Clinical trials: Insulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type 1, Metabolic Disorder
A Telematic Program for Optimization of Metabolic Control in Diabetes Mellitus Type 1 (DM1) Patients
A greater visit frequency between the diabetes mellitus 1 (DM1) patient and the medical team increases the possibilities to improve metabolic control. The support of telematic visits can support the patient and the health system.
- Trial name
- NCT01337141
- Testing
- Control, Telecare system
- Where
- 5 sites in Spain
- Volunteers
- 154 people
- Sponsor
- Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders
Nephropathy, Hypoxia
Acute Effects of SGLT2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes
Background: Inhibiting the sodium-glucose cotransporter-2 (SGLT2) has been observed to reduce risk of cardiovascular events and kidney failure in type 2 diabetes.
- Conditions
- Nephropathy, Hypoxia, Mitochondrial Alteration, Type 1 Diabetes
- Trial name
- Astronaut (NCT04193566)
- Testing
- Forxiga
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes
Technology Knowledge Optimization in Type 1 Diabetes (TeKnO T1D): Parents
This study aims to identify the unmet psychoeducational needs of parents of children 8-12 years of age using insulin pump and CGM for pediatric T1D management and to leverage that information to develop an innovative app-based…
- Trial name
- TeKnO T1D (NCT05300022)
- Testing
- TeKnO T1D: Parents
- Where
- United States
- Sponsor
- Children's Hospital of Philadelphia
Type 1 Diabetes
Healthy And Positive Pathways for Young People With Type 1 Diabetes (HAPPY T1D)
In this 2-year randomized clinical trial, we will implement and assess the impact of a behavioral/psychoeducational intervention to reduce diabetes distress and improve glycemic outcomes in adolescents and young adults, aged…
- Trial name
- NCT05413239
- Testing
- Psychoeducation to reduce diabetes distress and improve glycemic outcomes
- Where
- 2 sites in United States
- Volunteers
- 217 people
- Sponsor
- Joslin Diabetes Center
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Chronotype of Patients With Diabetes and Effect on Glycaemic Control
The aim of this study is to explore the associations between chronotype and glycaemic control, cardiometabolic health and other lifestyle factors.
- Trial name
- CODEC (NCT02973412)
- Where
- United Kingdom
- Volunteers
- 3,447 people
- Sponsor
- University of Leicester
Type1 Diabetes
Yale-Harvard Hotel-based Closed-Loop Studies in Children (HY-GRAID)
The aim of this clinical study is to determine the feasibility, safety, and preliminary effectiveness of the Zone-Model Predictive Control Artificial Pancreas (ZMPC_AP) system in pediatric subjects with type 1 diabetes in an…
- Trial name
- HY-GRAID (NCT04255381)
- Testing
- Zone-Model Predictive Control Artificial Pancreas (ZMPC_AP)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Type 1 Diabetes, Type 2 Diabetes
Blood Glucose Differences Using CGMs Between the Left and Right Arm in Patients With Diabetes
There are multiple CGMs that are FDA approved. However, there are few studies looking at the variability of measurements between the left and right arm, and none looking at this effect in diabetic patients.
- Trial name
- NCT05849428
- Testing
- Freestyle Libre 3
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of the Pacific
Type 1 Diabetes
Glucose Variability in Type 1 Diabetes (T1D) and Glycaemic Responses to Food Composition.
The study proposed to recruit approximately 435 children and young people who have T1D and who regularly use Dexcom continuous glucose monitoring (CGM). Recruitment was be via their local dietitian.
- Trial name
- NCT06546657
- Testing
- Breakfast
- Where
- United Kingdom
- Volunteers
- 96 people
- Sponsor
- University of Stirling
Diabetes Mellitus, Type 1
Feasibility Study of Extended Wear Insulin Infusion Set Options During Home Use in People With Type 1 Diabetes
This feasibility study is a prospective, single center, multi-arm study evaluating possible enhancements to the SteadiSet extended wear infusion set.
- Trial name
- NCT07325461
- Testing
- SteadiSet Infusion Set
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tandem Diabetes Care, Inc.
Diabetes Mellitus, Type 1
Joint Application of Human Insulin and Rapid Insulin Analogue in Control of Postprandial Glycemia
Postprandial glycemic control is essential for diabetes compensation. Insulin pump therapy control blood glucose released in response to both high and low glycemic index carbohydrates in a mixed diet using normal, square and…
- Trial name
- CPIT (NCT01088451)
- Testing
- Combined prandial insulin therapy (CPIT)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- University Hospital Hradec Kralove
Diabetes Mellitus, Type 1, Hypertension
Correlation of Flicker Induced and Flow Mediated Vasodilatation in Patients With Endothelial Dysfunction and Healthy Volunteers.
