Clinical trials: Insulin-Dependent Diabetes Mellitus
Cardiovascular Diseases, Heart Diseases
Physical Activity, Hypertension, Diabetes, and Coronary Heart Disease
To study the influences of physical activity on the incidence of hypertension, non-insulin-dependent diabetes (NIDDM), and coronary heart disease (CHD), taking into account the influences of other life-style elements such as body…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Diabetes Mellitus, Coronary Disease
- Trial name
- NCT00005419
- Sponsor
- Stanford University
Type 1 Diabetes
Genome-wide Association Study of Different Types of Diabetes and Construction of Genetic Risk Score
To enhance the genetic profile of T1D patients in China and construct a Chinese-specific GRS and evaluated its ability to differentiate between T1D and controls, as well as between T1D and T2D.
- Trial name
- NCT06791330
- Volunteers
- 7,000 people
- Sponsor
- Second Xiangya Hospital of Central South University
Type 1 Diabetes Mellitus
Effect of Dietary Carbohydrate Content and Inulin-Fructooligosaccharide Supplementation on Glycemic Control in Individuals With Type 1 Diabetes Mellitus
Diabetes is a chronic metabolic disease in which nutrients such as carbohydrates, fats and proteins cannot be utilized sufficiently due to the inability to produce insulin or defects in the effect of the produced insulin.
- Trial name
- NCT07673523
- Testing
- fructooligosaccharide and inulin, Dietary carbohydrate 30%, Dietary carbohydrate 50-55%
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Type 1 Diabetes, Type 1 Diabetes (T1D)
Study of IMC-S118AI in Type 1 Diabetes
This is a first-in-human (FIH) study designed to assess the safety, tolerability, and pharmacokinetic (PK) profile of IMC-S118AI in single-ascending dose (SAD) and multiple-ascending dose (MAD) regimens.
- Conditions
- Type 1 Diabetes, Type 1 Diabetes (T1D), Diabetes Type 1
- Trial name
- NCT07493122
- Testing
- IMC-S118AI
- Volunteers
- 154 people
- Sponsor
- Immunocore Ltd
Diabetes, Diabetes Mellitus, Type 1
Safety of Inhaled Human Insulin in Subjects With Diabetes Mellitus and Chronic Obstructive Pulmonary Disease (COPD)
This trial is conducted in Europe, Asia and South America. A one-year clinical trial to compare the safety of inhaled human insulin to subcutaneous insulin aspart in subjects with type 1 or type 2 diabetes and chronic obstructive…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Chronic Obstructive Pulmonary Disease
- Trial name
- iINHALE 8 (NCT00472953)
- Testing
- inhaled human insulin, insulin aspart
- Where
- 27 sites in Argentina, India and 5 more
- Volunteers
- 38 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Rituximab in New Onset Type 1 Diabetes
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks the insulin-producing beta cells in the pancreas.
- Trial name
- TN05 (NCT00279305)
- Testing
- Anti-CD20 (rituximab)
- Where
- 16 sites in United States, Australia and 2 more
- Volunteers
- 87 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Non-Insulin-Dependent
Safety and Efficacy of INGAP-Peptide in Patients With Type 2 Diabetes
Insulin is a chemical that the body needs in order to use or store sugar. It is made by a type of cell called a beta cell which resides in an organ known as the pancreas.
- Trial name
- NCT00071422
- Testing
- INGAP-Peptide
- Where
- 17 sites in United States
- Volunteers
- 126 people
- Sponsor
- Exsulin Corporation
Diabetes, Diabetes Mellitus, Type 1
A Trial to Assess the Efficacy and Safety of BioChaperone Combo and Humalog Mix 25 in Subjects With Type 1 Diabetes
BioChaperone Combo is a liquid formulation containing both Insulin Glargine and Insulin Lispro. The aim of this trial is to assess the efficacy and safety of BioChaperone® Combo in subjects with type 1 diabetes under a dose of…
- Trial name
- NCT01981031
- Testing
- BioChaperone® Combo, Humalog® Mix25
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- Adocia
Diabetes Mellitus, Type 1
Bioavailability, Biopotency and Food Effect Study of SCD0503 Compared to Subcutaneous Regular Human Insulin
Reason for the study The participants have been diagnosed with type 1 diabetes and are being treated with standard insulin therapy.
- Trial name
- NCT07634770
- Testing
- oral insulin, subcutaneous insulin
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Sam Chun Dang Pharm. Co. Ltd.
