- Adjustment of pre-prandial insulin doses on the bases of glycaemic load of the meal, Adjustment of pre-prandial insulin doses on the bases of carbohydrates content of the meal
- Volunteers
- 9 people
- Sponsor
- Federico II University