A couple of studies have shown that illuminating the eye with diffuse flickering light is accompanied by an increase of retinal vessel diameters, optic nerve head blood flow and retinal blood flow.
- Conditions
- Diabetes Mellitus, Type 1, Hypertension, Hypercholesterolemia, Regional Blood Flow
- Trial name
- NCT00432029
- Testing
- Forearm blood flow measurement, Flow mediated dilation (FMD), Zeiss Retinal Vessel Analyzer (RVA), Stimulation with Flicker-light
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Type 1 Diabetes Mellitus
Continuous Subcutaneous Insulin Infusion Versus Multiple Dose Insulin Injections in Routine Clinical Practice
Observational study about effectiveness and safety of continuous subcutaneous insulin infusion compared to multiple dose insulin injections in Type 1 Diabetes Mellitus (T1DM) adult patients in routine clinical practice.
- Trial name
- real-ECIMI (NCT03793283)
- Testing
- CSII, Multiple dose insulin injections
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Castilla-La Mancha Health Service
Type1 Diabetes Mellitus
The International Diabetes Closed Loop (iDCL) Trial: Protocol 1
The objective of the study is to assess the efficacy and safety of home use of a Control-to-Range (CTR) closed-loop (CL) system.
- Trial name
- iDCL (NCT02985866)
- Testing
- Artificial Pancreas, Sensor Augmented Therapy
- Where
- 7 sites in United States
- Volunteers
- 127 people
- Sponsor
- University of Virginia
Diabetes Type 1
A Study of LY900014 and Insulin Lispro With an External Continuous Subcutaneous Insulin Infusion System in Adult Participants With Type 1 Diabetes
The purpose of this study is to evaluate the compatibility and safety of LY900014 and insulin lispro with an external continuous subcutaneous insulin infusion system in adult participants with type 1 diabetes.
- Trial name
- PRONTO-Pump (NCT03433677)
- Testing
- LY900014, Insulin lispro
- Where
- 5 sites in United States, Spain
- Volunteers
- 49 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus
Measurement Algorithm Control and Optimization With Subsequent Performance Evaluation of Sanmina Non-invasive Biosensors During a Standardized Meal Test in Patients With Diabetes Mellitus Type 1 and Type 2
Measurement algorithm control and optimization with subsequent performance evaluation of Sanmina biosensors in monitoring of glucose, heart rate (HR), and SpO2 in patients with type 1 and type 2 diabetes during a standardized…
- Trial name
- NCT04379427
- Testing
- Sanmina Biosensor
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sciema UG
Diabetes Mellitus, Type 1, Diabetes Mellitus
Evaluation of a Flash Glucose Monitoring System in Ambulatory Patients With Type 1 Diabetes
To evaluate the accuracy of the Flash Glucose Monitoring system (FGM), Abbot FreeStyle Libre, used today in clinical practice in Sweden in estimating plasma glucose levels.
- Trial name
- NCT02677454
- Testing
- Flash Glucose Monitor
- Where
- Sweden
- Volunteers
- 56 people
- Sponsor
- Vastra Gotaland Region
Type 1 Diabetes
Evaluation of Long-Term Implanted Sensor in Patients on Quality of Life
Evaluation of Long-Term Implanted Sensor in Patients on Quality of life
- Trial name
- NCT04161651
- Testing
- eversense
- Volunteers
- 22 people
- Sponsor
- Meir Medical Center
Type 1 Diabetes Mellitus
Endothelial Dysfunction and Diabetes
The aim of the study is to progress in the understanding of the early retinal vascular and neural abnormalities in patients with diabetes, using a new device, the Dynamic Vessel Analyzer.
- Trial name
- DENDI (NCT01097551)
- Testing
- Trinitrin, Neosynephrine 10% collyrium, Iontophoresis with acetylcholine delivery
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Celiac Disease in Children, Diabetes Mellitus, Type I
Auto-antibody Dosage From Blood Spots for Diagnosis of Type 1 Diabetes and Celiace Disease
Early diagnosis of type 1 diabetes and celiac disease is very useful, allows early therapy and prevents deaths from the onset of diabetic ketoacidosis.
- Conditions
- Celiac Disease in Children, Diabetes Mellitus, Type I, Screening
- Trial name
- CELDI (NCT06849622)
- Testing
- Test on blood sample, Test on dried blood sample
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Meyer Children's Hospital IRCCS
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 15 Weeks in Adolescents and Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02846857
- Testing
- 15-week intervention with sensor-augmented pump, 15-week intervention with single-hormone closed-loop, 15-week intervention with dual-hormone closed-loop
- Sponsor
- Institut de Recherches Cliniques de Montreal
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