Type1 Diabetes Mellitus
Safety and Efficacy of BC LisPram
This pilot study is a 50-hour randomized, open-label, crossover study in an inpatient setting assessing the safety, pharmacodynamics, pharmacokinetics, and closed-loop efficacy of i) BC LisPram delivery and ii) rapid insulin…
- Trial name
- NCT04972175
- Testing
- 50-Hour Intervention - Rapid Insulin lispro, 50-Hour Intervention - BC LisPram
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Michael Tsoukas
Diabetes
The Different Response of Endocrine Hormones to Hypoglycemia in Patients With Type 1 or Type 2 Diabetes
Endocrine hormones, not only blood glucose responsive hormones, but also sexual hormones, thyroid hormones, growth hormones and so on, may have response and activites in hypoglycemia.
- Trial name
- NCT05290207
- Testing
- The hyperinsulinaemic hypoglycaemic clamp
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Type 1 Diabetes
The Separate and Combined Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Subjects With and Without Type 1 Diabetes
The hormone glucose-dependent insulinotropic polypeptide (GIP) is naturally produced in the intestine during a meal and stimulates insulin secretion from the pancreas.
- Trial name
- GIPALANIN (NCT06881472)
- Testing
- Glucose-dependent Insulinotropic Polypeptide (GIP), alanine
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Asger Lund, MD
Esophageal Cancer
Study of Anti-PD-L1 in Combination With Chemo(Radio)Therapy for Oesophageal Cancer
This is an open-label, Phase 1/2 study to evaluate the safety of durvalumab (MEDI4736) in combination with oxaliplatin/capecitabine chemotherapy in metastatic/locally advanced oesophageal cancer (OC) and with neoadjuvant…
- Trial name
- NCT02735239
- Testing
- Durvalumab, Tremelimumab, Oxaliplatin
- Where
- 4 sites in United Kingdom
- Volunteers
- 73 people
- Sponsor
- Ludwig Institute for Cancer Research
Type 1 Diabetes
Happy Bob App: A Preliminary Evaluation of Its Use in Youth With Diabetes
The goal of this clinical trial is to evaluate the impact of peer support via the Happy Bob phone app in youth with Type 1 Diabetes.
- Trial name
- NCT06412601
- Testing
- RPM, app
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Diabetes Mellitus, Type 1
Interventions to Prevent Adolescents With Type 1 Diabetes From Long-term Complications
The purpose of this study is to evaluate the effectiveness of diabetes management training combined with the method of Motivational Interviewing with elements of Cognitive Behaviour Therapy and E-mail support in the treatment of…
- Trial name
- NCT01520428
- Testing
- Motivational Interviewing, CBT and E-mail support
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Type 1 Diabetes, Type 2 Diabetes
To Evaluate the Efficacy and Safety of the Insulin Patch Pump System in Patients With Diabetes.
Patients will be enrolled and randomly assigned to either the test group or the control group for short-time intensive insulin therapy in inpatient setting.
- Trial name
- NCT07403565
- Testing
- Insulin Patch Pump System, Minimed 700
- Where
- 5 sites in China
- Volunteers
- 161 people
- Sponsor
- Suzhou Hechun Medical Technology Co., Ltd.
Diabetes, Diabetes Mellitus, Type 1
Efficacy and Safety of Biphasic Insulin Aspart 30 in Type 1 or 2 Diabetes
This trial is conducted in Asia. The aim of this trial is to investigate the efficacy of biphasic insulin aspart 30 on postprandial glycaemic control.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00617565
- Testing
- biphasic insulin aspart, biphasic human insulin
- Where
- 6 sites in China
- Volunteers
- 219 people
- Sponsor
- Novo Nordisk A/S
LRBA Deficiency, CTLA4 Haploinsufficiency
New Biomarkers for Diagnosis and Follow-up of Patients With LRBA or CTLA4 Deficiencies
Primary immune deficiencies (PID) are a group of chronic diseases characterized by recurrent infections. Apart from recurrent infections, in some of PIDs autoimmunity, allergy or malignancy could be accompanied to the diseases.
- Trial name
- NCT04377867
- Testing
- Abatacept Injection [Orencia]
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marmara University
Type 1 Diabetes
Assessment of Beta Cell Mass by PET Scans With [11C] Dihydrotetrabenazine (DTBZ) in Longstanding Type 1 Diabetes.
We hypothesize that quantitative measurements of the beta cell mass within the endocrine pancreas can be obtained by PET via targeting of vesicular monoamine type 2 transporters with the radioligand [11C]DTBZ.
- Trial name
- NCT00738907
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes type1, Diabetes Mellitus, Type 1
Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART
This study is designed to compare two behavioral approaches to reduce diabetes distress ("the expected burdens, concerns, fears, and threats that arise from the challenges of living with diabetes") in adults with type 1 diabetes.
- Conditions
- Diabetes type1, Diabetes Mellitus, Type 1, Diabetes, Autoimmune, Diabetes Mellitus
- Trial name
- ChargeUp (NCT06405373)
- Testing
- ReCharge, TakeCharge
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of North Carolina, Chapel Hill
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